EP1622579B1 - Cosmetic compositions and methods for using same to improve the aesthetic appearance of skin - Google Patents
Cosmetic compositions and methods for using same to improve the aesthetic appearance of skin Download PDFInfo
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- EP1622579B1 EP1622579B1 EP04760943A EP04760943A EP1622579B1 EP 1622579 B1 EP1622579 B1 EP 1622579B1 EP 04760943 A EP04760943 A EP 04760943A EP 04760943 A EP04760943 A EP 04760943A EP 1622579 B1 EP1622579 B1 EP 1622579B1
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- acid
- skin
- extract therefrom
- aging
- extract
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Definitions
- the present invention relates to methods of using compositions that improve the aesthetic appearance of skin. Further, the present invention relates to methods of applying the compositions to the skin to effect treatment and to improve the aesthetic appearance of skin, particularly, by providing anti-aging benefits to the skin.
- Such anti-aging active ingredients include, for example, a-hydroxy acids (e.g., lactic, glycolic, citric), b-hydroxy acids (e.g., salicylic; 5-n-octanoylsalicylic aids) and retinoids (retinoic acids; retinol). It is known that these anti-aging active ingredients have a significant disadvantage in that they frequently are associated with consumer discomfort characterized by burning, smarting, itching or sensation of tightness after application. There remains a general need in the cosmetics industry for products that retard or counter aging effects on the skin, and more specifically for products that produce such effects without undesirable side effects:
- WO 02/49580 A1 discloses compositions and methods for treating hyperpigmentation relying, inter alia, on 3,3'-thiodipropionic acid as an active agent.
- WO 94/03149 relates to lipid-soluble esters of 3,3'-thiodipropionic acid in cosmetic preparations said to be suitable to counteract aging of the human skin.
- US 5,780,042 discloses cosmetic and dermatological formulations comprising at least one substance chosen from the group consisting of 2,4-O-furfurylidenesorbitol and alkyl ethers thereof and at least one substance chosen from the group consisting of tocopherols and tocopheryl esters, optionally in combination with an antioxidant such as 3,3'-Thiodipropionic acid
- BE 1000724 relates to compositions containing dithranole, optionally in combination with 3,3'-thiodipropionic acid for the treatments of psoriasis.
- the present invention discloses anti-aging compositions containing an effective amount of 3,3'-thiodipropionic acid which, whey applied to human skin, prevent, treat and/or ameliorate various signs of aging at the area or portion of skin to which they are applied.
- the present invention provides anti-aging benefits to and improves the aesthetic appearance of the skin.
- the present invention provides compositions and methods for treating skin to ameliorate the signs of dermatological aging due to, for example, chronological aging, hormonal aging, and/or photoaging.
- the signs of aging are fine wrinkles, coarse wrinkles, laxness, sagging, turgor and/or undereye paffiness.
- the anti-aging agent is present in the composition at an amount effect to ameliorate the various signs of aging in the area or portion of skin to which it is applied.
- the anti-aging agent is preferably present at about 0.0001 percentage by weight (wt%) to about 98 wt%, more preferably at about 0.001 wt% to about 30 wt%, and most preferably at about 0.05 wt% to about 10 wt% based on the total weight of the composition.
- the composition is preferably applied to an affective area of skin for a period of time to improve the aesthetic appearance of the area of skin to which the composition is applied.
- the amount of times per day and the period of time that the composition is to be applied to be effective will vary according to the percentage of active used in the composition, the additional ingredients in the composition (e.g., whether or not there is a penetration enhancer or additional anti-agents), the targeted improvement as well as other factors known by those skilled in the art.
- the present invention provides methods for treating skin to ameliorate the signs of dermatological aging due to, for example, chronological aging, hormonal aging, and/or photoaging.
- compositions disclosed herein are used in methods of ameliorating the following signs of aging skin: fine wrinkles, coarse wrinkles, sallowness, laxness, sagging, turgor and/or undereye puffiness.
- compositions for use in the context of the present invention comprise a pharmaceutically and/or cosmetically acceptable vehicle to provide bulk and physical form.
- the vehicle is hypoallergenic, as allergens and other irritating agents exacerbate pigmentation.
- Suitable vehicles include, but are not limited to, cetyl alcohol, ethanol, glycerin, myristyl palmitate, polyvinyl alcohol, propylene glycol, propanol, and water, and mixtures thereof.
- the anti-aging agent is admixed with the vehicle(s) along with any other adjuvants or ingredients to form the topical composition.
- the compositions of the present invention may also include actives in the form of liposomes.
- the present composition may take any suitable form such as a solution, cream, serum, stick, patch, mask, towelette, lotion, emulsion, ointment or gel.
- the present composition may optionally have one or more of the following ingredients: anesthetics, antiallergenics, antimicrobial agents, antiseptics, chelating agents, colorants, demulcents, emollients, emulsifiers, exfolients, fragrances, humectants, lubricants, moisturizers, preservatives, skin penetration enhancers, stabilizers, surfactants, thickeners, viscosity modifiers, vitamins, and mixtures thereof.
- anesthetics antiallergenics, antimicrobial agents, antiseptics, chelating agents, colorants, demulcents, emollients, emulsifiers, exfolients, fragrances, humectants, lubricants, moisturizers, preservatives, skin penetration enhancers, stabilizers, surfactants, thickeners, viscosity modifiers, vitamins, and mixtures thereof.
- the present invention may also include conventional cosmetic acitive agents, such as conventional hypopigmenting agents, such as hydroquinone, ascorbic acid (Vitamin C) and/or licorice extract; retinoids, such as retinol or retinoic acid; anti-inflammatory agents, such as bisabolol, anti-acne agents, such as salicylic acid; exfoliants, such as alpha-hydroxy acids, beta-hydroxy acids, keto acids, oxa acids or oxa diacids (disclosed in U.S. Patent Nos. 5,847,003 and 5,834,513 ); ascorbyl-phosphoryl-cholesterol (disclosed in U.S. Patent No.
- sunscreens such as oxybenzone, octyl methoxycinnamate, octyl salicylate, octocrylene, titanium dioxide, zinc oxide, butyl methoxydibenzoylmethane, methylene bis-benzotriazoylteramehtylbuthylphenol (MBBT), bis-ethylhexyl oxyphenol methoxyphenol triazine (BEMT); or anti-aging agents; or any combination thereof.
- sunscreens such as oxybenzone, octyl methoxycinnamate, octyl salicylate, octocrylene, titanium dioxide, zinc oxide, butyl methoxydibenzoylmethane, methylene bis-benzotriazoylteramehtylbuthylphenol (MBBT), bis-ethylhexyl oxyphenol methoxyphenol triazine (BEMT); or anti-aging agents; or any combination thereof.
- Preferred alpha-hydroxy acids include lactic acid, glycolic add, or a mixture thereof.
- the preferred oxa diadd is 3,6,9-trioxaundecanedioic acid.
- 3,3'-thiodipropionic acid may be used to enhance the effectiveness of other skin care actives, such as those disclosed above and those skin care actives disclosed in U.S. Patent No. 6,492,326 at col. 5, lines 9 through col. 20, line 50, which is incorporated herein by reference.
- Ingredient wt% anti-aging agent (3,3'-thiodipropionic acid) 0.001 to 98 pH adjusting agent (e.g. ammonium 0.001 to 4 Humectants (e.g. glycols, glycerols) 0.5 to 15 Thickeners (e.g. gums, starches polymers) 0.1 to 4 Chelating Agents (e.g. EDTA) 0.001 to 0.5 Emollients (e.g. isopropyl myristate, fatty esters) 1 to 10 Silicones (cyclomethicone-pentamer) 0.1 to 15 Preservative (e.g. parabens) 0.01 to 2 Alcohols (e.g.
- Antioxidants e.g. vitamin E acetate
- Anti-inflammatory e.g. bisabolol
- Sunscreen e.g. titanium dioxide/benzophenone-3, Butyl methoxydibenzoylmethane
- the cosmetic composition includes at least one ingredient selected from the group consisting of: palmatoyl tetrapeptide-3 (available under the trade name RIGIN from Sederma, France), Gymnostemma pentaphyllum and/or an extract therefrom, Stenolama chusana and/or an extract therefrom, Morinda citrifolia and/or an extract therefrom, Butea frondosa and/or an extract therefrom, Luteoline 7-beta-glucoside, Chlorosalicylic Acid, Naringi crenulata and/or an extract therefrom, Methylthioadenosine, Ferutinin, Ilex purpurea and/or an extract therefrom, Asmunda japonica and/or an extract therefrom, Rhapontin, Uncaria gambir and/or an extract therefrom, lopanic acid, Ellagic acid, 2,4,6,3,4-p
Abstract
Description
- The present invention relates to methods of using compositions that improve the aesthetic appearance of skin. Further, the present invention relates to methods of applying the compositions to the skin to effect treatment and to improve the aesthetic appearance of skin, particularly, by providing anti-aging benefits to the skin.
- There is active contemporary interest in the cosmetics industry to develop products that may be applied topically to the skin that provide anti-aging, hydrating, and/or skin texturizing benefits. Cosmetic products, which enhance the appearance of skin, are increasingly in demand. Consumers are interested in mitigating or delaying the signs of aged or photo-aged skin, such as fine lines, wrinkles, drying, and sagging skin. During the aging process, the complexion of the skin, i.e., the color and appearance of the skin, deteriorates slowly from aging and/or exposure to sunlight. Cosmetic surgery can be used as a treatment for aged skin. However, such treatment is costly and carries the risks normally associated with anesthesia and surgery. Alternatively, cosmetic products that provide anti-aging benefits are highly desirable, to both manufacturers and consumers.
- The number of cosmetic products directed to help the skin of consumers look younger and less wrinkled is steadily increasing. Commonly, such products contain exfoliating acids as active ingredients. Such anti-aging active ingredients include, for example, a-hydroxy acids (e.g., lactic, glycolic, citric), b-hydroxy acids (e.g., salicylic; 5-n-octanoylsalicylic aids) and retinoids (retinoic acids; retinol). It is known that these anti-aging active ingredients have a significant disadvantage in that they frequently are associated with consumer discomfort characterized by burning, smarting, itching or sensation of tightness after application. There remains a general need in the cosmetics industry for products that retard or counter aging effects on the skin, and more specifically for products that produce such effects without undesirable side effects:
- Also, in spite of the various anti-aging cosmetic products on the market for the treatment of skin, there remains a need for effective anti-aging compositions that can be applied topically to the skin. More particularly, there remains a need for topically applied cosmetic compositions that have anti-aging and skin texture benefits.
-
WO 02/49580 A1 -
WO 94/03149 -
US 5,780,042 discloses cosmetic and dermatological formulations comprising at least one substance chosen from the group consisting of 2,4-O-furfurylidenesorbitol and alkyl ethers thereof and at least one substance chosen from the group consisting of tocopherols and tocopheryl esters, optionally in combination with an antioxidant such as 3,3'-Thiodipropionic acid -
BE 1000724 - It is an object of the present invention to provide methods for ameliorating the signs of dermatological aging of human skin.
- It is yet a further object of the present invention to provide methods of using cosmetic compositions that improve the aesthetic appearance of skin and remediate the effects of aging skin and signs of aging on skin.
- The objects of the present invention are achieved by the methods /the use defined in the annexed claims, comprising topically applying to the skin a composition comprising 3,3'-thiodipropionic acid and a vehicle.
- The present invention discloses anti-aging compositions containing an effective amount of 3,3'-thiodipropionic acid which, whey applied to human skin, prevent, treat and/or ameliorate various signs of aging at the area or portion of skin to which they are applied. The present invention provides anti-aging benefits to and improves the aesthetic appearance of the skin. In particular, the present invention provides compositions and methods for treating skin to ameliorate the signs of dermatological aging due to, for example, chronological aging, hormonal aging, and/or photoaging. The signs of aging are fine wrinkles, coarse wrinkles, laxness, sagging, turgor and/or undereye paffiness.
- The anti-aging agent is present in the composition at an amount effect to ameliorate the various signs of aging in the area or portion of skin to which it is applied. The anti-aging agent is preferably present at about 0.0001 percentage by weight (wt%) to about 98 wt%, more preferably at about 0.001 wt% to about 30 wt%, and most preferably at about 0.05 wt% to about 10 wt% based on the total weight of the composition. The composition is preferably applied to an affective area of skin for a period of time to improve the aesthetic appearance of the area of skin to which the composition is applied. As can be understood by those in the art, the amount of times per day and the period of time that the composition is to be applied to be effective will vary according to the percentage of active used in the composition, the additional ingredients in the composition (e.g., whether or not there is a penetration enhancer or additional anti-agents), the targeted improvement as well as other factors known by those skilled in the art.
- In particular, the present invention provides methods for treating skin to ameliorate the signs of dermatological aging due to, for example, chronological aging, hormonal aging, and/or photoaging.
- The compositions disclosed herein are used in methods of ameliorating the following signs of aging skin: fine wrinkles, coarse wrinkles, sallowness, laxness, sagging, turgor and/or undereye puffiness.
- The compositions for use in the context of the present invention comprise a pharmaceutically and/or cosmetically acceptable vehicle to provide bulk and physical form. Preferably, the vehicle is hypoallergenic, as allergens and other irritating agents exacerbate pigmentation. Suitable vehicles include, but are not limited to, cetyl alcohol, ethanol, glycerin, myristyl palmitate, polyvinyl alcohol, propylene glycol, propanol, and water, and mixtures thereof. The anti-aging agent is admixed with the vehicle(s) along with any other adjuvants or ingredients to form the topical composition. The compositions of the present invention may also include actives in the form of liposomes.
- The present composition may take any suitable form such as a solution, cream, serum, stick, patch, mask, towelette, lotion, emulsion, ointment or gel.
- The present composition may optionally have one or more of the following ingredients: anesthetics, antiallergenics, antimicrobial agents, antiseptics, chelating agents, colorants, demulcents, emollients, emulsifiers, exfolients, fragrances, humectants, lubricants, moisturizers, preservatives, skin penetration enhancers, stabilizers, surfactants, thickeners, viscosity modifiers, vitamins, and mixtures thereof.
- The present invention may also include conventional cosmetic acitive agents, such as conventional hypopigmenting agents, such as hydroquinone, ascorbic acid (Vitamin C) and/or licorice extract; retinoids, such as retinol or retinoic acid; anti-inflammatory agents, such as bisabolol, anti-acne agents, such as salicylic acid; exfoliants, such as alpha-hydroxy acids, beta-hydroxy acids, keto acids, oxa acids or oxa diacids (disclosed in
U.S. Patent Nos. 5,847,003 and5,834,513 ); ascorbyl-phosphoryl-cholesterol (disclosed inU.S. Patent No. 5,866,147 ); sunscreens, such as oxybenzone, octyl methoxycinnamate, octyl salicylate, octocrylene, titanium dioxide, zinc oxide, butyl methoxydibenzoylmethane, methylene bis-benzotriazoylteramehtylbuthylphenol (MBBT), bis-ethylhexyl oxyphenol methoxyphenol triazine (BEMT); or anti-aging agents; or any combination thereof. - Preferred alpha-hydroxy acids include lactic acid, glycolic add, or a mixture thereof. The preferred oxa diadd is 3,6,9-trioxaundecanedioic acid.
- 3,3'-thiodipropionic acid, may be used to enhance the effectiveness of other skin care actives, such as those disclosed above and those skin care actives disclosed in
U.S. Patent No. 6,492,326 at col. 5, lines 9 through col. 20, line 50, which is incorporated herein by reference. -
Ingredient wt% anti-aging agent (3,3'-thiodipropionic acid) 0.001 to 98 pH adjusting agent (e.g. ammonium 0.001 to 4 Humectants (e.g. glycols, glycerols) 0.5 to 15 Thickeners (e.g. gums, starches polymers) 0.1 to 4 Chelating Agents (e.g. EDTA) 0.001 to 0.5 Emollients (e.g. isopropyl myristate, fatty esters) 1 to 10 Silicones (cyclomethicone-pentamer) 0.1 to 15 Preservative (e.g. parabens) 0.01 to 2 Alcohols (e.g. ethanol) 0 to 10 Antioxidants (e.g. vitamin E acetate) 0.01 to 5 Anti-inflammatory (e.g. bisabolol) 0.01 to 10 Sunscreen (e.g. titanium dioxide/benzophenone-3, Butyl methoxydibenzoylmethane) 0.01 to 15 Water q.s. - It is preferred that in addition to 3,3'-thiodipropionic add, the cosmetic composition includes at least one ingredient selected from the group consisting of: palmatoyl tetrapeptide-3 (available under the trade name RIGIN from Sederma, France), Gymnostemma pentaphyllum and/or an extract therefrom, Stenolama chusana and/or an extract therefrom, Morinda citrifolia and/or an extract therefrom, Butea frondosa and/or an extract therefrom, Luteoline 7-beta-glucoside, Chlorosalicylic Acid, Naringi crenulata and/or an extract therefrom, Methylthioadenosine, Ferutinin, Ilex purpurea and/or an extract therefrom, Asmunda japonica and/or an extract therefrom, Rhapontin, Uncaria gambir and/or an extract therefrom, lopanic acid, Ellagic acid, 2,4,6,3,4-pentahydroxychalcone, Ligusticum chianxiong or an extract therefrom, Azadirachta indica (Neem) and/or an extract therefrom, Aframomum melegueata and/or an extract therefrom, 2'amino 4,5-methyl thiazole, or any combination thereof. More preferably, the cosmetic composition contains at least two ingredients selected from the foregoing group.
- As used herein, singular can mean plural.
Claims (8)
- A method for ameliorating the following signs of aging skin: fine wrinkles, coarse wrinkles, laxness, sagging, turgor and/or undereye puffiness,
comprising topically applying to the skin in need of improvement a cosmetically effective amount of a composition comprising 3,3'-thiodipropionic acid and a vehicle. - The method of claim 1, wherein the 3,3'-thiodipropionic acid is present in an amount of from 0.001 wt% to 30 wt% based on the total weight of the composition.
- The method of claim 1, wherein the 3,3'-thiodipropionic acid is present in an amount of from 0.05 wt% to 10 wt% based on the total weight of the composition.
- The method of claim 1, wherein the cosmetic composition further comprises an ingredient selected from the group consisting of hydroquinone, ascorbic acid, licorice extract, retinoid, bisabolol, salicylic acid, an oxa acid, oxa diacid, an alpha hydroxy acid, a beta hydroxy acid, a keto acid, and any combination thereof.
- The method of claim 4, wherein the ingredient is selected from the group consisting of: lactic acid, glycolic acid, 3,6,9-trioxaundecanedioic acid, and any combination thereof.
- The method of claim 1, wherein the cosmetic composition further comprises an ingredient selected from the group consisting of palmatoyl tetrapeptide-3, Gymnostemma pentaphyllum and/or an extract therefrom, Stenolama chusana and/or an extract therefrom, Morinda citrifolia and/or an extract therefrom, Butea frondosa and/or an extract therefrom, Luteoline 7-beta-glucoside, chlorosalicylic Acid, Naringi crenulata and/or an extract therefrom, methylthioadenosine, ferutinin, Ilex purpurea and/or an extract therefrom, Asmunda japonica and/or an extract therefrom, rhapontin, Uncaria gambir and/or an extract therefrom, iopanic acid, ellagic acid, 2,4,6,3,4-pentahydroxychalcone, Ligusticum chianxiong or an extract therefrom, Azadirachta indica (Neem) and/or an extract therefrom, Aframomum melegueata and/or an extract therefrom, 2'amino 4,5-methyl thiazole, or any combination thereof.
- The method of claim 1, wherein the vehicle includes water.
- Use of 3,3'-thiodipropionic acid as an anti-aging agent for ameliorating the following signs of aging skin: fine wrinkles, coarse wrinkles, laxness, sagging, turgor and/or undereye puffiness by topical application of the agent to the skin.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL04760943T PL1622579T3 (en) | 2003-05-12 | 2004-05-07 | Cosmetic compositions and methods for using same to improve the aesthetic appearance of skin |
EP11160243A EP2409681A1 (en) | 2003-05-12 | 2004-05-07 | Method for improving the aesthetic appearance of skin by enhancing the skin thickness |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/436,310 US20040067245A1 (en) | 2000-12-20 | 2003-05-12 | Cosmetic compositions and methods for using same to improve the aesthetic appearance of skin |
PCT/US2004/014468 WO2004100889A2 (en) | 2003-05-12 | 2004-05-07 | Cosmetic compositions and methods for using same to improve the aesthetic appearance of skin |
Publications (3)
Publication Number | Publication Date |
---|---|
EP1622579A2 EP1622579A2 (en) | 2006-02-08 |
EP1622579A4 EP1622579A4 (en) | 2007-12-12 |
EP1622579B1 true EP1622579B1 (en) | 2011-03-30 |
Family
ID=33449708
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04760943A Active EP1622579B1 (en) | 2003-05-12 | 2004-05-07 | Cosmetic compositions and methods for using same to improve the aesthetic appearance of skin |
EP11160243A Withdrawn EP2409681A1 (en) | 2003-05-12 | 2004-05-07 | Method for improving the aesthetic appearance of skin by enhancing the skin thickness |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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EP11160243A Withdrawn EP2409681A1 (en) | 2003-05-12 | 2004-05-07 | Method for improving the aesthetic appearance of skin by enhancing the skin thickness |
Country Status (13)
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US (3) | US20040067245A1 (en) |
EP (2) | EP1622579B1 (en) |
JP (2) | JP2006514997A (en) |
CN (1) | CN1697645A (en) |
AT (1) | ATE503454T1 (en) |
AU (1) | AU2004238316B9 (en) |
BR (1) | BRPI0403036B1 (en) |
CA (1) | CA2477748C (en) |
DE (1) | DE602004032018D1 (en) |
MX (1) | MX282977B (en) |
PL (1) | PL1622579T3 (en) |
TW (1) | TWI280139B (en) |
WO (1) | WO2004100889A2 (en) |
Families Citing this family (28)
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DE3176658D1 (en) * | 1981-12-10 | 1988-03-31 | Revlon | Process for making metallic leafing pigments |
US7189419B2 (en) * | 2002-12-17 | 2007-03-13 | Avon Products, Inc. | Use of active extracts to lighten skin, lips, hair, and/or nails |
US20050136028A1 (en) * | 2003-12-19 | 2005-06-23 | Dmitri Ptchelintsev | Cosmetic compositions having extracts of Amomum melegueta and methods of treating skin |
US20070259057A1 (en) * | 2004-08-30 | 2007-11-08 | Kao Corporation | Wrinkle Reduction Agent, Lipolysis Accelerator, Composition for External Use on Skin, and Food or Beverage Composition |
CN101076254B (en) * | 2004-12-22 | 2012-10-31 | 雅芳产品公司 | Method and composition for reducing the appearance of wrinkles |
FR2902324B1 (en) * | 2006-06-20 | 2009-04-03 | Oreal | USE OF ELLAGIC ACID FOR THE TREATMENT OF CANITIA |
JPWO2008018133A1 (en) * | 2006-08-10 | 2009-12-24 | 株式会社ノエビア | Moisturizer, cell activator, whitening agent, neutral fat accumulation inhibitor, antioxidant, and external preparation for skin |
EP1902756A1 (en) * | 2006-09-19 | 2008-03-26 | Cognis IP Management GmbH | Composition and method for treating skin by administering silybin and piperine/terahydropiperine |
EP1902755A1 (en) * | 2006-09-19 | 2008-03-26 | Cognis IP Management GmbH | Cosmetic compositions decreasing GM-CSF release induced by nickel salts |
WO2008151890A1 (en) * | 2007-06-11 | 2008-12-18 | Chanel Parfums Beaute | Use of active agents for stimulating the expression of fn3k and/or fn3k rp for combating ageing of the skin |
JP2011520768A (en) * | 2007-06-11 | 2011-07-21 | シャネル パフュームズ ビューテ | Cosmetic use of an active agent for stimulating the expression of FN3K and / or FN3KRP for improving the barrier function of the skin |
CA2739523A1 (en) | 2007-10-01 | 2009-04-09 | The University Of British Columbia | Treatment of dissection, aneurysm, and atherosclerosis using granzyme b inhibitors |
CA2739512A1 (en) | 2007-10-01 | 2009-04-09 | The University Of British Columbia | Granzyme a and granzyme b diagnostics |
US20090092561A1 (en) * | 2007-10-09 | 2009-04-09 | Lupia Joseph A | Body-care and household products and compositions comprising specific sulfur-containing compounds |
JP5425413B2 (en) * | 2008-05-26 | 2014-02-26 | モリンダ インコーポレーテッド | Elastase inhibitor |
US7994175B2 (en) * | 2008-12-29 | 2011-08-09 | Avon Products, Inc | Cosmetic use of 1-aroyl-N-(2-oxo-3-piperidinyl)-2-piperazine carboxamides and related compounds |
MX368365B (en) * | 2009-12-22 | 2019-09-30 | Avon Prod Inc | Paxillin stimulating compositions and cosmetic uses thereof. |
US20110262505A1 (en) | 2010-04-22 | 2011-10-27 | Gina Athwal | Seaweed-derived cosmetic compositions |
JP5850929B2 (en) * | 2010-06-30 | 2016-02-03 | エイボン プロダクツ インコーポレーテッド | Composition for improving the appearance of the skin by stimulating MAGP-1 |
EP2838617A2 (en) * | 2012-04-20 | 2015-02-25 | The Procter & Gamble Company | Compositions and methods for improving the appearance of facial pores |
CA2877084C (en) * | 2012-08-30 | 2020-07-21 | Avon Products, Inc. | Dickkopf-1 expression modulating compositions and uses thereof |
US9023327B2 (en) | 2012-08-30 | 2015-05-05 | Avon Products, Inc. | DICKKOPF-1 expression modulating compositions and uses thereof |
PL2964334T3 (en) | 2013-03-07 | 2021-10-25 | Avon Products, Inc. | Compositions and methods for treating damaged hair |
WO2014163896A1 (en) * | 2013-03-12 | 2014-10-09 | Avon Products, Inc | A topical lightening composition and methods of use thereof |
KR102020817B1 (en) * | 2013-08-14 | 2019-09-11 | 주식회사 엘지생활건강 | Composition for skin cell regeneration, anti-wrinkle, antioxidant and anti-imflamation |
CN111032203B (en) * | 2017-04-03 | 2022-11-15 | 欧莱雅 | System for forming a cosmetic composition and skin care management system |
KR102362617B1 (en) * | 2018-05-16 | 2022-02-11 | 오오타 유시 가부시키가이샤 | Skin photo-aging preventive agent and functional cosmetic containing the same |
CN110200883A (en) * | 2019-06-19 | 2019-09-06 | 武汉百思凯瑞生物科技有限公司 | A kind of antiallergic conveys nano-composition and its preparation method and application altogether |
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US5686489A (en) * | 1986-12-23 | 1997-11-11 | Tristrata Technology, Inc. | Alpha hydroxyacid esters for skin aging |
BE1000724A6 (en) * | 1987-05-20 | 1989-03-21 | Stiefel Lab Ltd | Topical compsns. for psoriasis treatment - contg. dithranol in emulsion base |
FR2659554B1 (en) * | 1990-03-16 | 1994-09-30 | Oreal | COMPOSITION FOR THE COSMETIC AND / OR PHARMACEUTICAL TREATMENT OF THE TOP LAYERS OF THE EPIDERMIS BY TOPICAL APPLICATION TO THE SKIN AND PREPARATION METHOD THEREOF. |
CH686285A5 (en) * | 1992-08-06 | 1996-02-29 | Beiersdorf Ag | Cosmetic or pharmaceutical preparation used to delay the aging of human skin. |
DE4305788C2 (en) * | 1993-02-25 | 1997-06-12 | Beiersdorf Ag | Cosmetic and dermatological formulations to protect the skin against oxidation processes |
DE4444238A1 (en) * | 1994-12-13 | 1996-06-20 | Beiersdorf Ag | Cosmetic or dermatological drug combinations of cinnamic acid derivatives and flavone glycosides |
US5866147A (en) | 1995-05-15 | 1999-02-02 | Avon Products, Inc. | Ascorbyl-phosphoryl-cholesterol |
FR2742750B1 (en) * | 1995-12-22 | 1998-01-30 | Oreal | NOVEL DERIVATIVES OF L-2-OXOTHIAZOLIDINE 4-CARBOXYLIC ACID AND THEIR USE FOR SKIN CARE |
US5834513A (en) * | 1996-04-25 | 1998-11-10 | Avon Products, Inc. | Oxa diacids and related compounds for treating skin conditions |
US5847003A (en) | 1996-06-04 | 1998-12-08 | Avon Products, Inc. | Oxa acids and related compounds for treating skin conditions |
US6068848A (en) * | 1997-12-17 | 2000-05-30 | Color Access, Inc. | Antioxidant mixture comprising tocopherol |
US6323219B1 (en) * | 1998-04-02 | 2001-11-27 | Ortho-Mcneil Pharmaceutical, Inc. | Methods for treating immunomediated inflammatory disorders |
US6284234B1 (en) * | 1998-08-04 | 2001-09-04 | Johnson & Johnson Consumer Companies, Inc. | Topical delivery systems for active agents |
US6087385A (en) * | 1998-10-30 | 2000-07-11 | University Of Mississippi | Flavonoid derivatives |
US6492326B1 (en) | 1999-04-19 | 2002-12-10 | The Procter & Gamble Company | Skin care compositions containing combination of skin care actives |
DE19929511C2 (en) * | 1999-06-29 | 2003-04-10 | Cognis Deutschland Gmbh | Highly concentrated flowable anionic surfactant mixtures |
CA2413919A1 (en) * | 2000-03-21 | 2001-09-13 | Avon Products, Inc. | Methods using phytol to improve the appearance of skin and compositions for such methods |
FR2807323A1 (en) * | 2000-04-10 | 2001-10-12 | Oreal | COMPOSITION, ESPECIALLY COSMETIC, CONTAINING A STEROID AND A 2-ALKYL ALKANOL OR AN ESTER |
JP3636973B2 (en) * | 2000-06-26 | 2005-04-06 | 株式会社カネボウ化粧品 | Radical scavengers and cosmetics |
US6562321B2 (en) * | 2000-12-20 | 2003-05-13 | Avon Products, Inc. | Compositions and methods for treating hyperpigmentation |
US6500857B1 (en) * | 2001-08-16 | 2002-12-31 | Nicholas V. Perricone | Subcutaneous muscle treatment using electronic stimulation and topical compositions |
DE10132338A1 (en) * | 2001-07-04 | 2003-01-16 | Basf Ag | Use of 5'-deoxy-5'-methylthioadenosine in skin cosmetic products |
US7241456B2 (en) * | 2002-10-25 | 2007-07-10 | Australian Importers Ltd. | Formulations for topical delivery of bioactive substances and methods for their use |
-
2003
- 2003-05-12 US US10/436,310 patent/US20040067245A1/en not_active Abandoned
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2004
- 2004-05-07 JP JP2005518232A patent/JP2006514997A/en active Pending
- 2004-05-07 CA CA2477748A patent/CA2477748C/en active Active
- 2004-05-07 MX MXPA04008328 patent/MX282977B/en active IP Right Grant
- 2004-05-07 WO PCT/US2004/014468 patent/WO2004100889A2/en active Application Filing
- 2004-05-07 AU AU2004238316A patent/AU2004238316B9/en not_active Ceased
- 2004-05-07 BR BRPI0403036-2A patent/BRPI0403036B1/en active IP Right Grant
- 2004-05-07 CN CNA2004800001282A patent/CN1697645A/en active Pending
- 2004-05-07 EP EP04760943A patent/EP1622579B1/en active Active
- 2004-05-07 EP EP11160243A patent/EP2409681A1/en not_active Withdrawn
- 2004-05-07 DE DE602004032018T patent/DE602004032018D1/en active Active
- 2004-05-07 PL PL04760943T patent/PL1622579T3/en unknown
- 2004-05-07 AT AT04760943T patent/ATE503454T1/en not_active IP Right Cessation
- 2004-05-10 TW TW093113081A patent/TWI280139B/en active
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2008
- 2008-10-08 JP JP2008261918A patent/JP2009046510A/en active Pending
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2012
- 2012-08-13 US US13/584,136 patent/US8808765B2/en not_active Expired - Lifetime
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2014
- 2014-06-30 US US14/319,661 patent/US20140308376A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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DE602004032018D1 (en) | 2011-05-12 |
CN1697645A (en) | 2005-11-16 |
WO2004100889A2 (en) | 2004-11-25 |
BRPI0403036B1 (en) | 2014-12-16 |
ATE503454T1 (en) | 2011-04-15 |
JP2009046510A (en) | 2009-03-05 |
JP2006514997A (en) | 2006-05-18 |
AU2004238316A1 (en) | 2004-11-25 |
CA2477748C (en) | 2011-12-06 |
TWI280139B (en) | 2007-05-01 |
US20120315344A1 (en) | 2012-12-13 |
US20040067245A1 (en) | 2004-04-08 |
EP1622579A2 (en) | 2006-02-08 |
MXPA04008328A (en) | 2005-02-03 |
AU2004238316B2 (en) | 2007-08-23 |
EP1622579A4 (en) | 2007-12-12 |
WO2004100889A3 (en) | 2005-03-24 |
MX282977B (en) | 2011-01-17 |
US20140308376A1 (en) | 2014-10-16 |
BRPI0403036A (en) | 2005-11-22 |
TW200505490A (en) | 2005-02-16 |
AU2004238316B9 (en) | 2007-08-23 |
EP2409681A1 (en) | 2012-01-25 |
PL1622579T3 (en) | 2011-08-31 |
US8808765B2 (en) | 2014-08-19 |
CA2477748A1 (en) | 2004-11-12 |
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