EP1713394A1 - Appareil et procede pour dispositif medical a ultrasons fonctionnant en modes de torsion et transversal - Google Patents

Appareil et procede pour dispositif medical a ultrasons fonctionnant en modes de torsion et transversal

Info

Publication number
EP1713394A1
EP1713394A1 EP04709418A EP04709418A EP1713394A1 EP 1713394 A1 EP1713394 A1 EP 1713394A1 EP 04709418 A EP04709418 A EP 04709418A EP 04709418 A EP04709418 A EP 04709418A EP 1713394 A1 EP1713394 A1 EP 1713394A1
Authority
EP
European Patent Office
Prior art keywords
ultrasonic probe
ultrasonic
probe
vibration
medical device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04709418A
Other languages
German (de)
English (en)
Inventor
Robert A. Rabiner
Bradley A. Hare
Rebecca I. Marciante
Mark J. Varady
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omnisonics Medical Technologies Inc
Original Assignee
Omnisonics Medical Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnisonics Medical Technologies Inc filed Critical Omnisonics Medical Technologies Inc
Publication of EP1713394A1 publication Critical patent/EP1713394A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A61B2017/22014—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being outside patient's body; with an ultrasound transmission member; with a wave guide; with a vibrated guide wire
    • A61B2017/22015—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being outside patient's body; with an ultrasound transmission member; with a wave guide; with a vibrated guide wire with details of the transmission member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/320068—Surgical cutting instruments using mechanical vibrations, e.g. ultrasonic
    • A61B2017/320098—Surgical cutting instruments using mechanical vibrations, e.g. ultrasonic with transverse or torsional motion

Definitions

  • the present invention relates to ultrasonic medical devices, and more particularly to an apparatus and method of using an ultrasonic probe operating in torsional and transverse modes.
  • Prior art medical instruments have relied on longitudinal vibrations of the tip of the instrument. By creating longitudinal vibrations of the tip, the tip of the prior art medical instrument must contact the biological material and, similar to a jackhammer, remove the biological material through successive motion of the tip of the instrument. In many cases, the prior art instruments operating in a longitudinal mode have a tip having both a small cross sectional area and a small surface area, thereby removing small amounts of biological material and increasing the overall time of the medical procedure.
  • U.S. Patent No. 4,961,424 to Kubota et al. discloses an ultrasonic treatment device operating in a longitudinal mode that is urged or brought into contact with an area to he treated, with energy delivered to the tip of the device.
  • U.S. Patent No. 4,870,953 to DonMicheal et al. discloses an intravascular ultrasonic catheter/probe and method for treating intra ascular blockage that delivers ultrasonic energy via a bulbous tip of the instrument where the bulbous tip is placed in contact with a blockage.
  • U.S. Patent No. 5,391,144 to Sakurai et al. discloses an ultrasonic treatment apparatus that includes an instrument operating in a longitudinal mode that emulsifies tissue at the tip of the instrument.
  • Torsional mode vibration of objects is known in the art.
  • the prior art does not describe the torsional mode vibration of a medical device.
  • the prior art requires additional objects to be attached to the prior art instruments, thereby preventing a minimally invasive solution of destroying biological material using torsional mode vibration.
  • U.S. Patent No. 4,771,202 and U.S. Patent No. 4,498,025 both to Takahashi disclose a tuning fork using the fundamental vibration of a flexural mode coupled with the fundamental mode of torsion. The fundamental frequency of the torsional mode is adjusted by placing masses near the side edges of the tine tips.
  • U.S. Patent No. 4,652,786 to Mishiro discloses a torsional vibration apparatus having a plurality of electrodes formed on the two surfaces of a circular member of electrostrictive material. Therefore, there remains a need in the art for an apparatus and a method of destroying biological material that utilizes a medical device that can vibrate in a torsional mode to destroy the biological material in the body in a time efficient manner.
  • the prior art does not provide a solution for destroying biological material in a safe, effective and time efficient manner.
  • the prior art does not provide an effective solution for increasing a surface area for biological material destruction.
  • Prior art ultrasonic instruments are limited in that they require contact between the device and the biological material and only treat the biological material using the tip of the ultrasonic instrument. Therefore, there remains a need in the art for an apparatus and a method for an ultrasonic medical device operating in a torsional mode and a transverse mode to ablate biological material in a safe, effective and time efficient manner.
  • the present invention provides an apparatus and a method for an ultrasonic medical device operating in a torsional mode and a transverse mode to treat a biological material.
  • the present invention is an ultrasonic medical device comprising an ultrasonic probe having a proximal end, a distal end and a longitudinal axis therebetween.
  • the ultrasonic medical device includes a transducer for creating a torsional vibration of the ultrasonic probe.
  • a coupling engages the proximal end of the ultrasonic probe to a distal end of the transducer.
  • An ultrasonic energy source engaged to a proximal end of the transducer produces an electrical energy to power the ultrasonic medical device.
  • the torsional vibration of the ultrasonic probe induces a transverse vibration along an active area of the ultrasonic probe, the active area supporting the torsional vibration and the transverse vibration.
  • the present invention is a medical device comprising an elongated, flexible probe comprising a proximal end, a distal end and a longitudinal axis between the proximal end and the distal end.
  • the medical device includes a transducer that converts electrical energy into mechanical energy, creating a torsional vibration along the longitudinal axis of the elongated, flexible probe.
  • a coupling engages the proximal end of the elongated, flexible probe to a distal end of the transducer.
  • An ultrasonic energy source engaged to a proximal end of the transducer provides electrical energy to the transducer.
  • the torsional vibration induces a transverse vibration along the longitudinal axis of the elongated, flexible probe.
  • the present invention is a method of treating a biological material in a body with an ultrasonic medical device comprising: providing an ultrasonic probe having a proximal end, a distal end and a longitudinal axis therebetween; moving the ultrasonic probe to a treatment site of the biological material to place the ultrasonic probe in communication with the biological material; activating an ultrasonic energy source engaged to the ultrasonic probe to produce an ultrasonic energy that is converted into a torsional vibration of the ultrasonic probe; and inducing a transverse vibration in an active area of the ultrasonic probe by the torsional vibration wherein the active area of the ultrasonic probe supports the torsional vibration and the transverse vibration.
  • the present invention is a method of removing a biological material in a body comprising providing an ultrasonic medical device comprising a flexible probe having a proximal end, a distal end and a longitudinal axis between the proximal end and the distal end.
  • the flexible probe is moved in the body and placed in communication with the biological material.
  • An ultrasonic energy source of the ultrasonic medical device is activated to produce an electrical signal that drives a transducer of the ultrasonic medical device to produce a torsional vibration of the flexible probe.
  • the torsional vibration induces a transverse vibration along the longitudinal axis of the ultrasonic probe.
  • the present invention provides an apparatus and a method for an ultrasonic medical device operating in a torsional mode and a transverse mode.
  • the active area of the ultrasonic probe operating in the torsional mode and the transverse mode is vibrated in a direction not parallel to the longitudinal axis of the ultrasonic probe while equally spaced points along the active area are vibrated back and forth in a short arc in a plane parallel to the longitudinal axis along the active area of the ultrasonic probe.
  • the present invention provides an ultrasonic medical device that is simple, user-friendly, time efficient, reliable and cost effective.
  • FIG. 1 is a side plan view of an ultrasonic medical device of the present invention capable of operating in a torsional mode and a transverse mode.
  • FIG. 2 is a side plan view of an ultrasonic probe of the present invention having a uniform diameter from a proximal end of the ultrasonic probe to a distal end of the ultrasonic probe.
  • FIG. 3 is a fragmentary perspective view of an ultrasonic probe of the present invention having a torsional vibration and a transverse vibration along an active area of the ultrasonic probe.
  • FIG. 4 is a fragmentary perspective view of the ultrasonic probe of the present invention undergoing a torsional vibration.
  • FIG. 5 A is a fragmentary side plan view of the ultrasonic probe of the present invention undergoing a torsional vibration.
  • FIG. 5B is a graph corresponding to the torsional vibration shown in FIG. 5A
  • FIG. 6 is a fragmentary side plan view of the ultrasonic probe of the present invention undergoing a transverse vibration.
  • FIG. 7 is a fragmentary perspective view of the ultrasonic probe of the present invention undergoing a transverse vibration along an active area of the ultrasonic probe and a torsional vibration along a section proximal to the active area of the ultrasonic probe.
  • FIG. 8 is a fragmentary side plan view of the ultrasonic probe of the present invention having a plurality of nodes and a plurality of anti-nodes along an active area of the ultrasonic probe.
  • FIG. 9 is a fragmentary perspective view of a portion of a longitudinal axis of an ultrasonic probe of the present invention comprising an approximately circular cross section at a proximal end of the ultrasonic probe and a radially asymmetric cross section at a distal end of the ultrasonic probe.
  • FIG. 10 is a side plan view of the ultrasonic probe of the present invention located within a sheath. While the above-identified drawings set forth preferred embodiments of the present invention, other embodiments of the present invention are also contemplated, as noted in the discussion. This disclosure presents illustrative embodiments of the present invention by way of representation and not limitation. Numerous other modifications and embodiments can be devised by those skilled in the art which fall within the scope and spirit of the principles of the present invention.
  • the present invention provides an apparatus and a method for using an ultrasonic medical device vibrating in a torsional mode and transverse mode to treat a biological material.
  • the ultrasonic medical device comprises an ultrasonic probe, a transducer, a coupling engaging a proximal end of the ultrasonic probe to a distal end of the transducer and an ultrasonic energy source engaged to a proximal end of the transducer.
  • the ultrasonic energy source produces an ultrasonic energy that is transmitted to the transducer, where the transducer creates a torsional vibration of the ultrasonic probe.
  • the torsional vibration induces a transverse vibration along an active area of the ultrasonic probe, creating a plurality of nodes and a plurality of anti-nodes along the active area resulting in cavitation along the active area.
  • the active area of the ultrasonic probe supports the torsional vibration and the transverse vibration.
  • “Ablate” as used herein refers to removing, clearing, destroying or taking away a biological material. “Ablation” as used herein refers to a removal, clearance, destruction, or taking away of the biological material. “Node” as used herein refers to a region of a minimum energy emitted by an ultrasonic probe at or proximal to a specific location along a longitudinal axis of the ultrasonic probe.
  • Anti-node refers to a region of a maximum energy emitted by an ultrasonic probe at or proximal to a specific location along a longitudinal axis of the ultrasonic probe.
  • Probe refers to a device capable of propagating an energy emitted by the ultrasonic energy source along a longitudinal axis of the ultrasonic probe, resolving the energy into an effective cavitational energy at a specific resonance (defined by a plurality of nodes and a plurality of anti-nodes along an "active area" of the probe) and is capable of an acoustic impedance transformation of an ultrasound energy to a mechanical energy.
  • Bio material refers to a collection of a matter including, but not limited to, a group of similar cells, intravascular blood clots or thrombus, fibrin, calcified plaque, calcium deposits, occlusional deposits, atherosclerotic plaque, fatty deposits, adipose tissues, atherosclerotic cholesterol buildup, fibrous material buildup, arterial stenoses, minerals, high water content tissues, platelets, cellular debris, wastes and other occlusive materials.
  • Vibration refers to movement wherein portions of an object move alternately in opposite directions from a position of equilibrium. Vibration also refers to motion, oscillation and wave propagation.
  • the ultrasonic medical device 11 includes an ultrasonic probe 15 which is coupled to an ultrasonic energy source or generator 99 for the production of an ultrasonic energy.
  • a handle 88 comprising a proximal end 87 and a distal end
  • the ultrasonic probe 15 includes the proximal end 31 , a distal end 24 that ends in a probe tip 9 and a longitudinal axis between the proximal end 31 and the distal end 24. In a preferred embodiment of the present invention shown in FIG.
  • a diameter of the ultrasonic probe decreases from a first defined interval 26 to a second defined interval 28 along the longitudinal axis of the ultrasonic probe 15 over a diameter transition 82.
  • a coupling 33 that engages the proximal end 31 of the ultrasonic probe 15 to the transducer within the handle 88 is illustrated generally in FIG. 1.
  • the coupling is a quick attachment- detachment system.
  • An ultrasonic medical device with a quick attachment-detachment system is described in the Assignee's co-pending patent applications U.S. Serial No. 09/975,725; U.S. Serial No. 10/268,487 and U.S. Serial No. 10/268,843, and the entirety of all these applications are hereby incorporated herein by reference.
  • FIG. 2 shows an alternative embodiment of the ultrasonic probe 15 of the present invention.
  • the diameter of the ultrasonic probe 15 is approximately uniform from the proximal end 31 of the ultrasonic probe 15 to the distal end 24 of the ultrasonic probe 15.
  • the ultrasonic probe 15 is a wire. In a preferred embodiment of the present invention, a cross section of the ultrasonic probe is approximately circular from the proximal end 31 of the ultrasonic probe 15 to the distal end 24 of the ultrasonic probe 15. In an embodiment of the present invention, the ultrasonic probe 15 is elongated. In an embodiment of the present invention, the diameter of the ultrasonic probe 15 decreases at greater than two defined intervals. In an embodiment of the present invention, the diameter transitions 82 of the ultrasonic probe 15 are tapered to gradually change the diameter from the proximal end 31 to the distal end 24 along the longitudinal axis of the ultrasonic probe 15.
  • the diameter transitions 82 of the ultrasonic probe 15 are stepwise to change the diameter from the proximal end 31 to the distal end 24 along the longitudinal axis of the ultrasonic probe 15.
  • the diameter transitions can be of any shape known in the art and be within the spirit and scope of the present invention.
  • the gradual change of the diameter from the proximal end 31 to the distal end 24 occurs over the at least one diameter transitions 82, with each diameter transition 82 having an approximately equal length. In another embodiment of the present invention, the gradual change of the diameter from the proximal end 31 to the distal end 24 occurs over a plurality of diameter transitions 82 with each diameter transition 82 having a varying length.
  • the diameter transition 82 refers to a section where the diameter varies from a first diameter to a second diameter.
  • the probe tip 9 can be any shape including, but not limited to, bent, a ball or larger shapes.
  • the ultrasonic energy source 99 is a physical part of the ultrasonic medical device 11.
  • the ultrasonic energy source 99 is not an integral part of the ultrasonic medical device 11.
  • the ultrasonic probe 15 is used to treat a biological material and may be disposed of after use.
  • the ultrasonic probe 15 is for a single use and on a single patient.
  • the ultrasonic probe 15 is disposable.
  • the ultrasonic probe 15 can be used multiple times.
  • the ultrasonic probe 15 has a stiffness that gives the ultrasonic probe 15 a flexibility allowing the ultrasonic probe 15 to be deflected and articulated when the ultrasonic medical device 11 is in motion.
  • the ultrasonic probe 15 can be bent, flexed and deflected to reach the biological material at locations in the vasculature of the body that are difficult to reach.
  • the ultrasonic probe 15 has a flexibility to support a torsional vibration and a transverse vibration.
  • the ultrasonic probe 15 comprises a substantially uniform cross section from the proximal end 31 to the distal end 24.
  • a cross section of the ultrasonic probe 15 is approximately circular.
  • a portion of the longitudinal axis of the ultrasonic probe 15 is radially asymmetric.
  • the cross section of the ultrasonic probe 15 is spline shaped with a plurality of projections extending from an outer surface of the ultrasonic probe 15.
  • the shape of the cross section of the ultrasonic probe 15 includes, but is not limited to, square, trapezoidal, elliptical, rectangular, oval, triangular, circular with a flat spot and similar cross sections. Those skilled in the art will recognize that other cross sectional geometries known in the art would be within the spirit and scope of the present invention.
  • the ultrasonic probe comprises a varying cross section from the proximal end 31 of the ultrasonic probe 15 to the distal end 24 of the ultrasonic probe 15.
  • Various cross sectional shapes including, but not limited to square, trapezoidal, elliptical, spline shaped, rectangular, oval, triangular, circular with a flat spot and similar cross sections can be used to modify the active area.
  • the ultrasonic probe 15 comprises titanium or a titanium alloy.
  • the ultrasonic probe 15 comprises titanium alloy Ti-6A1-4V.
  • the elements comprising Ti-6A1-4V and the representative elemental weight percentages of Ti-6A1-4V are titanium (about 90%), aluminum (about 6%), vanadium (about 4%), iron (maximum about 0.25%) and oxygen (maximum about 0.2%).
  • Titanium is a strong, flexible, low density, low radiopacity and easily fabricated metal that is used as a structural material. Titanium and its alloys have excellent corrosion resistance in many environments and have good elevated temperature properties.
  • the ultrasonic probe 15 comprises stainless steel.
  • the ultrasonic probe 15 comprises an alloy of stainless steel.
  • the ultrasonic probe 15 comprises aluminum.
  • the ultrasonic probe 15 comprises an alloy of aluminum.
  • the ultrasonic probe 15 comprises a combination of titanium and stainless steel.
  • the ultrasonic probe can be comprised of many other materials known in the art and be within the spirit and scope of the present invention.
  • the ultrasonic probe 15 has a small diameter. In an embodiment of the present invention, the diameter of the ultrasonic probe 15 gradually decreases from the proximal end 31 to the distal end 24. In an embodiment of the present invention, the diameter of the distal end 24 of the ultrasonic probe 15 is about 0.004 inches. In another embodiment of the present invention, the diameter of the distal end 24 of the ultrasonic probe 15 is about 0.015 inches. In other embodiments of the present invention, the diameter of the distal end 24 of the ultrasonic probe 15 varies between about 0.003 inches and about 0.025 inches.
  • an ultrasonic probe 15 can have a diameter at the distal end 24 smaller than about 0.003 inches, larger than about 0.025 inches, and between about 0.003 inches and about 0.025 inches and be within the spirit and scope of the present invention.
  • the diameter of the proximal end 31 of the ultrasonic probe 15 is about 0.012 inches. In another embodiment of the present invention, the diameter of the proximal end 31 of the ultrasonic probe 15 is about 0.025 inches. In other embodiments of the present invention, the diameter of the proximal end 31 of the ultrasonic probe 15 varies between about 0.003 inches and about 0.025 inches. Those skilled in the art will recognize the ultrasonic probe 15 can have a diameter at the proximal end 31 smaller than about 0.003 inches, larger than about 0.025 inches, and between about 0.003 inches and about 0.025 inches and be within the spirit and scope of the present invention.
  • the length of the ultrasonic probe 15 of the present invention is chosen so as to be resonant in a torsional mode and a transverse mode.
  • the ultrasonic probe 15 is between about 30 centimeters and about 300 centimeters in length.
  • the ultrasonic probe 15 should be detuned from the transducer, meaning that the length of the ultrasonic probe 15 should not be an integer multiple of one-half wavelength of the fundamental torsional resonance of the transducer.
  • the ultrasonic probe 15 is detuned from the transducer when the resonant frequency of the ultrasonic probe 15 is different from the resonant frequency of the transducer.
  • the section below entitled "Theory of Operation” provides details and equations for determining the length for the ultrasonic probe operating in the torsional mode and the transverse mode.
  • the length of the ultrasonic probe should not be an integer multiple of one-half wavelength (approximately 7.58 centimeters (about 3 inches)).
  • an ultrasonic probe can have a length shorter than about 30 centimeters, a length longer than about 300 centimeters and a length between about 30 centimeters and about 300 centimeters and be within the spirit and scope of the present invention.
  • the handle 88 surrounds the transducer located between the proximal end 31 of the ultrasonic probe 15 and the connector 93.
  • the transducer includes, but is not limited to, a horn, an electrode, an insulator, a backnut, a washer, a piezo microphone, and a piezo drive.
  • the transducer converts electrical energy provided by the ultrasonic energy source 99 to mechanical energy and sets the operating frequency of the ultrasonic medical device 11.
  • the horn creates a torsional wave along at least a portion of the longitudinal axis of the ultrasonic probe 15, causing the ultrasonic probe 15 to vibrate in a torsional mode with a torsional vibration.
  • the transducer crystals are vibrated in a direction approximately tangential to the cylindrical surface of the ultrasonic probe 15.
  • U.S. Patent No. 2,838,695 to Thurston describes how an appropriately oriented and driven cylindrical array of transducer crystals creates torsional waves, and the entirety of this patent is hereby incorporated herein by reference.
  • the transducer transmits ultrasonic energy received from the ultrasonic energy source 99 to the ultrasonic probe 15, causing the ultrasonic probe 15 to vibrate in a torsional mode.
  • the transducer is capable of engaging the ultrasonic probe 15 at the proximal end 31 with sufficient restraint to form an acoustical mass that can propagate the ultrasonic energy provided by the ultrasonic energy source 99.
  • the ultrasonic probe 15 is moved to a treatment site of the biological material and the ultrasonic probe 15 is placed in communication with the biological material.
  • the ultrasonic probe 15 may be swept, twisted or rotated along the treatment site of the biological material.
  • the ultrasonic probe can be placed in communication with the biological material in many other ways known in the art and be within the spirit and scope of the present invention.
  • the ultrasonic energy source 99 is activated to produce the ultrasonic energy that produces a torsional vibration of the ultrasonic probe 15.
  • the ultrasonic energy source 99 provides the electrical power to the transducer at the resonant frequency of the transducer.
  • the ultrasonic energy source 99 provides a low power electric signal of between about 2 watts to about 15 watts to the transducer that is located within the handle 88.
  • Piezoelectric ceramic crystals inside the transducer create a torsional vibration that is converted into a standing torsional wave along the longitudinal axis of the ultrasonic probe 15.
  • the ultrasonic energy source 99 finds the resonant frequency of the transducer through a Phase Lock Loop (PLL) circuit.
  • PLL Phase Lock Loop
  • the torsional wave produces a component of force in a transverse direction relative to the longitudinal axis of the ultrasonic probe 15, thereby exciting a transverse wave along the longitudinal axis of the ultrasonic probe 15.
  • the ultrasonic probe 15 undergoes both a torsional vibration and a transverse vibration.
  • the torsional vibration along the longitudinal axis of the ultrasonic probe 15 induces a transverse vibration along an active area of the ultrasonic probe 15.
  • the active area is at least a portion of the longitudinal axis of the ultrasonic probe 15.
  • the active area is at the distal end 24 of the ultrasonic probe 15.
  • FIG. 3 shows a perspective view of the ultrasonic probe 15 of the present invention undergoing a torsional vibration and a transverse vibration along the active area of the ultrasonic probe 15.
  • the torsional vibration is shown as the alternating clockwise and counterclockwise sets of arrows, with each set comprising five arrows in FIG. 3.
  • the transverse vibration is shown with a wave-like motion in a repeating form where the vibration rises from the longitudinal axis to a maximum amplitude, descends back down to the longitudinal axis to a minimum amplitude, proceeds from the longitudinal axis to a maximum amplitude and returns to the longitudinal axis of the ultrasonic probe 15.
  • the transverse vibration is excited by the torsional vibration.
  • the active area of the ultrasonic probe 15 undergoes both the torsional vibration and the transverse vibration.
  • the ultrasonic probe 15 is operated in a torsional mode of vibration and a transverse mode of vibration. Coupling of the torsional mode of vibration and the transverse mode of vibration is possible because of common shear components for the elastic forces.
  • the transverse vibration is induced when the frequency of the transducer is close to a transverse resonant frequency of the ultrasonic probe 15.
  • the combination of the torsional mode of vibration and the transverse mode of vibration is possible because for each torsional mode of vibration, there are many close transverse modes of vibration.
  • the torsional wave motion along the longitudinal axis of the ultrasonic probe 15 creates a shear force gradient along the longitudinal axis of the ultrasonic probe 15.
  • the shear force gradient generates a transverse motion when the frequency of the torsional motion is close to a transverse resonant frequency of the ultrasonic probe 15.
  • the shear force is in the approximate same direction as the transverse motion.
  • the magnitude of the shear force is proportional to the torsional or angular displacement. As shown in FIG. 3, the wavelength for the transverse mode of vibration is less than the wavelength for the torsional mode of vibration.
  • two or more wavelengths for the transverse mode of vibration are produced for one wavelength for the torsional mode of vibration.
  • the transverse vibration wavelength is about one-fifth (1/5) of the torsional vibration wavelength.
  • the transverse and torsional vibrations are shifted in frequency.
  • bending the ultrasonic probe 15 causes the transverse and torsional vibration to shift in frequency. Bending the ultrasonic probe 15 causes a shift in frequency resulting from the changes in tension.
  • the ultrasonic probe 15 is coupled to the transducer through an acoustic impedance mismatch so that the tuning of the ultrasonic probe 15 will not affect the drive frequency.
  • the acoustic impedance mismatch can be achieved by maintaining a large difference between the moment of inertia of the transducer and the moment of inertia of the ultrasonic probe 15.
  • the acoustic impedance mismatch can be created by a discontinuity at the transducer or created further down the longitudinal axis of the ultrasonic probe 15 by reducing the diameter in a stepwise manner toward the distal end 24 of the ultrasonic probe 15.
  • An ultrasonic probe device having an impedance mismatch with rapid attachment and detachment means is described in Assignee's co- pending patent application U.S. Serial No. 10/268,487, the entirety of which is hereby incorporated herein by reference.
  • FIG. 4 shows a fragmentary perspective view of the ultrasonic probe 15 of the present invention undergoing the torsional vibration.
  • the alternating clockwise and counterclockwise arrows represent the torsional vibration, showing the rotational and counterrotational motion of the ultrasonic probe 15.
  • FIG. 5 A shows a fragmentary side plan view of the ultrasonic probe 15 of the present invention undergoing the torsional vibration while FIG. 5B shows a graph corresponding to the torsional vibration shown in FIG. 5A.
  • FIG. 6 shows the ultrasonic probe 15 undergoing the transverse vibration. To clearly describe the torsional vibration and the transverse vibration, the torsional vibration will be examined while discussing FIG. 4, FIG. 5A and FIG. 5B while the transverse vibration will be separately examined while discussing FIG. 6.
  • the torsional vibration of the ultrasonic probe 15 in FIG. 4 and FIG. 5 A is shown as movement of the ultrasonic probe in alternating clockwise and counterclockwise directions along the longitudinal axis of the ultrasonic probe 15.
  • the torsional vibration shown in FIG. 4 and FIG. 5A is a torsional oscillation whereby equally spaced points along the longitudinal axis of the ultrasonic probe 15 including the probe tip 9 vibrate back and forth in a short arc of the same amplitude in a plane perpendicular to the longitudinal axis of the ultrasonic probe 15.
  • the vibration creates a plurality of torsional nodes 50 and a plurality of torsional anti-nodes 52 along an active area of the ultrasonic probe 15.
  • a section proximal to each of the plurality of torsional nodes 50 and a section distal to each of the plurality of torsional nodes 50 are vibrated out of phase, with the proximal section vibrated in a clockwise direction and the distal section vibrated in a counterclockwise direction, or vice versa.
  • the torsional vibration produces a rotation and counterrotation along the longitudinal axis of the ultrasonic probe 15. As shown in FIG. 5 A and FIG. 5B, the torsional vibration is propagated in a forward direction and a reverse direction about a torsional node 50.
  • FIG. 5 A shows the alternating clockwise and counterclockwise motion about the torsional node 50 and shows an expansion and a compression of the ultrasonic probe 15 in the torsional mode.
  • 5 A shows the expansion of the ultrasonic probe 15 as the clockwise and counterclockwise motion of the ultrasonic probe 15 extends away from the torsional node 50. As the alternating clockwise and counterclockwise motion returns back to the torsional node 50, the ultrasonic probe 15 is compressed. The ultrasonic probe 15 will expand and compress about the plurality of torsional nodes 50 along an active area of the ultrasonic probe 15.
  • the transverse vibration of the ultrasonic probe 15 shown in FIG. 6 results in a portion of the longitudinal axis of the ultrasonic probe 15 vibrated in a direction not parallel to the longitudinal axis of the ultrasonic probe 15.
  • the transverse vibration results in movement of the longitudinal axis of the ultrasonic probe 15 in a direction approximately perpendicular to the longitudinal axis of the ultrasonic probe 15.
  • the transverse vibration creates a plurality of transverse nodes 60 and a plurality of transverse anti-nodes 62 along the active area of the ultrasonic probe 15.
  • the torsional vibration shown in FIG. 4 and the transverse vibration shown in FIG. 6 are combined at the active area of the ultrasonic probe 15 to produce the torsional vibration and transverse vibration shown in FIG. 3.
  • the torsional vibration and the transverse vibration create a plurality of nodes 50, 60 and a plurality of anti-nodes 52, 62 along the active area of the ultrasonic probe 15.
  • the active area of the ultrasonic probe 15 is vibrated in a direction not parallel to the longitudinal axis of the ultrasonic probe 15 while equally spaced points along the longitudinal axis of the ultrasonic probe 15 in a proximal section vibrate back and forth in a short arc about the longitudinal axis of the ultrasonic probe 15.
  • the torsional vibration and the transverse vibration are superimposed over the active area of the ultrasonic probe 15 (FIG. 3).
  • FIG. 3 In an alternative embodiment of the present invention shown in FIG.
  • the torsional vibration of the ultrasonic probe 15 creates the transverse vibration along an active area of the ultrasonic probe, where the active area undergoes the transverse vibration without the torsional vibration.
  • the transverse vibration creates the plurality of transverse nodes 60 and the plurality of transverse anti-nodes 62 along the longitudinal axis of the ultrasonic probe 15.
  • FIG. 7 shows the alternative embodiment wherein the torsional vibration and the transverse vibration are segregated over the longitudinal axis of the ultrasonic probe 15.
  • a segregation section of the ultrasonic probe 15 is between the torsional vibration and the transverse vibration.
  • Those skilled in the art will recognize a length of the segregation section between the torsional vibration and the transverse vibration can vary and be within the spirit and scope of the present invention.
  • FIG. 8 shows a fragmentary perspective view of the ultrasonic probe 15 with the plurality of nodes 50, 60 and the plurality of anti-nodes 52, 62 for the torsional mode of vibration and the transverse mode of vibration along the active area of the ultrasonic probe 15 caused by the torsional vibration and the transverse vibration of the ultrasonic probe 15.
  • FIG. 8 and FIG. 3 both show the pattern of the plurality of nodes 50, 60, and the plurality of anti-nodes 52, 62 for the torsional mode of vibration and the transverse mode of vibration are independently created for each mode of vibration.
  • the pattern of the plurality of nodes 50, 60 and the plurality of anti-nodes 52, 62 has a different spacing for the torsional mode of vibration and the transverse mode of vibration.
  • the plurality of nodes 50, 60 are areas of minimum energy and minimum vibration.
  • the plurality of anti-nodes 52, 62 areas of maximum energy and maximum vibration, also occur at repeating intervals along the active area of the ultrasonic probe 15.
  • the torsional vibration and the transverse vibration at the active area of the ultrasonic probe 15 create the plurality of nodes 50, 60 and the plurality of anti-nodes 52, 62 along the active area of the ultrasonic probe 15 resulting in cavitation in a medium surrounding the ultrasonic probe 15 that ablates the biological material.
  • the combined torsional motion and transverse motion of the ultrasonic probe 15 caused by the torsional vibration and the transverse vibration causes an interaction between the surface of the ultrasonic probe 15 and the medium surrounding the ultrasonic probe 15 to cause an acoustic wave in the medium surrounding the ultrasonic probe 15.
  • acoustic energy is generated in the medium surrounding the ultrasonic probe 15.
  • the motion caused by the torsional vibration and the transverse vibration causes cavitation in the medium surrounding the ultrasonic probe 15 over an active area of the ultrasonic probe 15.
  • Cavitation is a process in which small voids are formed in a surrounding fluid through the rapid motion of the ultrasonic probe 15 and the voids are subsequently forced to compress.
  • the compression of the voids creates a wave of acoustic energy which acts to dissolve the matrix binding the biological material, while having no damaging effects on healthy tissue.
  • the biological material is resolved into a particulate having a size on the order of red blood cells (approximately 5 microns in diameter).
  • the size of the particulate is such that the particulate is easily discharged from the body through conventional methods or simply dissolves into the blood stream.
  • a conventional method of discharging the particulate from the body includes transferring the particulate through the blood stream to the kidney where the particulate is excreted as bodily waste.
  • the torsional motion of the ultrasonic probe 15 is less than the transverse motion of the ultrasonic probe 15. Once the transverse motion is established on the ultrasonic probe 15, almost all additional energy goes into transverse motion and the amplitude of the torsional motion does not increase appreciably past this point. Cavitation is created primarily because of the transverse motion of the ultrasonic probe 15.
  • the number of nodes 50, 60 and the number of anti-nodes 52, 62 occurring along the active area of the ultrasonic probe 15 is modulated by changing the frequency of energy supplied by the ultrasonic energy source 99.
  • the exact frequency, however, is not critical and the ultrasonic energy source 99 run at, for example, about 20 kHz is sufficient to create an effective number of biological material destroying anti-nodes 52, 62 along the longitudinal axis of the ultrasonic probe 15.
  • the low frequency requirement of the present invention is a further advantage in that the low frequency requirement leads to less damage to healthy tissue.
  • the present invention allows the use of ultrasonic energy to be applied to the biological material selectively, because the ultrasonic probe 15 conducts energy across a frequency range from about 10 kHz through about 100 kHz.
  • the amount of ultrasonic energy to be applied to a particular treatment site is a function of the amplitude and frequency of vibration of the ultrasonic probe 15.
  • the amplitude or throw rate of energy is in the range of about 25 microns to about 250 microns, and the frequency in the range of about 10 kHz to about 100 kHz.
  • the frequency of ultrasonic energy is from about 20 kHz to about 35 kHz.
  • the torsional motion of the ultrasonic probe 15 is less than the transverse motion of the ultrasonic probe 15.
  • FIG. 9 shows a perspective view of another embodiment of the present invention where the cross section of the ultrasonic probe 15 varies from the proximal end 31 of the ultrasonic probe 15 to the distal end 24 of the ultrasonic probe 15.
  • the cross section of the ultrasonic probe varies from an approximately circular cross at the proximal end 31 of the ultrasonic probe 15 to a radially asymmetric cross section at the distal end 24 of the ultrasonic probe 15.
  • the radially asymmetric cross section at the distal end 24 of the ultrasonic probe 15 is approximately rectangular.
  • radially asymmetric cross sections at the distal end 24 of the ultrasonic probe 15 that can be used to create torsional motion that subsequently produces cavitation along a portion of the length of the longitudinal axis include, but are not limited to, square, trapezoidal, elliptical, star shaped, rectangular, oval, triangular, circular with a flat spot and similar cross sections. Those skilled in the art will recognize other radially asymmetric cross sections known in the art are within the spirit and scope of the present invention.
  • the torsional vibration and the transverse vibration of the ultrasonic probe 15 according to the present invention differ from an axial (or longitudinal) mode of vibration disclosed in the prior art. Rather than vibrating in an axial direction, the ultrasonic probe 15 of the present invention vibrates both torsionally and transversely along the active area of the ultrasonic probe 15. As a consequence of the torsional vibration and the transverse vibration of the ultrasonic probe 15, the biological material destroying effects of the ultrasonic medical device 11 are not limited to the tip of the ultrasonic probe 15.
  • the biological material is removed in all areas adjacent to the plurality of nodes 50, 60 and the plurality of anti-nodes 52, 62 that are produced by the torsional vibration and transverse vibration along the active area of the ultrasonic probe 15, typically in a region having a radius of up to about 6 mm around the ultrasonic probe 15.
  • the torsional mode of vibration and transverse mode of vibration results in an ultrasonic energy transfer to the biological material with minimal loss of ultrasonic energy that could limit the effectiveness of the ultrasonic medical device 11.
  • the probe tip 9 is able to ablate the biological material when the probe tip 9 encounters the biological material and the ultrasonic probe 15 is vibrated torsionally and transversely.
  • the ultrasonic probe 15 is swept along the treatment site of the biological material.
  • the ultrasonic probe 15 is moved back and forth along the treatment site of the biological material.
  • the ultrasonic probe 15 is twisted along the treatment site of the biological material.
  • the ultrasonic probe 15 is rotated along the treatment site of the biological material.
  • an active area of the ultrasonic probe 15 operating in the torsional mode and transverse mode extends from the probe tip 9 and along a portion of a longitudinal axis of the ultrasonic probe 15.
  • the section below entitled “Theory of Operation” discusses some differences between the longitudinal mode of operation used in the prior art and the torsional mode and transverse mode of operation used in the present invention.
  • the biological material is removed in all areas adjacent to the plurality of nodes 50, 60 and the plurality of anti-nodes 52, 62 that are produced by the torsional vibration and transverse vibration along the active area of the ultrasonic probe 15.
  • FIG. 10 shows the ultrasonic probe 15 of the present invention extending from a distal end 34 of a sheath 36. As shown in FIG. 10, the ultrasonic probe 15 is placed within the sheath 36, which can provide an at least one irrigation channel 38 and an at least one aspiration channel 39. In an embodiment of the present invention, irrigation is provided between the ultrasonic probe 15 and the sheath 36.
  • the ultrasonic probe 15 may be moved in an axial direction within the sheath 36 to move the distal end 24 of the ultrasonic probe 15 axially inwardly and outwardly relative to the distal end 34 of the sheath 36. By extending or retracting the ultrasonic probe 15 relative to the sheath 36, the amount of the ultrasonic probe 15 exposed is modified, thereby modifying the biological material destroying area of the ultrasonic probe 15.
  • the sheath 36 is comprised of polytetrafluoroethylene (PTFE). In another embodiment of the present invention, the sheath 36 is comprised of teflon tubing or similar fluoropolymer tubing.
  • the sheath absorbs the ultrasonic energy emanating from the portions of the ultrasonic probe 15 located within the sheath 36, thereby allowing control over the amount of biological material affected by the ultrasonic probe 15.
  • the sheath 36 is preferably comprised of a material which is resistant to heat from the ultrasonic energy, even though the irrigation fluid can act as a coolant for the sheath 36.
  • the present invention provides a method of treating a biological material in the body with the ultrasonic medical device 11.
  • the ultrasonic probe 15 of the ultrasonic medical device 11 is moved to the treatment site of the biological material and placed in communication with the biological material.
  • the ultrasonic energy source 99 of the ultrasonic medical device 11 engaged to the ultrasonic probe 15 is activated to produce the torsional vibration of the ultrasonic probe 15.
  • the transducer engaging the ultrasonic energy source 99 at the proximal end of the transducer and the ultrasonic probe 15 at the distal end of the transducer creates the torsional vibration along the longitudinal axis of the ultrasonic probe 15.
  • the torsional vibration of the ultrasonic probe 15 induces the transverse vibration in the active area of the ultrasonic probe, wherein the active area of the ultrasonic probe 15 supports the torsional vibration and the transverse vibration.
  • the present invention also provides a method of removing a biological material in the body.
  • the ultrasonic probe 15 of the ultrasonic medical device 11 is moved in the body and placed in communication with the biological material.
  • the ultrasonic energy source 99 of the ultrasonic medical device 11 produces an electric signal that drives the transducer of the ultrasonic medical device 11 to produce a torsional vibration of the ultrasonic probe 15.
  • the torsional vibration of the ultrasonic probe 15 induces the transverse vibration along the longitudinal axis of the ultrasonic probe 15, creating a plurality of nodes 50, 60 and a plurality of anti-nodes 52, 62 along an active area of the ultrasonic probe 15.
  • the torsional mode of vibration and transverse mode of vibration of the present invention differs from longitudinal mode of vibration of the prior art.
  • the frequencies of the individual modes depend on the modulus of elasticity E and the density p.
  • the expression is the same except the shear modulus, G, is used instead of the modulus of elasticity, E.
  • the shear modulus, G, and the modulus of elasticity, E, are linked through Poisson's ratio ⁇ :
  • K ⁇ is the torsional stiffness factor of the cross section and I is the moment of inertia of the cross section.
  • K ⁇ /I 1, while for radially asymmetric cross sections the ratio K-r/I ⁇ 1 ⁇ Therefore, the speed of propagation will be slower for the torsional wave by a factor of: _ K ⁇ 2(1 + ---)/
  • the operating frequencies of the longitudinal and torsional modes are dependent on the properties of the ultrasonic probe. Selection of material properties depends primarily on acoustic loss, the choice of operating frequency and the desired amplitude of vibration. As discussed previously, with the ultrasonic probe comprised of titanium and operating at a frequency of about 20 kHz, the torsional wave speed for a circular cross section is as follows:
  • the length of the ultrasonic probe should not be an integer multiple of 7.58 cm (about 3 inches) for this particular case.
  • the present invention provides an apparatus and a method for an ultrasonic medical device operating in a torsional mode and a transverse mode.
  • the active area of the ultrasonic probe is vibrated in a direction not parallel to the longitudinal axis of the ultrasonic probe while equally spaced points along the active area are vibrated back and forth in a short arc along the active area of the ultrasonic probe.
  • the present invention provides an ultrasonic medical device that is simple, user-friendly, time efficient, reliable and cost effective.

Landscapes

  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Mechanical Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)

Abstract

L'invention concerne un appareil et un procédé se rapportant à un dispositif médical (11) à ultrasons fonctionnant en modes de torsion et transversal. Une sonde (15) à ultrasons de ce dispositif médical (11) est placée en communication avec un matériau biologique. Une source d'énergie (99) à ultrasons est activée en vue de produire un signal électrique qui entraîne un transducteur afin de produire une vibration de torsion de la sonde (15). La vibration de torsion produit un composant de force dans un sens transversal par rapport à un axe longitudinal de la sonde (15) à ultrasons, ce qui excite une vibration transversale sur l'axe longitudinal et amène la sonde (15) à supporter une vibration de torsion et une vibration transversale. Les deux vibrations de torsion et transversale produisent une cavitation dans un milieu entourant la sonde (15) à ultrasons pour ablater le matériau biologique.
EP04709418A 2004-02-09 2004-02-09 Appareil et procede pour dispositif medical a ultrasons fonctionnant en modes de torsion et transversal Withdrawn EP1713394A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2004/003694 WO2005084552A1 (fr) 2004-02-09 2004-02-09 Appareil et procede pour dispositif medical a ultrasons fonctionnant en modes de torsion et transversal

Publications (1)

Publication Number Publication Date
EP1713394A1 true EP1713394A1 (fr) 2006-10-25

Family

ID=34920920

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04709418A Withdrawn EP1713394A1 (fr) 2004-02-09 2004-02-09 Appareil et procede pour dispositif medical a ultrasons fonctionnant en modes de torsion et transversal

Country Status (2)

Country Link
EP (1) EP1713394A1 (fr)
WO (1) WO2005084552A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6582392B1 (en) 1998-05-01 2003-06-24 Ekos Corporation Ultrasound assembly for use with a catheter
US7220239B2 (en) 2001-12-03 2007-05-22 Ekos Corporation Catheter with multiple ultrasound radiating members
US8226629B1 (en) 2002-04-01 2012-07-24 Ekos Corporation Ultrasonic catheter power control
CA2553165A1 (fr) 2004-01-29 2005-08-11 Ekos Corporation Methode et appareil de detection d'etats vasculaires a l'aide d'un catheter
EP2015846A2 (fr) 2006-04-24 2009-01-21 Ekos Corporation Systeme de therapie par ultrasons
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
PL2111261T3 (pl) 2007-01-08 2015-08-31 Ekos Corp Parametry mocy cewnika ultradźwiękowego
PL2170181T3 (pl) 2007-06-22 2014-08-29 Ekos Corp Sposób i aparat do leczenia wylewów wewnątrzczaszkowych
US8623040B2 (en) 2009-07-01 2014-01-07 Alcon Research, Ltd. Phacoemulsification hook tip
WO2011003031A1 (fr) 2009-07-03 2011-01-06 Ekos Corporation Paramètres d'énergie pour cathéter ultrasonore
US8740835B2 (en) 2010-02-17 2014-06-03 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
US10888657B2 (en) 2010-08-27 2021-01-12 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
US10258505B2 (en) 2010-09-17 2019-04-16 Alcon Research, Ltd. Balanced phacoemulsification tip
US11458290B2 (en) 2011-05-11 2022-10-04 Ekos Corporation Ultrasound system
JP6479753B2 (ja) 2013-03-14 2019-03-06 エコス コーポレーション 目標の箇所に薬物を送達するための方法および装置
US10092742B2 (en) 2014-09-22 2018-10-09 Ekos Corporation Catheter system
WO2016201136A1 (fr) 2015-06-10 2016-12-15 Ekos Corporation Cathéter à ultrasons

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3565062A (en) * 1968-06-13 1971-02-23 Ultrasonic Systems Ultrasonic method and apparatus for removing cholesterol and other deposits from blood vessels and the like
US4498025A (en) 1980-12-12 1985-02-05 Seiko Instruments & Electronics Ltd. Tuning fork
JPS58182311A (ja) 1982-04-20 1983-10-25 Seiko Instr & Electronics Ltd 音叉型振動子
JPS60257777A (ja) 1984-06-04 1985-12-19 Taga Denki Kk ねじり振動装置
US4961424A (en) 1987-08-05 1990-10-09 Olympus Optical Co., Ltd. Ultrasonic treatment device
US4870953A (en) 1987-11-13 1989-10-03 Donmicheal T Anthony Intravascular ultrasonic catheter/probe and method for treating intravascular blockage
US5391144A (en) 1990-02-02 1995-02-21 Olympus Optical Co., Ltd. Ultrasonic treatment apparatus
US6551337B1 (en) 1999-10-05 2003-04-22 Omnisonics Medical Technologies, Inc. Ultrasonic medical device operating in a transverse mode
US6652547B2 (en) 1999-10-05 2003-11-25 Omnisonics Medical Technologies, Inc. Apparatus and method of removing occlusions using ultrasonic medical device operating in a transverse mode
US20030212331A1 (en) * 2002-05-13 2003-11-13 Paul Fenton Ultrasonic soft tissue cutting and coagulation systems having multiple superposed vibrational modes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2005084552A1 *

Also Published As

Publication number Publication date
WO2005084552A1 (fr) 2005-09-15

Similar Documents

Publication Publication Date Title
US7794414B2 (en) Apparatus and method for an ultrasonic medical device operating in torsional and transverse modes
US20050187514A1 (en) Apparatus and method for an ultrasonic medical device operating in a torsional mode
EP1713393A1 (fr) Appareil et procede pour dispositif medical a ultrasons fonctionnant en mode de torsion
US20100087759A1 (en) Apparatus and method for an ultrasonic medical device with variable frequency drive
JP4343434B2 (ja) 超音波切断ツール
EP1713394A1 (fr) Appareil et procede pour dispositif medical a ultrasons fonctionnant en modes de torsion et transversal
WO2004098426A1 (fr) Appareil et procede destines a une sonde ultrasonore preformee
JP4588452B2 (ja) 流体管理機能を備えた超音波外科器具
US20050119679A1 (en) Apparatus and method for an ultrasonic medical device to treat chronic total occlusions
AU725566B2 (en) Methods and devices for increasing ultrasonic effects
US20040162571A1 (en) Apparatus and method for an ultrasonic medical device to treat deep vein thrombosis
US20050043629A1 (en) Apparatus and method for an ultrasonic medical device having a probe with a small proximal end
US20050096669A1 (en) Apparatus and method for an ultrasonic medical device to treat coronary thrombus bearing lesions
US20050043753A1 (en) Apparatus and method for an ultrasonic medical device to treat peripheral artery disease
JP2007521880A (ja) トーショナル切開チップ
WO2006101644A2 (fr) Lame a ultrasons presentant des caracteristiques d'equilibre d'extremite terminale
WO2009018406A2 (fr) Instruments chirurgicaux ultrasonores
JP2003527884A (ja) 横方向モードで作動する超音波医療装置
WO2006059966A1 (fr) Dispositif medical a ultrasons dote d’une commande a frequence variable
US20050256410A1 (en) Apparatus and method for an ultrasonic probe capable of bending with aid of a balloon
CA2499358C (fr) Instrument chirurgical ultrasonore a longueur d'intervention accrue
US20040210140A1 (en) Apparatus and method for preshaped ultrasonic probe
EP1744813A1 (fr) Sonde echographique pouvant se plier a l'aide d'un ballonnet
JPS62213744A (ja) 超音波処置装置
WO2006041475A1 (fr) Appareil et procede pour dispositif medical a ultrasons dote d'une sonde presentant une petite extremite proximale

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20060522

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

DAX Request for extension of the european patent (deleted)
18W Application withdrawn

Effective date: 20070504