GB846795A - New piperazine derivatives and process for the preparation thereof - Google Patents

New piperazine derivatives and process for the preparation thereof

Info

Publication number
GB846795A
GB846795A GB9740/58A GB974058A GB846795A GB 846795 A GB846795 A GB 846795A GB 9740/58 A GB9740/58 A GB 9740/58A GB 974058 A GB974058 A GB 974058A GB 846795 A GB846795 A GB 846795A
Authority
GB
United Kingdom
Prior art keywords
hydroxyethoxy
piperazine
preparation
dihydroxyphenacyl
hydroxyphenacyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB9740/58A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of GB846795A publication Critical patent/GB846795A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises piperazine derivatives of the general formula :- <FORM:0846795/IV(b)/1> (in which R and R1 are hydrogen or hydroxyl, each R1 is hydrogen or methyl and R11 is a 2-hydroxyethyl or 2-(2-hydroxyethoxy) ethyl radical) and salts thereof with mineral and organic acids, together with a process for their preparation by reacting an a -chloro-3-R-4-R1-acetophenone with a 1-R11 piperazine. Specified 4-(2-hydroxyethyl) piperazines are 1-phenacyl-, 1-(4-hydroxyphenacyl), 1-(4-hydroxyphenacyl-2, 5-dimethyl-, 1-(3, 4-dihydroxyphenacyl), and 1-(3, 4-dihydroxyphenacyl)- 2, 5-dimethyl-, and specified 4-[2-(2-hydroxyethoxy)ethyl] piparezines are 1-phenacyl-, 1- (4-hydroxyphenacyl)- and 1-3, 4-dihydroxyphenacyl)-. 1-(2-hydroxyethyl)- 2, 5-dimethylpiperazine is prepared from aqueous 2, 5-dimethylpiperazine and ethylene oxide ; 1-[2-(2-hydroxyethoxy)-ethyl]-piperazine is obtained from piperazine and 2-(2-hydroxyethoxy) ethanol in toluene.
GB9740/58A 1957-03-29 1958-03-26 New piperazine derivatives and process for the preparation thereof Expired GB846795A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE846795X 1957-03-29

Publications (1)

Publication Number Publication Date
GB846795A true GB846795A (en) 1960-08-31

Family

ID=3882027

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9740/58A Expired GB846795A (en) 1957-03-29 1958-03-26 New piperazine derivatives and process for the preparation thereof

Country Status (1)

Country Link
GB (1) GB846795A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3300497A (en) * 1964-08-19 1967-01-24 Hoffmann La Roche 2-aryl-2-piperazinylacetophenones
EP1651235A2 (en) * 2003-08-05 2006-05-03 Samaritan Pharmaceuticals, Inc. Sigma-1 receptor ligand with acetylcholinesterase inhibition properties

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3300497A (en) * 1964-08-19 1967-01-24 Hoffmann La Roche 2-aryl-2-piperazinylacetophenones
EP1651235A2 (en) * 2003-08-05 2006-05-03 Samaritan Pharmaceuticals, Inc. Sigma-1 receptor ligand with acetylcholinesterase inhibition properties
JP2007501254A (en) * 2003-08-05 2007-01-25 サマリタン，ファーマスーティカルス，インク． Sigma-1 receptor ligand with acetylcholinesterase inhibitory properties
EP1651235A4 (en) * 2003-08-05 2008-12-17 Samaritan Pharmaceuticals Inc Sigma-1 receptor ligand with acetylcholinesterase inhibition properties

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