EP1490324A4 - Propargylaminoindanderivate und propargylaminotetralinderivate als hirnselektive mao-inhibitoren - Google Patents
Propargylaminoindanderivate und propargylaminotetralinderivate als hirnselektive mao-inhibitorenInfo
- Publication number
- EP1490324A4 EP1490324A4 EP03716197A EP03716197A EP1490324A4 EP 1490324 A4 EP1490324 A4 EP 1490324A4 EP 03716197 A EP03716197 A EP 03716197A EP 03716197 A EP03716197 A EP 03716197A EP 1490324 A4 EP1490324 A4 EP 1490324A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- propargylamino
- derivatives
- brain
- tetralin
- indan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/26—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8567402A | 2002-02-27 | 2002-02-27 | |
US85674 | 2002-02-27 | ||
PCT/US2003/005871 WO2003072055A2 (en) | 2002-02-27 | 2003-02-27 | Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective mao inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1490324A2 EP1490324A2 (de) | 2004-12-29 |
EP1490324A4 true EP1490324A4 (de) | 2007-10-10 |
Family
ID=27765338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP03716197A Withdrawn EP1490324A4 (de) | 2002-02-27 | 2003-02-27 | Propargylaminoindanderivate und propargylaminotetralinderivate als hirnselektive mao-inhibitoren |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1490324A4 (de) |
JP (1) | JP2005523289A (de) |
AU (1) | AU2003219913A1 (de) |
CA (1) | CA2477218A1 (de) |
WO (1) | WO2003072055A2 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2526944B1 (de) | 2002-11-15 | 2016-06-01 | Teva Pharmaceutical Industries Limited | Verwendung von Rasagilin mit oder ohne Riluzol zur Behandlung amyotropher Lateralsklerose |
MX2007010233A (es) | 2005-02-23 | 2007-11-07 | Teva Pharma | Formulaciones de rasagilina de uniformidad de contenido mejorada. |
EP1848417A1 (de) | 2005-02-24 | 2007-10-31 | Teva Pharmaceutical Industries Ltd | Formulierungen von ladostigiltartrat |
NZ564130A (en) | 2005-06-02 | 2009-12-24 | Jenrin Discovery | N-propargyl-1-aminoindan compounds useful for treating obesity |
AU2006265639A1 (en) | 2005-07-01 | 2007-01-11 | Jenrin Discovery | MAO-B inhibitors useful for treating obesity |
WO2007061717A2 (en) * | 2005-11-17 | 2007-05-31 | Teva Pharmaceutical Industries, Ltd. | Methods for isolating propargylated aminoindans |
US7572834B1 (en) | 2005-12-06 | 2009-08-11 | Teva Pharmaceutical Industries, Ltd. | Rasagiline formulations and processes for their preparation |
TW200744576A (en) | 2006-02-24 | 2007-12-16 | Teva Pharma | Propargylated aminoindans, processes for preparation, and uses thereof |
JP5769923B2 (ja) | 2006-04-03 | 2015-08-26 | テバ ファーマシューティカル インダストリーズ リミティド | レストレスレッグス症候群の治療のためのラサギリンの使用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993011761A1 (en) * | 1991-12-18 | 1993-06-24 | H. Lundbeck A/S | Aryl-triflates and related compounds |
WO1996036596A1 (en) * | 1995-05-19 | 1996-11-21 | Chiroscience Limited | 3,4-disubstituted-phenylsulphonamides and their therapeutic use |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1187017A (en) * | 1966-07-16 | 1970-04-08 | Aspro Nicholas Ltd | Substituted 1-Amino Indanes and Tetrahydronaphthalens |
EP0697894A4 (de) * | 1993-03-31 | 1996-05-01 | Univ Pennsylvania | Dopamin d-3 und serotonin (5-ht 1a) rezeptor-liganden und bildgebunde mittel |
DE69535315T2 (de) * | 1994-01-10 | 2007-06-28 | Teva Pharmaceutical Industries Ltd. | 1-aminoindanderivate und zusammensetzungen hiervon |
EP0882046A1 (de) * | 1996-02-21 | 1998-12-09 | Darwin Discovery Limited | Chinolone und ihre therapeutische verwendung |
HU229507B1 (en) * | 1996-12-18 | 2014-01-28 | Technion Res & Dev Foundation | 1,2,3,4-tetrahydro-amino-naphtalenyl- and aminoindan derivatives and pharmaceutical compositions comprising them |
-
2003
- 2003-02-27 AU AU2003219913A patent/AU2003219913A1/en not_active Abandoned
- 2003-02-27 JP JP2003570802A patent/JP2005523289A/ja active Pending
- 2003-02-27 EP EP03716197A patent/EP1490324A4/de not_active Withdrawn
- 2003-02-27 CA CA002477218A patent/CA2477218A1/en not_active Abandoned
- 2003-02-27 WO PCT/US2003/005871 patent/WO2003072055A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993011761A1 (en) * | 1991-12-18 | 1993-06-24 | H. Lundbeck A/S | Aryl-triflates and related compounds |
WO1996036596A1 (en) * | 1995-05-19 | 1996-11-21 | Chiroscience Limited | 3,4-disubstituted-phenylsulphonamides and their therapeutic use |
Non-Patent Citations (6)
Title |
---|
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; CHUMPRADIT, SUMALEE ET AL: "Synthesis and optical resolution of (R)- and (S)-trans-7-hydroxy-2- [N-propyl-N-(3'-iodo-2'-propenyl)amino]tetralin: a new D3 dopamine receptor ligand", XP002434898, retrieved from STN Database accession no. 1994:8313 * |
HAZELHOFF, BERNARD ET AL: "N-Methyl,N-propargyl-2-aminotetralins: novel dopamine agonists with monoamine oxidase inhibiting properties", EUROPEAN JOURNAL OF PHARMACOLOGY , 109(2), 229-40 CODEN: EJPHAZ; ISSN: 0014-2999, 1985, XP002434896 * |
JOURNAL OF MEDICINAL CHEMISTRY , 36(26), 4308-12 CODEN: JMCMAR; ISSN: 0022-2623, 1993 * |
R. SARGES, J.R. TRETTER, S.S. TENEN, A. WEISSMAN: "5,8-Disubstituted 1-Aminotetralines. A Class of Compounds with a Novel Profile of Central Nervous System Activity.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 16, 1973, pages 1003 - 1011 * |
STERLING, JEFFREY ET AL: "Novel Dual Inhibitors of AChE and MAO Derived from Hydroxy Aminoindan and Phenethylamine as Potential Treatment for Alzheimer's Disease", JOURNAL OF MEDICINAL CHEMISTRY , 45(24), 5260-5279 CODEN: JMCMAR; ISSN: 0022-2623, 2002, XP002296523 * |
Y.C. MARTIN, C.H. JARBOE, R.A. KRAUSE, K.R. LYNN, D. DUNNIGAN, J.B. HOLLAND: "Potential Anti-Parkinson Drugs Designed by Receptor Mapping", JOURNAL OF MEDICINAL CHEMISTRY, vol. 16, 1973, pages 147 - 150 * |
Also Published As
Publication number | Publication date |
---|---|
WO2003072055A2 (en) | 2003-09-04 |
CA2477218A1 (en) | 2003-09-04 |
AU2003219913A8 (en) | 2003-09-09 |
AU2003219913A1 (en) | 2003-09-09 |
WO2003072055A3 (en) | 2003-12-31 |
EP1490324A2 (de) | 2004-12-29 |
JP2005523289A (ja) | 2005-08-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IS7749A (is) | Pýrimídínafleiður og notkun þeirra sem CB2 beina | |
AUPS138502A0 (en) | Browsing tools and methods | |
EP1539941A4 (de) | Adzyme und deren verwendungen | |
AU2003259271A1 (en) | Bipolar articles and related methods | |
AU2003266321A1 (en) | Tetrahydropyrimidine-2-one derivatives and their uses | |
SI1499589T1 (sl) | Derivati N-(fenil(piperidin-2-il)metil)benzamida,njihova priprava in njihova terapevtska uporaba | |
IL163868A0 (en) | Hermiasterlin derivatives and uses thereof | |
EG25683A (en) | Benzoxazine derivatives and uses thereof | |
AU2003243594A8 (en) | Novel boronic chalcone derivatives and uses thereof | |
AU2003216221A1 (en) | Attachment and articles using same | |
PL374581A1 (en) | Diaminothiazoles and use thereof as cdk4 inhibitors | |
SI1551805T1 (sl) | Substituirani gama-fenil-delta-laktami in njihova uporaba | |
AU2003219913A8 (en) | Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective mao inhibitors | |
PL375416A1 (en) | Thiazole derivatives | |
AU2003297612A8 (en) | 2-substituted-3-propenamide derivatives and methods of using the same | |
AU2003258942A1 (en) | Imidazolidinedione-derivatives and their use as metalloproteinase inhibitors | |
EP1553101A4 (de) | N-acetylglucosaminderivate und deren verwendung | |
AU2003231827A8 (en) | Pseudo-tissues and uses thereof | |
DE60323960D1 (de) | Enzen 900 und 1800 mhz | |
DE50306262D1 (de) | Schäl- und Glattwalzwerkzeug | |
GB0214163D0 (en) | MP3 player and method for operating the same | |
GB0220776D0 (en) | FOXP2 and uses thereof | |
DE60311722D1 (de) | Bolzen und Walzbacken | |
GB0307231D0 (en) | 7-Nitroindoline derivatives and their uses | |
AU2003216442A8 (en) | Enkurin and uses thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20040923 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20070907 |
|
17Q | First examination report despatched |
Effective date: 20081112 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20100619 |