EP1708987B1 - L-(-)-moprolol l-(+)-tartrate - Google Patents

L-(-)-moprolol l-(+)-tartrate Download PDF

Info

Publication number
EP1708987B1
EP1708987B1 EP05701093A EP05701093A EP1708987B1 EP 1708987 B1 EP1708987 B1 EP 1708987B1 EP 05701093 A EP05701093 A EP 05701093A EP 05701093 A EP05701093 A EP 05701093A EP 1708987 B1 EP1708987 B1 EP 1708987B1
Authority
EP
European Patent Office
Prior art keywords
moprolol
tartrate
pharmaceutical composition
salt
organic solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP05701093A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1708987A1 (en
Inventor
Mario Pinza
Caterina Maugeri
Nicola Cazzolla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Angelini Acraf SpA
Original Assignee
Aziende Chimiche Riunite Angelini Francesco ACRAF SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aziende Chimiche Riunite Angelini Francesco ACRAF SpA filed Critical Aziende Chimiche Riunite Angelini Francesco ACRAF SpA
Priority to SI200531291T priority Critical patent/SI1708987T1/sl
Priority to PL05701093T priority patent/PL1708987T3/pl
Publication of EP1708987A1 publication Critical patent/EP1708987A1/en
Application granted granted Critical
Publication of EP1708987B1 publication Critical patent/EP1708987B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/34—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid

Definitions

  • the present invention thus relates to a method for preparing L-(-)-moprolol L-(+)-tartrate (2:1), characterized in that it includes the addition of L-(+)-tartaric acid, dissolved in a suitable organic solvent, to L-(-)-moprolol, also dissolved in a suitable organic solvent, in a 2:1 molar ratio.
  • the pharmaceutical composition according to the present invention may comprise other pharmacologically active ingredients whose simultaneous administration is useful.
  • the first group was treated with 0.1 ml of the first test solution three times a day for fifteen days.
  • the second group was treated with 0.1 ml of the second test solution three times a day for fifteen days.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Detergent Compositions (AREA)
EP05701093A 2004-01-30 2005-01-14 L-(-)-moprolol l-(+)-tartrate Expired - Lifetime EP1708987B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI200531291T SI1708987T1 (sl) 2004-01-30 2005-01-14 L-(-)-MOPROLOL l-(+)-tartrat
PL05701093T PL1708987T3 (pl) 2004-01-30 2005-01-14 L-(+)-Winian L-(-)-moprololu

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000145A ITMI20040145A1 (it) 2004-01-30 2004-01-30 L-moprololo lpiu' tartrato
PCT/EP2005/000560 WO2005075408A1 (en) 2004-01-30 2005-01-14 L-(-)-moprolol l-(+)-tartrate

Publications (2)

Publication Number Publication Date
EP1708987A1 EP1708987A1 (en) 2006-10-11
EP1708987B1 true EP1708987B1 (en) 2011-03-16

Family

ID=34835572

Family Applications (1)

Application Number Title Priority Date Filing Date
EP05701093A Expired - Lifetime EP1708987B1 (en) 2004-01-30 2005-01-14 L-(-)-moprolol l-(+)-tartrate

Country Status (19)

Country Link
US (1) US7524886B2 (it)
EP (1) EP1708987B1 (it)
JP (1) JP4646922B2 (it)
KR (1) KR101122173B1 (it)
CN (1) CN100480232C (it)
AT (1) ATE502003T1 (it)
AU (1) AU2005211458B2 (it)
BR (1) BRPI0507150A (it)
CA (1) CA2550302C (it)
DE (1) DE602005026908D1 (it)
DK (1) DK1708987T3 (it)
EA (1) EA200601402A1 (it)
ES (1) ES2361518T3 (it)
IL (1) IL176280A (it)
IT (1) ITMI20040145A1 (it)
PL (1) PL1708987T3 (it)
PT (1) PT1708987E (it)
SI (1) SI1708987T1 (it)
WO (1) WO2005075408A1 (it)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1211589A (en) * 1968-08-06 1970-11-11 Ici Ltd Enantiomer isolation process
IT1113029B (it) * 1979-03-01 1986-01-20 Simes Processo per la separazione dei due isomeri ottici del moprololo e composizioni farmaceutiche dell'antipodo levogiro
IT1163107B (it) * 1983-02-15 1987-04-08 Simes Composizioni farmaceutiche e loro uso nel trattamento del glaucoma
DE3544172A1 (de) * 1985-12-13 1987-06-19 Lentia Gmbh Neue kristalline salze von aryloxy-propanolaminen, verfahren zu ihrer herstellung und ihre verwendung
AR030414A1 (es) * 2000-04-03 2003-08-20 Astrazeneca Ab Combinacion farmaceutica que comprende un beta bloqueante y un inhibidor de hmg-coa reductasa , formulacion farmaceutica, equipo transportable de partes , uso de esta combinacion y de esta formulacion para preparar medicamentos

Also Published As

Publication number Publication date
IL176280A0 (en) 2006-10-05
JP2007519661A (ja) 2007-07-19
EA200601402A1 (ru) 2006-12-29
DE602005026908D1 (de) 2011-04-28
CA2550302C (en) 2012-04-24
AU2005211458A1 (en) 2005-08-18
SI1708987T1 (sl) 2011-06-30
PT1708987E (pt) 2011-05-31
CN1910138A (zh) 2007-02-07
PL1708987T3 (pl) 2011-08-31
DK1708987T3 (da) 2011-06-27
WO2005075408A1 (en) 2005-08-18
US7524886B2 (en) 2009-04-28
ATE502003T1 (de) 2011-04-15
AU2005211458B2 (en) 2010-06-24
KR101122173B1 (ko) 2012-03-15
JP4646922B2 (ja) 2011-03-09
CN100480232C (zh) 2009-04-22
KR20070000451A (ko) 2007-01-02
ES2361518T3 (es) 2011-06-17
ITMI20040145A1 (it) 2004-04-30
HK1093962A1 (en) 2007-03-16
US20080015258A1 (en) 2008-01-17
BRPI0507150A (pt) 2007-06-26
IL176280A (en) 2010-12-30
EP1708987A1 (en) 2006-10-11
CA2550302A1 (en) 2005-08-18

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