WO2002044378A3 - Wnt signalling assay, methods and uses thereof - Google Patents

Wnt signalling assay, methods and uses thereof Download PDF

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Publication number
WO2002044378A3
WO2002044378A3 PCT/US2001/044862 US0144862W WO0244378A3 WO 2002044378 A3 WO2002044378 A3 WO 2002044378A3 US 0144862 W US0144862 W US 0144862W WO 0244378 A3 WO0244378 A3 WO 0244378A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
wnt signalling
signalling assay
present
wnt signaling
Prior art date
Application number
PCT/US2001/044862
Other languages
French (fr)
Other versions
WO2002044378A2 (en
Inventor
David Bumcrot
Original Assignee
Curis Inc
David Bumcrot
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curis Inc, David Bumcrot filed Critical Curis Inc
Priority to AU2002217970A priority Critical patent/AU2002217970A1/en
Publication of WO2002044378A2 publication Critical patent/WO2002044378A2/en
Publication of WO2002044378A3 publication Critical patent/WO2002044378A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

The present invention relates to methods for monitoring the level of activity of the Wnt signaling pathway and provides means to identify factors capable of modulating Wnt signaling. The present invention further concerns nucleic acid constructs, chimeric proteins and cell lines for carrying out the methods of the invention.
PCT/US2001/044862 2000-11-28 2001-11-28 Wnt signalling assay, methods and uses thereof WO2002044378A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002217970A AU2002217970A1 (en) 2000-11-28 2001-11-28 Wnt signalling assay, methods and uses thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US25368700P 2000-11-28 2000-11-28
US60/253,687 2000-11-28
US26457901P 2001-01-26 2001-01-26
US60/264,579 2001-01-26

Publications (2)

Publication Number Publication Date
WO2002044378A2 WO2002044378A2 (en) 2002-06-06
WO2002044378A3 true WO2002044378A3 (en) 2003-03-06

Family

ID=26943481

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/044862 WO2002044378A2 (en) 2000-11-28 2001-11-28 Wnt signalling assay, methods and uses thereof

Country Status (2)

Country Link
AU (1) AU2002217970A1 (en)
WO (1) WO2002044378A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1385994A2 (en) * 2001-04-02 2004-02-04 Bayer HealthCare AG Method for specifically detecting, isolating and characterizing cells from body samples by transfecting nucleic acid constructs
US7682607B2 (en) 2001-05-01 2010-03-23 The Regents Of The University Of California Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
US7713526B2 (en) 2001-05-01 2010-05-11 The Regents Of The University Of California Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
US20090131445A1 (en) * 2004-10-14 2009-05-21 Compass Pharmaceuticals Llc Furazano '3, 4-B! Pyrazines and Their Use as Anti-Tumor Agents
DE602006017849D1 (en) * 2005-06-29 2010-12-09 Schering Corp 5,6-DISUBSTITUTED OXADIAZOLO PYRAZINES AND THIADIAZOLOPYRACINES AS LIGANDS OF THE CXC CHEMOKIN RECEPTOR
CN102027133A (en) * 2008-05-07 2011-04-20 温瑟瑞克斯有限公司 Methods for identifying compounds that modulate Wnt signaling in cancer cells
WO2009155001A2 (en) 2008-05-27 2009-12-23 The Board Of Regents Of The University Of Texas System Wnt protein signalling inhibitors
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US9359311B2 (en) 2011-07-14 2016-06-07 Neuroscios Gmbh Substituted aromatic oligomers
US20160045498A1 (en) * 2013-04-04 2016-02-18 The Walter And Eliza Hall Institute Of Medical Research Methods of treating diseases characterized by excessive wnt signalling
WO2017151063A1 (en) * 2016-03-03 2017-09-08 Agency For Science, Technology And Research Use of furazano[3,4-b]pyrazine derivatives for chemotherapy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998041631A2 (en) * 1997-03-20 1998-09-24 The Johns Hopkins University β-CATENIN, TCF-4, AND APC INTERACT TO PREVENT CANCER

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998041631A2 (en) * 1997-03-20 1998-09-24 The Johns Hopkins University β-CATENIN, TCF-4, AND APC INTERACT TO PREVENT CANCER

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BEHRENS JUERGEN ET AL: "Functional interaction of beta-catenin with the transcription factor LEF-1.", NATURE (LONDON), vol. 382, no. 6592, 1996, pages 638 - 642, XP002221400, ISSN: 0028-0836 *
HECHT ANDREAS ET AL: "Functional characterization of multiple transactivating elements in beta-catenin, some of which interact with the TATA-binding protein in vitro.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 25, 18 June 1999 (1999-06-18), pages 18017 - 18025, XP002221396, ISSN: 0021-9258 *
MOLENAAR M ET AL: "XTCF-3 TRANSCRIPTION FACTOR MEDIATES BETA-CATENIN-INDUCED AXIS FORMATION IN XENOPUS EMBRYOS", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 86, 9 August 1996 (1996-08-09), pages 391 - 399, XP002070156, ISSN: 0092-8674 *
PLAYFORD MARTIN P ET AL: "Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 97, no. 22, 24 October 2000 (2000-10-24), October 24, 2000, pages 12103 - 12108, XP002221463, ISSN: 0027-8424 *
ROOSE J ET AL: "TCF transcription factors: molecular switches in carcinogenesis", BBA - REVIEWS ON CANCER, ELSEVIER SCIENCE BV, AMSTERDAM, NL, vol. 1424, no. 2-3, 29 October 1999 (1999-10-29), pages M23 - M37, XP004281861, ISSN: 0304-419X *
TAGO KEN-ICHI ET AL: "Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein.", GENES & DEVELOPMENT, vol. 14, no. 14, 15 July 2000 (2000-07-15), pages 1741 - 1749, XP002221398, ISSN: 0890-9369 *
TAKEMARU KEN-ICHI ET AL: "The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression.", JOURNAL OF CELL BIOLOGY, vol. 149, no. 2, 17 April 2000 (2000-04-17), pages 249 - 254, XP002221399, ISSN: 0021-9525 *
VLEMINCKX KRIS ET AL: "The C-terminal transactivation domain of beta-catenin is necessary and sufficient for signaling by the LEF-1/beta-catenin complex in Xenopus laevis.", MECHANISMS OF DEVELOPMENT, vol. 81, no. 1-2, March 1999 (1999-03-01), pages 65 - 74, XP002221397, ISSN: 0925-4773 *

Also Published As

Publication number Publication date
WO2002044378A2 (en) 2002-06-06
AU2002217970A1 (en) 2002-06-11

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