Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
  • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
  • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
  • A61K8/988—Honey; Royal jelly, Propolis
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin

Definitions

• the present invention relates to the use in a cosmetic or dermatological composition, or for the preparation of such a composition, of an effective amount of a honey substitute obtained by cultivating microorganisms with sugars whose composition is close to that of honey; the honey substitute or the composition being intended to accelerate healing and to hydrate the skin.
• honey was used not only as food, but also as medicine. Its development has long accompanied that of civilizations, because for thousands of years, honey was the only source of sweetness. The ancient Egyptians, but also the Assyrians, the Chinese, the Greeks and the Romans used honey for the treatment of wounds and stomach aches. More recently, the traditional therapeutic effects of honey have been studied. The anti-bacterial activities of honey have been confirmed, but also its action on wounds, ulcers and burns. Honey is a product of choice for many skin problems.
• honey In cosmetics, honey is commonly used for its bactericidal and moisturizing properties and in the treatment of wounds. It is also used as a depigmenting or whitening agent for the treatment of pigmentary spots on the skin, acting directly on melanogenesis and as a kerat ⁇ lytic agent to improve the radiance of the skin tone and treat wrinkles.
• the Applicant has unexpectedly found that certain microorganisms can, under certain conditions, provide a biotechnological substitute for honey, and that the application of an effective amount of such a biotechnological substitute for honey makes it possible to accelerate the healing.
• the present invention therefore relates to the use in a cosmetic or dermatological composition, or for the preparation of such a composition, of an effective amount of a biotechnological substitute for honey obtained by cultivating microorganisms with sugars of which the composition is close to that of honey; the substitute or the composition being intended to accelerate the healing.
• the present invention also relates to the use in a cosmetic or dermatological composition, or for the preparation of such a composition, of an effective amount of a biotechnological substitute for honey obtained by cultivating microorganisms with sugars of which the composition is close to that of honey; the substitute or the composition being intended for skin hydration.
• biotechnological honey substitute must be understood by “biotechnological honey substitute”.
• honey substitute the applicant understands a compound rich in sugars, which has the properties attributed to honey in terms of soothing and healing.
• biotechnological origin means obtained using microorganisms.
• honey has certain anti-bacterial properties.
• honey has certain anti-bacterial properties.
• the Applicant has selected natural microorganisms, close to those naturally present in honey, and whose growth is not inhibited by honey. It therefore becomes possible to cultivate, under certain conditions, these microorganisms with honey, or a product close to honey, and then to extract the intra-cytoplasmic and extra-cytoplasmic content of the microorganisms thus cultivated.
• the biotechnological honey substitute thus obtained contains:
• biotechnological substitute for honey is obtained by cultivating microorganisms with sugars whose composition is close to that of honey.
• the microorganism used is a yeast and preferably the microorganism used is Saccharomyces sp.
• sugars whose composition is close to that of honey is meant a mixture of commercial sugars present in honey in their natural state.
• these sugars those present mainly in honey are: a mixture of glucose and levulose (fructose) representing approximately 70% to 75% of honey, but also dextrin and sucrose representing respectively 10% and 2.5% of honey .
• the distribution between the different sugars does not influence the use of the product, but preferably glucose and levulose are predominant compared to the other sugars.
• the biotechnological substitute for honey is obtained by cultivating microorganisms with sugars which are a mixture of glucose, levulose, dextrins and sucrose.
• the biotechnological substitute for honey is obtained by cultivating microorganisms with sugars used in an amount representing from 1% to 20% of the culture medium of the microorganism and preferably the sugars are used in an amount representing from 6% to 14% of the culture medium of the microorganism.
• biotechnological substitute for honey contains from 10% to 50% of a glycol, and preferably the glycol used is hexylene glycol.
• compositions according to the present invention will be in a dosage form suitable for administration by the topical skin route, and cover all cosmetic or dermatological forms.
• These compositions must therefore contain a cosmetically and / or dermatologically acceptable medium, that is to say compatible with the skin, body hair or hair.
• These compositions may in particular be in the form of creams, oil-in-water emulsions, water-in-oil or multiple emulsions, solutions, suspensions, or even powders, suitable for application to the skin, the lips and / or the hair. .
• This composition may be more or less fluid and have the appearance of a cream, a lotion, a milk, a serum, an ointment, a gel, a paste or a foam. It can also be in solid form, like a stick, or be applied to the skin in the form of an aerosol. It can be used as a care product and / or as a skin makeup product.
• compositions comprise, in a known manner, the adjuvants necessary for their formulation, such as solvents, thickeners, diluents, antioxidants, dyes, filters, pigments, fillers, preservatives, perfumes, odor absorbers.
• these adjuvants as well as their proportions, will be chosen so as not to harm the properties sought in the invention.
• These adjuvants can for example correspond to 0.01 to 20% of the total weight of the composition.
• the fatty phase can represent from 5 to 80% by weight, and preferably from 5 to 50% by weight relative to the total weight of the composition.
• the emulsifiers and coemulsifiers used in the composition will be chosen from those conventionally used in the field under consideration. For example, they can be used in a proportion ranging from 0.3 to 30% by weight, relative to the total weight of the composition.
• biotechnological honey substitute as defined above, in an amount representing from 0.01% to 20% of the total weight of the composition and preferably in an amount representing from 0.1% to 10% of the total weight of the composition.
• another subject of the invention consists of a cosmetic or dermatological composition containing, in a cosmetically or dermatologically acceptable medium, a biotechnological substitute for honey obtained by cultivating microorganisms with sugars whose composition is close to that of honey.
• the biotechnological honey substitute is present in an amount ranging from 0.01% to 20% of the total weight of the composition, and preferably in an amount ranging from 0.1% to 10% by weight total of the composition.
• the invention also relates to a cosmetic process which facilitates the healing of the skin, and which consists in applying the composition as defined above to scarified skin.
• the invention finally relates to a cosmetic method for moisturizing the skin, consisting in applying the composition as defined above to the skin.
• the microorganism used is a yeast.
• the microorganism used is Saccharomyces sp. and preferably Saccharomyces cerevisiae. Saccharomyces cerevisiae yeasts are cultivated in a defined suitable medium.
• the yeasts When the yeast concentration is high, the yeasts are concentrated by centrifugation, then returned to culture in an essentially aqueous liquid medium, with a high concentration of sugars.
• a wet pellet of 150 grams of yeast is cultivated in a liter of an essentially aqueous medium for 18 to 36 hours containing 60 g / l of glucose, 65 g / l of levulose, 10 g / l of dextrin and 5 g 1 of sucrose.
• 20% hexylene glycol can be added to the extract.
• the extract is then treated and sterilized to comply with cosmetic requirements (color, odor, appearance, sterility ).
• the product obtained is the biotechnological substitute for honey.
• Example 2 Effect of the Biotechnological Substitute of Example 1 on Healing
• the stretching is 28.7 mm + or - 2.2 mm.
• the stretch is 23.2 mm + or - 1.6 mm.
• the honey substitute of Example 1 has a healing power, a power which has been demonstrated on the one hand visually, on the other hand with stretching with a dynamometer.
• compositions were obtained by simple mixing of the various components.
• the quantities indicated are given as a percentage by weight.
• Aqueous phase a Glycerin 5.00% a Allantoin 0.10% a Biotechnological substitute from Example 1 5.00% a Sepigel 305 (Polyacrylamide and C13-14 Isoparaffin and Laureth-7) 0.30% a Preservative 0, 50% a Perfume 0.50%
• a Carbopol Ultrez lO (2% sol.) 25.00% a Triethanolamine 0.50% a Biotechnology substitute from Example 1 3.00% a Preservative 0.20% a EDTA (sequestering) 0.10% a Perfume 0.50% a Water qs 100%
• a Mono Propylene Glycol 1.00% a Allantoin 0.30% a Glycerin 1.00% a Cetiol HE (PEG-7 Glyceryl Cocoate) 1.00% a Biotechnology substitute of example 1 1.00% a Preservative 0, 20% a Perfume 0.50% a Water qs 100%

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Veterinary Medicine (AREA)
• Public Health (AREA)
• General Health & Medical Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• Epidemiology (AREA)
• Pharmacology & Pharmacy (AREA)
• Medicinal Chemistry (AREA)
• Chemical & Material Sciences (AREA)
• Molecular Biology (AREA)
• Zoology (AREA)
• Birds (AREA)
• Dermatology (AREA)
• Cosmetics (AREA)

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• 2002
  • 2002-02-21 EP EP02704875A patent/EP1476172A1/de not_active Withdrawn
  • 2002-02-21 AU AU2002238681A patent/AU2002238681A1/en not_active Abandoned
  • 2002-02-21 WO PCT/FR2002/000653 patent/WO2003077934A1/fr not_active Application Discontinuation

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