EP1673389A2 - Nouveaux variants de la proteine cd40l - Google Patents

Nouveaux variants de la proteine cd40l

Info

Publication number
EP1673389A2
EP1673389A2 EP04794935A EP04794935A EP1673389A2 EP 1673389 A2 EP1673389 A2 EP 1673389A2 EP 04794935 A EP04794935 A EP 04794935A EP 04794935 A EP04794935 A EP 04794935A EP 1673389 A2 EP1673389 A2 EP 1673389A2
Authority
EP
European Patent Office
Prior art keywords
group
cd40l
amino acid
variant
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04794935A
Other languages
German (de)
English (en)
Inventor
Aaron Keith Chamberlain
John R. Desjarlais
Gregory L. Moore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xencor Inc
Original Assignee
Xencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xencor Inc filed Critical Xencor Inc
Publication of EP1673389A2 publication Critical patent/EP1673389A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne des protéines variantes CD40L solubles, recombinées, pouvant s'exprimer de manière soluble dans les bactéries E.coli. Les variants de l'invention peuvent présenter une capacité sensiblement réduite à la liaison à l'intégrine alpha- IIb bêta-3, et peuvent agir comme antagonistes ou agonistes de CD40L. L'invention concerne par ailleurs des procédés de préparation correspondants.
EP04794935A 2003-10-10 2004-10-12 Nouveaux variants de la proteine cd40l Withdrawn EP1673389A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US51043003P 2003-10-10 2003-10-10
US51772803P 2003-11-05 2003-11-05
US52354503P 2003-11-20 2003-11-20
PCT/US2004/033707 WO2005035570A2 (fr) 2003-10-10 2004-10-12 Nouveaux variants de la proteine cd40l

Publications (1)

Publication Number Publication Date
EP1673389A2 true EP1673389A2 (fr) 2006-06-28

Family

ID=34437673

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04794935A Withdrawn EP1673389A2 (fr) 2003-10-10 2004-10-12 Nouveaux variants de la proteine cd40l

Country Status (2)

Country Link
EP (1) EP1673389A2 (fr)
WO (1) WO2005035570A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7381792B2 (en) 2002-01-04 2008-06-03 Xencor, Inc. Variants of RANKL protein
JP2005530482A (ja) 2002-01-04 2005-10-13 ゼンコー・インコーポレイテッド ドミナントネガティブタンパク質およびそれらの用法
US7553930B2 (en) 2003-01-06 2009-06-30 Xencor, Inc. BAFF variants and methods thereof
WO2005113598A2 (fr) * 2004-05-21 2005-12-01 Xencor, Inc. Membres de la superfamille des tnf avec immunogenicite modifiee
WO2007054658A1 (fr) * 2005-11-14 2007-05-18 King's College London Contrôle de réponses immunitaires
EP2517723B1 (fr) 2006-09-18 2019-11-06 The Board of Trustees of The University of Arkansas Compositions et procédés d'amélioration des réponses immunitaires
US20100150931A1 (en) * 2006-11-22 2010-06-17 Centre Hospitalier De L'universite De Montreal Novel receptor for cd40l and uses thereof
BRPI0818736A2 (pt) 2007-10-30 2017-06-13 Univ Arkansas composições e métodos para intensificar imunorrepostas à bactéria flagelada
HUE047164T2 (hu) 2007-11-01 2020-04-28 Univ Arkansas Kompozíciók és eljárások eimeria elleni immunválasz fokozására
CA2730316A1 (fr) 2008-07-11 2010-01-14 Phylogica Limited Inhibiteurs peptidiques de la signalisation faisant intervenir cd40l et leurs utilisations
EP2525817B8 (fr) 2010-01-21 2017-09-20 The Board of Trustees of The University of Arkansas Vecteurs de vaccin et procédés d'amplification de réponses immunitaires
HUE046858T2 (hu) 2010-06-09 2020-03-30 Univ Arkansas Vakcina és eljárások campylobacter fertõzés csökkentésére
MY173328A (en) 2013-02-14 2020-01-16 Texas A & M Univ Sys Compositions and methods of enhancing immune responses to eimeria or limiting eimeria infection
EA033538B1 (ru) 2013-03-15 2019-10-31 Univ Arkansas Композиции и способы усиления иммунного ответа на кишечные патогены
TWI758288B (zh) 2016-05-03 2022-03-21 阿肯色州大學董事會 包含免疫刺激性及抗原性多肽的酵母菌疫苗載體以及其使用方法
AU2018288863A1 (en) 2017-06-22 2020-01-30 Board Of Regents, The University Of Texas System Methods for producing regulatory immune cells and uses thereof
US20200390815A1 (en) 2018-02-21 2020-12-17 Board Of Regents, The University Of Texas System Universal antigen presenting cells and uses thereof
AU2020272944A1 (en) * 2019-04-12 2021-11-25 Board Of Regents, The University Of Texas System Methods for producing regulatory B cells and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69631331T2 (de) * 1995-06-07 2004-11-18 Immunex Corp., Seattle Cd40l mutein
AU8867501A (en) * 2000-09-01 2002-03-13 Biogen Inc Co-crystal structure of monoclonal antibody 5c8 and cd154, and use thereof in drug design
EP1390076A4 (fr) * 2001-04-27 2004-12-15 Xcyte Therapies Inc Maturation des cellules presentatrices des antigenes au moyen de lymphocytes t actives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO2005035570A3 *

Also Published As

Publication number Publication date
WO2005035570A2 (fr) 2005-04-21
WO2005035570A3 (fr) 2005-11-03

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