EP1564299A4 - Verfahren zum screening nach verbindungen, die die enzymatische aktivität des gwt1 genproduktes hemmen - Google Patents

Verfahren zum screening nach verbindungen, die die enzymatische aktivität des gwt1 genproduktes hemmen

Info

Publication number
EP1564299A4
EP1564299A4 EP03774148A EP03774148A EP1564299A4 EP 1564299 A4 EP1564299 A4 EP 1564299A4 EP 03774148 A EP03774148 A EP 03774148A EP 03774148 A EP03774148 A EP 03774148A EP 1564299 A4 EP1564299 A4 EP 1564299A4
Authority
EP
European Patent Office
Prior art keywords
inhibit
compounds
screening
gene product
enzymatic activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP03774148A
Other languages
English (en)
French (fr)
Other versions
EP1564299B1 (de
EP1564299A1 (de
Inventor
Kappei Tsukahara
Mamiko Tsuchiya
Yoshifumi Jigami
Kenichi Nakayama
Mariko Umemura
Michiyo Okamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Institute of Advanced Industrial Science and Technology AIST
Eisai R&D Management Co Ltd
Original Assignee
Eisai Co Ltd
National Institute of Advanced Industrial Science and Technology AIST
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd, National Institute of Advanced Industrial Science and Technology AIST filed Critical Eisai Co Ltd
Publication of EP1564299A1 publication Critical patent/EP1564299A1/de
Publication of EP1564299A4 publication Critical patent/EP1564299A4/de
Application granted granted Critical
Publication of EP1564299B1 publication Critical patent/EP1564299B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP03774148A 2002-11-22 2003-11-21 Verfahren zum screening nach verbindungen, die die enzymatische aktivität des gwt1 genproduktes hemmen Expired - Lifetime EP1564299B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002339418 2002-11-22
JP2002339418 2002-11-22
PCT/JP2003/014909 WO2004048604A1 (ja) 2002-11-22 2003-11-21 Gwt1遺伝子産物の酵素活性を阻害する化合物をスクリーニングする方法

Publications (3)

Publication Number Publication Date
EP1564299A1 EP1564299A1 (de) 2005-08-17
EP1564299A4 true EP1564299A4 (de) 2006-07-05
EP1564299B1 EP1564299B1 (de) 2007-06-20

Family

ID=32375774

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03774148A Expired - Lifetime EP1564299B1 (de) 2002-11-22 2003-11-21 Verfahren zum screening nach verbindungen, die die enzymatische aktivität des gwt1 genproduktes hemmen

Country Status (8)

Country Link
US (1) US8323917B2 (de)
EP (1) EP1564299B1 (de)
JP (1) JP4061309B2 (de)
CN (1) CN100371456C (de)
AT (1) ATE365224T1 (de)
AU (1) AU2003284635A1 (de)
DE (1) DE60314538T2 (de)
WO (1) WO2004048604A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2286387C2 (ru) * 2000-07-07 2006-10-27 Эйсай Ко., Лтд. Ген синтеза клеточной стенки грибков
KR20070065452A (ko) * 2002-11-22 2007-06-22 에자이 알앤드디 매니지먼트 가부시키가이샤 말라리아 기생충에서 ｇｐｉ의 생합성을 억제하는 화합물을스크리닝하는 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9400600A (pt) * 1994-02-17 1995-10-24 Finep Financiadora De Estudos Processos para produção de uma protéina recombinante e/ou de glicosilfosfatidilinositol (GPI) em células de microorganismos eucariontes e para a obtenção de leveduras de S. cerevisae; célula de levedura sequência de nucleotídios; meio de cultura; medicamento ou vacina; e produto dos ditos processos
US6747137B1 (en) * 1998-02-13 2004-06-08 Genome Therapeutics Corporation Nucleic acid sequences relating to Candida albicans for diagnostics and therapeutics
RU2286387C2 (ru) * 2000-07-07 2006-10-27 Эйсай Ко., Лтд. Ген синтеза клеточной стенки грибков
CN100467598C (zh) * 2000-07-07 2009-03-11 卫材R&D管理有限公司 真菌细胞壁合成基因
JP2004515235A (ja) * 2000-12-08 2004-05-27 ノボ ノルディスク アクティーゼルスカブ Ｔｆｆペプチド
JP2005168301A (ja) 2001-12-28 2005-06-30 Eisai Co Ltd 真菌細胞壁合成阻害活性を有する化合物をスクリーニングする方法
KR20070065452A (ko) 2002-11-22 2007-06-22 에자이 알앤드디 매니지먼트 가부시키가이샤 말라리아 기생충에서 ｇｐｉ의 생합성을 억제하는 화합물을스크리닝하는 방법

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KINOSHITA TAROH ET AL: "Dissecting and manipulating the pathway for glycosylphosphatidylinosi tol-anchor biosynthesis", CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 4, no. 6, December 2000 (2000-12-01), pages 632 - 638, XP002370586, ISSN: 1367-5931 *

Also Published As

Publication number Publication date
DE60314538D1 (de) 2007-08-02
ATE365224T1 (de) 2007-07-15
JP4061309B2 (ja) 2008-03-19
EP1564299B1 (de) 2007-06-20
JPWO2004048604A1 (ja) 2006-03-23
AU2003284635A8 (en) 2004-06-18
AU2003284635A1 (en) 2004-06-18
CN100371456C (zh) 2008-02-27
EP1564299A1 (de) 2005-08-17
WO2004048604A1 (ja) 2004-06-10
US8323917B2 (en) 2012-12-04
DE60314538T2 (de) 2008-02-28
US20060240429A1 (en) 2006-10-26
CN1742095A (zh) 2006-03-01

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