EP1648372A2 - Installation comprising a machine for the production of tablets which are intended, in particular, for therapeutic use - Google Patents

Installation comprising a machine for the production of tablets which are intended, in particular, for therapeutic use

Info

Publication number
EP1648372A2
EP1648372A2 EP04767599A EP04767599A EP1648372A2 EP 1648372 A2 EP1648372 A2 EP 1648372A2 EP 04767599 A EP04767599 A EP 04767599A EP 04767599 A EP04767599 A EP 04767599A EP 1648372 A2 EP1648372 A2 EP 1648372A2
Authority
EP
European Patent Office
Prior art keywords
enclosure
gas
installation according
temperature
machine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP04767599A
Other languages
German (de)
French (fr)
Other versions
EP1648372B1 (en
Inventor
Christophe Brisset
Florian Battung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ethypharm SAS
Original Assignee
Ethypharm SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethypharm SAS filed Critical Ethypharm SAS
Publication of EP1648372A2 publication Critical patent/EP1648372A2/en
Application granted granted Critical
Publication of EP1648372B1 publication Critical patent/EP1648372B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/0082—Dust eliminating means; Mould or press ram cleaning means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/005—Control arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/08—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/34—Heating or cooling presses or parts thereof

Definitions

  • the invention relates to the manufacture of tablets, in particular tablets comprising a substance for therapeutic or cosmetic use.
  • tablets comprising ibuprofen.
  • the ibuprofen molecule has a softening point at 42 ° C and a melting point at 70 ° C. It is known to form ibuprofen tablets from a powder by means of a machine comprising a series of dies and punches between which the tablets are formed. Within the machine, the compression dynamics generate temperature rises, which causes a softening of the raw material used for the manufacture of the tablets. This can cause a problem of sticking of the powder or tablets within the machine, which is detrimental to its proper functioning.
  • the document FR-2 440 188 discloses in FIG.
  • an installation is provided according to the invention comprising a machine for manufacturing tablets, the machine having at least an enclosure, the installation comprising means for bringing a gas into the enclosure and making it pass through the enclosure.
  • the invention can be easily adapted to an existing machine without excessive cost.
  • the circulation of gas in the enclosure makes it possible to cool it efficiently without excessive energy expenditure.
  • said means are arranged to control a temperature of the gas.
  • said means are arranged to control a humidity of the gas.
  • the machine may also have at least any of the following characteristics: - said means are arranged to control a temperature of the gas; - Said means are arranged to control a temperature of the gas at a predetermined location upstream of the enclosure to ensure that a temperature of the gas in the enclosure reaches a predetermined value; - Said means are arranged to control a temperature of the gas at a predetermined location upstream of the enclosure, to ensure that the temperature reaches a predetermined value; - Said means are arranged to cool and / or heat the gas; - Said means comprise at least one particle filter; - Said means comprise at least one fan, for example placed upstream or downstream of the enclosure; -
  • the enclosure includes organs for shaping the tablets; - the enclosure includes a motor; - the enclosure includes an electronic device; - the enclosures are at least two in number and the machine comprises means for bringing a gas into each enclosure and making it pass through it; • - it comprises gas pipes arranged to supply the enclosures with gas in a parallel arrangement
  • a method of manufacturing tablets in which a gas is introduced into an enclosure forming part of a tablet manufacturing machine, and it is made to travel through the enclosure.
  • the process may have at least any one of the following characteristics: - a temperature of the gas is controlled; - A temperature of the gas is controlled at a predetermined location upstream of the enclosure to ensure that a temperature of the gas in the enclosure reaches a predetermined value; and - One controls a temperature of the gas at a predetermined location upstream of the enclosure to ensure that the temperature reaches a predetermined value.
  • FIG. 1 is an overall diagram of the installation according to a preferred embodiment of the invention
  • - Figure 2 is a schematic plan view of the air handling unit of the installation of Figure 1
  • - Figure 3 is a schematic view of part of the air heating and cooling system of the installation of Figure 1
  • - Figure 4 is a partial perspective view of the machine of the installation of Figure 1, showing the conduits associated with the compression enclosure
  • - Figure 5 is a partial perspective view of the interior of the compression chamber of the machine of Figure 1
  • - Figure 6 is a view similar to Figure 4 showing a pipe associated with the engine mount
  • - Figure 7 is a perspective view with partial cutaway showing the interior of the engine mount
  • - Figure 8 is a view similar to Figure 4 showing the pipes associated with the electronic frame
  • - Figure 9 is a perspective view with partial cutaway showing the interior of the electronic frame.
  • the installation 2 comprises a machine 4 which is used for the manufacture of tablets, for therapeutic use comprising ibuprofen, this machine being of a type known per se even.
  • a machine 4 which is used for the manufacture of tablets, for therapeutic use comprising ibuprofen, this machine being of a type known per se even.
  • it conventionally comprises a compression enclosure 6 containing organs for manufacturing tablets, a motor frame 8 comprising in particular a motor actuating the organs located in the enclosure compression, and an electronic frame 10 ensuring the regulation of the machine.
  • the compression enclosure, the motor frame, and the electronic frame are contiguous to each other and enclosed in a common casing.
  • Such a machine is for example of the type of that disclosed in the aforementioned document FR-2,440,188 and will not be described below in detail in all of its constituent elements.
  • the installation 2 in this case comprises means for cooling the machine 4 by blowing cooled air. It includes in particular an upstream supply fan ventilateur. It also includes an air treatment unit 12 in this case ensuring filtration, dehumidification and possibly heating or cooling of the air. It comprises a downstream exhaust fan 14. Finally, it comprises pipes or ducts 16, for example made of stainless steel, bringing the various parts of the installation into gas communication 2. Thus a first common duct 16 extends downstream of the air handling unit and communicates with three other ducts connected in an assembly parallel to the compression enclosure 6, to the motor frame 8, and to the electronic frame 10 respectively. Finally, two sheaths 16 are understood according to a parallel mounting downstream respectively of the motor frame and the electronic frame. They communicate with a common duct 16, itself in communication with the downstream supply fan 14.
  • the air is brought in at three points from the compression machine 4. It is all firstly brought into the compression enclosure 6 as close as possible to the manufacturing members to bring frigories making it possible to combat the calories generated by the rapid displacement of the manufacturing turret and friction. Air is also brought into the engine mount 8 in order to minimize the phenomena of heat diffusion towards the adjacent compression enclosure, phenomena due to heating of the mechanical elements of the engine. Finally, and similarly, bringing frigories into the electronic frame 10 makes it possible to minimize the phenomena of heat diffusion towards the engine frame and the compression enclosure, phenomena due to heating of electrical and electronic components.
  • the air handling unit 12 is preferably installed in a technical room different from the room receiving the compressor 4. This unit makes it possible to ensure the conditioning of the blown air.
  • this power station ensures particulate quality control by filtration, dehumidification, and if necessary heating and / or cooling of the air.
  • it is a Hydronic brand CCM20 type power station capable of providing an air flow of 1500 m 3 / hour and offering an available pressure of 350 Pa.
  • this power station works in all fresh air, i.e. it does not receive air that has already passed through the machine.
  • FIG 2 we will present the different organs constituting this central 12 from left to right, that is to say in the direction of gas flow, the air entering the left end of the central to exit at the right end.
  • the plant has a F6 type particle filter 20 (according to standard EN779).
  • the power station Downstream of the filter 20, the power station comprises first of all an electric hot battery 22 with a power of 7.8 kW, then a battery 24 operating with chilled water having a temperature between 0 to 5 ° C. a power of 24 kW. It is followed by a second battery of chilled water 26. There is then one. electric hot battery 28 with a power of 15.6 kW.
  • the power station comprises downstream of these elements the aforementioned upstream supply fan 9 which in the present example is therefore integrated into the power station and provides a flow rate of 1500 m 3 / hour by providing an available pressure of 300 Pa. these are fitted with an F8 30 particle filter (according to standard EN779) and an H13 32 particle filter (according to standard EN1822).
  • All of these filters have the particular function of making the gas "clean", that is to say compatible with pharmaceutical use in order to allow it to come into contact with the tablets.
  • differential pressure measurements are carried out regularly in order to ensure monitoring of the fouling of these filters.
  • the machine sizing calculations were carried out according to different climatic and geographic data. Thus, in summer and winter, we want to maintain a vacuum in the machine from 0 to 30 Pa, a temperature in the compression turret of 25 ° C and a humidity of the supply air less than 5 g of water per kg dry air. Outdoor conditions of -7 ° C with 90% relative humidity were assumed in winter and an outdoor temperature of 29 ° C with 43% relative humidity in summer.
  • Each cold battery 24, 26 of the power station 12 is supplied by a common chilled water circuit connected to a refrigeration unit 34 illustrated in FIG. 3. This group is associated with buffer tanks respectively of
  • a duct 16 downstream of the central 12, the air is routed through a duct 16 which, as we have seen, is divided into 3 parts: - a duct for blowing the air towards the enclosure compression 6; - a sheath for blowing air to the engine mount 8; and - a sheath for blowing air to the electronic frame 10.
  • a blowing register 36a, 36b and 36c On the path of each of these last three sheaths is positioned a blowing register 36a, 36b and 36c. It is a motorized damper 36a on the way to the compression enclosure.
  • the registers 36b and 36c on the path to the engine and electronic frames are not motorized.
  • the motorized register 36a makes it possible to isolate the compression enclosure in a sealed manner with respect to the air blowing network in the event of the machine stopping. This is a pharmaceutical constraint making it possible to avoid any contamination of the blowing network with powder present in the machine.
  • Each of these registers also makes it possible to modify the air flow rate in each of the associated ducts 16 to vary this flow rate between different values of non-zero flow rate, or even to completely shut off the duct.
  • the ducts 16 are in this case made of AISI 316 L stainless steel. Each of these three ducts leaves the room receiving the central 12 and ends up in the room housing the compression machine 4. This room has a controlled atmosphere.
  • each of these three sheaths 16 has a removable central part, and two respectively upstream and downstream parts located on either side of the removable part and permanently fixed respectively to the room and to the machine.
  • the presence of these dismountable sections makes it possible to use the machine 4 in its original configuration if necessary, to have this without blowing the cooled air.
  • plugs for example made of stainless steel, are positioned on the fixed sheath sections associated with the machine in order to ensure the basic performance of the machine.
  • the sheath 16 associated with the compression enclosure 6 arrives there from above the enclosure. It makes it possible to diffuse the air as close as possible to the compression matrices 39.
  • a box or deflector 40 in the shape of a rectangular parallelepiped and made of sheet metal.
  • This box receives the air arriving from the sheath 16. It has openings 42 on its vertical lateral faces 44 and 46, as well as on its lower 48 and rear faces (not shown). It allows a good distribution of the air flow in order to ensure a perfect diffusion of the air inside the compression enclosure.
  • the front face 49 of the deflector does not have an air outlet opening. In fact, this face faces the inside of the enclosure 6.
  • the compression machine is moreover equipped with a system for spraying a pulverulent lubricant which makes it possible to lubricate the dies 39 in a manner known per se and which is a very volatile compound.
  • the deflector 40 extends in the upper part of the enclosure 6.
  • the downstream sheath 16, aimed at extracting the gas from the enclosure 6, opens in the lower part of the enclosure on a face of this enclosure opposite to the deflector.
  • the cooling means of the chamber 8 associated with the engine mount are shown in Figures 6 and 7. The air is fed directly into the engine frame in order to reduce the temperature of the frame 'and minimize the diffusion of heat from the engine frame to the compression enclosure 6.
  • a box 50 or deflector, also made of perforated sheet metal, is installed inside the enclosure 8 of the engine mount.
  • the deflector is placed on the horizontal lower face of the enclosure 8 and is open on its upper 52, front 54 and vertical lateral 56 faces, having on each of them a network of orifices 42.
  • the sheath 16 of outlet air is arranged on a different face from the face of the enclosure 8 receiving the air inlet sheath intended for the deflector.
  • the implementation of the cooling of the electronic frame 10 is finally illustrated in FIGS. 8 and 9.
  • the air is sent directly into the electronic unit in order to reduce the temperature of this frame and thus minimize the heat diffusion from the electronic frame to the compression enclosure.
  • the air is brought in from below an electrical cabinet 60 of the electronic frame 10.
  • a deflector or box is provided for the introduction of air within the enclosure 10.
  • the deflector is installed in the lower part of the enclosure after dismantling the fans generally located in the lower part of the cabinet.
  • the box is open on its upper face by presenting several networks of openings 42.
  • This system allows a good distribution of the air flow in order to ensure a perfect diffusion of the air inside the electronic frame.
  • the upstream sheath 16 introducing the air into the enclosure 10 is located in the lower part of the cabinet while the downstream sheath 16 extracting the air from this enclosure is located in the upper part of the engine mount.
  • the two sheaths are associated with the same side wall 64 of the cabinet. As can be seen, the air is extracted via the ducts 16 only at two points on the machine, namely the motor frame 8 and the electronic frame 10. This extraction is carried out by means of the extraction fan 14.
  • the two downstream ducts 16 associated with the engine and electronic frames are provided with motorized extraction registers 70 which make it possible to seal the extraction network from the blowing network in a sealed manner in the event of the machine stopping.
  • This pharmaceutical constraint makes it possible to avoid any contamination of the blowing network by contaminated air having circulated within mechanical and electronic elements.
  • the machine includes means for controlling the air blowing system, making it possible in particular to adjust the various parameters and operating modes.
  • This system could include a terminal built into a room partition fitted with a control screen. This terminal allows entry of instructions and monitoring of operating parameters. It also allows you to manage alarms.
  • it will include means for recording the entire history of the operation of the installation.
  • the installation includes an automatic on / off control between the air blowing system, the compression machine and the vacuum cleaner associated with it.
  • the first one that we can call manual mode includes the step of entering a target supply air temperature.
  • This setpoint temperature is chosen by the operator within a predetermined range, for example from 5 to 15 ° C.
  • the minimum blowing temperature at 5 ° C makes it possible to avoid condensation phenomena which can appear below this temperature.
  • This setpoint is naturally associated with a tolerance range (for example between 9 and 11 ° C) for the oscillation of the temperature around this setpoint.
  • the installation controls the temperature of the gas leaving the power station 12 by means of a sensor 80 located on the sheath 16 communicating directly downstream with the latter.
  • the installation therefore controls the central unit 12, in particular its heating and cooling batteries, so that the temperature measured at the sensor 80 remains as close as possible to the set temperature, here 10 ° C.
  • the probe 80 continuously reads the air temperature at this point. If this temperature changes, the installation will control the central unit to ensure temperature regulation.
  • This operating mode makes it possible to lower the temperature in the engine mount and the electronic mount.
  • the temperature of the air blown into these two zones is identical to that of the air blown into the compression enclosure.
  • the moisture content of the gas is controlled by means of a probe 82 located next to the temperature probe 80 downstream of the plant 12.
  • the flow rate provided in the compression enclosure 6 is 150 m 3 / hour.
  • the flows in the engine mount and the electronic mount are each planned at 700 m 3 / hour.
  • the flow rate of 150 m 3 / hour at the level of the compression enclosure is regulated as a function of the vacuum prevailing in the compression enclosure.
  • this enclosure is connected to a vacuum cleaner 69 ensuring permanent dusting of the machine in a manner known per se.
  • This vacuum cleaner eliminates excess lubricant present in the machine. It draws a flow of 190 m 3 / hour. The vacuum cleaner sucks more than the system blows in the compression enclosure, there is a permanent vacuum in the compression enclosure located between 0 and 30 Pa.
  • This vacuum allows to contain the dust, and to avoid excessive dusting of the machine and a powder leak in the room.
  • the air flow entering the enclosure 6 is regulated to maintain the vacuum. This regulation is done via the blowing fan9 located in the control unit 12. This regulation is necessary because the vacuum cleaner becomes dirty as the operation progresses, thus generating a reduction in the suction flow rate.
  • the compression enclosure 6 is associated with a differential pressure transmitter 84 simultaneously measuring the pressure inside and outside the enclosure. The differential pressure measurement provided by this sensor allows the machine to control the fan9. Pressure measurements are also carried out permanently by means of two sensors 86 and 88 respectively located downstream of the central 12 and upstream of the extractor fan 14.
  • a possible speed variation of the ventilator 9 generated by the sensor 84 results in a change in the pressure measured by the sensor 86 at the outlet of the central and in the pressure measured by the sensor 88 in the extraction network.
  • the installation therefore acts on the fan 14 for this purpose.
  • the vacuum cleaner 69 generating an air vacuum inside the compression enclosure is provided with a pressure switch measuring the differential pressure at the inlet of the vacuum cleaner and outside the machine. It thus measures the fouling rate of the vacuum cleaner. When this rate reaches a critical threshold, an alarm warns the operator that unclogging the filter is necessary.
  • the machine then goes into default, the upstream register 36 of the compression enclosure and the downstream registers 70 are then closed to isolate the machine to be compressed.
  • the other operating mode of the process can be called automatic mode.
  • the operator provides as data to the installation a gas temperature setpoint in the compression enclosure 6, for example 25 ° C., here again with a certain tolerance.
  • the system controls the central unit 12 in order to blow air into the enclosure 6 and ensure that the temperature of the gas in the enclosure reaches the set value.
  • the machine comprises a temperature sensor 90 disposed in the enclosure. This sensor continuously measures the temperature in the enclosure.
  • the installation controls the central unit 12, in particular the heating and cooling batteries, in order to heat or cool the air to return to the set temperature.
  • This operating mode also ensures a lowering of the temperature in the engine 8 and electronic 10 frames.
  • These zones are not directly controlled in temperature but are subject indirectly to the set point associated with the compression enclosure 6.
  • the humidity level is regulated in the same way as in manual mode. The same is true for the regulation of pressure differences.
  • the installation and the method according to the invention make it possible to avoid the phenomena of sticking of the tablets.
  • the invention generally consists of blowing pre-treated air (heating, cooling, filtration and treatment of the relative humidity of the air) within the machine in three suitably chosen places.
  • the blowing of cold air within these last two frames makes it possible to cool these elements and therefore to minimize the phenomena of heat conduction towards the compression enclosure.
  • By blowing cold air as close as possible to the compaction zone it is possible to reduce the temperature rise phenomena generated by the friction forces combined with the kinetic energy of the moving compression turret. Since the compression machine can be located in a room in which the renewal of the air is controlled, like aerolic flows, the invention has the advantage of avoiding disturbing these flows.
  • the regulations implemented by the invention for controlling the temperature and the flow make it possible not to disturb the possible recommendations of the manufacturer of the basic compressor (viscosity of the lubricating oil of the different parts, temperature of operation of motors and electrical components, etc.).
  • the invention can be easily implemented by adapting an existing compression machine because it minimizes the modifications to be made. Indeed, it will suffice to pierce the casing and add the corresponding deflectors.
  • the invention requires relatively large auxiliary technical organs, namely an air handling unit, a cold group and preferably insulated pipes as well as automatic means for controlling the system.
  • the invention allows temperature control at a relatively low cost.
  • many modifications can be made to the invention without departing from the scope thereof.
  • the tablets may include a substance for therapeutic or cosmetic use other than ibuprofen.
  • substance for therapeutic use means a substance which can be administered for preventive or curative purposes.
  • the compression machine could include at least one enclosure which is not associated with the gas blowing system. A system for humidifying the air entering the compression machine can be provided.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Structures Of Non-Positive Displacement Pumps (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention relates to an installation comprising a machine (4) for the production of tablets, said machine comprising at least one chamber (6). The inventive installation comprises means for releasing a gas into the chamber and for moving the gas around same.

Description

INSTALLATION COMPRENANT UNE MACHINE DE FABRICATION DE COMPRIMES EN PARTICULIER A USAGE THERAPEUTIQUE INSTALLATION COMPRISING A TABLET MAKING MACHINE IN PARTICULAR FOR THERAPEUTIC USE
L'invention concerne la fabrication de comprimés, en particulier les comprimés comprenant une substance à usage thérapeutique ou cosmétique. Il s'agit par exemple de comprimés comprenant de l'ibuprofen. La molécule d'ibuprofen présente un point de ramollissement à 42°C et un point de fusion à 70°C. Il est connu de mettre en forme des comprimés d'ibuprofen à partir d'une poudre au moyen d'une machine comprenant une série de matrices et de poinçons entre lesquels les comprimés sont formés. Au sein de la machine, la dynamique de compression génère des élévations de température, ce qui engendre un ramollissement de la matière première utilisée pour la fabrication des comprimés. Il peut s'ensuivre un problème de collage de la poudre ou des comprimés au sein de la machine, ce qui est préjudiciable à son bon fonctionnement. Le document FR-2 440 188 divulgue à la figure 3 une machine de fabrication de comprimés dont certaines pièces présentent des canaux internes parcourus par un fluide de refroidissement. De tels moyens de refroidissement doivent être pris en compte dès la conception et la réalisation de la machine, de sorte que ce procédé ne peut pas être mis en œuvre sur une machiné existante sans de lourdes modifications de celle-ci. Dans un autre mode de réalisation illustré à la figure 7, le document prévoit d'enfermer la machine tout entière dans une enceinte comprenant un gaz dont la température est contrôlée. Or l'énergie dépensée pour maintenir la température du gaz, et donc la température de la machine, au niveau souhaité est très élevée. Un but de l'invention est de résoudre le problème de collage lors de la fabrication des comprimés par des moyens facilement adaptables à une machine existante et dont la mise en œuvre ne nécessite pas une dépense d'énergie trop élevée. A cet effet, on prévoit selon l'invention une installation comprenant une machine de fabrication de comprimés, la machine présentant au moins une enceinte, l'installation comprenant des moyens pour faire entrer un gaz dans l'enceinte et lui faire parcourir l'enceinte.The invention relates to the manufacture of tablets, in particular tablets comprising a substance for therapeutic or cosmetic use. These are, for example, tablets comprising ibuprofen. The ibuprofen molecule has a softening point at 42 ° C and a melting point at 70 ° C. It is known to form ibuprofen tablets from a powder by means of a machine comprising a series of dies and punches between which the tablets are formed. Within the machine, the compression dynamics generate temperature rises, which causes a softening of the raw material used for the manufacture of the tablets. This can cause a problem of sticking of the powder or tablets within the machine, which is detrimental to its proper functioning. The document FR-2 440 188 discloses in FIG. 3 a machine for manufacturing tablets, certain parts of which have internal channels through which a cooling fluid passes. Such cooling means must be taken into account from the design and construction of the machine, so that this method cannot be implemented on an existing machine without major modifications thereof. In another embodiment illustrated in FIG. 7, the document provides for enclosing the entire machine in an enclosure comprising a gas whose temperature is controlled. However, the energy expended to maintain the temperature of the gas, and therefore the temperature of the machine, at the desired level is very high. An object of the invention is to solve the problem of bonding during the manufacture of the tablets by means easily adaptable to an existing machine and the implementation of which does not require too high an energy expenditure. To this end, an installation is provided according to the invention comprising a machine for manufacturing tablets, the machine having at least an enclosure, the installation comprising means for bringing a gas into the enclosure and making it pass through the enclosure.
Ainsi, l'invention peut être facilement adaptée à une machine existante sans coût excessif. De plus, la mise en circulation du gaz dans l'enceinte permet de refroidir celle-ci de façon efficace sans dépense énergétique trop importante. Avantageusement, lesdits moyens sont agencés pour contrôler une température du gaz. Ainsi, on pourra plus efficacement, notamment plus rapidement, obtenir la température souhaitée pour la fabrication des comprimés. Avantageusement, lesdits moyens sont agencés pour contrôler une hygrométrie du gaz. En effet, l'hygrométrie du gaz environnant la machine, en particulier les organes de fabrication des comprimés, est un paramètre également important pour éviter le collage lors de la fabrication. La machine pourra en outre présenter au moins l'une quelconque des caractéristiques suivantes : - lesdits moyens sont agencés pour contrôler une température du gaz ; - lesdits moyens sont agencés pour contrôler une température du gaz à un endroit prédéterminé en amont de l'enceinte pour faire en sorte qu'une température du gaz dans l'enceinte atteigne une valeur prédéterminée ; - lesdits moyens sont agencés pour contrôler une température du gaz à un endroit prédéterminé en amont de l'enceinte, pour faire en sorte que la température atteigne une valeur prédéterminée ; - lesdits moyens sont agencés pour refroidir et/ou chauffer le gaz ; - lesdits moyens comprennent au moins un filtre à particules ; - lesdits moyens comprennent au moins un ventilateur, par exemple placé en amont ou en aval de l'enceinte ; - l'enceinte comprend des organes de mise en forme des comprimés ; - l'enceinte comprend un moteur ; - l'enceinte comprend un dispositif électronique ; - les enceintes sont au moins au nombre de deux et la machine comprend des moyens pour faire entrer un gaz dans chaque enceinte et la lui faire parcourir ; • - elle comprend des conduites de gaz agencées pour alimenter les enceintes en gaz suivant une disposition en parallèle ; - les moyens sont en partie communs aux enceintes ; - lesdits moyens comprennent au moins une conduite de gaz raccordée de façon démontable à l'enceinte ; - elle comprend un obturateur pour interrompre une communication de gaz entre l'enceinte et le reste de l'installation ; - lesdits moyens sont agencés pour contrôler un débit de gaz associé à l'enceinte en permettant de choisir le débit parmi différentes valeurs de débit non nulles ; - lesdits moyens comprennent un caisson disposé dans l'enceinte et présentant au moins deux ouvertures d'entrée du gaz dans l'enceinte ; - les ouvertures s'étendent sur des faces différentes du caisson ; - les comprimés comprennent une substance à usage thérapeutique ou cosmétique ; et - les comprimés comprennent de l'ibuprofen. On prévoit également selon l'invention un procédé de fabrication de comprimés dans lequel on fait entrer un gaz dans une enceinte faisant partie d'une machine de fabrication de comprimés, et on lui fait parcourir l'enceinte. Le procédé pourra présenter au moins l'une quelconque des caractéristiques suivantes : - on contrôle une température du gaz ; - on contrôle une température du gaz à un endroit prédéterminé en amont de l'enceinte pour faire en sorte qu'une température du gaz dans l'enceinte atteigne une valeur prédéterminée ; et - on contrôle une température du gaz à un endroit prédéterminé en amont de l'enceinte pour faire en sorte que la température atteigne une valeur prédéterminée. D'autres caractéristiques et avantages de l'invention apparaîtront encore dans la description suivante d'un mode préféré de réalisation donné à titre d'exemple non limitatif en référence aux dessins annexés sur lesquels : - La figure 1 est un schéma d'ensemble de l'installation selon un mode préféré de réalisation de l'invention ; - La figure 2 est une vue schématique en plan de la centrale de traitement d'air de l'installation de la figure 1 ; - La figure 3 est une vue schématique d'une partie du système de chauffage et de refroidissement de l'air de l'installation de la figure 1 ; - La figure 4 est une vue en perspective partielle de la machine de l'installation de la figure 1 , montrant les conduits associés à l'enceinte de compression ; - La figure 5 est une vue partielle en perspective de l'intérieur de l'enceinte de compression de la machine de la figure 1 ; - La figure 6 est une vue analogue à la figure 4 montrant une conduite associée au bâti moteur ; - La figure 7 est une vue en perspective avec arrachement partiel montrant l'intérieur du bâti moteur ; - La figure 8 est une vue analogue à la figure 4 montrant les conduites associées au bâti électronique ; et - La figure 9 est une vue en perspective avec arrachement partiel montrant l'intérieur du bâti électronique. Dans le mode de réalisation de l'invention qui va être décrit, l'installation 2 comprend une machine 4 qui sert à la fabrication de comprimés , à usage thérapeutique comprenant de l'ibuprofen, cette machine étant d'un type connu en lui-même. En référence à la figure 1 , elle comprend classiquement une enceinte de compression 6 renfermant des organes de fabrication des comprimés, un bâti moteur 8 comprenant en particulier un moteur actionnant les organes situés dans l'enceinte de compression, et un bâti électronique 10 assurant la régulation de la machine. L'enceinte de compression, le bâti moteur, et le bâti électronique sont contigus les uns aux autres et enfermés dans un carter commun. Une telle machine est par exemple du type de celle divulguée dans le document FR-2 440 188 précité et ne sera pas décrite ci-après en détail dans tous ses éléments constitutifs. L'installation 2 comprend en l'espèce des moyens pour refroidir la machine 4 par soufflage d'air refroidi. Elle comprend en particulier un ventilateur de soufflage amontθ. Elle comprend également une centrale de traitement d'air 12 assurant en l'espèce la filtration, la déshumidification et éventuellement le chauffage ou le refroidissement de l'air. Elle comprend un ventilateur d'extraction aval 14. Elle comprend enfin des conduites ou gaines 16, par exemple en inox, mettant en communication de gaz les différentes parties de l'installation 2. Ainsi une première gaine commune 16 s'étend en aval de la centrale de traitement d'air et communique avec trois autres gaines reliées suivant un montage en parallèle à l'enceinte de compression 6, au bâti moteur 8, et au bâti électronique 10 respectivement. Enfin, deux gaines 16 s'entendent suivant un montage en parallèle en aval respectivement du bâti moteur et du bâti électronique. Elles communiquent avec une gaine 16 commune, elle-même en communication avec le ventilateur de soufflage aval 14. Ainsi, comme on le voit, dans cette installation, l'air est amené en trois points de la comprimeuse 4. Il est tout d'abord amené dans l'enceinte de compression 6 au plus près des organes de fabrication pour amener des frigories permettant de lutter contre les calories générées par le déplacement rapide de la tourelle de fabrication et les frottements. L'air est également amené dans le bâti moteur 8 afin d'y minimiser les phénomènes de diffusion de chaleur en direction de l'enceinte de compression adjacente, phénomènes dus à réchauffement des éléments mécaniques du moteur. Enfin, et de façon similaire, l'amenée de frigories dans le bâti électronique 10 permet de minimiser les phénomènes de diffusion de chaleur en direction du bâti moteur et de l'enceinte de compression, phénomènes dus à réchauffement des composants électriques et électroniques. La centrale de traitement d'air 12 est de préférence installée dans un local technique différent du local recevant la comprimeuse 4. Cette centrale permet d'assurer le conditionnement de l'air soufflé. Elle assure le contrôle de la qualité particulaire par filtration, la déshumidification, et le cas échéant la chauffage et/ou le refroidissement de l'air. Il s'agit en l'espèce d'une centrale de marque Hydronic de type CCM20 pouvant assurer un débit d'air de 1500 m3/heure et offrant une pression disponible de 350 Pa. Dans le présent exemple, cette centrale fonctionne en tout air neuf, c'est-à-dire qu'elle ne reçoit pas d'air ayant déjà traversé la machine. En référence à la figure 2, nous allons présenter les différents organes constituant cette centrale 12 de gauche à droite, c'est-à-dire dans le sens de l'écoulement du gaz, l'air entrant à l'extrémité gauche de la centrale pour en sortir à l'extrémité droite. La centrale comporte un filtre 20 à particules de type F6 (selon la norme EN779). En aval du filtre 20, la centrale comprend tout d'abord une batterie chaude électrique 22 d'une puissance de 7,8 kW, puis une batterie 24 fonctionnant à l'eau glacée ayant une température située entre 0 à 5°C d'une puissance de 24 kW. Elle est suivie d'une deuxième batterie d'eau glacée 26. On trouve ensuite une. batterie chaude électrique 28 d'une puissance de 15,6 kW. La centrale comprend en aval de ces éléments le ventilateur de soufflage amont 9 précité qui dans le présent exemple est donc intégré à la centrale et assure un débit de 1500 m3/heure en offrant une pression disponible de 300 Pa. En aval de celui-ci sont disposés un filtre à particules F8 30 (selon la norme EN779) et un filtre à particules H13 32 (selon la norme EN1822). Tous ces filtres ont notamment pour fonction de rendre le gaz « propre » c'est-à-dire compatible avec un usage pharmaceutique afin de permettre sa mise en contact avec les comprimés. Dans le présent exemple, au niveau de ces deux derniers filtres, des mesures de pression différentielle sont réalisées régulièrement afin d'assurer une surveillance de l'encrassement de ces filtres. Les calculs de dimensionnement de la machine ont été réalisés selon différentes données climatiques et géographiques. Ainsi, on souhaite en été comme en hiver maintenir dans la machine une dépression de 0 à 30 Pa, une température dans la tourelle de compression de 25°C et une humidité de l'air de soufflage inférieure à 5 g d'eau par kg d'air sec. On a pris pour hypothèse en hiver des conditions extérieures de - 7°C avec 90% d'humidité relative et en été une température extérieure de 29°C avec 43% d'humidité relative. Chaque batterie froide 24, 26 de la centrale 12 est alimentée par un circuit d'eau glacée commun relié à un groupe frigorifique 34 illustré à la figure 3. Ce groupe est associé à des ballons tampons respectivement deThus, the invention can be easily adapted to an existing machine without excessive cost. In addition, the circulation of gas in the enclosure makes it possible to cool it efficiently without excessive energy expenditure. Advantageously, said means are arranged to control a temperature of the gas. Thus, it will be possible more efficiently, in particular more quickly, to obtain the desired temperature for the manufacture of the tablets. Advantageously, said means are arranged to control a humidity of the gas. Indeed, the hygrometry of the gas surrounding the machine, in particular the organs for manufacturing the tablets, is also an important parameter to avoid sticking during manufacture. The machine may also have at least any of the following characteristics: - said means are arranged to control a temperature of the gas; - Said means are arranged to control a temperature of the gas at a predetermined location upstream of the enclosure to ensure that a temperature of the gas in the enclosure reaches a predetermined value; - Said means are arranged to control a temperature of the gas at a predetermined location upstream of the enclosure, to ensure that the temperature reaches a predetermined value; - Said means are arranged to cool and / or heat the gas; - Said means comprise at least one particle filter; - Said means comprise at least one fan, for example placed upstream or downstream of the enclosure; - The enclosure includes organs for shaping the tablets; - the enclosure includes a motor; - the enclosure includes an electronic device; - the enclosures are at least two in number and the machine comprises means for bringing a gas into each enclosure and making it pass through it; • - it comprises gas pipes arranged to supply the enclosures with gas in a parallel arrangement; - the means are partly common to the enclosures; - Said means comprise at least one gas pipe detachably connected to the enclosure; - It includes a shutter to interrupt a gas communication between the enclosure and the rest of the installation; - Said means are arranged to control a gas flow rate associated with the enclosure by allowing the flow rate to be chosen from among different non-zero flow values; - Said means comprise a box disposed in the enclosure and having at least two gas inlet openings in the enclosure; - The openings extend on different faces of the box; - the tablets include a substance for therapeutic or cosmetic use; and - the tablets include ibuprofen. According to the invention, a method of manufacturing tablets is also provided in which a gas is introduced into an enclosure forming part of a tablet manufacturing machine, and it is made to travel through the enclosure. The process may have at least any one of the following characteristics: - a temperature of the gas is controlled; - A temperature of the gas is controlled at a predetermined location upstream of the enclosure to ensure that a temperature of the gas in the enclosure reaches a predetermined value; and - One controls a temperature of the gas at a predetermined location upstream of the enclosure to ensure that the temperature reaches a predetermined value. Other characteristics and advantages of the invention will appear in the following description of a preferred embodiment given by way of nonlimiting example with reference to the appended drawings in which: - Figure 1 is an overall diagram of the installation according to a preferred embodiment of the invention; - Figure 2 is a schematic plan view of the air handling unit of the installation of Figure 1; - Figure 3 is a schematic view of part of the air heating and cooling system of the installation of Figure 1; - Figure 4 is a partial perspective view of the machine of the installation of Figure 1, showing the conduits associated with the compression enclosure; - Figure 5 is a partial perspective view of the interior of the compression chamber of the machine of Figure 1; - Figure 6 is a view similar to Figure 4 showing a pipe associated with the engine mount; - Figure 7 is a perspective view with partial cutaway showing the interior of the engine mount; - Figure 8 is a view similar to Figure 4 showing the pipes associated with the electronic frame; and - Figure 9 is a perspective view with partial cutaway showing the interior of the electronic frame. In the embodiment of the invention which will be described, the installation 2 comprises a machine 4 which is used for the manufacture of tablets, for therapeutic use comprising ibuprofen, this machine being of a type known per se even. Referring to FIG. 1, it conventionally comprises a compression enclosure 6 containing organs for manufacturing tablets, a motor frame 8 comprising in particular a motor actuating the organs located in the enclosure compression, and an electronic frame 10 ensuring the regulation of the machine. The compression enclosure, the motor frame, and the electronic frame are contiguous to each other and enclosed in a common casing. Such a machine is for example of the type of that disclosed in the aforementioned document FR-2,440,188 and will not be described below in detail in all of its constituent elements. The installation 2 in this case comprises means for cooling the machine 4 by blowing cooled air. It includes in particular an upstream supply fan ventilateur. It also includes an air treatment unit 12 in this case ensuring filtration, dehumidification and possibly heating or cooling of the air. It comprises a downstream exhaust fan 14. Finally, it comprises pipes or ducts 16, for example made of stainless steel, bringing the various parts of the installation into gas communication 2. Thus a first common duct 16 extends downstream of the air handling unit and communicates with three other ducts connected in an assembly parallel to the compression enclosure 6, to the motor frame 8, and to the electronic frame 10 respectively. Finally, two sheaths 16 are understood according to a parallel mounting downstream respectively of the motor frame and the electronic frame. They communicate with a common duct 16, itself in communication with the downstream supply fan 14. Thus, as can be seen, in this installation, the air is brought in at three points from the compression machine 4. It is all firstly brought into the compression enclosure 6 as close as possible to the manufacturing members to bring frigories making it possible to combat the calories generated by the rapid displacement of the manufacturing turret and friction. Air is also brought into the engine mount 8 in order to minimize the phenomena of heat diffusion towards the adjacent compression enclosure, phenomena due to heating of the mechanical elements of the engine. Finally, and similarly, bringing frigories into the electronic frame 10 makes it possible to minimize the phenomena of heat diffusion towards the engine frame and the compression enclosure, phenomena due to heating of electrical and electronic components. The air handling unit 12 is preferably installed in a technical room different from the room receiving the compressor 4. This unit makes it possible to ensure the conditioning of the blown air. It ensures particulate quality control by filtration, dehumidification, and if necessary heating and / or cooling of the air. In this case, it is a Hydronic brand CCM20 type power station capable of providing an air flow of 1500 m 3 / hour and offering an available pressure of 350 Pa. In the present example, this power station works in all fresh air, i.e. it does not receive air that has already passed through the machine. Referring to Figure 2, we will present the different organs constituting this central 12 from left to right, that is to say in the direction of gas flow, the air entering the left end of the central to exit at the right end. The plant has a F6 type particle filter 20 (according to standard EN779). Downstream of the filter 20, the power station comprises first of all an electric hot battery 22 with a power of 7.8 kW, then a battery 24 operating with chilled water having a temperature between 0 to 5 ° C. a power of 24 kW. It is followed by a second battery of chilled water 26. There is then one. electric hot battery 28 with a power of 15.6 kW. The power station comprises downstream of these elements the aforementioned upstream supply fan 9 which in the present example is therefore integrated into the power station and provides a flow rate of 1500 m 3 / hour by providing an available pressure of 300 Pa. these are fitted with an F8 30 particle filter (according to standard EN779) and an H13 32 particle filter (according to standard EN1822). All of these filters have the particular function of making the gas "clean", that is to say compatible with pharmaceutical use in order to allow it to come into contact with the tablets. In the present example, at the level of these last two filters, differential pressure measurements are carried out regularly in order to ensure monitoring of the fouling of these filters. The machine sizing calculations were carried out according to different climatic and geographic data. Thus, in summer and winter, we want to maintain a vacuum in the machine from 0 to 30 Pa, a temperature in the compression turret of 25 ° C and a humidity of the supply air less than 5 g of water per kg dry air. Outdoor conditions of -7 ° C with 90% relative humidity were assumed in winter and an outdoor temperature of 29 ° C with 43% relative humidity in summer. Each cold battery 24, 26 of the power station 12 is supplied by a common chilled water circuit connected to a refrigeration unit 34 illustrated in FIG. 3. This group is associated with buffer tanks respectively of
100 litres et 300 litres afin d'assurer une stabilité importante au niveau de la précision de la température de l'eau. En référence à la figure 1 , en aval de la centrale 12, l'air est acheminé dans une gaine 16 qui comme on l'a vu se divise en 3 parties : - une gaine pour le soufflage de l'air vers l'enceinte de compression 6 ; - une gaine pour le soufflage de l'air vers le bâti moteur 8; et - une gaine pour le soufflage de l'air vers le bâti électronique 10. Sur le cheminement de chacune de ces trois dernières gaines est positionné un registre de soufflage 36a, 36b et 36c. Il s'agit d'un registre motorisé 36a sur le cheminement vers l'enceinte de compression. Les registres 36b et 36c sur le cheminement vers les bâtis moteur et électronique ne sont pas motorisés. Le registre motorisé 36a permet d'isoler de façon étanche l'enceinte de compression à l'égard du réseau de soufflage d'air en cas d'arrêt de la machine. Il s'agit d'une contrainte pharmaceutique permettant d'éviter toute contamination du réseau de soufflage par de la poudre présente dans la machine. Chacun de ces registres permet par ailleurs de modifier le débit d'air dans chacune des gaines 16 associées pour faire varier ce débit entre différentes valeurs de débit non nulles, voire pour obturer totalement la gaine. Les gaines 16 sont en l'espèce en acier inoxydable AISI 316 L. Chacune de ces trois gaines part du local recevant la centrale 12 et aboutit dans la salle logeant la comprimeuse 4. Cette salle est à atmosphère contrôlée. Dans le présent exemple, chacune de ces trois gaines 16 présente une partie médiane démontable, et deux parties respectivement amont et aval situées de part et d'autre de la partie démontable et fixées à demeure respectivement à la salle et à la machine. La présence de ces tronçons démontables permet d'utiliser si nécessaire la machine 4 dans sa configuration d'origine, à avoir sans mettre en œuvre le soufflage d'air refroidi. Dans ce cas, on positionne des bouchons, par exemple en acier inoxydable, sur les tronçons de gaine fixes associés à la machine afin d'assurer les performances de base de la machine. On va maintenant présenter plus en détail en référence aux figures 4 et 5 la mise en œuvre du refroidissement de l'enceinte de compression 6. La gaine 16 associée à l'enceinte de compression 6 y arrive par le dessus de l'enceinte. Elle permet de diffuser l'air au plus proche des matrices de compression 39. Au sein de l'enceinte 6 est disposé un caisson ou déflecteur 40 en forme de parallélépipède rectangle et constitué en tôle. Ce caisson reçoit l'air arrivant de la gaine 16. Il présente des ouvertures 42 sur ses faces latérales verticales 44 et 46, ainsi que sur ses faces inférieure 48 et arrière (non illustrée). Il permet une bonne répartition du flux d'air afin d'assurer une parfaite diffusion de l'air à l'intérieur de l'enceinte de compression. Dans le présent exemple, la face avant 49 du déflecteur ne présente pas d'ouverture de sortie d'air. En effet, cette face fait face à l'intérieur de l'enceinte 6. La comprimeuse est par ailleurs équipée d'un système de pulvérisation de lubrifiant pulvérulent qui permet d'assurer la lubrification des matrices 39 d'une façon connue en soi et qui est un composé très volatile. Si cette face du caisson n'était pas bouchée, l'air soufflé provoquerait un nuage de lubrifiant pulvérulent au sein de l'enceinte 6 qui serait préjudiciable à la fabrication. Le déflecteur 40 s'étend en partie haute de l'enceinte 6. La gaine 16 aval, visant à extraire le gaz de l'enceinte 6, débouche en partie inférieure de l'enceinte sur une face de cette enceinte opposée au déflecteur. Les moyens de refroidissement de l'enceinte associée au bâti moteur 8 sont illustrés aux figures 6 et 7. L'air est envoyé directement dans le bâti moteur afin de réduire la température de ce bâti' et ainsi minimiser la diffusion de chaleur du bâti moteur vers l'enceinte de compression 6. Un caisson 50 ou déflecteur, également en tôle perforée, est installé à l'intérieur de l'enceinte 8 du bâti moteur. Le déflecteur est posé sur la face inférieure horizontale de l'enceinte 8 et est ouvert sur ses faces supérieure 52, avant 54 et latérale verticale 56 en présentant sur chacune d'elles un réseau d'orifices 42. La gaine 16 de sortie d'air est disposée sur une face différente de la face de l'enceinte 8 recevant la gaine d'entrée d'air à destination du déflecteur. La mise en œuvre du refroidissement du bâti électronique 10 est illustrée enfin aux figures 8 et 9. De même que pour le bâti moteur 8, l'air est envoyé directement dans le boîtier électronique afin de réduire la température de ce bâti et ainsi minimiser la diffusion de chaleur du bâti électronique vers l'enceinte de compression. Pour cela, l'air est amené par le dessous d'une armoire électrique 60 du bâti électronique 10. Ici encore, un déflecteur ou caisson est prévu pour l'introduction de l'air au sein de l'enceinte 10. Le déflecteur est mis en place en partie inférieure de l'enceinte après démontage des ventilateurs généralement situés en partie inférieure de l'armoire. Le caisson est ouvert sur sa face supérieure en présentant plusieurs réseaux d'ouvertures 42. Ce système permet une bonne répartition du flux d'air afin d'assurer une parfaite diffusion de l'air à l'intérieur du bâti électronique. La gaine 16 amont introduisant l'air dans l'enceinte 10 est située en partie basse de l'armoire tandis que la gaine 16 aval extrayant l'air de cette enceinte est située en partie haute du bâti moteur. Les deux gaines sont associées à la même paroi latérale 64 de l'armoire. Comme on le voit, l'air n'est extrait via les gaines 16 qu'en deux points de la machine, à savoir le bâti moteur 8 et le bâti électronique 10. Cette extraction est effectuée grâce au ventilateur d'extraction 14. De même que pour les gaines amont, les deux gaines aval 16 associées aux bâtis moteur et électronique sont munies de registres d'extraction motorisés 70 qui permettent d'isoler de façon étanche le réseau d'extraction du réseau de soufflage en cas d'arrêt de la machine. Cette contrainte pharmaceutique permet d'éviter toute contamination du réseau de soufflage par de l'air souillé ayant circulé au sein d'éléments mécaniques et électroniques. La machine comprend des moyens de contrôle du système de soufflage d'air permettant en particulier de régler les différents paramètres et modalités de fonctionnement. Ce système pourra comprendre un terminal encastré dans une cloison de la salle muni d'un écran de contrôle. Ce terminal permet l'entrée de consignes et le suivi des paramètres du fonctionnement. Il permet aussi de gérer les alarmes. Avantageusement, il comprendra des moyens d'enregistrement de tout l'historique du fonctionnement de l'installation. L'installation comprend un asservissement automatique marche/arrêt entre le système de soufflage d'air, la comprimeuse et l'aspirateur associé à celle-ci. Dans le cadre de la fabrication des comprimés, deux modes de fonctionnement de l'installation sont envisageables. Le premier que nous pourrons appeler mode manuel comprend l'étape d'entrée d'une température de consigne de l'air de soufflage. Cette température de consigne est choisie par l'opérateur dans une plage prédéterminée, par exemple de 5 à 15°C. La température minimale de soufflage à 5°C permet d'éviter les phénomènes de condensation pouvant apparaître en dessous de cette température. On choisira par exemple une température de consigne égale à 10 °C. Cette consigne est naturellement associée à une plage de tolérance (par exemple entre 9 et 11 °C) pour l'oscillation de la température autour de cette consigne. Dans ce mode de fonctionnement, l'installation contrôle la température du gaz sortant de la centrale 12 au moyen d'un capteur 80 situé sur la gaine 16 communiquant directement en aval avec celle-ci. L'installation pilote donc la centrale 12, en particulier ses batteries de chauffage et de refroidissement, de sorte que la température mesurée au niveau du capteur 80 demeure le plus près possible de la température de consigne, ici 10 °C. La sonde 80 lit en continu la température de l'air en ce point. Si cette température évolue, l'installation pilotera la centrale pour assurer une régulation de la température. Ce mode de fonctionnement permet d'abaisser la température dans le bâti moteur et le bâti électronique. La température de l'air soufflé dans ces deux zones est identique à celle de l'air soufflé dans l'enceinte de compression. La teneur en humidité du gaz est contrôlée au moyen d'une sonde 82 située à côté de la sonde de température 80 en aval de la centrale 12. Cette sonde agit directement sur les batteries froides de la centrale pour réguler l'humidité. Dans le présent exemple, le débit prévu dans l'enceinte de compression 6 est de 150 m3/heure. Les débits dans le bâti moteur et le bâti électronique sont chacun prévus à 700 m3/heure. Le débit de 150 m3/heure au niveau de l'enceinte de compression est régulé en fonction de la dépression régnant dans l'enceinte de compression. En effet, cette enceinte est reliée à un aspirateur 69 assurant un dépoussiérage permanent de la machine d'une façon connue en soi. Cet aspirateur permet d'éliminer les excès de lubrifiant présents dans la machine. Il aspire un débit de 190 m3/heure. L'aspirateur aspirant plus que le système ne souffle dans l'enceinte de compression, il existe une dépression permanente dans l'enceinte de compression située entre 0 et 30 Pa. Cette dépression permet de confiner les poussières, et d'éviter un empoussièrement excessif de la - machine ainsi qu'une fuite de poudre dans la salle. Le débit d'air entrant dans l'enceinte 6 est régulé pour assurer le maintien de la dépression. Cette régulation se fait via le ventilateur de soufflage9 situé dans la centrale 12. Cette régulation est nécessaire car l'aspirateur s'encrasse au fur et à mesure du fonctionnement, générant ainsi une diminution du débit d'aspiration. A cette fin, l'enceinte de compression 6 est associée à un transmetteur de pression différentielle 84 mesurant simultanément la pression dans l'enceinte et à l'extérieur de celle- ci. La mesure de pression différentielle assurée par ce capteur permet à la machine de piloter le ventilateur9. Des mesures de pression sont également effectuées eh permanence au moyen de deux capteurs 86 et 88 respectivement situés en aval de la centrale 12 et en amont du ventilateur d'extraction 14. Une éventuelle variation de vitesse du ventilateur9 générée par le capteur 84 entraîne une évolution de la pression mesurée par le capteur 86 en sortie de la centrale et de la pression mesurée par le capteur 88 dans le réseau d'extraction. On fera en sorte que le rapport des pressions mesurées par ces deux derniers capteurs reste continuellement constant. L'installation agit par conséquent sur le ventilateur 14 dans ce but. L'aspirateur 69 générant une dépression d'air à l'intérieur -de l'enceinte de compression est muni d'un pressostat mesurant la pression différentielle à l'entrée de l'aspirateur et à l'extérieur de la machine. Il mesure ainsi le taux d'encrassement de l'aspirateur. Lorsque ce taux atteint un seuil critique, une alarme avertit l'opérateur que le décolmatage du filtre est nécessaire. Si cette opération de décolmatage n'est pas effectuée, la machine se met alors en défaut, le registre amont 36 de l'enceinte de compression et les registres aval 70 sont alors obturés pour isoler la machine à comprimer. L'autre mode de fonctionnement du procédé peut être appelé mode automatique. Dans ce cas, l'opérateur fournit en tant que donnée à l'installation une consigne de température du gaz dans l'enceinte de compression 6, par exemple 25°C, ici encore avec une certaine tolérance. Ainsi, le système pilote la centrale 12 afin de souffler de l'air dans l'enceinte 6 et faire en sorte que la température du gaz dans l'enceinte atteigne la valeur de consigne. A cette fin, la machine comprend un capteur de température 90 disposé dans l'enceinte. Ce capteur mesure en permanence la température dans l'enceinte. Lorsque cette température n'est plus de 25°C, l'installation pilote la centrale 12, en particulier les batteries de chauffage et de refroidissement, afin de chauffer ou refroidir l'air pour retrouver la température de consigne. Ce mode de fonctionnement assure aussi un abaissement de la température dans les bâtis moteur 8 et électronique 10. Ces zones ne sont pas contrôlées directement en température mais sont soumises indirectement au point de consigne associé à l'enceinte de compression 6. La régulation du taux d'humidité s'effectue de la même façon qu'en mode manuel. Il en est de même pour la régulation des différences de pression. L'installation et le procédé selon l'invention permettent d'éviter les phénomènes de collage des comprimés. Comme on le voit, l'invention consiste globalement en un soufflage d'air préalablement traité (chauffage, refroidissement, filtration et traitement de l'humidité relative de l'air) au sein de la machine en trois endroits convenablement choisis. Il s'agit ici de l'enceinte de compression qui comprend les organes de compactage du mélange, du bâti moteur et du bâti électronique. Le soufflage d'air froid au sein de ces deux derniers bâtis permet de refroidir ces éléments et donc de minimiser les phénomènes de conduction de chaleur vers l'enceinte de compression. Le soufflage d'air froid au plus près de la zone de compactage permet de réduire les phénomènes d'élévation de température générés par les forces de frottement combinées à l'énergie cinétique de la tourelle de compression en mouvement. La comprimeuse pouvant se situer dans une pièce dont le renouvellement de l'air est contrôlé, tout comme les flux aéroliques, l'invention a pour avantage d'éviter de perturber ces flux. De plus, les régulations mises en œuvre par l'invention pour le contrôle de la température et du débit permettent de ne pas perturber les préconisations éventuelles du constructeur de la comprimeuse de base (viscosité de l'huile de lubrification des différentes pièces, température de fonctionnement des moteurs et des composants électriques, ....). L'invention peut être facilement mise en oeuvre en adaptant une comprimeuse existante car elle permet de minimiser les modifications à effectuer. En effet, il suffira de percer le carter et d'ajouter les déflecteurs correspondants. Naturellement, l'invention nécessite des organes techniques auxiliaires relativement importants, à savoir une centrale de traitement d'air, un groupe froid et des canalisations de préférence calorifugées ainsi que des moyens automatiques pour le pilotage du système. L'invention permet une maîtrise de la température pour un coût relativement faible. Bien entendu, on pourra apporter à l'invention de nombreuses modifications sans sortir du cadre de celle-ci. Les comprimés pourront comprendre une substance à usage thérapeutique ou cosmétique autre que l'ibuprofen. Par substance à usage thérapeutique, on entend une substance administrable à titre préventif ou curatif. Par ailleurs, la comprimeuse pourrait comprendre au moins une enceinte qui n'est pas associée au système de soufflage de gaz. On pourra prévoir un système d'humidification de l'air entrant dans la comprimeuse. 100 liters and 300 liters to ensure significant stability in terms of water temperature accuracy. Referring to Figure 1, downstream of the central 12, the air is routed through a duct 16 which, as we have seen, is divided into 3 parts: - a duct for blowing the air towards the enclosure compression 6; - a sheath for blowing air to the engine mount 8; and - a sheath for blowing air to the electronic frame 10. On the path of each of these last three sheaths is positioned a blowing register 36a, 36b and 36c. It is a motorized damper 36a on the way to the compression enclosure. The registers 36b and 36c on the path to the engine and electronic frames are not motorized. The motorized register 36a makes it possible to isolate the compression enclosure in a sealed manner with respect to the air blowing network in the event of the machine stopping. This is a pharmaceutical constraint making it possible to avoid any contamination of the blowing network with powder present in the machine. Each of these registers also makes it possible to modify the air flow rate in each of the associated ducts 16 to vary this flow rate between different values of non-zero flow rate, or even to completely shut off the duct. The ducts 16 are in this case made of AISI 316 L stainless steel. Each of these three ducts leaves the room receiving the central 12 and ends up in the room housing the compression machine 4. This room has a controlled atmosphere. In the present example, each of these three sheaths 16 has a removable central part, and two respectively upstream and downstream parts located on either side of the removable part and permanently fixed respectively to the room and to the machine. The presence of these dismountable sections makes it possible to use the machine 4 in its original configuration if necessary, to have this without blowing the cooled air. In this case, plugs, for example made of stainless steel, are positioned on the fixed sheath sections associated with the machine in order to ensure the basic performance of the machine. We will now present in more detail with reference to Figures 4 and 5 the implementation of the cooling of the compression enclosure 6. The sheath 16 associated with the compression enclosure 6 arrives there from above the enclosure. It makes it possible to diffuse the air as close as possible to the compression matrices 39. Within the enclosure 6 is disposed a box or deflector 40 in the shape of a rectangular parallelepiped and made of sheet metal. This box receives the air arriving from the sheath 16. It has openings 42 on its vertical lateral faces 44 and 46, as well as on its lower 48 and rear faces (not shown). It allows a good distribution of the air flow in order to ensure a perfect diffusion of the air inside the compression enclosure. In the present example, the front face 49 of the deflector does not have an air outlet opening. In fact, this face faces the inside of the enclosure 6. The compression machine is moreover equipped with a system for spraying a pulverulent lubricant which makes it possible to lubricate the dies 39 in a manner known per se and which is a very volatile compound. If this face of the box was not blocked, the blown air would cause a cloud of powdery lubricant within the enclosure 6 which would be detrimental to manufacturing. The deflector 40 extends in the upper part of the enclosure 6. The downstream sheath 16, aimed at extracting the gas from the enclosure 6, opens in the lower part of the enclosure on a face of this enclosure opposite to the deflector. The cooling means of the chamber 8 associated with the engine mount are shown in Figures 6 and 7. The air is fed directly into the engine frame in order to reduce the temperature of the frame 'and minimize the diffusion of heat from the engine frame to the compression enclosure 6. A box 50 or deflector, also made of perforated sheet metal, is installed inside the enclosure 8 of the engine mount. The deflector is placed on the horizontal lower face of the enclosure 8 and is open on its upper 52, front 54 and vertical lateral 56 faces, having on each of them a network of orifices 42. The sheath 16 of outlet air is arranged on a different face from the face of the enclosure 8 receiving the air inlet sheath intended for the deflector. The implementation of the cooling of the electronic frame 10 is finally illustrated in FIGS. 8 and 9. As for the engine frame 8, the air is sent directly into the electronic unit in order to reduce the temperature of this frame and thus minimize the heat diffusion from the electronic frame to the compression enclosure. For this, the air is brought in from below an electrical cabinet 60 of the electronic frame 10. Here again, a deflector or box is provided for the introduction of air within the enclosure 10. The deflector is installed in the lower part of the enclosure after dismantling the fans generally located in the lower part of the cabinet. The box is open on its upper face by presenting several networks of openings 42. This system allows a good distribution of the air flow in order to ensure a perfect diffusion of the air inside the electronic frame. The upstream sheath 16 introducing the air into the enclosure 10 is located in the lower part of the cabinet while the downstream sheath 16 extracting the air from this enclosure is located in the upper part of the engine mount. The two sheaths are associated with the same side wall 64 of the cabinet. As can be seen, the air is extracted via the ducts 16 only at two points on the machine, namely the motor frame 8 and the electronic frame 10. This extraction is carried out by means of the extraction fan 14. From same as for the upstream ducts, the two downstream ducts 16 associated with the engine and electronic frames are provided with motorized extraction registers 70 which make it possible to seal the extraction network from the blowing network in a sealed manner in the event of the machine stopping. This pharmaceutical constraint makes it possible to avoid any contamination of the blowing network by contaminated air having circulated within mechanical and electronic elements. The machine includes means for controlling the air blowing system, making it possible in particular to adjust the various parameters and operating modes. This system could include a terminal built into a room partition fitted with a control screen. This terminal allows entry of instructions and monitoring of operating parameters. It also allows you to manage alarms. Advantageously, it will include means for recording the entire history of the operation of the installation. The installation includes an automatic on / off control between the air blowing system, the compression machine and the vacuum cleaner associated with it. In the context of the manufacture of the tablets, two operating modes of the installation can be envisaged. The first one that we can call manual mode includes the step of entering a target supply air temperature. This setpoint temperature is chosen by the operator within a predetermined range, for example from 5 to 15 ° C. The minimum blowing temperature at 5 ° C makes it possible to avoid condensation phenomena which can appear below this temperature. We will choose for example a set temperature equal to 10 ° C. This setpoint is naturally associated with a tolerance range (for example between 9 and 11 ° C) for the oscillation of the temperature around this setpoint. In this operating mode, the installation controls the temperature of the gas leaving the power station 12 by means of a sensor 80 located on the sheath 16 communicating directly downstream with the latter. The installation therefore controls the central unit 12, in particular its heating and cooling batteries, so that the temperature measured at the sensor 80 remains as close as possible to the set temperature, here 10 ° C. The probe 80 continuously reads the air temperature at this point. If this temperature changes, the installation will control the central unit to ensure temperature regulation. This operating mode makes it possible to lower the temperature in the engine mount and the electronic mount. The temperature of the air blown into these two zones is identical to that of the air blown into the compression enclosure. The moisture content of the gas is controlled by means of a probe 82 located next to the temperature probe 80 downstream of the plant 12. This probe acts directly on the cold batteries of the plant to regulate the humidity. In the present example, the flow rate provided in the compression enclosure 6 is 150 m 3 / hour. The flows in the engine mount and the electronic mount are each planned at 700 m 3 / hour. The flow rate of 150 m 3 / hour at the level of the compression enclosure is regulated as a function of the vacuum prevailing in the compression enclosure. Indeed, this enclosure is connected to a vacuum cleaner 69 ensuring permanent dusting of the machine in a manner known per se. This vacuum cleaner eliminates excess lubricant present in the machine. It draws a flow of 190 m 3 / hour. The vacuum cleaner sucks more than the system blows in the compression enclosure, there is a permanent vacuum in the compression enclosure located between 0 and 30 Pa. This vacuum allows to contain the dust, and to avoid excessive dusting of the machine and a powder leak in the room. The air flow entering the enclosure 6 is regulated to maintain the vacuum. This regulation is done via the blowing fan9 located in the control unit 12. This regulation is necessary because the vacuum cleaner becomes dirty as the operation progresses, thus generating a reduction in the suction flow rate. To this end, the compression enclosure 6 is associated with a differential pressure transmitter 84 simultaneously measuring the pressure inside and outside the enclosure. The differential pressure measurement provided by this sensor allows the machine to control the fan9. Pressure measurements are also carried out permanently by means of two sensors 86 and 88 respectively located downstream of the central 12 and upstream of the extractor fan 14. A possible speed variation of the ventilator 9 generated by the sensor 84 results in a change in the pressure measured by the sensor 86 at the outlet of the central and in the pressure measured by the sensor 88 in the extraction network. We will make sure that the pressure ratio measured by these last two sensors remains continuously constant. The installation therefore acts on the fan 14 for this purpose. The vacuum cleaner 69 generating an air vacuum inside the compression enclosure is provided with a pressure switch measuring the differential pressure at the inlet of the vacuum cleaner and outside the machine. It thus measures the fouling rate of the vacuum cleaner. When this rate reaches a critical threshold, an alarm warns the operator that unclogging the filter is necessary. If this unclogging operation is not carried out, the machine then goes into default, the upstream register 36 of the compression enclosure and the downstream registers 70 are then closed to isolate the machine to be compressed. The other operating mode of the process can be called automatic mode. In this case, the operator provides as data to the installation a gas temperature setpoint in the compression enclosure 6, for example 25 ° C., here again with a certain tolerance. Thus, the system controls the central unit 12 in order to blow air into the enclosure 6 and ensure that the temperature of the gas in the enclosure reaches the set value. To this end, the machine comprises a temperature sensor 90 disposed in the enclosure. This sensor continuously measures the temperature in the enclosure. When this temperature is no more than 25 ° C., the installation controls the central unit 12, in particular the heating and cooling batteries, in order to heat or cool the air to return to the set temperature. This operating mode also ensures a lowering of the temperature in the engine 8 and electronic 10 frames. These zones are not directly controlled in temperature but are subject indirectly to the set point associated with the compression enclosure 6. The humidity level is regulated in the same way as in manual mode. The same is true for the regulation of pressure differences. The installation and the method according to the invention make it possible to avoid the phenomena of sticking of the tablets. As can be seen, the invention generally consists of blowing pre-treated air (heating, cooling, filtration and treatment of the relative humidity of the air) within the machine in three suitably chosen places. This is the compression enclosure which comprises the components for compacting the mixture, the engine mount and the electronic mount. The blowing of cold air within these last two frames makes it possible to cool these elements and therefore to minimize the phenomena of heat conduction towards the compression enclosure. By blowing cold air as close as possible to the compaction zone, it is possible to reduce the temperature rise phenomena generated by the friction forces combined with the kinetic energy of the moving compression turret. Since the compression machine can be located in a room in which the renewal of the air is controlled, like aerolic flows, the invention has the advantage of avoiding disturbing these flows. In addition, the regulations implemented by the invention for controlling the temperature and the flow make it possible not to disturb the possible recommendations of the manufacturer of the basic compressor (viscosity of the lubricating oil of the different parts, temperature of operation of motors and electrical components, etc.). The invention can be easily implemented by adapting an existing compression machine because it minimizes the modifications to be made. Indeed, it will suffice to pierce the casing and add the corresponding deflectors. Naturally, the invention requires relatively large auxiliary technical organs, namely an air handling unit, a cold group and preferably insulated pipes as well as automatic means for controlling the system. The invention allows temperature control at a relatively low cost. Of course, many modifications can be made to the invention without departing from the scope thereof. The tablets may include a substance for therapeutic or cosmetic use other than ibuprofen. The term substance for therapeutic use means a substance which can be administered for preventive or curative purposes. Furthermore, the compression machine could include at least one enclosure which is not associated with the gas blowing system. A system for humidifying the air entering the compression machine can be provided.

Claims

REVENDICATIONS
1. Installation (2) comprenant une machine" (4) de fabrication de comprimés, la machine présentant au moins une enceinte (6, 8, 10), caractérisée en ce que l'installation comprend des moyens (10, 12, 16, 14) pour faire entrer un gaz dans l'enceinte et lui faire parcourir l'enceinte.1. Installation (2) comprising a machine " (4) for manufacturing tablets, the machine having at least one enclosure (6, 8, 10), characterized in that the installation comprises means (10, 12, 16, 14) to bring a gas into the enclosure and make it pass through the enclosure.
2. Installation selon la revendication 1 , caractérisée en ce que lesdits moyens sont agencés pour contrôler une température du gaz.2. Installation according to claim 1, characterized in that said means are arranged to control a temperature of the gas.
3. Installation selon l'une quelconque des revendications précédentes, caractérisée en ce que lesdits moyens sont agencés pour contrôler une température du gaz à un endroit prédéterminé (80) en amont de l'enceinte (6) pour faire en sorte qu'une température du gaz dans l'enceinte (6) atteigne une valeur prédéterminée.3. Installation according to any one of the preceding claims, characterized in that said means are arranged to control a temperature of the gas at a predetermined location (80) upstream of the enclosure (6) to ensure that a temperature gas in the enclosure (6) reaches a predetermined value.
4. Installation selon l'une quelconque des revendications précédentes, caractérisée en ce que lesdits moyens sont agencés pour contrôler une température du gaz à un endroit prédéterminé (80) en amont de l'enceinte, pour faire en sorte que la température atteigne une valeur prédéterminée.4. Installation according to any one of the preceding claims, characterized in that said means are arranged to control a temperature of the gas at a predetermined location (80) upstream of the enclosure, to ensure that the temperature reaches a value predetermined.
5. Installation selon l'une quelconque des revendications précédentes, caractérisée en ce que lesdits moyens sont agencés pour refroidir le gaz.5. Installation according to any one of the preceding claims, characterized in that said means are arranged to cool the gas.
6. Installation selon l'une quelconque des revendications précédentes, caractérisée en ce que lesdits moyens sont agencés pour chauffer le gaz.6. Installation according to any one of the preceding claims, characterized in that said means are arranged to heat the gas.
7. Installation selon l'une quelconque des revendications précédentes, caractérisée en ce que lesdits moyens sont agencés pour contrôler une hygrométrie du gaz. 7. Installation according to any one of the preceding claims, characterized in that said means are arranged to control a hygrometry of the gas.
8. Installation selon l'une quelconque des revendications précédentes, caractérisée en ce que lesdits moyens comprennent au moins un filtre à particules (30, 32).8. Installation according to any one of the preceding claims, characterized in that said means comprise at least one particle filter (30, 32).
9. Installation selon l'une quelconque des revendications précédentes, caractérisée en ce que lesdits moyens comprennent au moins un ventilateur (10, 14), par exemple placé en amont ou en aval de l'enceinte (6, 8, 10).9. Installation according to any one of the preceding claims, characterized in that said means comprise at least one fan (10, 14), for example placed upstream or downstream of the enclosure (6, 8, 10).
10. Installation selon l'une quelconque des revendications précédentes, caractérisée en ce que l'enceinte (6) comprend des organes (39) de mise en forme des comprimés. 10. Installation according to any one of the preceding claims, characterized in that the enclosure (6) comprises members (39) for shaping the tablets.
11. Installation selon l'une quelconque des revendications précédentes, caractérisée en ce que l'enceinte (8) comprend un moteur.11. Installation according to any one of the preceding claims, characterized in that the enclosure (8) comprises a motor.
12. Installation selon l'une quelconque des revendications précédentes, caractérisée en ce que l'enceinte (10) comprend un dispositif électronique.12. Installation according to any one of the preceding claims, characterized in that the enclosure (10) comprises an electronic device.
13. Installation selon l'une quelconque des revendications précédentes, caractérisée en ce que les enceintes (6, 8, 10) sont au moins au nombre de deux et la machine comprend des moyens pour faire entrer un gaz dans chaque enceinte et la lui faire parcourir.13. Installation according to any one of the preceding claims, characterized in that the enclosures (6, 8, 10) are at least two in number and the machine comprises means for bringing a gas into each enclosure and doing it Browse.
14. Installation conforme à la revendication précédente, caractérisée en ce qu'elle comprend des conduites de gaz (16) agencées pour alimenter les enceintes (6, 8, 10) en gaz suivant une disposition en parallèle.14. Installation according to the preceding claim, characterized in that it comprises gas pipes (16) arranged to supply the enclosures (6, 8, 10) with gas in a parallel arrangement.
15. Installation selon l'une quelconque des revendications 13 ou 14, caractérisée en ce que les moyens sont en partie communs aux enceintes (6, 8, 10). 15. Installation according to any one of claims 13 or 14, characterized in that the means are partly common to the enclosures (6, 8, 10).
- 16. Installation selon l'une quelconque des revendications précédentes, caractérisée en ce que lesdits moyens comprennent au moins une conduite de gaz (16) raccordée de façon démontable à l'enceinte (6, 8, 10). - 16. Installation according to any one of the preceding claims, characterized in that said means comprise at least one gas pipe (16) detachably connected to the enclosure (6, 8, 10).
17. Installation selon l'une quelconque des revendications précédentes, caractérisée en ce qu' elle comprend au moins un obturateur (36a-c, 70) pour interrompre une communication de gaz entre l'enceinte et le reste de l'installation.17. Installation according to any one of the preceding claims, characterized in that it comprises at least one shutter (36a-c, 70) for interrupting a gas communication between the enclosure and the rest of the installation.
18. Installation selon l'une quelconque des revendications précédentes, caractérisée en ce que lesdits moyens sont agencés pour contrôler un débit de gaz associé à l'enceinte en permettant de choisir le débit parmi différentes valeurs de débit non nulles.18. Installation according to any one of the preceding claims, characterized in that said means are arranged to control a gas flow rate associated with the enclosure by allowing the flow rate to be chosen from among different non-zero flow values.
19. Installation selon l'une quelconque des revendications précédentes, caractérisée en ce que lesdits moyens comprennent un caisson (40, 50, 62) disposé dans l'enceinte (6, 8, 10) et présentant au moins deux ouvertures (42) d'entrée du gaz dans l'enceinte.19. Installation according to any one of the preceding claims, characterized in that said means comprise a box (40, 50, 62) disposed in the enclosure (6, 8, 10) and having at least two openings (42) d entry of gas into the enclosure.
20. Installation selon la revendication précédente, caractérisée en ce que les ouvertures (42) s'étendent sur des faces différentes du caisson (40, 50, 62).20. Installation according to the preceding claim, characterized in that the openings (42) extend on different faces of the box (40, 50, 62).
21. Installation selon l'une quelconque des revendications précédentes, caractérisée en ce que les comprimés comprennent une substance à usage thérapeutique ou cosmétique. 21. Installation according to any one of the preceding claims, characterized in that the tablets comprise a substance for therapeutic or cosmetic use.
22. Installation selon l'une quelconque des revendications précédentes, caractérisée en ce que les comprimés comprennent de l'ibuprofen. 22. Installation according to any one of the preceding claims, characterized in that the tablets comprise ibuprofen.
23. Procédé de fabrication de comprimés, caractérisé en ce qu'on fait entrer un gaz dans une enceinte (6, 8, 10) faisant partie d'une machine (2) de fabrication de comprimés, et on lui fait parcourir l'enceinte. 23. A method of manufacturing tablets, characterized in that a gas is introduced into an enclosure (6, 8, 10) forming part of a machine (2) for manufacturing tablets, and it is made to travel through the enclosure .
24. Procédé selon la revendication précédente, caractérisé en ce qu'on contrôle une température du gaz.24. Method according to the preceding claim, characterized in that a temperature of the gas is controlled.
25. Procédé selon l'une quelconque des revendications 23 à 24, caractérisé en ce qu'on contrôle une température du gaz à un endroit prédéterminé (80) en amont de l'enceinte pour faire en sorte qu'une température du gaz dans l'enceinte atteigne une valeur prédéterminée.25. Method according to any one of claims 23 to 24, characterized in that a temperature of the gas is controlled at a predetermined location (80) upstream of the enclosure to ensure that a temperature of the gas in the the enclosure reaches a predetermined value.
26. Procédé selon l'une quelconque des revendications 23 à 25, caractérisé en ce qu'on contrôle une température du gaz à un endroit prédéterminé (80) en amont de l'enceinte de sorte que la température atteigne une valeur prédéterminée. 26. Method according to any one of claims 23 to 25, characterized in that a temperature of the gas is controlled at a predetermined location (80) upstream of the enclosure so that the temperature reaches a predetermined value.
EP04767599A 2003-07-07 2004-07-07 Installation comprising a machine for the production of tablets which are intended, in particular, for therapeutic use Expired - Lifetime EP1648372B1 (en)

Applications Claiming Priority (2)

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FR0308268A FR2857253B1 (en) 2003-07-07 2003-07-07 INSTALLATION COMPRISING A COMPRESSOR MANUFACTURING MACHINE, PARTICULARLY FOR THERAPEUTIC USE
PCT/FR2004/001764 WO2005004784A2 (en) 2003-07-07 2004-07-07 Installation comprising a machine for the production of tablets which are intended, in particular, for therapeutic use

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EP1648372A2 true EP1648372A2 (en) 2006-04-26
EP1648372B1 EP1648372B1 (en) 2008-12-10

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EP (1) EP1648372B1 (en)
JP (1) JP2007525252A (en)
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AT (1) ATE416749T1 (en)
CA (1) CA2531514A1 (en)
DE (1) DE602004018318D1 (en)
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FR2857253A1 (en) 2005-01-14
CN100420431C (en) 2008-09-24
FR2857253B1 (en) 2007-02-09
WO2005004784A2 (en) 2005-01-20
ATE416749T1 (en) 2008-12-15
CN1832718A (en) 2006-09-13
JP2007525252A (en) 2007-09-06
EP1648372B1 (en) 2008-12-10
WO2005004784A3 (en) 2005-04-07
US20060157878A1 (en) 2006-07-20
DE602004018318D1 (en) 2009-01-22
CA2531514A1 (en) 2005-01-20

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