EP1649007A4 - Verfahren zur ex-vivo-expansion von stamm-/ vorläuferzellen - Google Patents
Verfahren zur ex-vivo-expansion von stamm-/ vorläuferzellenInfo
- Publication number
- EP1649007A4 EP1649007A4 EP04744983A EP04744983A EP1649007A4 EP 1649007 A4 EP1649007 A4 EP 1649007A4 EP 04744983 A EP04744983 A EP 04744983A EP 04744983 A EP04744983 A EP 04744983A EP 1649007 A4 EP1649007 A4 EP 1649007A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- progenitor cells
- expanding stem
- vivo expanding
- vivo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 210000000130 stem cell Anatomy 0.000 title 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
- C12N5/0692—Stem cells; Progenitor cells; Precursor cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/44—Thiols, e.g. mercaptoethanol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/113—Acidic fibroblast growth factor (aFGF, FGF-1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2306—Interleukin-6 (IL-6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/237—Oncostatin M [OSM]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48762303P | 2003-07-17 | 2003-07-17 | |
US49026803P | 2003-07-28 | 2003-07-28 | |
US50388403P | 2003-09-22 | 2003-09-22 | |
PCT/IL2004/000643 WO2005007799A2 (en) | 2003-07-17 | 2004-07-15 | Methods for ex-vivo expanding stem/progenitor cells |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1649007A2 EP1649007A2 (de) | 2006-04-26 |
EP1649007A4 true EP1649007A4 (de) | 2008-05-14 |
Family
ID=34084524
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04744983A Withdrawn EP1649007A4 (de) | 2003-07-17 | 2004-07-15 | Verfahren zur ex-vivo-expansion von stamm-/ vorläuferzellen |
Country Status (3)
Country | Link |
---|---|
US (1) | US20060205071A1 (de) |
EP (1) | EP1649007A4 (de) |
WO (1) | WO2005007799A2 (de) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU770896C (en) | 1998-09-29 | 2006-09-07 | Gamida Cell Ltd. | Methods of controlling proliferation and differentiation of stem and progenitor cells |
IL152904A0 (en) * | 2002-01-24 | 2003-06-24 | Gamida Cell Ltd | Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations |
WO2003062404A1 (en) | 2002-01-25 | 2003-07-31 | Gamida-Cell Ltd. | Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby |
AU2003214614B2 (en) * | 2002-03-18 | 2008-11-20 | Gamida-Cell Ltd. | Methods of inducing differentiation in ex vivo expanded stem cells |
US20050054097A1 (en) * | 2002-11-17 | 2005-03-10 | Tony Peled | EX-VIVO expansion of hematopoietic system cell populations in mononuclear cell cultures |
IL161903A0 (en) * | 2003-07-17 | 2005-11-20 | Gamida Cell Ltd | Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs |
WO2006030442A2 (en) | 2004-09-16 | 2006-03-23 | Gamida-Cell Ltd. | Methods of ex vivo progenitor and stem cell expansion by co-culture with mesenchymal cells |
US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
US20080020049A1 (en) * | 2005-02-25 | 2008-01-24 | Andrew Darling | Super-sparger microcarrier beads and precision extrusion deposited poly-epsilon-caprolactone structures for biological applications |
WO2006093881A2 (en) * | 2005-02-28 | 2006-09-08 | Regenetech, Inc. | Method and composition for repairing epithelial and other cells and tissue |
BRPI0607882A2 (pt) * | 2005-02-28 | 2009-11-24 | Regenetech Inc | método e composição para tratamento de diabetes |
WO2006116717A2 (en) * | 2005-04-28 | 2006-11-02 | The Board Of Regents Of The University Of Texas System | Autologous somatic cells from peripheral blood and uses thereof |
CA2607060A1 (en) * | 2005-05-04 | 2006-11-09 | Australian Stem Cell Centre Limited | Selecting, culturing and creating lineage committed hematopoietic stem cells |
US8647867B2 (en) * | 2005-09-30 | 2014-02-11 | National University Corportion Okayama University | Cell cultivation method and cell culture |
US8846393B2 (en) | 2005-11-29 | 2014-09-30 | Gamida-Cell Ltd. | Methods of improving stem cell homing and engraftment |
US7682822B2 (en) | 2006-03-31 | 2010-03-23 | Aastrom Biosciences, Inc. | Ex vivo generated tissue system |
AU2007265147B2 (en) * | 2006-06-26 | 2013-11-07 | Terumo Bct, Inc. | Method of culturing mesenchymal stem cells |
US8173427B2 (en) * | 2006-07-24 | 2012-05-08 | The University Of Queensland | Method of producing a population of post-mitotic cells of the neutrophil lineage |
JP2010509316A (ja) * | 2006-11-09 | 2010-03-25 | ガミダ セル リミテッド | 末梢血管疾患を治療するためのエクスビボ培養された造血細胞の使用 |
US7569268B2 (en) * | 2007-01-29 | 2009-08-04 | Rohm And Haas Electronic Materials Cmp Holdings, Inc. | Chemical mechanical polishing pad |
AT505008B1 (de) * | 2007-06-06 | 2008-10-15 | Angewandte Biotechnologie Gmbh | Verfahren zum kultivieren von sehnenzellen aus nicht embryonalen pluripotenten zellen mesenchymaler herkunft |
TW200916583A (en) * | 2007-06-08 | 2009-04-16 | Novathera Ltd | Cell expansion |
ITMI20071421A1 (it) * | 2007-07-16 | 2009-01-17 | Fond Irccs Istituto Di Ricove | Coltura per espandere cellule staminali ex-vivo |
US20100197007A1 (en) * | 2007-07-31 | 2010-08-05 | Inserm(Institut National De La Sante Et De La Recherche Medicale) | Method for Culturing Mammalian Stem Cells |
US8529888B2 (en) * | 2007-09-19 | 2013-09-10 | Pluristem Ltd. | Adherent cells from adipose or placenta tissues and use thereof in therapy |
US8569060B2 (en) | 2008-01-08 | 2013-10-29 | The University Of Queensland | Method of producing a population of cells |
US9458431B2 (en) | 2008-03-17 | 2016-10-04 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
US20120219531A1 (en) * | 2008-03-17 | 2012-08-30 | Agency For Science, Technology And Research | Microcarriers for Stem Cell Culture |
EP2479260B1 (de) | 2008-03-17 | 2016-01-06 | Agency For Science, Technology And Research | Mikroträger für die Stammzellenkultur |
US8993231B2 (en) | 2008-03-18 | 2015-03-31 | Marshall University Research Corporation | Methods for stem cell production and therapy |
KR20110013450A (ko) * | 2008-05-07 | 2011-02-09 | 본 테라퓨틱스 소시에테아노님 | 간엽 줄기 세포 및 골-형성 세포 |
US9845455B2 (en) * | 2008-05-15 | 2017-12-19 | Ge Healthcare Bio-Sciences Ab | Method for cell expansion |
WO2010021993A1 (en) * | 2008-08-19 | 2010-02-25 | Cytori Therapeutics, Inc. | Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease |
JP2010193879A (ja) | 2009-01-27 | 2010-09-09 | Jms Co Ltd | 臍帯血造血幹細胞の増殖制御方法およびその用途 |
US8790638B2 (en) * | 2009-02-04 | 2014-07-29 | Stemedica Cell Technologies, Inc. | Compositions of stem cells and stem cell factors and methods for their use and manufacture |
KR101422690B1 (ko) * | 2009-02-27 | 2014-07-23 | (주)차바이오앤디오스텍 | 배아줄기세포 유래 혈관형성전구세포의 배양 분비물을 포함하는 피부재생용 조성물 및 이의 용도 |
KR20110137805A (ko) | 2009-03-20 | 2011-12-23 | 에이전시 포 사이언스, 테크놀로지 앤드 리서치 | 마이크로캐리어 상의 다분화성 및 다능성 세포의 배양 방법 |
US20110076254A1 (en) * | 2009-09-28 | 2011-03-31 | University Of Washington | Porous scaffolds for stem cell renewal |
US8278101B2 (en) * | 2009-12-07 | 2012-10-02 | Synthecon, Inc. | Stem cell bioprocessing and cell expansion |
CN107254439B (zh) | 2009-12-29 | 2022-01-11 | 加米达细胞有限公司 | 增强自然杀伤细胞增殖和活性的方法 |
US9845457B2 (en) * | 2010-04-30 | 2017-12-19 | Cedars-Sinai Medical Center | Maintenance of genomic stability in cultured stem cells |
WO2012045047A2 (en) | 2010-09-30 | 2012-04-05 | University Of Maryland Baltimore County | Non-invasive analyte sensing and monitoring system and method |
EP2625263B1 (de) | 2010-10-08 | 2020-03-11 | Terumo BCT, Inc. | Konfigurierbare verfahren und systeme für züchtung und ernte von zellen in einem hohlfaser-bioreaktorsystem |
SG189414A1 (en) * | 2010-10-18 | 2013-05-31 | Sunshine Biotech Inc | Human multipotent embryonic stem cell-like progenitor cells |
US9453196B2 (en) | 2010-12-16 | 2016-09-27 | General Electric Company | Cell carrier, methods of making and use |
US9534206B2 (en) | 2010-12-16 | 2017-01-03 | General Electric Company | Cell carrier, associated methods for making cell carrier and culturing cells using the same |
US9926523B2 (en) | 2010-12-16 | 2018-03-27 | General Electric Company | Cell carriers and methods for culturing cells |
US9518249B2 (en) | 2010-12-16 | 2016-12-13 | General Electric Company | Cell carrier, associated methods for making cell carrier and culturing cells using the same |
US9453197B2 (en) | 2010-12-16 | 2016-09-27 | General Electric Company | Methods of making cell carrier |
US9157908B2 (en) | 2011-04-22 | 2015-10-13 | University Of Washington Through Its Center For Commercialization | Chitosan-alginate scaffold cell culture system and related methods |
WO2012168295A1 (en) | 2011-06-06 | 2012-12-13 | ReGenesys BVBA | Expansion of stem cells in hollow fiber bioreactors |
SG11201400851PA (en) * | 2011-09-22 | 2014-04-28 | Cytomatrix Pty Ltd | Method for the ex vivo expansion of hematopoietic stem and progenitor cells |
AU2013214187B2 (en) * | 2012-02-03 | 2017-02-09 | Technische Universitat Munchen - Klinikum Rechts Der Isar | Device-based methods for localised delivery of cell-free carriers with stress-induced cellular factors |
EP2814951B1 (de) | 2012-02-13 | 2019-04-03 | Gamida-Cell Ltd. | Kultivierung mesenchymaler stammzellen |
US8940294B2 (en) | 2012-03-02 | 2015-01-27 | Tissuetech, Inc. | Methods of isolating and culturing stem cells |
US9175266B2 (en) | 2012-07-23 | 2015-11-03 | Gamida Cell Ltd. | Enhancement of natural killer (NK) cell proliferation and activity |
US9567569B2 (en) | 2012-07-23 | 2017-02-14 | Gamida Cell Ltd. | Methods of culturing and expanding mesenchymal stem cells |
WO2014028493A2 (en) | 2012-08-13 | 2014-02-20 | Cedars-Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
EP2902483B1 (de) * | 2012-09-28 | 2020-03-11 | Foundation for Biomedical Research and Innovation at Kobe | Verfahren zur in-vitro-proliferation von zellpopulation mit zellen zur behandlung ischämischer erkrankungen |
RU2525143C1 (ru) * | 2013-03-22 | 2014-08-10 | Федеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации-Институт медико-биологических проблем Российской академии наук | СПОСОБ ЭКСПАНСИИ МОНОНУКЛЕАРНЫХ КЛЕТОК ПУПОВИННОЙ КРОВИ (пкМНК) ex vivo В ПРИСУТСТВИИ МУЛЬТИПОТЕНТНЫХ СТРОМАЛЬНЫХ МЕЗЕНХИМАЛЬНЫХ КЛЕТОК (ММСК) |
EP3006561B1 (de) * | 2013-06-05 | 2019-12-04 | Seoul National University R&DB Foundation | Periphere blutstammzellen mit verbesserten angiogenen eigenschaften und verwendung davon |
US20150093775A1 (en) * | 2013-07-08 | 2015-04-02 | Govind Rao | System and method for analyte sensing and monitoring |
JP6633522B2 (ja) | 2013-11-16 | 2020-01-22 | テルモ ビーシーティー、インコーポレーテッド | バイオリアクターにおける細胞増殖 |
EP3613841B1 (de) | 2014-03-25 | 2022-04-20 | Terumo BCT, Inc. | Passives ersetzen von medien |
EP2995948A1 (de) * | 2014-09-09 | 2016-03-16 | Ecole Polytechnique Federale de Lausanne (EPFL) | Verfahren und Verbindungen für hämatopoetische Stammzellenmedizin |
JP6830059B2 (ja) | 2014-09-26 | 2021-02-17 | テルモ ビーシーティー、インコーポレーテッド | スケジュール化された細胞フィーディング |
CA2962444C (en) | 2014-10-03 | 2023-09-05 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
CN104388382B (zh) * | 2014-11-21 | 2017-05-10 | 吉林大学 | 利用搅拌式细胞培养转瓶机快速制备饲养层细胞的方法 |
CN104531609B (zh) * | 2014-12-10 | 2017-11-03 | 吉林大学 | 一种悬浮‑贴壁法制备饲养层细胞的方法 |
CN104830772A (zh) * | 2015-05-28 | 2015-08-12 | 深圳富利鑫健康产业发展有限公司 | 一种造血干细胞培养基及其应用和干细胞培养方法 |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
KR20180092951A (ko) | 2015-10-30 | 2018-08-20 | 더 리전츠 오브 더 유니버시티 오브 캘리포니아 | 줄기세포로부터 t-세포를 생산하는 방법 및 상기 t-세포를 이용한 면역치료 방법 |
EP3402543B1 (de) | 2016-01-11 | 2021-09-08 | Cedars-Sinai Medical Center | Aus kardiosphäre stammende zellen und durch solche zellen sekretierte exosomen in der behandlung von herzversagen mit konservierter auswurffraktion |
RU2628092C1 (ru) * | 2016-02-10 | 2017-08-14 | Федеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации - Институт медико-биологических проблем Российской академии наук (ГНЦ РФ - ИМБП РАН) | Способ получения МСК-ассоциированных недифференцированных гемопоэтических клеток-предшественников с фенотипов CD34+/CD133+ |
WO2017210652A1 (en) | 2016-06-03 | 2017-12-07 | Cedars-Sinai Medical Center | Cdc-derived exosomes for treatment of ventricular tachyarrythmias |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
EP3515459A4 (de) | 2016-09-20 | 2020-08-05 | Cedars-Sinai Medical Center | Kardiosphärenzellen und deren extrazelluläre vesikel zur verzögerung oder umkehr des alterungsprozesses und altersbedingten erkrankungen |
CA3050264A1 (en) * | 2017-01-24 | 2018-08-02 | Fred Hutchinson Cancer Research Center | Systems and methods for hematopoietic cell expansion utilizing hydrogels |
EP3601521A2 (de) | 2017-03-31 | 2020-02-05 | Terumo BCT, Inc. | Zellexpansion |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
JP7336769B2 (ja) | 2017-04-19 | 2023-09-01 | シーダーズ―シナイ メディカル センター | 骨格筋ジストロフィーを治療する方法及び組成物 |
EP3727351A4 (de) | 2017-12-20 | 2021-10-06 | Cedars-Sinai Medical Center | Manipulierte extrazelluläre vesikel für verbesserte freisetzung in gewebe |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999040783A1 (en) * | 1998-02-17 | 1999-08-19 | Gamida Cell Ltd. | Method of controlling proliferation and differentiation of stem and progenitor cells |
WO2000018885A1 (en) * | 1998-09-29 | 2000-04-06 | Gamida Cell Ltd. | Methods of controlling proliferation and differentiation of stem and progenitor cells |
WO2003062404A1 (en) * | 2002-01-25 | 2003-07-31 | Gamida-Cell Ltd. | Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby |
WO2003062369A2 (en) * | 2002-01-24 | 2003-07-31 | Gamida-Cell Ltd. | Expansion of renewable stem cell populations |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6440734B1 (en) * | 1998-09-25 | 2002-08-27 | Cytomatrix, Llc | Methods and devices for the long-term culture of hematopoietic progenitor cells |
US6541249B2 (en) * | 1999-12-22 | 2003-04-01 | Human Genome Sciences, Inc. | Immortalized human stromal cell lines |
EP1290141A4 (de) * | 2000-06-05 | 2005-01-05 | Burnham Inst | Verfahren zur differenzierung und zum schutz von zellen durch modulierung des p38/mef stoffwechselwegs |
US7247477B2 (en) * | 2002-04-16 | 2007-07-24 | Technion Research & Development Foundation Ltd. | Methods for the in-vitro identification, isolation and differentiation of vasculogenic progenitor cells |
-
2004
- 2004-07-15 EP EP04744983A patent/EP1649007A4/de not_active Withdrawn
- 2004-07-15 US US10/564,777 patent/US20060205071A1/en not_active Abandoned
- 2004-07-15 WO PCT/IL2004/000643 patent/WO2005007799A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999040783A1 (en) * | 1998-02-17 | 1999-08-19 | Gamida Cell Ltd. | Method of controlling proliferation and differentiation of stem and progenitor cells |
WO2000018885A1 (en) * | 1998-09-29 | 2000-04-06 | Gamida Cell Ltd. | Methods of controlling proliferation and differentiation of stem and progenitor cells |
WO2003062369A2 (en) * | 2002-01-24 | 2003-07-31 | Gamida-Cell Ltd. | Expansion of renewable stem cell populations |
WO2003062404A1 (en) * | 2002-01-25 | 2003-07-31 | Gamida-Cell Ltd. | Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby |
Also Published As
Publication number | Publication date |
---|---|
WO2005007799A3 (en) | 2005-03-03 |
EP1649007A2 (de) | 2006-04-26 |
US20060205071A1 (en) | 2006-09-14 |
WO2005007799A2 (en) | 2005-01-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1649007A4 (de) | Verfahren zur ex-vivo-expansion von stamm-/ vorläuferzellen | |
CY2019038I2 (el) | Μεθοδοι για την κινητοποιηση κυτταρων προγεννητορων/βλαστοκυτταρων | |
EP1631307A4 (de) | Verfahren zur mobilisierung von vorläufer/stammzellen | |
GB2441530B (en) | Stem Cells | |
IL178232A0 (en) | Methods for growing pluripotent stem cells | |
SI1888580T1 (sl) | Pirido d pirimidini uporabni kot inhibitorjiHCV in postopki za njihovo pripravo | |
EP1838874A4 (de) | Verfahren zur regulation von stammzellen | |
EP1897008A4 (de) | Verfahren zur erzeugung primitiver standardzellen | |
GB2429717B (en) | Cell preservation method | |
IL186750A0 (en) | Pteridines useful as hcv inhibitors and methods for the preparation thereof | |
PL375067A1 (en) | Method of obtaining viable human liver cells, including hepatic stem/progenitor cells | |
PT2457999T (pt) | Sistema de cultura para células estaminais pluripotentes | |
EP1778855A4 (de) | Carotenoidhydroxylase-enzyme | |
PL1737594T3 (pl) | Hydrauliczny rozprężny uchwyt zaciskowy | |
GB2407821B (en) | Stem Cells | |
AU2003247514A8 (en) | Meningeal-derived stem cells | |
EP1769066A4 (de) | Modifizierte antigen präsentierende zellen | |
EP1948788A4 (de) | Verfahren zur expansion doppelt negativer t-zellen | |
EP1627912A4 (de) | Herstellung endodermaler stammzellen | |
EP1802744A4 (de) | Verfahren zur erhaltung der pluripotenz von stamm-/vorläuferzellen | |
AU2003216822A8 (en) | Stem cell culture | |
ZA200706646B (en) | Brown algae cell lyophilisate, method for the obtention thereof | |
AU2003902776A0 (en) | Method for expanding cells | |
EP1781337A4 (de) | Verfahren und zusammensetzungen zur zellaktivierung | |
HK1100965A1 (en) | Gas socket |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20060207 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20080415 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 5/06 20060101ALI20080409BHEP Ipc: C12N 5/02 20060101AFI20080409BHEP Ipc: A61K 35/12 20060101ALI20080409BHEP |
|
17Q | First examination report despatched |
Effective date: 20080708 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20081119 |