EP1648480A2 - Utilisation de toxine botulique pour preparer un medicament destine a prevenir ou traiter la detresse pulmonaire en phase terminale - Google Patents
Utilisation de toxine botulique pour preparer un medicament destine a prevenir ou traiter la detresse pulmonaire en phase terminaleInfo
- Publication number
- EP1648480A2 EP1648480A2 EP04767694A EP04767694A EP1648480A2 EP 1648480 A2 EP1648480 A2 EP 1648480A2 EP 04767694 A EP04767694 A EP 04767694A EP 04767694 A EP04767694 A EP 04767694A EP 1648480 A2 EP1648480 A2 EP 1648480A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- botulinum toxin
- use according
- type
- botulinum
- preventing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- botulinum toxin to prepare a medicine to prevent or treat end-stage pulmonary distress
- the subject of the present invention is the use of botulinum toxin to prepare a medicament intended for preventing or treating terminal pulmonary distress.
- the treatment currently recommended for these patients is the administration of scopolamine, a compound known for its unpleasant side effects.
- the object of the present invention is to offer a much simpler alternative solution and furthermore devoid of side effects. Furthermore, taking into account the time when the treatment according to the invention is administered, an isolated administration will be sufficient to ensure the treatment.
- Botulinum toxin in particular botulinum toxin type A (Dysport ® marketed by Ipsen or Botox ® marketed by Allergan), has been used since the 1980s in humans for the treatment of various and varied diseases / disorders.
- diseases / disorders that can be treated with botulinum toxin there may be mentioned, among others, muscular disorders (for example blepharospasm, spasticity in adults or children or torticollis), migraine, pain in general, diabetes, hyperpidrosis (or excessive sweating), hypersalivation or even wrinkles.
- botulinum toxin is used to eliminate the aforementioned sound disorders.
- the toxin will be administered preventively to patients known to be in the terminal life stage.
- the invention therefore relates to the use of botulinum toxin to prepare a medicament intended for preventing or treating terminal pulmonary distress, the symptoms of which are agonistic noise disorders ("rales of agony” or " death rattle ”.
- the drug prepared will be intended to be administered preventively to the patient likely to be suffering from pulmonary distress in the terminal phase and therefore from sound disorders linked to agony or rales of agony.
- This patient will in particular be a patient in the terminal phase of cancer, and in particular a patient suffering from a brain tumor or from lung cancer; this patient could also be a patient suffering from a terminal neurodegenerative disease.
- the drug prepared will be intended to be administered to treat terminal pulmonary distress and therefore sonic or raging agony disorders already reported in the dying patient.
- the botulinum toxin used for the preparation of a medicament according to the invention will be chosen from botulinum toxins of type A (including Ai, A 2 and A 3 ), B, C (including Ci and C 2 ), D, E, F and G.
- it will be chosen from botulinum toxins of type A, B and F.
- it will be chosen from botulinum toxins of type A and B; in particular, it will be botulinum toxin type A.
- botulinum toxin used for the preparation of a medicament according to the invention may be in the form of a complex comprising the botulinum toxin or else in free form (i.e. free of any protein complexing it).
- the medicament prepared may be a lyophilized powder comprising the botulinum toxin (in which case the doctor will reconstitute the solution with water or an aqueous saline solution before injecting it into the patient) or alternatively an injectable solution comprising said toxin.
- the medicament prepared according to the invention is intended to be injected either at the level of the parotid gland, or at the level of the muscle M.
- botulinum toxin to be provided according to the present invention for the treatment of the sound disorders mentioned above varies according to the age and the body weight of the subject to treat as well as the state of the latter, and it will be decided ultimately by the attending physician or veterinarian. Such an amount determined by the attending physician or veterinarian is referred to herein as a "therapeutically effective amount”.
- the administration dose envisaged for a medicament according to the invention is from 20 to 2,000 LD 50 units of botulinum toxin type A per patient, preferably from 50 'to 1 000 'LD 50 units of botulinum toxin type A per patient and more preferably 100 to 500 LD 50 units of botulinum toxin type A per patient (for example approximately 200 LD 50 units of botulinum toxin type A per patient).
- LD 50 units of botulinum toxin type A per patient for example approximately 200 LD 50 units of botulinum toxin type A per patient.
- botulinum toxins of other types a person skilled in the art will adapt the dose necessary insofar as he knows the relative therapeutic activity of each of these botulinum toxins with respect to botulinum toxin type A.
- the LD 50 units are commonly used by the practitioner using botulinum toxin; one LD 50 unit of botulinum toxin corresponding to the equivalent dose of toxin killing 50% of a group of 18 to 20 female Swiss-Webster mice weighing approximately 20 grams each.
- approximately refers to an interval around the value considered.
- approximately X means a range of X minus 10% of X to X plus 10% of X, and preferably a range of X minus 5% of X to X plus 5% of X .
- a patient in his sixties with an incurable and dying brain tumor suffers from sound disorders related to his condition ("death rattles” or "death rattle” in English). It is subjected to injection of 250 LD 50 units of botulinum toxin type A (Dysport ®; supplier: Ipsen) in the parotid gland in order to eliminate said noise disturbances.
- Dysport ® botulinum toxin type A
- a patient in his sixties with an incurable and dying brain tumor suffers from noise disturbances linked to his condition.
- After local anesthesia tetracaine hydrochloride
- he is subjected to an injection of 250 LD 50 units of botulinum toxin type A (Dysport ® ; supplier: Ipsen) in the muscle M.
- veli tensor palatini in order to eliminate said disorders sound.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0308800A FR2857595B1 (fr) | 2003-07-18 | 2003-07-18 | Utilisation de toxine botulique pour preparer un medicament destine a prevenir ou traiter les troubles sonores lies a l'agonie |
PCT/FR2004/001870 WO2005009450A2 (fr) | 2003-07-18 | 2004-07-16 | Utilisation de toxine botulique pour preparer un medicament destine a prevenir ou traiter la detresse pulmonaire en phase terminale |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1648480A2 true EP1648480A2 (fr) | 2006-04-26 |
Family
ID=33548253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04767694A Withdrawn EP1648480A2 (fr) | 2003-07-18 | 2004-07-16 | Utilisation de toxine botulique pour preparer un medicament destine a prevenir ou traiter la detresse pulmonaire en phase terminale |
Country Status (4)
Country | Link |
---|---|
US (1) | US20070082013A1 (fr) |
EP (1) | EP1648480A2 (fr) |
FR (1) | FR2857595B1 (fr) |
WO (1) | WO2005009450A2 (fr) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2319860T3 (es) * | 1993-12-28 | 2009-05-14 | Allergan, Inc. | Uso de toxina botulinica de tipo b para la fabricacion de un medicamento para reducir el dolor asociado a un trastorno muscular. |
US5766605A (en) * | 1994-04-15 | 1998-06-16 | Mount Sinai School Of Medicine Of The City University Of New York | Treatment of autonomic nerve dysfunction with botulinum toxin |
US6265379B1 (en) * | 1999-10-13 | 2001-07-24 | Allergan Sales, Inc. | Method for treating otic disorders |
US6139845A (en) * | 1999-12-07 | 2000-10-31 | Allergan Sales, Inc. | Method for treating cancer with a neurotoxin |
US6429189B1 (en) * | 1999-12-10 | 2002-08-06 | Botulinum Toxin Research Associates, Inc. | Cytotoxin (non-neurotoxin) for the treatment of human headache disorders and inflammatory diseases |
-
2003
- 2003-07-18 FR FR0308800A patent/FR2857595B1/fr not_active Expired - Fee Related
-
2004
- 2004-07-16 US US10/564,825 patent/US20070082013A1/en not_active Abandoned
- 2004-07-16 EP EP04767694A patent/EP1648480A2/fr not_active Withdrawn
- 2004-07-16 WO PCT/FR2004/001870 patent/WO2005009450A2/fr active Application Filing
Non-Patent Citations (1)
Title |
---|
See references of WO2005009450A2 * |
Also Published As
Publication number | Publication date |
---|---|
WO2005009450A2 (fr) | 2005-02-03 |
FR2857595A1 (fr) | 2005-01-21 |
FR2857595B1 (fr) | 2005-10-07 |
US20070082013A1 (en) | 2007-04-12 |
WO2005009450A3 (fr) | 2005-09-15 |
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Legal Events
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Effective date: 20060315 |
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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR |
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