EP1539781A4 - Inhibiteurs rsk et utilisations therapeutiques de ces derniers - Google Patents
Inhibiteurs rsk et utilisations therapeutiques de ces derniersInfo
- Publication number
- EP1539781A4 EP1539781A4 EP03760343A EP03760343A EP1539781A4 EP 1539781 A4 EP1539781 A4 EP 1539781A4 EP 03760343 A EP03760343 A EP 03760343A EP 03760343 A EP03760343 A EP 03760343A EP 1539781 A4 EP1539781 A4 EP 1539781A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- therapeutic uses
- rsk inhibitors
- rsk
- inhibitors
- therapeutic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/06—Benzopyran radicals
- C07H17/065—Benzo[b]pyrans
- C07H17/07—Benzo[b]pyran-4-ones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38800602P | 2002-06-12 | 2002-06-12 | |
US388006P | 2002-06-12 | ||
US44955303P | 2003-02-24 | 2003-02-24 | |
US449553P | 2003-02-24 | ||
PCT/US2003/018734 WO2003105766A2 (fr) | 2002-06-12 | 2003-06-12 | Inhibiteurs rsk et utilisations therapeutiques de ces derniers |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1539781A2 EP1539781A2 (fr) | 2005-06-15 |
EP1539781A4 true EP1539781A4 (fr) | 2009-12-02 |
Family
ID=29739979
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP03760343A Withdrawn EP1539781A4 (fr) | 2002-06-12 | 2003-06-12 | Inhibiteurs rsk et utilisations therapeutiques de ces derniers |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1539781A4 (fr) |
AU (1) | AU2003251513A1 (fr) |
CA (1) | CA2488864A1 (fr) |
WO (1) | WO2003105766A2 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9920393D0 (en) | 1999-08-27 | 1999-11-03 | Medix Scient Uk Limited | Plant extract mixtures and their uses |
KR100590818B1 (ko) | 2004-10-11 | 2006-06-19 | 재단법인서울대학교산학협력재단 | 소분자 유기화합물의 직접적 p90 리보솜 S6 키나제 1(RSK1)의 활성증진에 의한 당뇨병, 비만 및대사증후군의 예방 및 치료용도 |
EP1845778A2 (fr) | 2005-01-10 | 2007-10-24 | University Of Virginia Patent Foundation | Synthese d'inhibiteurs de p90rsk |
US20100151050A1 (en) * | 2005-06-07 | 2010-06-17 | Shinji Mizuarai | Method for evaluation of compound using RSK1 |
GB0512206D0 (en) | 2005-06-15 | 2005-07-27 | Biosynth As | Synthesis |
US7659313B2 (en) * | 2007-09-13 | 2010-02-09 | Gateway Health Alliances, Inc. | Methods and related compositions using specific indanes to reduce weight and inhibit lipase, α-amylase and α-glucosidase activity in mammals |
GB0718870D0 (en) * | 2007-09-27 | 2007-11-07 | Univ Dundee | Modulation of RSK |
US9040673B2 (en) | 2009-08-14 | 2015-05-26 | University Of Virginia Patent Foundation | Synthesis and identification of novel RSK-specific inhibitors |
WO2013181742A1 (fr) * | 2012-06-04 | 2013-12-12 | Phoenix Molecular Diagnostics Ltd. | Procédés d'inhibition de rsk dans le traitement du cancer du sein |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000066721A2 (fr) * | 1999-04-30 | 2000-11-09 | Beth Israel Deaconess Medical Center | Reduction de la masse adipeuse par modification de l'activite du gene rsk2 |
-
2003
- 2003-06-12 AU AU2003251513A patent/AU2003251513A1/en not_active Abandoned
- 2003-06-12 EP EP03760343A patent/EP1539781A4/fr not_active Withdrawn
- 2003-06-12 WO PCT/US2003/018734 patent/WO2003105766A2/fr not_active Application Discontinuation
- 2003-06-12 CA CA002488864A patent/CA2488864A1/fr not_active Abandoned
Non-Patent Citations (7)
Title |
---|
CHUNG H S ET AL: "FLAVONOID CONSTITUENTS OF CHORIZANTHE DIFFUSA WITH POTENTIAL CANCER CHEMOPREVENTIVE ACTIVITY", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 47, no. 1, 1 January 1999 (1999-01-01), pages 36 - 41, XP000801963, ISSN: 0021-8561 * |
JIN-RUI DAI ET AL.: "zerumbone,an HIV-inhibitory and cytotoxic sesquiterpene of zingiber aromaticum", NATURAL PRODUCT LETTERS, vol. 10, no. 2, 1997, amsterdam, pages 115 - 118, XP008113448 * |
KOSTAS DIMAS ET AL.: "cytotoxic activity of kaempferol glycosides against human leukaemic cell line in vitro", PHARMACOLOGICAL RESEARCH, vol. 41, no. 1, 2000, engl., pages 85 - 88, XP002551403 * |
MATSUDA H ET AL: "Structural Requirements of Flavonoids and Related Compounds for Aldose Reductase Inhibitory Activity", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 50, no. 6, 1 January 2002 (2002-01-01), pages 788 - 795, XP002996843, ISSN: 0009-2363 * |
N.ALIGIANNIS ET AL.: "flavonoids as cycline-dependent kinase inhibitors.", PLANTA MED, vol. 67, no. 5, 2001, stuttgart-new-york, pages 468 - 470, XP002551401 * |
NAKATANI N ET AL: "Flavonoid Constituents of Zingiber zerumbet Smith", AGRICULTURAL AND BIOLOGICAL CHEMISTRY, JAPAN SOC. FOR BIOSCIENCE, BIOTECHNOLOGY AND AGROCHEM, TOKYO, JP, vol. 55, no. 2, 1 January 1991 (1991-01-01), pages 455 - 460, XP008113444, ISSN: 0002-1369 * |
TOSHIYA MASUDA ET AL.: "acetylated flavonol glycosides from zingiber zerumbet", PHYTOCHEMISTRY, vol. 30, no. 7, 1991, gb, pages 2391 - 2392, XP002551402 * |
Also Published As
Publication number | Publication date |
---|---|
AU2003251513A8 (en) | 2003-12-31 |
EP1539781A2 (fr) | 2005-06-15 |
AU2003251513A1 (en) | 2003-12-31 |
CA2488864A1 (fr) | 2003-12-24 |
WO2003105766A3 (fr) | 2004-03-11 |
WO2003105766A2 (fr) | 2003-12-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20050112 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20091030 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20100128 |