EP1423113A4 - Composes de liaison au recepteur nucleaire nr1h4 - Google Patents

Composes de liaison au recepteur nucleaire nr1h4

Info

Publication number
EP1423113A4
EP1423113A4 EP02750474A EP02750474A EP1423113A4 EP 1423113 A4 EP1423113 A4 EP 1423113A4 EP 02750474 A EP02750474 A EP 02750474A EP 02750474 A EP02750474 A EP 02750474A EP 1423113 A4 EP1423113 A4 EP 1423113A4
Authority
EP
European Patent Office
Prior art keywords
receptor binding
nuclear receptor
binding compounds
nr1h4
nr1h4 nuclear
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP02750474A
Other languages
German (de)
English (en)
Other versions
EP1423113A1 (fr
Inventor
Ulrike Bauer
Zach Cheruvallath
Ulrich Deuschle
Elena Dneprovskaia
Tim Gahman
Kristina Giegrich
Ronnie Hanecak
Normand Hebert
John Kiely
Ingo Kober
Manfred Kogl
Harald Kranz
Claus Kremoser
Matthew Lee
Kerstin Otte
Carlton Sage
Manish Sud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phenex Pharmaceuticals AG
Original Assignee
Phenex Pharmaceuticals AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP01119473A external-priority patent/EP1285914B1/fr
Application filed by Phenex Pharmaceuticals AG filed Critical Phenex Pharmaceuticals AG
Priority to EP02750474A priority Critical patent/EP1423113A4/fr
Publication of EP1423113A1 publication Critical patent/EP1423113A1/fr
Publication of EP1423113A4 publication Critical patent/EP1423113A4/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms
    • C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
EP02750474A 2001-08-13 2002-08-13 Composes de liaison au recepteur nucleaire nr1h4 Ceased EP1423113A4 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP02750474A EP1423113A4 (fr) 2001-08-13 2002-08-13 Composes de liaison au recepteur nucleaire nr1h4

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP01119473 2001-08-13
EP01119473A EP1285914B1 (fr) 2001-08-13 2001-08-13 Ligands du récepteur nucéaire nr1h4
US185731 2002-07-01
US10/185,731 US6974830B2 (en) 2001-08-13 2002-07-01 NR1H4 nuclear receptor binding compounds
EP02750474A EP1423113A4 (fr) 2001-08-13 2002-08-13 Composes de liaison au recepteur nucleaire nr1h4
PCT/US2002/025438 WO2003015777A1 (fr) 2001-08-13 2002-08-13 Composes de liaison au recepteur nucleaire nr1h4

Publications (2)

Publication Number Publication Date
EP1423113A1 EP1423113A1 (fr) 2004-06-02
EP1423113A4 true EP1423113A4 (fr) 2007-04-18

Family

ID=26076685

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02750474A Ceased EP1423113A4 (fr) 2001-08-13 2002-08-13 Composes de liaison au recepteur nucleaire nr1h4

Country Status (2)

Country Link
EP (1) EP1423113A4 (fr)
WO (1) WO2003015777A1 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE48286E1 (en) 2001-03-12 2020-10-27 Intercept Pharmaceuticals, Inc. Steroids as agonists for FXR
US6987121B2 (en) 2002-04-25 2006-01-17 Smithkline Beecham Corporation Compositions and methods for hepatoprotection and treatment of cholestasis
GB0315111D0 (en) 2003-06-27 2003-07-30 Cancer Rec Tech Ltd Substituted 5-membered ring compounds and their use
TWI349550B (en) 2003-12-26 2011-10-01 A thiazole derivative and adenosine a2a receptor antagonist containing the same
EP1734970B1 (fr) 2004-03-12 2014-12-31 Intercept Pharmaceuticals, Inc. Traitement de la fibrose au moyen de ligands de fxr
US10987362B2 (en) 2004-03-12 2021-04-27 Intercept Pharmaceuticals, Inc. Treatment of fibrosis using FXR ligands
PL1773768T3 (pl) 2004-07-30 2019-03-29 Exelixis, Inc. Pochodne pirolu jako środki farmaceutyczne
WO2006029719A2 (fr) * 2004-09-14 2006-03-23 Bayer Healthcare Ag Diagnostics et traitements de maladies associees a la sous-famille 1, du groupe h, membre 4 de recepteur nucleaire (nr1h4)
ITMI20050912A1 (it) 2005-05-19 2006-11-20 Erregierre Spa Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici
CN101679476B (zh) 2007-01-19 2014-05-07 英特塞普特医药品公司 23取代的胆汁酸作为tgr5调节剂及其使用方法
WO2010014836A2 (fr) 2008-07-30 2010-02-04 Intercept Pharmaceuticals, Inc. Modulateurs de tgr5 et leurs procédés d'utilisation
PL2698375T3 (pl) 2008-11-19 2018-08-31 Intercept Pharmaceuticals, Inc. Modulatory TGR5 i sposób ich zastosowania
WO2010069604A1 (fr) 2008-12-19 2010-06-24 Royal College Of Surgeons In Ireland Traitement de la diarrhée
EP2545964A1 (fr) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Nouveaux composés se liant au fxr (nr1 h4) et modulant son activité
US9982008B2 (en) 2012-06-19 2018-05-29 Intercept Pharmaceuticals, Inc. Preparation and uses of obeticholic acid
ES2822375T3 (es) 2012-06-19 2021-04-30 Intercept Pharmaceuticals Inc Preparación de la forma no cristalina del ácido obeticólico
KR102269305B1 (ko) 2016-06-13 2021-06-25 길리애드 사이언시즈, 인코포레이티드 Fxr (nr1h4) 조정 화합물
CA2968836A1 (fr) 2016-06-13 2017-12-13 Gilead Sciences, Inc. Composes modulant fxr (nr1h4)
CN110461328A (zh) 2017-03-28 2019-11-15 吉利德科学公司 治疗肝疾病的治疗组合
DK3911647T3 (da) 2019-01-15 2024-02-26 Gilead Sciences Inc Isoxazol-forbindelse som FXR-agonist og farmaceutiske sammensætninger, der omfatter en sådan
JP2022519906A (ja) 2019-02-19 2022-03-25 ギリアード サイエンシーズ， インコーポレイテッド Ｆｘｒアゴニストの固体形態
WO2020249064A1 (fr) * 2019-06-14 2020-12-17 Nanjing Ruijie Pharma Co., Ltd. Composés pour la modulation de fxr
MX2022000742A (es) 2019-07-18 2022-02-14 Enyo Pharma Metodo para disminuir los efectos adversos del interferon.
IL293892A (en) 2020-01-15 2022-08-01 Inserm Institut National De La Sant? Et De La Rech M?Dicale Use of fxr agonists to treat hepatitis d virus infection
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
US20240100125A1 (en) 2021-01-14 2024-03-28 Enyo Pharma Synergistic effect of a fxr agonist and ifn for the treatment of hbv infection
TW202308629A (zh) 2021-04-28 2023-03-01 法商Ｅｎｙｏ製藥公司 使用fxr激動劑作為組合治療以增強tlr3激動劑之療效

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2022085A (en) * 1978-06-02 1979-12-12 Pfizer Novel Aminothiazoles
JPH04173782A (ja) * 1990-11-08 1992-06-22 Taisho Pharmaceut Co Ltd ２―スルホンアミド―４，５―ジフェニルチアゾール誘導体
EP0592664A1 (fr) * 1991-03-07 1994-04-20 Hisamitsu Pharmaceutical Co., Inc. Nouveau derive de diphenylthiazole
JPH07149745A (ja) * 1993-11-30 1995-06-13 Hisamitsu Pharmaceut Co Inc 新規な２−アミノチアゾール誘導体
FR2735777A1 (fr) * 1995-06-21 1996-12-27 Sanofi Sa Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
FR2796380A1 (fr) * 1999-07-15 2001-01-19 Sanofi Synthelabo Nouveaux derives d'aminothiazoles, leur preparation et les compositions pharmaceutiques les contenant

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692893B1 (fr) * 1992-06-24 1994-09-02 Sanofi Elf Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
FR2714059B1 (fr) * 1993-12-21 1996-03-08 Sanofi Elf Dérivés amino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
WO1996016650A1 (fr) * 1994-11-29 1996-06-06 Hisamitsu Pharmaceutical Co., Inc. Antibacterien et bactericide comprenant un derive de 2-aminothiazole et sels de ce derive
JP4136024B2 (ja) * 1995-12-29 2008-08-20 富山化学工業株式会社 ２−アミノチアゾ−ル誘導体またはその塩

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2022085A (en) * 1978-06-02 1979-12-12 Pfizer Novel Aminothiazoles
JPH04173782A (ja) * 1990-11-08 1992-06-22 Taisho Pharmaceut Co Ltd ２―スルホンアミド―４，５―ジフェニルチアゾール誘導体
EP0592664A1 (fr) * 1991-03-07 1994-04-20 Hisamitsu Pharmaceutical Co., Inc. Nouveau derive de diphenylthiazole
JPH07149745A (ja) * 1993-11-30 1995-06-13 Hisamitsu Pharmaceut Co Inc 新規な２−アミノチアゾール誘導体
FR2735777A1 (fr) * 1995-06-21 1996-12-27 Sanofi Sa Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
FR2796380A1 (fr) * 1999-07-15 2001-01-19 Sanofi Synthelabo Nouveaux derives d'aminothiazoles, leur preparation et les compositions pharmaceutiques les contenant

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MALONEY P R ET AL: "Identification of a Chemical Tool for the rphan Nuclear Receptor FXR", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 43, no. 16, 10 August 2000 (2000-08-10), pages 2971 - 2974, XP002992679, ISSN: 0022-2623 *
See also references of WO03015777A1 *

Also Published As

Publication number Publication date
EP1423113A1 (fr) 2004-06-02
WO2003015777A1 (fr) 2003-02-27

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Inventor name: SUD, MANISH

Inventor name: SAGE, CARLTON

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Inventor name: LEE, MATTHEW

Inventor name: KREMOSER, CLAUS

Inventor name: KRANZ, HARALD

Inventor name: KOGL, MANFRED

Inventor name: KOBER, INGO

Inventor name: KIELY, JOHN

Inventor name: HEBERT, NORMAND

Inventor name: HANECAK, RONNIE

Inventor name: GIEGRICH, KRISTINA

Inventor name: GAHMAN, TIM

Inventor name: DNEPROVSKAIA, ELENA

Inventor name: DEUSCHLE, ULRICH

Inventor name: CHERUVALLATH, ZACH

Inventor name: BAUER, ULRIKE

RIN1 Information on inventor provided before grant (corrected)

Inventor name: SUD, MANISH

Inventor name: SAGE, CARLTON

Inventor name: OTTE, KERSTIN

Inventor name: LEE, MATTHEW

Inventor name: KREMOSER, CLAUS

Inventor name: KRANZ, HARALD

Inventor name: KOGL, MANFRED

Inventor name: KOBER, INGO

Inventor name: KIELY, JOHN

Inventor name: HEBERT, NORMAND

Inventor name: HANECAK, RONNIE

Inventor name: GIEGRICH, KRISTINA

Inventor name: GAHMAN, TIM

Inventor name: DNEPROVSKAIA, ELENA

Inventor name: DEUSCHLE, ULRICH

Inventor name: CHERUVALLATH, ZACH

Inventor name: BAUER, ULRIKE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: PHENEX PHARMACEUTICALS AG

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Owner name: PHENEX PHARMACEUTICALS AG

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Inventor name: SUD, MANISH

Inventor name: DNEPROVSKAIA, ELENAC

Inventor name: DEUSCHLE, ULRICH

Inventor name: CHERUVALLATH, ZACH

Inventor name: SAGE, CARLTON

Inventor name: OTTE, KERSTIN

Inventor name: LEE, MATTHEW

Inventor name: KREMOSER, CLAUS

Inventor name: KRANZ, HARALD

Inventor name: KOGL, MANFRED

Inventor name: KOBER, INGO

Inventor name: KIELY, JOHN

Inventor name: HEBERT, NORMANDC

Inventor name: HANECAK, RONNIE

Inventor name: GIEGRICH, KRISTINA

Inventor name: GAHMAN, TIM

Inventor name: BAUER, ULRIKE

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