EP1539781A4 - Rsk-inhibitoren und deren therapeutische anwendungen - Google Patents

Rsk-inhibitoren und deren therapeutische anwendungen

Info

Publication number
EP1539781A4
EP1539781A4 EP03760343A EP03760343A EP1539781A4 EP 1539781 A4 EP1539781 A4 EP 1539781A4 EP 03760343 A EP03760343 A EP 03760343A EP 03760343 A EP03760343 A EP 03760343A EP 1539781 A4 EP1539781 A4 EP 1539781A4
Authority
EP
European Patent Office
Prior art keywords
therapeutic uses
rsk inhibitors
rsk
inhibitors
therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP03760343A
Other languages
English (en)
French (fr)
Other versions
EP1539781A2 (de
Inventor
Jeffrey A Smith
Deborah A Lannigan-Macara
Celeste E Poteet-Smith
Sidney M Hecht
Yaming Xu
David L Brautigan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UVA Licensing and Ventures Group
University of Virginia UVA
Original Assignee
University of Virginia UVA
University of Virginia Patent Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Virginia UVA, University of Virginia Patent Foundation filed Critical University of Virginia UVA
Publication of EP1539781A2 publication Critical patent/EP1539781A2/de
Publication of EP1539781A4 publication Critical patent/EP1539781A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP03760343A 2002-06-12 2003-06-12 Rsk-inhibitoren und deren therapeutische anwendungen Withdrawn EP1539781A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US38800602P 2002-06-12 2002-06-12
US388006P 2002-06-12
US44955303P 2003-02-24 2003-02-24
US449553P 2003-02-24
PCT/US2003/018734 WO2003105766A2 (en) 2002-06-12 2003-06-12 Rsk inhibitors and therapeutic uses thereof

Publications (2)

Publication Number Publication Date
EP1539781A2 EP1539781A2 (de) 2005-06-15
EP1539781A4 true EP1539781A4 (de) 2009-12-02

Family

ID=29739979

Family Applications (1)

Application Number Title Priority Date Filing Date
EP03760343A Withdrawn EP1539781A4 (de) 2002-06-12 2003-06-12 Rsk-inhibitoren und deren therapeutische anwendungen

Country Status (4)

Country Link
EP (1) EP1539781A4 (de)
AU (1) AU2003251513A1 (de)
CA (1) CA2488864A1 (de)
WO (1) WO2003105766A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920393D0 (en) 1999-08-27 1999-11-03 Medix Scient Uk Limited Plant extract mixtures and their uses
KR100590818B1 (ko) 2004-10-11 2006-06-19 재단법인서울대학교산학협력재단 소분자 유기화합물의 직접적 ｐ90 리보솜 Ｓ6 키나제 1(ＲＳＫ1)의 활성증진에 의한 당뇨병, 비만 및대사증후군의 예방 및 치료용도
CA2594542C (en) * 2005-01-10 2014-03-25 University Of Virginia Patent Foundation Synthesis of inhibitors of p90rsk
JPWO2006132401A1 (ja) * 2005-06-07 2009-01-08 萬有製薬株式会社 Ｒｓｋ１を用いた化合物の評価方法
GB0512206D0 (en) 2005-06-15 2005-07-27 Biosynth As Synthesis
US7659313B2 (en) 2007-09-13 2010-02-09 Gateway Health Alliances, Inc. Methods and related compositions using specific indanes to reduce weight and inhibit lipase, α-amylase and α-glucosidase activity in mammals
GB0718870D0 (en) * 2007-09-27 2007-11-07 Univ Dundee Modulation of RSK
WO2011019995A2 (en) 2009-08-14 2011-02-17 Hecht Sidney M Synthesis and identification of novel rsk-specific inhibitors
WO2013181742A1 (en) * 2012-06-04 2013-12-12 Phoenix Molecular Diagnostics Ltd. Methods of inhibiting rsk for treatment of breast cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000066721A2 (en) * 1999-04-30 2000-11-09 Beth Israel Deaconess Medical Center Decreasing adipose mass by altering rsk2 activity

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CHUNG H S ET AL: "FLAVONOID CONSTITUENTS OF CHORIZANTHE DIFFUSA WITH POTENTIAL CANCER CHEMOPREVENTIVE ACTIVITY", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 47, no. 1, 1 January 1999 (1999-01-01), pages 36 - 41, XP000801963, ISSN: 0021-8561 *
JIN-RUI DAI ET AL.: "zerumbone,an HIV-inhibitory and cytotoxic sesquiterpene of zingiber aromaticum", NATURAL PRODUCT LETTERS, vol. 10, no. 2, 1997, amsterdam, pages 115 - 118, XP008113448 *
KOSTAS DIMAS ET AL.: "cytotoxic activity of kaempferol glycosides against human leukaemic cell line in vitro", PHARMACOLOGICAL RESEARCH, vol. 41, no. 1, 2000, engl., pages 85 - 88, XP002551403 *
MATSUDA H ET AL: "Structural Requirements of Flavonoids and Related Compounds for Aldose Reductase Inhibitory Activity", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 50, no. 6, 1 January 2002 (2002-01-01), pages 788 - 795, XP002996843, ISSN: 0009-2363 *
N.ALIGIANNIS ET AL.: "flavonoids as cycline-dependent kinase inhibitors.", PLANTA MED, vol. 67, no. 5, 2001, stuttgart-new-york, pages 468 - 470, XP002551401 *
NAKATANI N ET AL: "Flavonoid Constituents of Zingiber zerumbet Smith", AGRICULTURAL AND BIOLOGICAL CHEMISTRY, JAPAN SOC. FOR BIOSCIENCE, BIOTECHNOLOGY AND AGROCHEM, TOKYO, JP, vol. 55, no. 2, 1 January 1991 (1991-01-01), pages 455 - 460, XP008113444, ISSN: 0002-1369 *
TOSHIYA MASUDA ET AL.: "acetylated flavonol glycosides from zingiber zerumbet", PHYTOCHEMISTRY, vol. 30, no. 7, 1991, gb, pages 2391 - 2392, XP002551402 *

Also Published As

Publication number Publication date
AU2003251513A8 (en) 2003-12-31
AU2003251513A1 (en) 2003-12-31
CA2488864A1 (en) 2003-12-24
WO2003105766A2 (en) 2003-12-24
EP1539781A2 (de) 2005-06-15
WO2003105766A3 (en) 2004-03-11

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20050112

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL LT LV MK

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20091030

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20100128