EP1651235A4 - Sigma-1 rezeptor-ligand mit acetylcholinesterase-hemmenden eigenschaften - Google Patents

Sigma-1 rezeptor-ligand mit acetylcholinesterase-hemmenden eigenschaften

Info

Publication number
EP1651235A4
EP1651235A4 EP04757425A EP04757425A EP1651235A4 EP 1651235 A4 EP1651235 A4 EP 1651235A4 EP 04757425 A EP04757425 A EP 04757425A EP 04757425 A EP04757425 A EP 04757425A EP 1651235 A4 EP1651235 A4 EP 1651235A4
Authority
EP
European Patent Office
Prior art keywords
sigma
receptor ligand
inhibition properties
acetylcholinesterase inhibition
acetylcholinesterase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP04757425A
Other languages
English (en)
French (fr)
Other versions
EP1651235A2 (de
Inventor
Vassilios Papadopoulos
Laurent Lecanu
Janet Greeson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgetown University
Samaritan Pharmaceuticals Inc
Original Assignee
Georgetown University
Samaritan Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgetown University, Samaritan Pharmaceuticals Inc filed Critical Georgetown University
Publication of EP1651235A2 publication Critical patent/EP1651235A2/de
Publication of EP1651235A4 publication Critical patent/EP1651235A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP04757425A 2003-08-05 2004-08-05 Sigma-1 rezeptor-ligand mit acetylcholinesterase-hemmenden eigenschaften Withdrawn EP1651235A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49276903P 2003-08-05 2003-08-05
PCT/US2004/025295 WO2005016276A2 (en) 2003-08-05 2004-08-05 Sigma-1 receptor ligand with acetylcholinesterase inhibition properties

Publications (2)

Publication Number Publication Date
EP1651235A2 EP1651235A2 (de) 2006-05-03
EP1651235A4 true EP1651235A4 (de) 2008-12-17

Family

ID=34193147

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04757425A Withdrawn EP1651235A4 (de) 2003-08-05 2004-08-05 Sigma-1 rezeptor-ligand mit acetylcholinesterase-hemmenden eigenschaften

Country Status (6)

Country Link
EP (1) EP1651235A4 (de)
JP (1) JP2007501254A (de)
CN (1) CN1863536A (de)
AU (1) AU2004264342A1 (de)
CA (1) CA2534777A1 (de)
WO (1) WO2005016276A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060247248A1 (en) * 2003-08-05 2006-11-02 Vassilios Papadopoulos Sigma-1 receptor ligand with acetylcholinesterase
WO2010015040A1 (en) * 2008-08-07 2010-02-11 Powmri Ltd Therapy and prevention of tdp-43 proteinopathy
CN103420941B (zh) * 2013-08-26 2015-09-23 浙江大学 2-甲氧基苯基-二甲胺基甲酸酯衍生物及制备和用途

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB846795A (en) * 1957-03-29 1960-08-31 Henri Morren New piperazine derivatives and process for the preparation thereof
US3284453A (en) * 1964-09-29 1966-11-08 American Cyanamid Co 4-(2-aroylethyl)-1-piperazinecarboxylic acid esters
FR2339401A1 (fr) * 1976-02-02 1977-08-26 Orsymonde N-phenacyl-piperazines
US5143910A (en) * 1989-09-07 1992-09-01 Shionogi & Co., Ltd. Piperaziniocephalosporins
EP0602242A1 (de) * 1991-08-22 1994-06-22 Yoshitomi Pharmaceutical Industries, Ltd. Benzisoxazolverbindungen und ihre verwendung
US20030144285A1 (en) * 1998-03-31 2003-07-31 Mark Brann Compounds with activity on muscarinic receptors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214994B1 (en) * 1997-04-21 2001-04-10 Molecular Geriatrics Corporation Certain substituted 1-aryl-3-piperazin-1′-yl propanones
RU2230740C2 (ru) * 1998-03-31 2004-06-20 Акадиа Фармасьютикалз, Инк. Производные азотсодержащих гетероциклических соединений и фармацевтическая композиция на их основе
AU2003218180B2 (en) * 2002-03-15 2008-03-20 Georgetown University Neuroprotective spirostenol pharmaceutical compositions
CA2527211A1 (en) * 2003-06-02 2004-12-16 Samaritan Pharmaceuticals, Inc. Anti-hiv benzamide compounds

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB846795A (en) * 1957-03-29 1960-08-31 Henri Morren New piperazine derivatives and process for the preparation thereof
US3284453A (en) * 1964-09-29 1966-11-08 American Cyanamid Co 4-(2-aroylethyl)-1-piperazinecarboxylic acid esters
FR2339401A1 (fr) * 1976-02-02 1977-08-26 Orsymonde N-phenacyl-piperazines
US5143910A (en) * 1989-09-07 1992-09-01 Shionogi & Co., Ltd. Piperaziniocephalosporins
EP0602242A1 (de) * 1991-08-22 1994-06-22 Yoshitomi Pharmaceutical Industries, Ltd. Benzisoxazolverbindungen und ihre verwendung
US20030144285A1 (en) * 1998-03-31 2003-07-31 Mark Brann Compounds with activity on muscarinic receptors

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CHAWLA H P S ET AL: "AGENTS ACTING ON THE CENTRAL NERVOUS SYSTEM. XII. 3-T-AMINOPROPIOPHENONES AS CENTRAL MUSCLE RELAXANTS AND DIURETICS", JOURNAL OF MEDICINAL CHEMISTRY, US AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 13, no. 3, 1 January 1970 (1970-01-01), pages 480 - 488, XP001183938, ISSN: 0022-2623 *
CHITI W ET AL: "Synthesis of some new p-hydroxypropiophenone derivatives with local anesthetic activity", FARMACO, EDIZIONE SCIENTIFICA, SOCIETA CHIMICA ITALIANA, PAVIA, vol. 15, 1 January 1960 (1960-01-01), pages 773 - 787, XP009108062, ISSN: 0430-0920 *
GRINSTEINS V ET AL: "Synthesis and study of potential catechol-O-methyltransferase inhibitors. Synthesis of some nitrogen-containing pyrocatechol derivatives", AKADEMIYA NAUK LATVIISKOI S.S.R. IZVESTIYA. SERIYA KHIMICHESKAYA, IZDEVEJS ZINATNE TURGENEVA, RIGA, LV, no. 5, 1 January 1968 (1968-01-01), pages 593 - 596, XP009108050, ISSN: 0002-3248 *
KASE YOSHITOSHI ET AL: "Chemical-pharmacological studies on antitussives. II. Site of antitussive action of 1-(3,4-dihydroxyphenacyl)-4-(2-hydroxypropyl)pi perazine dihydrochloride", YAKUGAKU ZASSHI - JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 825, 1 January 1962 (1962-01-01), pages 1298 - 1302, XP009108068, ISSN: 0031-6903 *
MATSUNO KIYOSHI ET AL: "SA4503, a novel cognitive enhancer, with sigma-1 receptor agonistic properties", BEHAVIOURAL BRAIN RESEARCH, vol. 83, no. 1-2, 1997, pages 221 - 224, XP002502305, ISSN: 0166-4328 *
NATOVA L ET AL: "On the preparation and Structure of some Mannich Basis Prepared from Hydroxy - and Methoxyacetophenons = Synthesis and structure of some Mannich bases obtained from hydroxy- and methoxyacetophenones", GODISNIK NA VISSIA HIMIKOTEHNOLOGICLESKI INSTITUT-SOFIA -ANNUAIRE DE L'INSTITUT CHIMICO-TECHNOLOGIQUE, SOFIA, BG, vol. 24, no. 4, 1 January 1981 (1981-01-01), pages 57 - 66, XP009108051, ISSN: 0489-6211 *
PERRONE ROBERTO ET AL: "Synthesis and structure-affinity relationships of 1-[omega-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones as 5-HT(7) receptor ligands.", JOURNAL OF MEDICINAL CHEMISTRY 13 FEB 2003, vol. 46, no. 4, 13 February 2003 (2003-02-13), pages 646 - 649, XP002502303, ISSN: 0022-2623 *
SHAO G X ET AL: "Synthesis of catechol aminoketone and its analogs", YAO HSUEH HSUEH PAO - ACTA PHARMACEUTICA SINICA, BEIJING, CN, vol. 25, no. 2, 1 January 1990 (1990-01-01), pages 101 - 109, XP009108052, ISSN: 0513-4870 *
YOKOYAMA MATATSUGU ET AL: "Phenacylpiperazine derivatives", YAKUGAKU KENKYU - JAPANESE JOURNAL OF PHARMACY AND CHEMISTRY, SN, JP, vol. 33, 1 January 1961 (1961-01-01), pages 752 - 757, XP009108069, ISSN: 0372-7734 *

Also Published As

Publication number Publication date
WO2005016276A3 (en) 2005-07-07
CA2534777A1 (en) 2005-02-24
CN1863536A (zh) 2006-11-15
AU2004264342A1 (en) 2005-02-24
JP2007501254A (ja) 2007-01-25
WO2005016276A2 (en) 2005-02-24
EP1651235A2 (de) 2006-05-03

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Legal Events

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Effective date: 20081119

RIC1 Information provided on ipc code assigned before grant

Ipc: C07D 241/04 20060101ALI20081110BHEP

Ipc: A61P 25/28 20060101ALI20081110BHEP

Ipc: A61K 31/495 20060101ALI20081110BHEP

Ipc: A61K 31/56 20060101AFI20050721BHEP

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