EP1559676A3 - Microstructured device and method for bubble-free filling of a device for guiding liquids - Google Patents

Microstructured device and method for bubble-free filling of a device for guiding liquids Download PDF

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Publication number
EP1559676A3
EP1559676A3 EP04029633A EP04029633A EP1559676A3 EP 1559676 A3 EP1559676 A3 EP 1559676A3 EP 04029633 A EP04029633 A EP 04029633A EP 04029633 A EP04029633 A EP 04029633A EP 1559676 A3 EP1559676 A3 EP 1559676A3
Authority
EP
European Patent Office
Prior art keywords
liquid
bubble
microstructured
free filling
liquids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP04029633A
Other languages
German (de)
French (fr)
Other versions
EP1559676A2 (en
EP1559676B1 (en
Inventor
Gert Dr. Blankenstein
Claus Dipl.-Ing. Marquordt
Ralf-Peter Dr. Dipl.-Ing. Peters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Microparts GmbH
Original Assignee
Boehringer Ingelheim Microparts GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Microparts GmbH filed Critical Boehringer Ingelheim Microparts GmbH
Publication of EP1559676A2 publication Critical patent/EP1559676A2/en
Publication of EP1559676A3 publication Critical patent/EP1559676A3/en
Application granted granted Critical
Publication of EP1559676B1 publication Critical patent/EP1559676B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/110833—Utilizing a moving indicator strip or tape
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/111666—Utilizing a centrifuge or compartmented rotor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Micromachines (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Coating Apparatus (AREA)

Abstract

Die vorliegende Erfindung betrifft mikrostrukturierte Anordnung zur blasenfreien Befüllung zumindest eines Systems zur Ableitung von Flüssigkeiten (flüssigkeitsabführenden Systems, 5) mit einer Flüssigkeit. Die Anordnung weist einen Einlass (2) für eine Verbindung der Anordnung mit einem System zur Zufuhr von Flüssigkeiten (flüssigkeitszuführendes System, 9) und zumindest einen Auslass (4) für eine Verbindung der Anordnung mit dem zumindest einem flüssigkeitsabführenden System (5) auf. Die Anordnung weist einen Übergangsbereich (3) auf, durch welchen die Flüssigkeit von dem Einlass (2) zu dem zumindest einen Auslass (4) transportierbar ist. An einem Anfang des Übergangsbereichs (3) ist ein erstes Mikrostrukturelement zur Erzeugung einer Stelle (6) mit erhöhter Kapillarkraft vorgesehen, um eine lückenlose Benetzung der diese Stelle mit erhöhter Kapillarkraft begrenzenden Flächen insbesondere von Seitenwänden, einer Decke und/oder eines Bodens zu erreichen.

Figure imgaf001
The present invention relates to a microstructured arrangement for the bubble-free filling of at least one system for the discharge of liquids (liquid-discharging system, 5) with a liquid. The assembly comprises an inlet (2) for connection of the assembly to a system for supplying liquids (liquid supplying system, 9) and at least one outlet (4) for connection of the assembly to the at least one liquid discharging system (5). The arrangement has a transition region (3) through which the liquid can be transported from the inlet (2) to the at least one outlet (4). At a beginning of the transition region (3), a first microstructure element is provided for producing a position (6) with increased capillary force, in order to achieve a complete wetting of the area limiting this location with increased capillary force, in particular of side walls, a ceiling and / or a floor.
Figure imgaf001
EP04029633.7A 2003-12-20 2004-12-15 Microstructured device and method for bubble-free filling of a device for guiding liquids Active EP1559676B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10360220 2003-12-20
DE10360220A DE10360220A1 (en) 2003-12-20 2003-12-20 Fine structure arrangement in fluid ejection system, has predetermined region in transitional zone between inlet and discharge ports, at which capillary force is maximum

Publications (3)

Publication Number Publication Date
EP1559676A2 EP1559676A2 (en) 2005-08-03
EP1559676A3 true EP1559676A3 (en) 2008-12-03
EP1559676B1 EP1559676B1 (en) 2016-06-29

Family

ID=34638731

Family Applications (1)

Application Number Title Priority Date Filing Date
EP04029633.7A Active EP1559676B1 (en) 2003-12-20 2004-12-15 Microstructured device and method for bubble-free filling of a device for guiding liquids

Country Status (5)

Country Link
US (1) US7485118B2 (en)
EP (1) EP1559676B1 (en)
JP (1) JP4931345B2 (en)
CN (2) CN101632947B (en)
DE (1) DE10360220A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070280857A1 (en) * 2006-06-02 2007-12-06 Applera Corporation Devices and Methods for Positioning Dried Reagent In Microfluidic Devices
US20070280856A1 (en) * 2006-06-02 2007-12-06 Applera Corporation Devices and Methods for Controlling Bubble Formation in Microfluidic Devices
EP1977829A1 (en) * 2007-03-29 2008-10-08 Roche Diagnostics GmbH Device for performing multiple analyses in parallel
CN104062454B (en) 2007-10-30 2016-01-20 松下健康医疗控股株式会社 Analysis instrument
JP5059880B2 (en) * 2008-02-01 2012-10-31 日本電信電話株式会社 Flow cell
CA2716411C (en) 2008-02-27 2015-11-24 Boehringer Ingelheim Microparts Gmbh Apparatus for the separation of plasma
KR100998535B1 (en) 2008-04-11 2010-12-07 인싸이토 주식회사 Microfluidic circuit element comprising microfluidic channel with nano interstices and fabrication thereof
US10005082B2 (en) 2008-04-11 2018-06-26 Incyto Co., Ltd. Microfluidic circuit element comprising microfluidic channel with nano interstices and fabrication method thereof
KR101390717B1 (en) 2008-09-02 2014-04-30 삼성전자주식회사 Microfluidic device and method of loading sample thereto
EP2213364A1 (en) * 2009-01-30 2010-08-04 Albert-Ludwigs-Universität Freiburg Phase guide patterns for liquid manipulation
JP5706880B2 (en) * 2009-04-15 2015-04-22 コーニンクレッカ フィリップス エヌ ヴェ Fluid chamber without gas
EP2486978A1 (en) * 2010-10-28 2012-08-15 Roche Diagnostics GmbH Microfluid test carrier for separating a fluid volume in partial volumes
EP2455162A1 (en) * 2010-10-29 2012-05-23 Roche Diagnostics GmbH Microfluidic element for analysing a fluid sample
WO2013004673A1 (en) 2011-07-05 2013-01-10 Boehringer Ingelheim Microparts Gmbh Microfluidic structure having recesses
USD962471S1 (en) 2013-03-13 2022-08-30 Abbott Laboratories Reagent container
USD978375S1 (en) 2013-03-13 2023-02-14 Abbott Laboratories Reagent container
US9535082B2 (en) 2013-03-13 2017-01-03 Abbott Laboratories Methods and apparatus to agitate a liquid
US10058866B2 (en) 2013-03-13 2018-08-28 Abbott Laboratories Methods and apparatus to mitigate bubble formation in a liquid
WO2017117553A1 (en) * 2015-12-31 2017-07-06 Mec Dynamics Micro mechanical methods and systems for performing assays
US10258741B2 (en) 2016-12-28 2019-04-16 Cequr Sa Microfluidic flow restrictor and system
CN109072893B (en) * 2017-01-09 2019-11-29 华为技术有限公司 A kind of electrohydraulic dynamic device and the system comprising electrohydraulic dynamic device
CN108722504A (en) * 2017-04-19 2018-11-02 光宝电子(广州)有限公司 Detection device and its injection mouth structure
KR102012243B1 (en) * 2017-09-19 2019-11-04 한국기계연구원 Micro Fluid Element having Micro Sub Flow Paths and Mold for Manufacturing the Same

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999046045A1 (en) * 1998-03-11 1999-09-16 MICROPARTS GESELLSCHAFT FüR MIKROSTRUKTURTECHNIK MBH Sample support
EP1013341A2 (en) * 1998-12-23 2000-06-28 MICROPARTS GESELLSCHAFT FÜR MIKROSTRUKTURTECHNIK mbH Device for draining a liquid from a capillary
US6193471B1 (en) * 1999-06-30 2001-02-27 Perseptive Biosystems, Inc. Pneumatic control of formation and transport of small volume liquid samples
WO2001026813A2 (en) * 1999-10-08 2001-04-19 Micronics, Inc. Microfluidics without electrically of mechanically operated pumps
EP1201304A2 (en) * 2000-10-25 2002-05-02 MICROPARTS GESELLSCHAFT FÜR MIKROSTRUKTURTECHNIK mbH Microstructured platform for examining a liquid
US20020081669A1 (en) * 2000-07-28 2002-06-27 Gabriel Festoc Device for thermo-dependent chain reaction amplification of target nucleic acid sequences, measured in real-time
WO2003025547A1 (en) * 2001-09-21 2003-03-27 Biomedlab Corporation Method and device for screening analytes using surface plasmon resonance

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4233029A (en) * 1978-10-25 1980-11-11 Eastman Kodak Company Liquid transport device and method
US4310399A (en) * 1979-07-23 1982-01-12 Eastman Kodak Company Liquid transport device containing means for delaying capillary flow
US4271119A (en) * 1979-07-23 1981-06-02 Eastman Kodak Company Capillary transport device having connected transport zones
GB2090659A (en) * 1981-01-02 1982-07-14 Instrumentation Labor Inc Analytical device
US4426451A (en) * 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
US4473457A (en) * 1982-03-29 1984-09-25 Eastman Kodak Company Liquid transport device providing diversion of capillary flow into a non-vented second zone
US4549952A (en) * 1982-11-22 1985-10-29 Eastman Kodak Company Capillary transport device having means for increasing the viscosity of the transported liquid
US4618476A (en) * 1984-02-10 1986-10-21 Eastman Kodak Company Capillary transport device having speed and meniscus control means
US4963498A (en) * 1985-08-05 1990-10-16 Biotrack Capillary flow device
DE3851458T2 (en) * 1987-04-08 1995-02-09 Hitachi Ltd Device with a vaginal flow cell.
JPS63262565A (en) * 1987-04-20 1988-10-28 Hitachi Ltd Flow cell
US5051237A (en) * 1988-06-23 1991-09-24 P B Diagnostic Systems, Inc. Liquid transport system
US4957582A (en) * 1989-03-16 1990-09-18 Eastman Kodak Company Capillary transport zone coated with adhesive
US5039617A (en) * 1989-04-20 1991-08-13 Biotrack, Inc. Capillary flow device and method for measuring activated partial thromboplastin time
US5230866A (en) * 1991-03-01 1993-07-27 Biotrack, Inc. Capillary stop-flow junction having improved stability against accidental fluid flow
US5744366A (en) * 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
US6156270A (en) * 1992-05-21 2000-12-05 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US5885527A (en) * 1992-05-21 1999-03-23 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membrances
US5591643A (en) * 1993-09-01 1997-01-07 Abaxis, Inc. Simplified inlet channels
GB9509487D0 (en) * 1995-05-10 1995-07-05 Ici Plc Micro relief element & preparation thereof
US6143248A (en) * 1996-08-12 2000-11-07 Gamera Bioscience Corp. Capillary microvalve
US6113855A (en) * 1996-11-15 2000-09-05 Biosite Diagnostics, Inc. Devices comprising multiple capillarity inducing surfaces
DE19753849A1 (en) * 1997-12-04 1999-06-10 Roche Diagnostics Gmbh Analytical test element with a tapered capillary channel
EP1058697B1 (en) 1998-03-05 2008-11-26 E.I. Du Pont De Nemours And Company Polymeric films having controlled viscosity response to temperature and shear
AU763497B2 (en) * 1998-10-13 2003-07-24 Biomicro Systems, Inc. Fluid circuit components based upon passive fluid dynamics
US6653122B2 (en) * 2001-04-24 2003-11-25 Dade Microscan Inc. Indentification test device in a random access microbiological analyzer
US20040042930A1 (en) * 2002-08-30 2004-03-04 Clemens Charles E. Reaction chamber with capillary lock for fluid positioning and retention
US20040265172A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method and apparatus for entry and storage of specimens into a microfluidic device

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999046045A1 (en) * 1998-03-11 1999-09-16 MICROPARTS GESELLSCHAFT FüR MIKROSTRUKTURTECHNIK MBH Sample support
EP1013341A2 (en) * 1998-12-23 2000-06-28 MICROPARTS GESELLSCHAFT FÜR MIKROSTRUKTURTECHNIK mbH Device for draining a liquid from a capillary
US6193471B1 (en) * 1999-06-30 2001-02-27 Perseptive Biosystems, Inc. Pneumatic control of formation and transport of small volume liquid samples
WO2001026813A2 (en) * 1999-10-08 2001-04-19 Micronics, Inc. Microfluidics without electrically of mechanically operated pumps
US20020081669A1 (en) * 2000-07-28 2002-06-27 Gabriel Festoc Device for thermo-dependent chain reaction amplification of target nucleic acid sequences, measured in real-time
EP1201304A2 (en) * 2000-10-25 2002-05-02 MICROPARTS GESELLSCHAFT FÜR MIKROSTRUKTURTECHNIK mbH Microstructured platform for examining a liquid
WO2003025547A1 (en) * 2001-09-21 2003-03-27 Biomedlab Corporation Method and device for screening analytes using surface plasmon resonance

Also Published As

Publication number Publication date
CN1695808A (en) 2005-11-16
CN101632947A (en) 2010-01-27
US7485118B2 (en) 2009-02-03
DE10360220A1 (en) 2005-07-21
JP2005177754A (en) 2005-07-07
EP1559676A2 (en) 2005-08-03
US20050169778A1 (en) 2005-08-04
JP4931345B2 (en) 2012-05-16
EP1559676B1 (en) 2016-06-29
CN101632947B (en) 2012-08-08

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