EP1409040A4 - Catheter pour administration de medicaments a invasion minimale - Google Patents

Catheter pour administration de medicaments a invasion minimale

Info

Publication number
EP1409040A4
EP1409040A4 EP02749940A EP02749940A EP1409040A4 EP 1409040 A4 EP1409040 A4 EP 1409040A4 EP 02749940 A EP02749940 A EP 02749940A EP 02749940 A EP02749940 A EP 02749940A EP 1409040 A4 EP1409040 A4 EP 1409040A4
Authority
EP
European Patent Office
Prior art keywords
catheter
tip
delivery
tissue
implanted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02749940A
Other languages
German (de)
English (en)
Other versions
EP1409040A2 (fr
Inventor
Edward M Gillis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Durect Corp
Original Assignee
Durect Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Durect Corp filed Critical Durect Corp
Publication of EP1409040A2 publication Critical patent/EP1409040A2/fr
Publication of EP1409040A4 publication Critical patent/EP1409040A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/008—Strength or flexibility characteristics of the catheter tip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A61M25/0069—Tip not integral with tube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M2025/0042—Microcatheters, cannula or the like having outside diameters around 1 mm or less
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0693—Brain, cerebrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M25/0054—Catheters; Hollow probes characterised by structural features with regions for increasing flexibility
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure

Definitions

  • the invention relates to minimally invasive catheters and methods for long-term delivery of a drag to a highly sensitive and delicate area of the body, such as the brain, particularly to the brain stem. More particularly, the invention relates to a catheter that may be used for long-term delivery of chemotherapeutic agents to the brain stem of a human patient.
  • chemotherapeutic agents for example carboplatin and tamoxifen, are well known to cause general toxicity, nausea, vomiting, and reduction in bone marrow function that can result in anemia, risk of bruising or bleeding, and infection. Such undesirable side effects may be considerably reduced or eliminated if a lower dose is used and delivered directly to the tumor site.
  • Direct delivery of drags has certain difficulties and disadvantages, not least of all, those associated with local tissue destruction. Because catheters and needles need to be inserted through tissue to their target site, they inevitably cause some local tissue destruction.
  • a non- rigid catheter is customarily inserted through tissue using a rigid cannula.
  • the cannula is simply a hollow tube that is used to penetrate tissue, through which a catheter may be threaded.
  • the cannula of course, must have a diameter that is greater than that of the catheter.
  • the volume of tissue destroyed is generally proportional to the diameter of the needle or cannula. Movement of the needle or cannula, once inserted, will cause additional destruction.
  • wafers may be implanted at the site of the debulked tumor.
  • Such wafers are generally hard discs made of poly-lactate, that slowly dissolve and release a chemotherapeutic agent that destroys cells locally at the tumor site (e.g., the GLIADEL® wafer used to treat glioblastoma multiforme).
  • a chemotherapeutic agent that destroys cells locally at the tumor site (e.g., the GLIADEL® wafer used to treat glioblastoma multiforme).
  • a disadvantage of such tumors is that they cause an inflammatory response that is, obviously, undesirable.
  • water treatments only appear to increase life-span by a few months, at most.
  • continuous delivery of a drug would allow a lower dose to be delivered, at a steady rate, over a period of time, thereby reducing toxicity due to high initial drug concentrations. Continuous delivery would also reduce the need for repeated access to the target site, therefore reducing local tissue destruction.
  • Another currently employed method employs a cannula that is used to penetrate the tissue and access the desired area of interest.
  • This device then allows for the introduction of a flexible catheter that contains a stylet through the center lumen of the cannula.
  • the cannula can then be removed and the flexible catheter routed to the desired area of implantation.
  • This method suffers the disadvantage of having to use a cannula to place the catheter, which causes additional tissue damage.
  • the invention encompasses a catheter with a flexible portion that may be attached to a pump or drag reservoir, and a rigid tip portion that is used to penetrate a delicate and sensitive tissue, such as the brain stem, in a minimally invasive fashion and thereby deliver a drug either as a bolus, or as repeated bolus delivery, or continuously over a period of time.
  • the catheter is adapted to be implanted, and fixed in place, without the use of a trocar or cannula, such that tissue damage is minimized both at the time of implantation, and later, over the period that the catheter remains implanted.
  • the catheter may be placed by drilling a hole through the posterior aspect of the cranium to gain access to the brain stem.
  • the catheter is adapted to deliver a drag to a precise location, for instance to treat an inoperative tumor of the brain stem.
  • the present invention provides a device that can be implanted.
  • a substance such as a drug may be delivered either as a bolus, or as repeated/preiodic boluses, or by continual delivery. Repeated bolus delivery may be facilitated by use of an access port attached to the proximal end of the catheter, that may be repeatedly accessed by a syringe and needle.
  • the present invention thereby eliminates the need for repeated access to the target site as currently required by bolus injection, and that also reduces the need to deliver super-optimal initial doses of a drug, as currently required by bolus injection.
  • a catheter designed for the continuous delivery of a fluid into a target site comprising a tube having a flexible portion, said flexible portion having a proximal end and a distal end, and a rigid tip, said rigid tip having a proximal end and a distal end, and wherein said tip is either open at its distal end or is fenestrated, and wherein said proximal end of said flexible portion is communicably attached to a drug delivery apparatus, and wherein said distal portion of said flexible portion is communicably attached to said rigid tip, and wherein said tip is adapted for implantation into a tissue, and wherein said tip is further adapted to minimize damage to said tissue into which it is implanted and wherein a fluid may be delivered from said drag delivery apparatus via said flexible portion and thence to said tip, whereby said fluid is released from said tip into said target site.
  • FIG. 1 A general embodiment (not to scale) of the minimally invasive catheter of the invention. Although a sharpened open tip is shown, the tip may equally have a closed distal end but be fenestrated as shown in Fig. 2 and Fig. 3. Fig. 2. Engineering drawing of a fenestrated catheter tip with 1.5 cm spread. Fig. 3. Engineering drawings of a fenestrated catheter tip with 2 cm spread. Fig. 4. Schematic diagram of the catheter placed in the brain stem of a human. Fig. 5. CAT-scan showing caterer implanted into the brain stem of a cynomologous monkey.
  • CAT-scan showing clearly showing caterer tip (A) implanted into the brain stem of a cynomologous monkey.
  • Drug may include any substance meant to alter body physiology, such as to treat a disease, such as cancer.
  • a drug may be selected from the following types of substances: an anti-cancer chemotherapeutic agent (such as carboplatin and tamoxifen), an antibody (such as an antibody that binds to a cancer-associated growth hormone receptor), a peptide, protein, carbohydrate, nucleoprotein, mucoprotein, lipoprotein, synthetic polypeptide or protein, or a small molecule linked to a protein, glycoprotein, steroid, nucleic acid (e.g., DNA, including cDNA, or RNA, or a fragment thereof), nucleotide, nucleoside, oligonucleotides (including antisense oligonucleotides), gene, lipid, hormone, vitamin, or combination thereof.
  • an anti-cancer chemotherapeutic agent such as carboplatin and tamoxifen
  • an antibody such as an antibody that binds to a cancer-
  • a drug may include immunosuppressants, antioxidants, anesthetics, chemotherapeutic agents, steroids (including retinoids), hormones, antibiotics, antivirals, antifungals, antiproliferatives, anticoagulants, antiphotoaging agents, melanotropic peptides, nonsteroidal and steroidal anti- inflammatory compounds, antipsychotics, and radiation absorbers (such as molecules designed for use in photo-dynamic therapy to treat cancers), including UV-absorbers.
  • a drug may also include anti-infectives such as nitrofurazone, antibiotics, including penicillin, tetracycline etc; anti-virals including idoxuridine; antiallergenics such as antazoline, hydrocortisone etc; miotics and anticholinesterases such as pilocarpine, esperine salicylate etc; sedatives and hypnotics such as pentobarbital sodium; progestational agents such as progesterone, or megestrol; humoral agents such as the prostaglandins, for example PGEi and PGF 2 ; antispasmodics such as atropine; natural and synthetic bioactive peptides and proteins, including growth factors, cell adhesion factors, cytokines, and biological response modifiers.
  • a drag may also include a vaccine and the substance to be delivered is an antigen.
  • a drag may also include a narcotic analgesic, such as sufentanil and fentanyl and congeners thereof.
  • Continuous delivery means delivery of a substance over a period of time such that the procedure is distinguished from “bolus” delivery.
  • Continuous delivery generally involves delivery of a substance over a period of time without interraption.
  • the rate of delivery need not be constant, and the period of delivery need not be very long, ie: the period of constant delivery may be over a period of maybe half an hour or an hour or a few hours, but may also be over a period of days, weeks, months, or even a year or more.
  • Implanted means placed within the body, and maintained at that location for some extended period of time.
  • the period of time during which the implanted object is maintained in place will be generally considerably greater than that customarily required to introduce a bolus of a substance, such as a drug. Normally, injection of a drag takes only a few seconds to about a minute. Therefore a device that is placed in the body for any extended period greater about a few (say two) minutes could reasonably be considered to be implanted for purposes of this disclosure.
  • the catheter of the invention may be placed subcutaneously, or within a tissue or organ such that the catheter so implanted is intended to remain at the site of implantation for some time, at least for, say, half-an-hour, or an hour or more.
  • the catheter may be implanted for days, weeks, months or even longer.
  • Some of the drag delivery apparatuses that may be used with the catheter of the invention, for example the osmotic pumps, are designed to be implanted for periods greater than a month and to deliver drug during this period.
  • a drug delivery apparatus may be implanted, for example, subcutaneously, or within a tissue or organ, or within a body cavity such as the peritoneal cavity, the thoracic cavity, the pelvic cavity, or within the bladder, uteras, or any other cavity or location that is convenient for delivery of the intended substance.
  • a catheter may be implanted into a tissue, for example into brain tissue, and may be affixed in place by fixing the catheter to another tissue, such as bone or cartilage, using an adhesive or screws, clamps, sutures or any other suitable fixing means.
  • Target site means the site for intended delivery of a substance, for example the target site of an anti-tumor drug may be a tumor located within a tissue, or may be tissue in proximity to the tumor. In the case of delivery of a neurotropic substance to the brain, the target site may be the site of traumatic damage or a region of tissue where neurodegenerative pathology is present, such as in the treatment of Alzheimer's or Parkinson's disease.
  • Proximal end is a relative term, and generally refers to the end of a device, such as a catheter, than is nearest to the operator (i.e. the surgeon) and is furthest away from the treatment site.
  • the flexible portion of the catheter has a proximal end that may be communicably attached to an access port or drag delivery apparatus, such as a pump, or reservoir.
  • distal end is a relative term and generally refers to the end of a device, such as a catheter, that is furthest away from the operator (i.e. the surgeon) and is closest to the treatment site.
  • the distal end of flexible portion of the catheter maybe communicably attached to a rigid tip that is used to penetrate tissue.
  • Nevous tissue includes, but is not limited to brain tissue, the tissues of the eye or any tissue rich in nerve cells, such as spinal tissue or nerve plexus tissue.
  • Drag delivery apparatus includes but is not limited to a syringe, a drug reservoir or a pump of any kind, for example an osmotic pump, an electromechanical pump, an electroosmotic pump, an effervescent pump, a hydraulic pump, a piezoelectric pump, an elastomeric pump, a vapor pressure pump, or and an electrolytic pump.
  • a pump may be externally worn or may be implanted within the body.
  • the catheter of the invention is of a design adapted to be implanted, and fixed in place, without the use of a trocar or cannula, such that tissue damage is minimized both at the time of implantation, and later, over the period that the catheter remains implanted.
  • the catheter may be used to deliver a drug over a prolonged period of time, to a precise location, for instance to treat an inoperative tumor of the brain stem.
  • the catheter of the invention may be implanted, and maintained in place and used to deliver repeated doses of a drug to the same target over time without the necessity of repeatedly re-implanting a needle through tissue to access the target site.
  • the present invention is particularly directed to delivery of drugs to the brain and nervous tissue.
  • the present invention may also be used to deliver substances used for imaging in various organs, such as the delivery or radio-opaque substances or imaging substances used in MRI or other methods.
  • Drags delivered to treat cancers would include, but are not limited to tamoxifen and carboplatin.
  • Drags delivered to treat epilepsy would include, but are not limited to phenytonin.
  • Drugs delivered to treat psychosis would include, but are not limited to tri-cyclic anti-depressants such as chloromazine.
  • Drags delivered to treat schizophrenia would include, but are not limited to serotonin selective reuptake inhibitors (SSRI's) such as prozac.
  • SSRI's serotonin selective reuptake inhibitors
  • Drugs delivered to treat depression would include, but are not limited to SSRI's and 5-hydroxy-L-tryptophan.
  • Drugs delivered to treat pain would include, but are not limited to fentanyl, sufentanil, morphine, and derivatives and congeners of such drugs.
  • Drugs delivered to treat narcolepsy would include, but are not limited to dextroamphetamine sulfate.
  • Drags delivered to treat tinnitus would include, but are not limited to sodium channel receptor antagonists such as lidocane, GABA-A receptor agonists such as benzodiazopine, and MDNA receptor antagonists such as dextromethorphan.
  • Drags delivered to treat brain injury would include, but are not limited to steroids, and drugs that would stimulate nerve growth such as Brain Derived Neurotrophic Factor (BDNF), and MDNA receptor antagonists.
  • BDNF Brain Derived Neurotrophic Factor
  • Drags delivered to treat neurodegenerative disorders may include, but are not limited to acetylcholine esterase inhibitors, such as Aricept, to treat Alzheimer's, and L- DOPA to treat Parkinson's disease. Additionally the current invention could be used to deliver agents used in gene therapy, such as, for example, naked polynucleotides encoding proteins that stimulate neuron growth, such as BDNF. Such polynucleotides could also be delivered using microspheres, liposomes, synthetic viral capsids, or virus vectors such as adenoviras, adeno- associated virus, lentivirus, herpes virus etc. Such vectors are well know in the field of gene therapy and could be used to deliver genes encoding any protein of therapeutic value. Additionally such vectors can be used to deliver anti-sense polynucleotides to alter translation of mRMA's thereby altering the expression of specific proteins.
  • agents used in gene therapy such as, for example, naked polynucleotides encoding proteins that stimulate
  • the invention encompasses a catheter with a flexible portion that at the proximal end may be attached to a pump or drug reservoir, and a rigid tip portion at the distal end that is sufficiently rigid to penetrate tissue such that the tip can access an area of the body (i.e. the brain stem) in a minimally invasive fashion via direct penetration.
  • the catheter tip at the distal section may be a few centimeters in length (e.g.: from about 0.4cm to about 12cm) such that it is adapted to facilitate penetration of the tip to the desired area of drug delivery.
  • the Tip must be of a suitable length so as to allow for the piercing and placement of it yet not so long as to make the Catheter difficult to route to the desired area of pump implantation.
  • the tip of the catheter must be long enough to allow for penetration to the desired location of drug delivery yet not be so long as to not allow for routing it to the desired area.
  • the tip length will correspond to the distance from the outside of the organ in which the target is located to the target location within the organ.
  • a catheter designed to deliver a chemotherapeutic agent to a central area of the brain stem of a human being may have a tip of about 0.25-3 cm or optionally about 1.5-2.5 cm in length (e.g.: about 2.1 cm in length, which is the embodiment used experimentally) depending on exactly where the target point (tumor) is. If it were necessary to deliver a drag to the putainment, then a desirable length for the catheter tip may be about 6 - 12 cm in length.
  • the target point may be at the site of a tumor, identified and located by x-ray, ultrasound, MRI or NMR etc.
  • Positioning is commonly done using 3-D reconstruction of the brain from CAT scan images.
  • the catheter tip may be positioned directly via stereotaxis or other means to the desired location. Positioning may be done using 3- D reconstruction of the brain from CAT scan images
  • the outer diameter of the catheter tip may be from about 0.1 mm to about 2.0 mm, or optionally about 0.1 mm to about 1.0 mm. (The experimental catheter was 0.25 mm in outer diameter). The inside diameter of the catheter may be from about .05 mm to about 0.75 mm.
  • the tip may be sharpened to facilitate penetration of the tissue, and may have an open lumen tip such that fluid may pass directly from the open end of the tip, or may be closed at the end, but be "fenestrated” such that fluid may pass out from a plurality of holes distributed along the length of or towards the end of the tip .
  • the tip may be made of any number of reasonably rigid materials . Such materials may include, for example, metals (e.g.: steel, titanium, an alloy such as a nickel- titanium alloy), hard plastics and polymers (e.g.: polycarbonates, acetates etc), carbon-fiber composites, glass, etc. It is desirable to use a material that may be easily formed to provide the fine structure required, and may be easily sterilized, to allow for safe, aseptic implantation.
  • the proximal section of the catheter contains a substantially flexible section that allows for it to be indwelling and routed to a different area of the body and communicably attached to a reservoir or drug delivery apparatus such as a pump.
  • the flexible section provides the connection between the pumping device and the rigid distal catheter Tip.
  • the flexible proximal section may be made of any suitable flexible material such as, for example silicone rabber or polyurethane or low-density polyethylene.
  • the proximal section (as with the tip) should be made of a biocompatible material, i.e., a material that is non-toxic to a recipient and present no significant, deleterious or untoward effects on the recipient's body.
  • the catheter may be anchored in place at the junction of the rigid and floppy sections so as to allow for the tip to remain fixed at the site of desired delivery.
  • the proximal end can then be routed to the area of the body for attachment to the delivery device.
  • the rigid section is made from a Nickel-Titanium (“NiTi”) Alloy and can be minimally invasively placed and the junction fixed in place at the back of the brainstem via a cyanoacrylate adhesive or other means for affixing.
  • the catheter is ideally fixed at the proximal end of the rigid section or at the junction between the rigid and floppy section.
  • the rigid section needs to be approximately 1 to 8 cm (more likely 2-5 cm) in length to allow for access to the preferred site of implantation within the stem yet not so long as to cause difficulty in routing the catheter down through the base of the neck.
  • the floppy section which is made of silicone rabber, is then routed through the neck to the middle of the back (between the shoulder blades) where the drug delivery apparatus is implanted.
  • the floppy section needs to be of sufficient length so as to allow for routing to the desired location. This is typically 10 - 50 cm for a between the shoulder blades location. (See attached Figure)
  • the length can be longer if the dispensing device needs to be located in another region of the body (such as the abdomen).
  • the invention may be used to deliver drags to the putainment of the brain. This embodiment would, or course, require a longer catheter tip, since the putainment is deep within the brain. In other embodiments, the invention may be used to deliver drugs to the spinal cord, or the eye or to any delicate area such as a nerve plexus.
  • the catheter of the invention maybe adapted for use in long-term delivery of a drug, and for this purpose may be communicably attached to a drug reservoir and/or a pump.
  • a drug reservoir and/or a pump Many kinds of pump and/or drag reservoir could be used, including, for example an osmotic pump, an electromechanical pump, an electroosmotic pump, an effervescent pump, a hydraulic pump, a piezoelectric pump, an elastomeric pump, a vapor pressure pump, or and an electrolytic pump.
  • Such a pump may be externally worn or may be implanted subcutaneously, or within tissues, at any convenient location in the body, for example between the shoulder-blades, such that the pump may effectively deliver a desired amount of a drug at a desired rate, via the catheter, to the target tissue.
  • the rate of drug delivery may be varied as clinically appropriate. Practically any rate of delivery is possible depending on the pump used and may, for example be from about 0.01 microliters per day to about 2 milliliters per day.
  • a possible rate of daily delivery may be, for example 10 microliters per day.
  • an osmotic pump such as the Duros®
  • the rigid catheter tip is 2.5 cm in length.
  • the floppy section is 25 cm long, is made of silicone rabber, and is routed through the neck to the middle of the back (between the shoulder blades) where the drag delivery apparatus is implanted.
  • the catheter is attached to a drag delivery apparatus.
  • the drag delivery apparatus is an osmotic pump filled with a pharmaceutically acceptable formulation of carboplatin.
  • the catheter tip is implanted into the brain stem, and affixed in place by fixing it to the skull bone using a cyanoacrylate adhesive.
  • the catheter tip is placed by stereotaxis, in close proximity to the target site, which is a tumor within the brain stem.
  • the drag delivery apparatus and the catheter of the invention are implanted for a period of three months, during which time it delivers carboplatin at a rate of 10 microliters per day, thereby treating the tumor.
  • the catheter of the invention has been tested in vivo on primates. Two cynomologous monkeys were implanted with the catheter of the invention. The catheter used was a blunt-tipped catheter with side-pores extending 3-4 mm from the tip. The posterior aspect of the cranium was penetrated with a drill through the occipital bone, and then the catheter was placed through the cerebellum and fourth ventricle into the roof of the pons. The catheter tip was held in place by fixing it to the skull bone using cyanoacrylate adhesive. The floppy distal section of the catheter was routed subcutaneously through the neck to the middle of the back, and connected to an osmotic pump. See Figs. 5 and 6.
  • the osmotic pump was implanted subcutaneously between the shoulder blades. Saline was delivered from the pump, via the catheter continuously for a period of three months at a rate of 0.41 microliters per hour (about 10 microliters per day). No ill effects were observed in the subjects over the entire three-month period.
  • This in vivo experiment shows that the catheter described herein can be successfully implanted into the brain stem of a mammal, and used to deliver a substance to the brain stem over a period of three months without any observable ill-effects.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Le cathéter de l'invention présente une configuration adaptée pour l'implanter, et le fixer en place, sans trocart ni canule, de façon à réduire au minimum les dégâts sur les tissus aussi bien pendant l'opération d'implantation, qu'après, pendant la période où le cathéter demeure implanté. Dans un mode de réalisation, le cathéter peut être utilisé pour amener un médicament, sur une longue période, vers un site précis, par exemple dans le traitement d'une tumeur inopérable du tronc cérébral. Dans un autre mode de réalisation, le cathéter de l'invention peut être implanté, maintenu en place, et utilisé pour conduire, de façon répétée, des doses posologiques vers une même cible, pendant un certain temps, sans qu'il soit nécessaire de réimplanter de façon répétée un aiguille à travers des tissus pour accéder au site cible.
EP02749940A 2001-06-27 2002-06-27 Catheter pour administration de medicaments a invasion minimale Withdrawn EP1409040A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30163101P 2001-06-27 2001-06-27
US301631P 2001-06-27
PCT/US2002/021945 WO2003002170A2 (fr) 2001-06-27 2002-06-27 Catheter pour administration de medicaments a invasion minimale

Publications (2)

Publication Number Publication Date
EP1409040A2 EP1409040A2 (fr) 2004-04-21
EP1409040A4 true EP1409040A4 (fr) 2009-08-12

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EP02749940A Withdrawn EP1409040A4 (fr) 2001-06-27 2002-06-27 Catheter pour administration de medicaments a invasion minimale

Country Status (3)

Country Link
EP (1) EP1409040A4 (fr)
AU (1) AU2002320423A1 (fr)
WO (1) WO2003002170A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8946151B2 (en) 2003-02-24 2015-02-03 Northern Bristol N.H.S. Trust Frenchay Hospital Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
US8246569B1 (en) 2004-08-17 2012-08-21 California Institute Of Technology Implantable intraocular pressure drain
ATE497797T1 (de) 2006-03-14 2011-02-15 Univ Southern California Mems-vorrichtung zur wirkstofffreisetzung
US7988674B2 (en) * 2006-10-30 2011-08-02 Medtronic, Inc. Externally releasable body portal anchors and systems
GB0802634D0 (en) * 2008-02-13 2008-03-19 Renishaw Plc Catheter
US8480626B2 (en) 2007-11-30 2013-07-09 Medtronic, Inc. Infusion catheter assembly with reduced backflow
EP2242464B2 (fr) 2007-12-20 2017-03-01 University Of Southern California Appareil pour distribuer des agents thérapeutiques
EP2727616B1 (fr) 2008-01-03 2017-04-26 University Of Southern California Dispositifs de distribution de médicaments implantables, appareil et procédés de remplissage des dispositifs
MX2010012212A (es) 2008-05-08 2011-09-27 Minipumps Llc Dispositivos implantables para suministro de fármacos, y áparato y métodos para llenar los dispositivos.
WO2009137780A2 (fr) 2008-05-08 2009-11-12 Replenish Pumps, Llc Pompes implantables et canules à cet effet
EP2323716B1 (fr) 2008-05-08 2015-03-04 MiniPumps, LLC Pompes d'administration de médicaments
US9333297B2 (en) 2008-05-08 2016-05-10 Minipumps, Llc Drug-delivery pump with intelligent control
WO2011022484A1 (fr) 2009-08-18 2011-02-24 Replenish Pumps. Llc Pompe électrolytique d'administration de médicament avec commande adaptative
US9919099B2 (en) 2011-03-14 2018-03-20 Minipumps, Llc Implantable drug pumps and refill devices therefor
US10286146B2 (en) 2011-03-14 2019-05-14 Minipumps, Llc Implantable drug pumps and refill devices therefor
US9603997B2 (en) 2011-03-14 2017-03-28 Minipumps, Llc Implantable drug pumps and refill devices therefor

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991017787A1 (fr) * 1990-05-23 1991-11-28 Atos Medical Ab Drain, dispositif servant a appliquer ce drain et procede servant a appliquer un drain sinusal
US5683370A (en) * 1996-06-06 1997-11-04 Luther Medical Products, Inc. Hard tip over-the-needle catheter and method of manufacturing the same
US5873864A (en) * 1995-12-18 1999-02-23 Luther Medical Products, Inc. Catheter with beveled needle tip
US5997524A (en) * 1997-07-18 1999-12-07 Vasca, Inc. Catheter assembly for percutaneous access to subcutaneous port
WO2000013728A1 (fr) * 1998-09-03 2000-03-16 Luther Ronald B Aiguille d'injection intraveineuse en materiau mou

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1049287A (zh) * 1989-05-24 1991-02-20 住友电气工业株式会社 治疗导管
US5380307A (en) * 1992-09-30 1995-01-10 Target Therapeutics, Inc. Catheter with atraumatic drug delivery tip
US5620479A (en) * 1992-11-13 1997-04-15 The Regents Of The University Of California Method and apparatus for thermal therapy of tumors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991017787A1 (fr) * 1990-05-23 1991-11-28 Atos Medical Ab Drain, dispositif servant a appliquer ce drain et procede servant a appliquer un drain sinusal
US5873864A (en) * 1995-12-18 1999-02-23 Luther Medical Products, Inc. Catheter with beveled needle tip
US5683370A (en) * 1996-06-06 1997-11-04 Luther Medical Products, Inc. Hard tip over-the-needle catheter and method of manufacturing the same
US5997524A (en) * 1997-07-18 1999-12-07 Vasca, Inc. Catheter assembly for percutaneous access to subcutaneous port
WO2000013728A1 (fr) * 1998-09-03 2000-03-16 Luther Ronald B Aiguille d'injection intraveineuse en materiau mou

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EP1409040A2 (fr) 2004-04-21
WO2003002170A2 (fr) 2003-01-09
AU2002320423A1 (en) 2003-03-03

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