EP1720495B1 - Magenballon mit verbessertem formmittel und erhöhter mechanischer festigketi - Google Patents

Magenballon mit verbessertem formmittel und erhöhter mechanischer festigketi Download PDF

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Publication number
EP1720495B1
EP1720495B1 EP05729308A EP05729308A EP1720495B1 EP 1720495 B1 EP1720495 B1 EP 1720495B1 EP 05729308 A EP05729308 A EP 05729308A EP 05729308 A EP05729308 A EP 05729308A EP 1720495 B1 EP1720495 B1 EP 1720495B1
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EP
European Patent Office
Prior art keywords
intragastric balloon
outer envelope
balloon according
inflation chamber
balloon
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
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EP05729308A
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English (en)
French (fr)
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EP1720495A2 (de
Inventor
Pascal Paganon
Jean-Paul Gilbert Ricol
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Compagnie Europeenne dEtude et de Recherche de Dispositifs pour lImplantation par Laparoscopie SA
Original Assignee
Compagnie Europeenne dEtude et de Recherche de Dispositifs pour lImplantation par Laparoscopie SA
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Priority to PL05729308T priority Critical patent/PL1720495T3/pl
Publication of EP1720495A2 publication Critical patent/EP1720495A2/de
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Publication of EP1720495B1 publication Critical patent/EP1720495B1/de
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/0003—Apparatus for the treatment of obesity; Anti-eating devices
    • A61F5/0013—Implantable devices or invasive measures
    • A61F5/003—Implantable devices or invasive measures inflatable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/0003—Apparatus for the treatment of obesity; Anti-eating devices
    • A61F5/0013—Implantable devices or invasive measures
    • A61F5/0036—Intragastrical devices

Definitions

  • the present invention relates to the general technical field of implantable devices in the human body intended to be used in the context of a treatment of obesity, and in particular of morbid obesity, and more particularly to implants able to reduce artificially the volume of the stomach in particular to produce a feeling of satiety in the patient.
  • the present invention relates to an expandable intragastric balloon intended to be implanted in the stomach of a patient as part of a treatment of obesity, and having an outer envelope sufficiently flexible to move from a configuration to reduced volume to an expanded configuration conferring the balloon its functional form.
  • the intragastric balloons used for the treatment of obesity are generally in the form of a flexible bag, forming the outer envelope of the balloon, and may be filled, once the ball implanted inside the the stomach, with an inflation fluid, in particular air, to give the balloon its functional form, that is to say a volume and a form of use that allow it to occupy a large part of the space available for food.
  • the French request FR-2834202 shows an example of intra-gastric balloon composed of different bags, each being capable of being filled by an inflation fluid.
  • the known intragastric balloons often have a certain porosity, which will allow the progressive leakage of the fluid contained in the balloon (gas or liquid), and cause the gradual decrease in the volume of the balloon, and therefore the therapeutic efficacy of this last.
  • the volume of the balloon no longer corresponds to the desired volume for the treatment of obesity, it no longer creates the feeling of satiety desired in the patient.
  • the decrease of the volume of the balloon may cause the passage of the balloon through the pylorus in the intestinal tract, which can cause severe complications in the patient.
  • the properties or characteristics of the intragastric balloon such as its tightness, responsible for maintaining the balloon in its functional configuration over time, therefore appear as essential parameters whose control can improve the effectiveness of the therapeutic treatment.
  • the intragastric balloons generally encountered also suffer from a certain fragility, which comes in particular from the fact that the pocket containing the gas (or the liquid) for inflation also forms the outer envelope of the balloon. Said pocket is therefore directly subjected to external aggressions, which increases the risk of perforation, especially when the ball is handled by the practitioner.
  • the objects assigned to the invention are therefore intended to remedy the various disadvantages listed above and to propose a new expandable intragastric balloon for the treatment of obesity not having the disadvantages listed above and which, once positioned within of the stomach in its functional configuration, presents very small variations of volume over time.
  • Another object of the invention is to propose a novel intra-gastric balloon whose sealing is improved, and whose losses of inflation fluid, in particular gas, are limited, thereby increasing the therapeutic effectiveness of the balloon.
  • Another object of the invention is to propose a new intragastric balloon which, while having good elasticity properties, is sufficiently resistant and mechanically protected from external aggression.
  • Another object of the invention is to propose a new intragastric balloon whose shaping and expansion are particularly simplified and fast.
  • Another object of the invention is to propose a new intragastric balloon which, although having a significant volume, is sufficiently light, atraumatic and well supported by the patient.
  • the intragastric balloon 1 according to the invention is intended to be implanted in the stomach of a patient as part of a treatment for obesity.
  • the intragastric balloon 1 is expandable and comprises for this purpose an outer casing 2 which is sufficiently flexible to change from a reduced volume configuration (illustrated in FIG. 2) to an expanded configuration (illustrated on FIG. figure 1 ).
  • the reduced volume configuration may for example correspond to a configuration in which the balloon 1 is in a folded position occupying a reduced volume, facilitating the introduction of the balloon 1 into the esophagus.
  • Implantation of the intragastric balloon 1 in accordance with the invention is in fact generally performed, in a conventional manner and well known to those skilled in the art, by passage into the oesophageal oral passages in its folded, compressed or loose form.
  • the expansion, placement and release of the balloon occur at the end of the gastro-endoscopic operation, when the intragastric balloon 1 is properly positioned in the patient's stomach.
  • the balloon 1 in its expanded configuration that the balloon 1 will be able to occupy a non-negligible volume in the gastric cavity (no shown), the so-called expanded configuration then conferring the balloon its functional form.
  • the intragastric balloon 1 by occupying part of the internal volume of the stomach, the intragastric balloon 1 according to the invention makes it possible to create in the patient a rapid sensation of satiety, which is accompanied by a decrease in the quantity of food ingested.
  • the intragastric balloon 1 comprises shaping means 3 of the outer casing 2.
  • shaping means 3 are structurally integrated with the balloon, that is to say that they are part of the balloon before it is even implanted within the gastric cavity. More specifically, the shaping means 3 are integrated in the balloon 1 during its manufacture, thus forming part of the functional components of the balloon.
  • the shaping means 3 are dimensioned to exert a stress on the outer casing 2 of intensity substantially greater than the resistance force that can be opposed by said outer casing 2.
  • the outer envelope 2 designates the outer wall of the intragastric balloon 1, delimited internally by an inner surface 2I and externally by an outer surface 2 E forming the contact surface of the balloon 1 with the stomach .
  • the shaping means 3 are configured and adapted to exert a substantially normal and centrifugal stress on the outer casing 2, so as to push the latter according to the arrows F1 to F6 shown in FIG. figure 1 in such a way that the stress is exerted on substantially the entire inner surface 2I of the outer shell 2, that is to say substantially in all directions of the space.
  • the shaping means 3 are independent of the outer casing 2, and adapted to occupy an increasing volume within the outer casing 2 so as to generate the deployment of the latter. More specifically, the shaping means 3 are mainly disjoint from the outer casing 2, so that when the balloon 1 is in an unexpanded or folded configuration, illustrated in FIG. 2, the shaping means 3 are not necessarily in contact with the outer shell 2 over the entire inner surface 2I of the latter.
  • the shaping means 3 are thus mounted within the outer casing 2 with a possibility of mobility relative to the latter.
  • the shaping means 3 are thus adapted to occupy a sufficient volume within the outer casing 2 so that the latter can reach its expanded configuration.
  • the shaping means 3 have flexibility and elasticity properties, which are particularly advantageous in the present field of application.
  • the shaping means may advantageously be formed by a viscoelastic memory foam, having elastic return properties in the centrifugal direction sufficient to deploy the outer envelope of the balloon, when the latter is in an initial configuration at reduced volume within the stomach.
  • the shaping means 3 are formed by an inflation chamber 4 different from the outer casing 2, and disposed inside the latter so as to ensure the shaping of said outer casing 2 by introducing an inflation fluid into said inflation chamber. 4.
  • inflation chamber here designates an inflatable member, mounted inside the outer casing 2, and delimiting an internal volume that can be filled with an inflation fluid.
  • the inflation chamber 4 and the outer casing 2 are mainly disjoint, and are connected or secured at a connection means 10, of the valve type, allowing the connection of the inflation chamber 4 to a fluid reservoir, for fill the inflation chamber 4.
  • the inflation chamber 4 is thus capable of being actuated by inflation using a fluid such as a gas (or a liquid). As inflation proceeds, the inflation chamber 4 will thus expand and exert a stress on the outer shell 2, precisely on the inner surface 21 of the latter, tending to repel it in the centrifugal direction, such as this is represented on the figure 1 by the arrows F1 to F6, until the outer envelope 2 reaches its expanded and functional configuration.
  • a fluid such as a gas (or a liquid).
  • the inflation chamber 4 and the outer casing 2 are thus shaped so that during the inflation operation, the outer casing 2 exerts only a small resistance with respect to the pressure exerted on its inner surface 2I. by the inflation chamber 4.
  • the inflation chamber 4 thus constitutes a tight barrier between the inflation fluid that it contains and the outer casing 2, preventing the inflation fluid from migrating to the outer casing 2 of the balloon 1, whose sealing is lower. the inflation chamber 4.
  • the outer casing 2 being separate and independent of the shaping means 3, in particular of the inflation chamber 4, it is capable of effectively ensuring the mechanical protection of the latter.
  • the outer shell 2 will preferably be made from flexible materials, elastic and having good strength properties.
  • the inflation chamber 4 and the outer casing 2 are shaped so that, when the inflation chamber 4 occupies its expanded position, the outer casing 2 substantially matches the shape of said inflation chamber 4.
  • the inflation chamber 4 may be overinflated, that is to say filled with a quantity of fluid substantially greater than the amount of fluid that it is normally able to contain without undergoing deformation or elastic extension of its wall.
  • the inflation chamber 4 and the outer casing 2 are shaped so that during the inflation operation, a slight clearance remains between the outer surface 4E of the inflation chamber and the inner surface 2I of the casing external 2, this clearance J being sufficient to allow some relative mobility between the inflation chamber 4 and the outer casing 2.
  • the inflation chamber 4 is formed by an internal pocket 5 sufficiently flexible to move from a reduced volume position to an expanded position.
  • the inner bag 5 is preferably formed by an elastomeric material having sufficient elasticity to allow an over inflation of said inner bag 5.
  • the inflation chamber 4, specifically the inner bag 5, is intended to be filled with a gas forming the inflation fluid.
  • the inflation fluid could be a liquid and without departing from the scope of the invention.
  • the intragastric balloon 1 thus forms, with the inflation chamber 4 (or inner bag 5) and the outer casing 2, constituting an external pocket, a double bag balloon.
  • the inner bag 5 is delimited by a wall 6, which is distinct and mainly dissociated from the outer shell 2, comprising at least one screen that is substantially impervious to gases, in order to improve the overall tightness of the balloon.
  • the wall 6 can thus advantageously be formed by a multilayer film, the screen thus forming one of the layers of the film, or by a single-layer film, in which case the screen forms the single layer of the film.
  • the screen comprises in its composition at least one gas barrier polymer.
  • gas barrier polymer denotes polymers having a gas permeability significantly lower than that of silicone, and in particular an oxygen permeability (O 2 ) of less than approximately 10 times that of silicone.
  • the screen can thus be composed of one or more thermoplastic polymers with a gas barrier effect, such as ethylene vinyl alcohol (EVOH), polyvinylidene chloride (PVDC), polyacrylonitrile (PAN), polyamide ( PA), bi-oriented polyamide, polyethylene terephthalate (PET), bi-oriented polyethylene terephthalate, and elastomeric thermoplastic polyurethane.
  • EVOH ethylene vinyl alcohol
  • PVDC polyvinylidene chloride
  • PAN polyacrylonitrile
  • PA polyamide
  • bi-oriented polyamide polyethylene terephthalate
  • PET polyethylene terephthalate
  • elastomeric thermoplastic polyurethane elastomeric thermoplastic polyurethane
  • the inner bag 5 is formed by one or more film (s), for example two films of thermoplastic elastomer polyurethane, said films being able to be joined together, for example by gluing, or movable by compared to others.
  • film for example two films of thermoplastic elastomer polyurethane
  • Polyurethane has, among other interesting properties, a low stickiness effect, facilitating folding, and also shape memory properties.
  • the permeability to oxygen (O 2 ) of the polyurethane is of the order of 350 cm 3 .60 ⁇ m / m 2 . 24h. bar at 1600 cm 3 .100 ⁇ m.m 2 .24h.1bar, while the permeability of the silicone is of the order of 130 000 cm 3 . 100 ⁇ m / m 2 . 24h. bar (measured at 37 ° C and 90% relative humidity).
  • Such a material also has elastic properties allowing an over-inflation of the inner bag 5, while offering a satisfactory mechanical strength.
  • the inflation chamber 4 is adapted to present, in its expanded position, a substantially spherical shape.
  • the inner bag 5 is preferably manufactured using a heat-sealing, heat-sealing or thermoforming process. More specifically, the method of manufacturing the inner bag 5 comprises an assembly step, during which is assembled, by welding or gluing, along a peripheral weld line, one or more sheets (for example two sheets ) of predetermined shape of material substantially impervious to gases, such as elastomeric thermoplastic polyurethane, previously shaped, for example by thermoforming, so as to give them a hemispherical shape.
  • gases such as elastomeric thermoplastic polyurethane
  • Each sheet may be formed by a single polyurethane film, but is preferably formed by several, and for example, two superimposed polyurethane films, said films being able to be joined together, for example by gluing, or movable relative to one another .
  • the outer envelope 2 is in turn preferably carried out using an injection molding process.
  • the inflation chamber 4 and the outer casing 2 are substantially concentric and spherical, the spherical shape of the outer casing 2 thus conferring on the intragastric balloon 1 atraumatic character.
  • the outer envelope is formed by a bio-compatible material that can be well supported by the patient.
  • the outer casing 2 may be formed by an elastomeric material, of the silicone type, such a material having in particular advantageous elastic properties and mechanical strength.
  • the outer casing 2 advantageously has properties of radiological opacity.
  • the silicone used to form the outer shell 2 is advantageously colored white by treatment with barium sulfate.
  • the thickness of the inner bag 5 will be less than the thickness of the outer shell 2, the latter then providing a mechanical protection function relative to the inner bag 5, limiting the risk of damage and / or perforation of said internal pocket 5.
  • the design of the balloon 1 according to the invention makes it possible to use two different materials to produce the inner pocket 5 and the outer shell 2, and also to make an internal pocket 5 of particularly small thickness, which allows in particular to limit the space occupied by the balloon 1 when it is in its reduced volume configuration to be implanted in the stomach of a patient.
  • the outer casing 2 of parylene.
  • the inflation chamber 4 may also be covered with parylene.
  • Such a measure also has the advantage of reducing the sticky effect of the silicone.
  • the intragastric balloon 1 comprises weighting means formed by solid and dense bodies 8, preferably made of tungsten, intended to substantially weigh down the balloon 1.
  • the balloon 1 may have a tendency to go up in the upper part of the stomach and hinder the penetration of food into the gastric cavity.
  • weighting means thus improves the positioning of the balloon 1 in the stomach and at the same time eliminate a significant source of discomfort for the patient.
  • the solid and dense bodies 8 are connected to each other by portions of threads 9, so as to form a chain, which is advantageously disposed inside the inflation chamber 4 and preferably attached to the valve 10.
  • the intragastric balloon 1 Before implantation, the intragastric balloon 1 according to the invention is preferably in a folded form, or compressed, so as to facilitate its introduction and its passage into the oral pathways of the patient, and in particular the esophagus.
  • the balloon 1 can advantageously be folded into a holding bag, intended to facilitate the implantation of the balloon.
  • the balloon is introduced, with its cover, into the gastric cavity and then released, and the cover is removed.
  • the intragastric balloon 1 must undergo several operations on the part of the practitioner in order to make it functional, that is to say to give it a sufficient volume for it occupies part of the space of the gastric cavity reserved for food.
  • the practitioner connects, for example with the aid of a catheter extended by an inflation needle, the valve 10 to a source of fluid, preferably air, to inflate the inflation chamber 4.
  • a source of fluid preferably air
  • This operation has the effect to allow the expansion of said inflation chamber 4, which will come to exert a stress on the outer casing 2 tending to push it gradually in the centrifugal direction along the arrows F1 to F6.
  • the practitioner can remove from the body of the patient all the equipment necessary for inflation, namely the catheter and the inflation needle, this operation having the effect of releasing the balloon.
  • the system formed by the association of the inflation chamber 4 with the outer casing 2 thus has several characteristics in common with the conventional air-tire pair, particularly in terms of flexibility and elasticity, but also in terms of mechanical strength. and protection of the system vis-à-vis external aggressions.
  • the intragastric balloon 1 according to the invention is therefore advantageously designed to retain its functional form and its volume over time and this, even though the outer casing 2 could deteriorate gradually.
  • Another advantage of the intragastric balloon according to the invention is that it has particularly advantageous mechanical strength properties, in particular thanks to the outer casing 2 forming a means of mechanical protection of the balloon.
  • Another advantage of the intragastric balloon 1 according to the invention is that it has an improved seal compared to known balloons.
  • Another advantage of the intragastric balloon 1 according to the invention is that it is sufficiently robust to allow easy manipulation by the practitioner.
  • the invention finds its industrial application in the design and manufacture of implantable devices for combating obesity.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Nursing (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Toys (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Claims (18)

  1. Expandierbarer intragastraler Ballon, der dazu vorgesehen ist, in den Magen eines Patienten im Rahmen einer Behandlung von Fettleibigkeit implantiert zu werden, und eine äußere Hülle (2) enthält, die ausreichend nachgiebig ist, um von einer Konfiguration mit verringertem Volumen in eine expandierte Konfiguration überzugehen, die dem Ballon (1) seine funktionale Form verleiht, wobei der Ballon außerdem Mittel (3) zum Formen der äußeren Hülle (2) enthält, wobei diese Formgebungsmittel (3) von der äußeren Hülle (2) unabhängig und getrennt sind und strukturell in den Ballon (1) integriert sind und von der äußeren Hülle (2) hauptsächlich getrennt sind, wobei die Formgebungsmittel (3), sobald der Ballon (1) implantiert ist, betätigt werden können, um einerseits auf die äußere Hülle (2) einen ausreichenden Steuerdruck auszuüben, um sie zu einem Entfalten zu drängen, und um andererseits innerhalb der äußeren Hülle (2) ein Volumen einzunehmen, das ausreicht, um das Entfalten der äußeren Hülle (2) aus ihrer Konfiguration mit verringertem Volumen in ihre expandierte Konfiguration sicherzustellen, dadurch gekennzeichnet, dass die Formgebungsmittel (3) durch eine von der äußeren Hülle (2) verschiedene Aufblaskammer (4) gebildet sind, die in dieser Letzteren in der Weise angeordnet sind, dass ihre Formung durch Einleiten eines Aufblasfluids in die Aufblaskammer (4) sichergestellt ist, und dass die Aufblaskammer (4) und die äußere Hülle (2) aneinander angepasst sind, damit sich die äußere Hülle (2) dann, wenn die Auf- blaskammer (4) ihre expandierte Position einnimmt, im Wesentlichen an die Form der Aufblaskammer (4) anschmiegt.
  2. Intragastraler Ballon nach Anspruch 1, dadurch gekennzeichnet, dass die Aufblaskammer (4) durch eine Innentasche (5) gebildet ist, die ausreichend nachgiebig ist, um aus einer Position mit verringertem Volumen in eine expandierte Position überzugehen.
  3. Intragastraler Ballon nach Anspruch 2, dadurch gekennzeichnet, dass die Innentasche (5) aus einem Elastomermaterial gebildet ist.
  4. Intragastraler Ballon nach Anspruch 2 oder 3, dadurch gekennzeichnet, dass die Innentasche (5) durch eine Wand (6) begrenzt ist, die wenigstens eine für Gase im Wesentlichen undurchlässige Schicht enthält.
  5. Intragastraler Ballon nach Anspruch 4, dadurch gekennzeichnet, dass die Schicht in seiner Verbindung wenigstens ein Polymer mit Gassperrenwirkung enthält.
  6. Intragastraler Ballon nach Anspruch 5, dadurch gekennzeichnet, dass die Schicht aus einem oder mehreren thermoplastischen Polymeren mit Gassperrenwirkung zusammengesetzt ist.
  7. Intragastraler Ballon nach Anspruch 6, dadurch gekennzeichnet, dass die Schicht aus einem oder mehreren Polymeren gebildet ist, die aus der Gruppe von Polymeren mit Gassperrwirkung gewählt sind, etwa: Ethylenvinyl-Alkohol (EVOH), Polychlorid-Vinyliden (PVDC), Polyacrylonitril (PAN), Polyamid (PA), biorientiertes Polyamid, Polyethylen-Terephthalat (PET), biorientiertes Polyethylen-Terephthalat und elastomeres thermoplastisches Polyurethan.
  8. Intragastraler Bal-lon nach einem der Ansprüche 2 bis 7, dadurch gekennzeichnet, dass die Innentasche (5) durch wenigstens eine dünne Schicht aus thermoplastischem elastomeren Polyurethan gebildet ist.
  9. Intragastraler Ballon nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass die äußere Hülle (2) aus einem biokompatiblen Material gebildet ist.
  10. Intragastraler Ballon nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass die äußere Hülle (2) aus einem elastomeren Material gebildet ist.
  11. Intragastraler Ballon nach Anspruch 10, dadurch gekennzeichnet, dass die äußere Hülle (2) aus Silikon besteht.
  12. Intragastraler Ballon nach Anspruch 11, dadurch gekennzeichnet, dass das Silikon durch Behandlung mit Bariumsulfat weiß gefärbt ist.
  13. Intragastraler Ballon nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass die äußere Hülle (2) mit Parylen beschichtet ist.
  14. Intragastraler Ballon nach einem der Ansprüche 1 bis 13, dadurch gekennzeichnet, dass das Aufblasfluid ein Gas ist.
  15. Intragastraler Ballon nach einem der Ansprüche 1 bis 14, dadurch gekennzeichnet, dass die Aufblaskammer (4) dazu ausgelegt ist, in ihrer expandierten Position eine im Wesentlichen kugelförmige Gestalt aufzuweisen.
  16. Intragastraler Ballon nach einem der Ansprüche 1 bis 15, dadurch gekennzeichnet, dass die Aufblaskammer (4) und die äußere Hülle (2) relativ zueinander im Wesentlichen beweglich sind.
  17. Intragastraler Ballon nach einem der Ansprüche 1 bis 16, dadurch gekennzeichnet, dass die Aufblaskammer (4) und die äußere Hülle (2) im Wesentlichen konzentrisch sind.
  18. Intragastraler Ballon nach einem der Ansprüche 1 bis 17, dadurch gekennzeichnet, dass die Aufblaskammer (4) mit Parylen beschichtet ist.
EP05729308A 2004-02-20 2005-02-18 Magenballon mit verbessertem formmittel und erhöhter mechanischer festigketi Not-in-force EP1720495B1 (de)

Priority Applications (1)

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PL05729308T PL1720495T3 (pl) 2004-02-20 2005-02-18 Balon wewnątrzżołądkowy z poprawionymi środkami do kształtowania i o zwiększonej wytrzymałości mechanicznej

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0401733A FR2866558B1 (fr) 2004-02-20 2004-02-20 Ballon intra-gastrique avec moyens de mise en forme ameliores et a resistance mecanique renforcee
PCT/FR2005/000389 WO2005089686A2 (fr) 2004-02-20 2005-02-18 Ballon intra-gastrique avec moyens de mise en forme ameliores et a resistance mecanique renforcee

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EP1720495A2 EP1720495A2 (de) 2006-11-15
EP1720495B1 true EP1720495B1 (de) 2011-04-20

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US (1) US20080243167A1 (de)
EP (1) EP1720495B1 (de)
CN (1) CN1921811A (de)
AT (1) ATE506041T1 (de)
AU (1) AU2005224132A1 (de)
BR (1) BRPI0507926A (de)
CA (1) CA2556411A1 (de)
DE (1) DE602005027545D1 (de)
ES (1) ES2365349T3 (de)
FR (1) FR2866558B1 (de)
PL (1) PL1720495T3 (de)
WO (1) WO2005089686A2 (de)

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US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
US20120232652A1 (en) 2011-03-07 2012-09-13 Rolando Mora Implant with a visual indicator of a barrier layer
WO2012158972A2 (en) * 2011-05-17 2012-11-22 Endobese, Inc. Method and apparatus for buoyant gastric implant
CN104622851B (zh) * 2015-03-13 2017-09-12 山东省药学科学院 一种减肥胶囊及其制备方法
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ES2365349T3 (es) 2011-09-30
BRPI0507926A (pt) 2007-07-17
FR2866558A1 (fr) 2005-08-26
CA2556411A1 (en) 2005-09-29
CN1921811A (zh) 2007-02-28
US20080243167A1 (en) 2008-10-02
WO2005089686A3 (fr) 2006-05-04
AU2005224132A1 (en) 2005-09-29
EP1720495A2 (de) 2006-11-15
WO2005089686A2 (fr) 2005-09-29
DE602005027545D1 (de) 2011-06-01
PL1720495T3 (pl) 2011-09-30
ATE506041T1 (de) 2011-05-15
FR2866558B1 (fr) 2006-08-04

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