EP1667641A1 - Preparations cosmetiques ou dermatologiques a teneur en isoflavones et en licochalcone a - Google Patents

Preparations cosmetiques ou dermatologiques a teneur en isoflavones et en licochalcone a

Info

Publication number
EP1667641A1
EP1667641A1 EP04765527A EP04765527A EP1667641A1 EP 1667641 A1 EP1667641 A1 EP 1667641A1 EP 04765527 A EP04765527 A EP 04765527A EP 04765527 A EP04765527 A EP 04765527A EP 1667641 A1 EP1667641 A1 EP 1667641A1
Authority
EP
European Patent Office
Prior art keywords
preparations
sebum
isoflavones
acid
cosmetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04765527A
Other languages
German (de)
English (en)
Inventor
Stefan Gallinat
Ludger Kolbe
Christopher Mummert
Franz STÄB
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of EP1667641A1 publication Critical patent/EP1667641A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/121—Ketones acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/008—Preparations for oily skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/008—Preparations for oily hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments

Definitions

  • the present invention relates to the use of topical preparations for removing sebum from the skin, in particular for removing and clarifying comedones, for preventing comedone formation, for the prophylaxis and treatment of mild forms of acne, and for the prophylaxis and control of seborrhea.
  • Sebum is the secretion of the sebaceous gland. Sebaceous glands are bulges of the follicular epithelium and therefore part of the follicle with which they form a functional unit. They are holocrine glands, which means that most of the whole glandular cell is converted into the sebum secretion. The cells of the sebum gland, which are constantly renewed from below, grease and decay, and the skin sebum thus formed is emptied onto the surface of the skin through the follicle openings.
  • the lipids of the sebum gland form the so-called hydro-lipid film of the skin.
  • This surface film is an emulsion, which can be a water-in-oil or an oil-in-water emulsion. It has the function of keeping the skin surface supple and regulating the water content of the underlying skin layers. If the sebum is well hydrated, the water content is at least 10 to 20% by weight and the sebum is hydrophilic. If the hydrophilic-lipophilic equilibrium of the surface film is no longer given and the water content drops, the sebum changes and becomes hydrophobic. The sebum flow from the sebaceous gland and follicle is impeded. There is a build-up of skin sebum in the follicular mouth, which can then lead to comedones and inflammation of the follicles.
  • comedone formation can have various causes.
  • external influences such as incorrect cleaning habits and incorrect care, comedogenic substances in cosmetics, weather influences, alkaline soaps, harsh detergents.
  • Increased sebum secretion and the formation of comedones can also develop due to genetic factors and hormonal influences.
  • comedones, inflammation, pre-acne and acne with their after-effects can be the result.
  • soaps have the disadvantage that the water-insoluble calcium and magnesium salts of the higher fatty acids which form when the soaps are used in hard water form slimy deposits on the skin. If it is difficult to rinse off, these precipitates remain on the skin longer, clog the mouth of the fillet and can lead to the formation of comedones. Therefore, syndets (i.e. non-soap surfactants) in the form of washing creams or washing lotions are mainly used for skin cleaning. Although these syndets do not form lime soaps, treatment with highly surface-active agents has a more degreasing and drying effect on the skin than soap.
  • Seborrhea is an increased function of the sebaceous glands through predisposition. Both the scalp and facial skin appear greasy. The composition of the seborrhoeic sebum is different from that of normal sebum. There are 3 stages of seborrhea development: 1. Simple seborrhea. Mild cases, greasy after 8 days. 2. Oily seborrhea greasy after only 2-3 days.
  • Disorders are triggered and has an aesthetic disadvantage on the overall appearance of the hair. This disorder can also be the cause of hair loss.
  • the precursor is the seborrhoeic condition of the scalp. Vegetative disorders as well as improper care can worsen the skin and hair condition. Even with seborrhea, the hair can even be dry due to keratin build-up disorders. Dry, damaged hair is often caused by external stress such as B. sun or chemical treatments. Too hot blow drying or improper care of damaged hair can lead to damage.
  • the causes of oily hair lie in the human body and are caused by hormones. Each hair has its own sebum gland that produces fat (sebum, sebum). Sebum production is controlled hormone-wise, and depending on the hormone sensitivity of the sebaceous gland, over or under production can occur.
  • the sebum itself has the function of keeping the scalp supple. It comes out, the sebum gland on the scalp and only later the hairline. There it is normally taken up by the hair shaft and remains invisible.
  • a sebum overproduction means that the hair is no longer included in the position. It is visible as a greasy film on the hair. The result is streaky, greasy, shiny hair.
  • Anomalies are due to a disruption of sebum activity. If the sebaceous glands are overactive, we speak of seborrhea. A distinction is made between two forms: the oily form (seborrhea oleosa) and the dry form (seborrhea sicca).
  • the treatment of seborrhea includes regular and thorough head washing with special shampoos, which can be carried out as often as necessary.
  • the wash should be combined with a massage in the connective tissue, because this empties the sebum more, which delays the re-greasing.
  • the present invention is the.
  • the object of the invention is to provide a preparation which does not have the disadvantages of the known and previously used agents, which at the same time has a sebum-releasing, fat-regulating and nourishing effect, removes the already existing comedones without irritation, effectively prevents degreasing and dehydration of the skin, the formation of comedones and prevents the development of acne cosmetics, as well as improves existing acne and which cares for the skin equally.
  • This object is achieved according to the invention by the preparations containing active ingredient combinations of isoflavones and licochalcone A or an aqueous extract from Radix Glycyrrhizae infiatae containing licochalcone A or the use of active ingredient combinations from isoflavones and licochalcon A or an aqueous extract from Radix Glycyrrhizae infiatae containing licochalcon A to reduce the production of sebum.
  • the comedogenic effect of the raw materials used in the preparation is abolished and thus the formation of comedones and accordingly the development of acne are prevented.
  • Isoflavones are a group of flavonoids, sometimes also referred to as isoflavonoids, of mostly yellowish-colored plant dyes that are derived from isoflavone.
  • the unsubstituted body, the actual isoflavone (3-phenylchromone, 3-phenyl-4H-1-benzopyran-4-one) occurs in clover types.
  • isoflavones are Daidzeaidn (4 ', 7-dihydroxy-isoflavone), as 7-O-glucoside Daidzin in soy flour; Genistein (4 ', 5,7-trihydroxy isoflavone) from soybeans and red clover; Prunetine (4 ', 5-dihydroxy-7-methoxy-isoflavone) from the bark of plum trees; Biochanin A (5,7-dihydroxy-4'-methoxy-isoflavone) from chickpeas, red clover and other types of clover; Orobol (3 ', 4', 5,7-tetrahydroxy isoflavone); Santal (S ' ⁇ '.
  • the isoflavones to be used according to the invention are preferably the isoflavones listed in the table above.
  • genistein is preferred.
  • Genistein 5,7-Dihydroxy-3- (4-hydroxyphenyl) -4 / -M-benzopyran-4-one, 4 ', 5,7-Trihydroxyisofla- von, also called Differenol A, Prunetol and Sophoricol, has the following structure on:
  • Genistein is a secondary metabolite from plants (legumes, papilionoids, rosaceae), but was also found in cultures of microorganisms (Actinomycetes, Aspergillus, Mycobacteria). Weak estrogenic and antibacterial effects have been described.
  • the plant species Glycyrrhiza inflata like the licorice Glycyrrhiza glabra, which belongs to Europe, belongs to the genus Glycyrrhiza, which belongs to the Fabaceae (pea family) plant family.
  • the drug Radix Glycyrrhizae infiatae, ie the root of the plant, is used, for example, in Far Eastern medicine.
  • the use of the drug as an anti-inflammatory is also known. This is part of the aqueous extract from Radix Glycyrrhizae infiatae
  • Licochalcon A which is characterized by the following structural formula:
  • the preparations contain 0.0001 to 5% by weight, in particular 0.001 to 1% by weight, very particularly 0.005 to 0.15% by weight of licochalcone A, based on the total weight of the preparation.
  • the preparations contain 0.001 to 10% by weight, in particular 0.05 to 5% by weight, very particularly 0.01 to 2% by weight, of one or more polyols, based on the total weight of the Preparation.
  • the preparations contain icocalchon as a constituent of plant extracts, in particular of Radix Glycyrrhizae infiatae.
  • licochalcone is in the form of an aqueous extract in which - licochalcone A water, if appropriate, one or more polyols are present.
  • the cosmetic or dermatological preparations 0.001 to 10 wt .-%, in particular 0.05 to 5 wt .-%, very particularly 0.01 to Contain 2% by weight of an aqueous extract from Radix Glycyrrhizae infiatae, based on the total weight of the preparation.
  • the cosmetic or dermatological preparations contain 0.001 to 10% by weight, in particular 0.05 to 5% by weight, very particularly 0.01 to 2% by weight, of one or more polyols, based on the total weight of the preparation.
  • butylene glycol as the polyol.
  • Licochalcone A in other vehicle systems in a concentration of 0.0001 to 5% by weight, in particular 0.001 to 1% by weight, very particularly 0.005-0.05% by weight.
  • According to the invention therefore also provides a method for controlling for blemished skin, acne or seborrheic symptoms, in particular greasy hair and / or dandruff, characterized in 'that the active compound combinations according to the invention in a suitable cosmetic or dermatological carrier, bum pellet with that of increased Se affected area.
  • a further preferred embodiment of the present invention are therefore formulations to be used against dandruff, for example antidandruff shampoos.
  • the active compounds are preferably used in cosmetic or dermatological compositions with a content of 0.0005-50.0% by weight, in particular 0.01-20.0% by weight, based on the total weight of the composition being preferred.
  • the compositions advantageously contain 0.02-10.0% by weight, particularly preferably 0.02-10% 5.0% by weight of the active ingredients used according to the invention, very particularly advantageously 0.5-3.0% by weight, in each case based on the total weight of the composition.
  • agents which are effective against sebum for example selected from the group of starch phosphate, cyclodextrin,.
  • the active ingredients used according to the invention can be incorporated into common cosmetic or dermatological formulations without difficulty, advantageously in pump sprays, aerosol sprays, creams, ointments, tinctures, lotions and the like.
  • active substances used according to the invention with other active substances, for example with other antimicrobial, antimycotic or antiviral substances.
  • compositions according to the invention It is advantageous to buffer the compositions according to the invention.
  • a pH range of 3.5 - 7.5 is advantageous. It is particularly favorable to choose the pH in a range from 4.0 to 6.5.
  • the cosmetic and / or dermatological formulations according to the invention can be composed as usual and can be used to treat the skin and / or the hair in the sense of a dermatological treatment or a treatment in the sense of nourishing cosmetics. But they can also be used in make-up products in decorative cosmetics.
  • the cosmetic and / or dermatological formulations according to the invention are applied to the skin and / or the hair in a sufficient amount in the manner customary for cosmetics and dermatics.
  • the antioxidants are advantageously selected from the group consisting of amino acids (eg glycine, histidine, tyrosine, tryptophan) and their derivatives; Imidazoles (eg urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-camosine, L-carnosine and their derivatives (eg anserine), carotenoids, carotenes (eg ⁇ -carotene, ⁇ -carotene, lycopene ) and their derivatives, lipoic acid and its derivatives (e.g. dihydroliponic acid), aurothioglucose, propylthiouracil and other thiols (e.g.
  • amino acids eg glycine, histidine, tyrosine, tryptophan
  • Imidazoles eg urocanic acid
  • peptides such as D, L-carnosine, D-camosine, L-carnos
  • thioredoxin glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, Propyl, amyl, butyl and lauryl, palmitoyl, oleyl, ⁇ -linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and their derivatives (esters, ethers, peptides, lipi - de, nucleotides, nucleosides and salts) and sulfoximine compounds (e.g.
  • buthionine sulfoximines in very low tolerable dosages (e.g. pmol to ⁇ mol / kg), also (metal) chelators (eg ⁇ -hydroxy fatty acids, palmitic acid, phytic acid, Lactoferrin), hydroxy acids (e.g.
  • citric acid lactic acid, malic acid
  • humic acid bile acid
  • bile extracts bilirubin
  • biliverdin biliverdin
  • EDTA EGTA and their derivatives
  • unsaturated fatty acids and their derivatives e.g.
  • ⁇ -linolenic acid, linoleic acid, oleic acid) Folic acid and its derivatives, alanine diacetic acid, flavonoids, polyphenols, catechins, vitamin C and derivatives (eg ascorbyl palmitate, Mg-ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (eg vitamin E-acetate), as well as coniferyl benzoate Benzoin, rutinic acid and its derivatives, ferulic acid and its derivatives, butylated hydroxytoluene, butylated hydroxyanisole, nordihydroguajak resinic acid, nordihydroguajaretic acid, trihydroxybutyrophenone, uric acid and its derivatives, mannose and its derivatives.
  • alanine diacetic acid flavonoids
  • polyphenols eg ascorbyl palmitate, Mg-ascorbyl phosphate, ascorbyl acetate
  • vate zinc and its derivatives (eg ZnO, ZnSO 4 ) selenium and its derivatives (eg selenomethionine), silenes and their derivatives (eg stilbene oxide, trans-stilbene oxide) and the derivatives suitable according to the invention (salts, esters, ethers , Sugars, nucleotides, nucleosides, peptides and lipids) of these active ingredients.
  • zinc and its derivatives eg ZnO, ZnSO 4
  • silenes and their derivatives eg stilbene oxide, trans-stilbene oxide
  • suitable according to the invention salts, esters, ethers , Sugars, nucleotides, nucleosides, peptides and lipids
  • the amount of the antioxidants (one or more compounds) in the preparations is preferably 0.001 to 30% by weight, particularly preferably 0.05 to 20% by weight, in particular 1 to 10% by weight, based on the total weight of the preparation ,
  • the prophylaxis or the cosmetic or dermatological treatment with the active ingredient used according to the invention or with the cosmetic or topical dermatological preparations with an effective content of active ingredient used according to the invention is carried out in the usual way, namely in such a way that the active ingredient used according to the invention or the cosmetic or topical dermatological preparations with an effective content of active ingredient used according to the invention is applied to the affected skin areas.
  • the active ingredient used according to the invention can advantageously be incorporated into customary cosmetic and dermatological preparations, which can be in various forms. So you can e.g. a solution, an emulsion of the type water-in-oil (W / O) or of the type oil-in-water (O / W), or a multiple emulsions, for example of the type water-in-oil-in-water (W / O / W) or oil-in-water-in-oil (O / W / O), a hydrodispersion or lipodispersion, a gel, a solid stick or an aerosol.
  • Emulsions according to the invention in the sense of the present invention are advantageous and contain e.g. Fats, oils, waxes and / or other fat bodies, as well as water and one or more emulsifiers, as are usually used for such a type of formulation.
  • auxiliaries and additives include, for example, consistency agents, fillers, perfumes, dyes, emulsifiers, additional active ingredients such as vitamins or proteins, light stabilizers, stabilizers, insect repellents, alcohol, water, salts, antimicrobial, proteolytic or keratolytically active substances, etc.
  • Medical topical compositions in the sense of the present invention generally contain one or more medicaments in an effective concentration.
  • medicaments in an effective concentration.
  • Preparations according to the invention can therefore advantageously contain substances which absorb UV radiation in the UVB range, the total amount of filter substances e.g. 0.1% by weight to 30% by weight, preferably 0.5 to 10% by weight, in particular 1 to 6% by weight, based on the total weight of the preparations.
  • the total amount of filter substances e.g. 0.1% by weight to 30% by weight, preferably 0.5 to 10% by weight, in particular 1 to 6% by weight, based on the total weight of the preparations.
  • the UVB filters can be oil-soluble or water-soluble.
  • oil-soluble substances are: 3-benzylidene camphor and its derivatives, for example 3- (4-methylbenzylidene) camphor, 4-aminobenzoic acid derivatives, preferably 4- (dimethylamino) benzoic acid (2-ethylhexyl) ester, 4- (dimethylamino) ) benzoeklareamylester; Esters of cinnamic acid, preferably 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-methoxycinnamic acid isopentyl ester; Esters of salicylic acid, preferably salicylic acid (2-ethylhexyl) ester, salicylic acid
  • Advantageous water-soluble substances are: 2-phenylbenzimidazole-5-sulfonic acid and its salts, e.g. Sodium, potassium or
  • Triethanolammonium salts sulfonic acid derivatives of benzophenones, preferably 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and their salts; Sulfonic acid derivatives of 3-benzylidene camphor, e.g. 4- (2-oxo-3-bornylidene-methyl) benzenesulfonic acid, 2-methyl-5- (2-oxo-3-bomylidene-methyl) sulfonic acid and their salts.
  • UVB filters which can be used according to the invention, should of course not be limiting.
  • UVA filters in preparations according to the invention, which are usually contained in cosmetic and / or dermatological preparations.
  • Such filter substances are preferably derivatives of dibenzoylmethane, in particular 1- (4'-tert-butylphenyl) -3- (4'-methoxyphenyl) propane-1, 3-dione and 1-phenyl-3- (4'-isopropylphenyl) propane-1,3-dione. Preparations which contain these combinations are also the subject of the invention.
  • the same amounts of UVA filter substances that were mentioned for UVB filter substances can be used.
  • Cosmetic and / or dermatological preparations in the sense of the present invention can also contain inorganic pigments which are usually used in cosmetics to protect the skin from UV rays. These are oxides of titanium, zinc, iron, zirconium, silicon, manganese, aluminum, cerium and mixtures thereof, as well as modifications in which the oxides are the active agents. Pigments based on titanium dioxide are particularly preferred. The amounts mentioned for the above combinations can be used.
  • the cosmetic and dermatological preparations used according to the invention can contain cosmetic active ingredients, auxiliaries and / or additives as are usually used in such preparations, for example antioxidants, preservatives, bactericides, perfumes, substances for preventing foaming, dyes, pigments, which have a coloring effect, thickeners, surface-active substances, emulsifiers, softening, moisturizing and / or moisturizing substances, fats, oils, waxes or other usual components of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives ,
  • the cosmetic or dermatological preparation in the sense of the present invention is a solution or emulsion or dispersion
  • solvents water or aqueous solutions oils, such as triglycerides of capric or caprylic acid, but preferably castor oil; Fats, waxes and other natural and synthetic fat bodies, preferably esters of fatty acids with low C alcohols, e.g. with isopropanol, propylene glycol or glycerin, or esters of fatty alcohols with low C number alkanoic acids or with fatty acids; Alcohols, diols or polyols of low C.
  • oils such as triglycerides of capric or caprylic acid, but preferably castor oil
  • Fats, waxes and other natural and synthetic fat bodies preferably esters of fatty acids with low C alcohols, e.g. with isopropanol, propylene glycol or glycerin, or esters of fatty alcohols with low C number alkanoic acids or with
  • ethers preferably ethanol, isopropanol, propylene glycol, glycerin, ethylene glycol, ethylene glycol monoethyl or - monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and similar Products.
  • Water can also be a component of alcoholic solvents.
  • the oil phase of the emulsions, oleogels or hydrodispersions or lipodispersions for the purposes of the present invention is advantageously selected from the group of esters from saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 3 to 30 carbon atoms, from the group of esters from aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 3 to 30 carbon atoms. atoms.
  • Es- ter oils can then advantageously be selected from the group of isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate,
  • the oil phase can advantageously be selected from the group of branched and unbranched hydrocarbons and waxes, the silicone oils, the dialkyl ethers, the group of saturated or unsaturated, branched or unbranched alcohols, and also the fatty acid triglycerides, especially the triglycerol esters, saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 8 to 24, in particular 12 - 1 8 carbon atoms.
  • the fatty acid triglycerides can, for example, advantageously be selected from the group of synthetic, semi-synthetic and natural oils, e.g. Olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil and the like.
  • any mixtures of such oil and wax components can also be used advantageously for the purposes of the present invention. It may also be advantageous to use waxes, for example cetyl palmitate, as the sole lipid component of the oil phase.
  • the oil phase selected from the group 2-ethylhexyl isostearate, octyldodecanol, isotridecyl isononanoate, isoeicosane, 2-ethylhexyl cocoate, C 12 i 5 alkyl benzoate, caprylic-capric acid triglyceride, dicaprylyl ether.
  • Particularly advantageous are mixtures of C 12- ⁇ 5 -alkyl benzoate and 2-ethylhexyl isostearate, mixtures of C 12- i5-alkyl benzoate and isotridecyl isononanoate and mixtures of C- ⁇ 2-15 - benzoate, 2-ethylhexyl isostearate and isotridecyl isononanoate.
  • hydrocarbons paraffin oil, squalane and squalene can be used advantageously for the purposes of the present invention.
  • the oil phase can also advantageously contain cyclic or linear silicone oils. have or consist entirely of such oils, although it is preferred to use an additional content of other oil phase components in addition to the silicone oil or the silicone oils.
  • Cyclomethicone (octamethylcyclotetrasiloxane) is advantageously used as the silicone oil to be used according to the invention.
  • Other silicone oils can also be used advantageously for the purposes of the present invention, for example hexamethylcyclotrisiloxane, polydimethylsiloxane, poly (methylphenylsiloxane).
  • the aqueous phase of the preparations according to the invention advantageously advantageously contains alcohols, diols or polyols of low C number, and their ethers, preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether , Diethy- glycol monomethyl or monoethyl ether and analog products, furthermore alcohols of low C number, for example Ethanol, isopropanol, 1, 2-propanediol, glycerol and in particular one or more thickeners, which or which can advantageously be selected from the group consisting of silicon dioxide, aluminum silicates, polysaccharides and their derivatives.
  • alcohols, diols or polyols of low C number, and their ethers preferably ethanol, isopropanol, propylene glycol, g
  • Hyaluronic acid e.g. Hyaluronic acid, xanthan gum, hydroxypropylmethyl cellulose
  • group of polyacrylates preferably a polyacrylate from the group of so-called carbopoles, for example carbopoles of types 980, 981, 1382, 2984, 5984, each individually or in combination.
  • Gels used according to the invention usually contain alcohols of low C number, for example. Ethanol, isopropanol, 1, 2-propanediol, glycerol and water or an oil mentioned above in the presence of a thickener which is preferably silicon dioxide or an aluminum silicate in the case of oily-alcoholic gels, and is preferably a polyacrylate in the case of aqueous-alcoholic or alcoholic gels.
  • a thickener which is preferably silicon dioxide or an aluminum silicate in the case of oily-alcoholic gels, and is preferably a polyacrylate in the case of aqueous-alcoholic or alcoholic gels.
  • Solid sticks contain, for example, natural or synthetic waxes, fatty alcohols or fatty acid esters.
  • Usual base materials which are suitable for use as cosmetic sticks in the sense of the present invention are liquid oils (for example paraffin oils, castor oil, isopropyl myristate), semi-solid components (for example petroleum jelly, lanolin), solid components (for example beeswax, ceresin and microcrystallines) Waxes or ozokerite) and high-melting waxes (e.g. camauba wax, candelilla wax)
  • Suitable blowing agents for cosmetic and / or dermatological preparations which can be sprayed from aerosol containers for the purposes of the present invention are the customarily known volatile, liquefied blowing agents, for example hydrocarbons (propane, butane, isobutane), which can be used alone or in a mixture with one another. Compressed air can also be used advantageously.
  • volatile, liquefied blowing agents for example hydrocarbons (propane, butane, isobutane)
  • Cosmetic preparations in the sense of the present invention can also be present as gels which, in addition to an effective content of the active ingredient according to the invention and solvents usually used for this purpose, preferably water, or organic thickeners, for example.
  • the thickener is in the gel e.g. in an amount between 0.1 and 30% by weight, preferably between 0.5 and 15% by weight.
  • Example 1 0 / W cream

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des préparations contenant des combinaisons de principes actifs à base d'isoflavones et de licochalcone A ou d'un extrait aqueux de Radix glycyrrhizae inflatae contenant de la licochalcone A. L'invention concerne également l'utilisation de combinaisons de principes actifs à base d'isoflavones et de licochalcone A ou d'un extrait aqueux de Radix glycyrrhizae inflatae contenant de la licochalcone A pour réduire la production de sébum.
EP04765527A 2003-09-25 2004-09-23 Preparations cosmetiques ou dermatologiques a teneur en isoflavones et en licochalcone a Withdrawn EP1667641A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10344531A DE10344531A1 (de) 2003-09-25 2003-09-25 Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an Isoflavonen und Licochalcon A oder einem wässrigen Extrakt aus Radix Glycyrrhizae inflatae, enthaltend Licochalcon A, sowie die Verwendung von Isoflavonen und Licochalcon A oder einem wässrigen Extrakt aus Radix Glycyrrhizae inflatae, enthaltend Licochalcon A, zur Herstellung kosmetischer und dermatologischer Zubereitungen zur Bekämpfung von Sebum
PCT/EP2004/010667 WO2005030157A1 (fr) 2003-09-25 2004-09-23 Preparations cosmetiques ou dermatologiques a teneur en isoflavones et en licochalcone a

Publications (1)

Publication Number Publication Date
EP1667641A1 true EP1667641A1 (fr) 2006-06-14

Family

ID=34384279

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04765527A Withdrawn EP1667641A1 (fr) 2003-09-25 2004-09-23 Preparations cosmetiques ou dermatologiques a teneur en isoflavones et en licochalcone a

Country Status (3)

Country Link
EP (1) EP1667641A1 (fr)
DE (1) DE10344531A1 (fr)
WO (1) WO2005030157A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108042414A (zh) * 2017-11-30 2018-05-18 赵茹伊 一种润发发膜

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10356164A1 (de) * 2003-12-02 2005-08-04 Beiersdorf Ag Wirkstoffkombinationen aus Licochalcon A oder einem Extrakt aus Radix Clycyrrhizae inflatae, enthaltend Licochalcon A, Phenoxyethanol und gewünschtenfalls Glycerin
DE10356864A1 (de) * 2003-12-03 2005-07-07 Beiersdorf Ag Kosmetische und dermatologische Zubereitungen mit einem Gehalt an Licochalcon A und Sojabohnenkeimextrakten
DE102006055046A1 (de) * 2006-11-17 2008-05-21 Beiersdorf Ag Kosmetische Formulierung mit Glucosylglyceriden und Puderrohstoffen
DE102010012384A1 (de) * 2010-03-22 2011-09-22 Beiersdorf Ag Hautfreundliche Wirkstoffkombination gegen Akne
GB2481629A (en) * 2010-07-01 2012-01-04 Kartar Singh Lalvani Anti-acne composition
FR2997626B1 (fr) * 2012-11-05 2016-08-19 Laboratoires Dermatologiques Duriage Composition cosmetique destinee au traitement des peaux grasses
DE102015203444A1 (de) * 2015-02-26 2016-09-01 Beiersdorf Ag Wirkstoffe und kosmetische oder dermatologische Zubereitungen, solche Wirkstoffe enthaltend, zur Pflege der Haut von Patienten des Diabetes mellitus

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02193919A (ja) * 1989-01-23 1990-07-31 Kao Corp 皮脂線抑制剤
JP2001163718A (ja) * 1999-12-10 2001-06-19 Maruzen Pharmaceut Co Ltd 皮脂分泌抑制剤および皮膚外用剤
JP2001253823A (ja) * 2000-03-09 2001-09-18 Yasukazu Tanuma Ｈｉｖ遺伝子発現抑制剤
JP2003238379A (ja) * 2002-02-08 2003-08-27 Maruzen Pharmaceut Co Ltd 皮膚化粧料および頭髪化粧料
DE10211192A1 (de) * 2002-03-14 2003-09-25 Beiersdorf Ag Isoflavanoide gegen Hautalterung und Akne
DE10224387A1 (de) * 2002-06-01 2003-12-11 Beiersdorf Ag Kosmetische oder dermatologische Zubereitungen mit einem aufbereiteten Extrakt aus Radix Glycyrrhizae inflatae

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO2005030157A1 *
TSUTOMU HATANO ET AL: "Phenolic constituents of licorive. VIII. Structures of glicophenone and glicoisoflavone and effects of licorice phenolics on methicillin-resistant staphylococcus aureus", CHEMICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, vol. 48, no. 9, 1 January 2000 (2000-01-01), pages 1286 - 1292, XP002969544, ISSN: 0009-2363 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108042414A (zh) * 2017-11-30 2018-05-18 赵茹伊 一种润发发膜

Also Published As

Publication number Publication date
DE10344531A1 (de) 2005-04-28
WO2005030157A1 (fr) 2005-04-07

Similar Documents

Publication Publication Date Title
EP1642559B1 (fr) Utilisation de créatine et/ou de dérivés de créatine et de l'acide folique dans des préparations cosmétiques ou dermatologiques
EP1594455B1 (fr) Preparations cosmetiques ou dermatologiques contenant de la creatine, de la creatinine et / ou leurs derives en combinaison avec des extraits de germe de graines de soja
EP0945126B1 (fr) Composition cosmétique ou dermatologique contenant de la carnitine et/ou un acylcarnitine et au moins un antioxydant
WO1996018379A1 (fr) Preparations cosmetiques et dermatologiques aux flavonoïdes
EP1623698A1 (fr) Utilisation d'une combinaison comprenant au moins un bioquinone et au moins un isoflavanoïde pour améliorer l'état de la peau
EP1172084A2 (fr) Composition cosmétique et dermatologique pour éliminer du sébum
EP1414402A1 (fr) Preparations cosmetiques ou dermatologiques a combinaison de creatinine et/ou de derives de creatinine avec la creatinine et ou ses derives
EP1686952A1 (fr) Utilisation de licochalcone a ou d'un extrait contenant de la licochalcone a a base de radix glycyrrhizae inflatae pour lutter contre le vieillissement de la peau
DE10132338A1 (de) Verwendung von 5'-Desoxy-5'-methylthioadenosin in hautkosmetischen Mitteln
EP1179338A1 (fr) Compositions cosmétiques et dermatologiques comprenant des cyclodextrines pour enlever le sebum
EP1667641A1 (fr) Preparations cosmetiques ou dermatologiques a teneur en isoflavones et en licochalcone a
EP1414401A1 (fr) Utilisation de creatinine et/ou de derives de la creatinine dans des preparations cosmetiques ou dermatologiques
EP1377254A2 (fr) Preparations cosmetiques et dermatologiques contenant des isoflavones
DE10352367A1 (de) Verwendung von Licochalkon A gegen Rosacea
JP3973912B2 (ja) 津液作用を有する生薬のエキス及び血管新生活性を有する生薬エキスからなる育毛用の皮膚外用剤
EP1529520A1 (fr) Utilisation de licochalcone A ou d'un extrait de Radix Glycyrrhizae inflatae contenant du licochalcone A contre la hyperpigmentation postinflammatoire
EP0963754A1 (fr) Composition cosmétique ou dermatologique contenant de la carnitine et/ou un acylcarnitine et au moins un retinoide
EP1397119A2 (fr) Utilisation de polystyrene sulfonate de sodium pour raffermir la peau
EP0945127A2 (fr) Utilisation de l'acylcarnitine
WO2002076410A2 (fr) Preparations cosmetiques et dermatologiques renfermant un extrait de houblon ou de houblon-malt et utilisation d'un extrait de houblon ou de houblon-malt dans la production de preparations cosmetiques et dermatologiques servant a reduire la secretion de sebum cutane
WO2022037927A1 (fr) Nouveaux dérivés d'isobutyrylamide, préparations cosmétiques et/ou dermatologiques contenant ces composés et leur utilisation pour la prophylaxie et le traitement de peaux sensibles, en particulier de peaux enflammées ou d'affections cutanés inflammatoires
DE102004006829A1 (de) Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an Isoflavonen und Antitranspirantwirkstoffen, sowie die Verwendung von Isoflavonen und Antitranspirantwirkstoffen zur Herstellung kosmetischer und dermatologischer Zubereitungen zur Bekämpfung von Sebum
WO2004089326A1 (fr) Preparations cosmetiques ou dermatologiques contenant une combinaison de creatinine, de creatine et de quinones biologiques
EP2589374B1 (fr) Utilisation d'extrait d'écorce de magnolia pour améliorer l'aspect de la peau ou lutter contre la cellulite
DE10127432A1 (de) Wirkstoffkombination zur Verhinderung unerwünschter Hautpigmentierung

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20060425

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
17Q First examination report despatched

Effective date: 20061026

RIN1 Information on inventor provided before grant (corrected)

Inventor name: GALLINAT, STEFAN

Inventor name: KOLBE, LUDGER

Inventor name: MUMMERT, CHRISTOPHER

Inventor name: STAEB, FRANZ

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20140311