EP1406663A2 - Pflanzliche polymerzusammensetzung mit immobilisierten wirkstoffen - Google Patents
Pflanzliche polymerzusammensetzung mit immobilisierten wirkstoffenInfo
- Publication number
- EP1406663A2 EP1406663A2 EP02703667A EP02703667A EP1406663A2 EP 1406663 A2 EP1406663 A2 EP 1406663A2 EP 02703667 A EP02703667 A EP 02703667A EP 02703667 A EP02703667 A EP 02703667A EP 1406663 A2 EP1406663 A2 EP 1406663A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- composition according
- gel
- water
- polymer
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 31
- 229920000642 polymer Polymers 0.000 title claims abstract description 26
- 235000013311 vegetables Nutrition 0.000 title abstract description 5
- 239000013543 active substance Substances 0.000 title description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 230000000694 effects Effects 0.000 claims abstract description 15
- 239000002537 cosmetic Substances 0.000 claims abstract description 12
- 235000005911 diet Nutrition 0.000 claims abstract description 12
- 230000000378 dietary effect Effects 0.000 claims abstract description 12
- 230000000903 blocking effect Effects 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 239000004480 active ingredient Substances 0.000 claims description 8
- 230000000994 depressogenic effect Effects 0.000 claims description 7
- 230000002255 enzymatic effect Effects 0.000 claims description 7
- 102000004190 Enzymes Human genes 0.000 claims description 6
- 108090000790 Enzymes Proteins 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 6
- 235000000346 sugar Nutrition 0.000 claims description 5
- 239000003963 antioxidant agent Substances 0.000 claims description 4
- 150000008163 sugars Chemical class 0.000 claims description 4
- 102000016938 Catalase Human genes 0.000 claims description 3
- 108010053835 Catalase Proteins 0.000 claims description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- 102000003992 Peroxidases Human genes 0.000 claims description 3
- 238000009472 formulation Methods 0.000 claims description 3
- 230000036542 oxidative stress Effects 0.000 claims description 3
- 108040007629 peroxidase activity proteins Proteins 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- 239000011573 trace mineral Substances 0.000 claims description 2
- 235000013619 trace mineral Nutrition 0.000 claims description 2
- 239000011782 vitamin Substances 0.000 claims description 2
- 229940088594 vitamin Drugs 0.000 claims description 2
- 229930003231 vitamin Natural products 0.000 claims description 2
- 235000013343 vitamin Nutrition 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 238000001223 reverse osmosis Methods 0.000 claims 1
- 235000010356 sorbitol Nutrition 0.000 claims 1
- 230000000881 depressing effect Effects 0.000 abstract 1
- 239000000499 gel Substances 0.000 description 18
- 241000196324 Embryophyta Species 0.000 description 8
- 241000282472 Canis lupus familiaris Species 0.000 description 6
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 6
- 235000019441 ethanol Nutrition 0.000 description 6
- 230000009469 supplementation Effects 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 229920002494 Zein Polymers 0.000 description 4
- 229940088598 enzyme Drugs 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000005019 zein Substances 0.000 description 4
- 229940093612 zein Drugs 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 239000008121 dextrose Substances 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 108060006613 prolamin Proteins 0.000 description 3
- XXRYFVCIMARHRS-UHFFFAOYSA-N propan-2-yl n-dimethoxyphosphorylcarbamate Chemical compound COP(=O)(OC)NC(=O)OC(C)C XXRYFVCIMARHRS-UHFFFAOYSA-N 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 108010061711 Gliadin Proteins 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 description 2
- 229940089206 anhydrous dextrose Drugs 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 235000015872 dietary supplement Nutrition 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 238000004898 kneading Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 102000006587 Glutathione peroxidase Human genes 0.000 description 1
- 108700016172 Glutathione peroxidases Proteins 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000008271 cosmetic emulsion Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- -1 sorbitol sugars Chemical class 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 229940032362 superoxide dismutase Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- composition based on plant polymers immobilizing active ingredients.
- the invention relates to a composition for dietetic or cosmetic use based on edible vegetable polymers, the process for obtaining such a composition and its use.
- Plant polymers are numerous, in particular in the form of structural polysaccharides such as cellulose or functional polysaccharides such as starch. Apart from cellulose derivatives, plant polymers are not widely used in dosage form for the oral route.
- microspheres are produced from corn prolamins (zein).
- zein corn prolamins
- This process consists in producing a solution of zein in a solvent (alcohol), of introducing the active substance, for example insulin, and to mix with this solution another immiscible solvent such as a vegetable oil with zein.
- the alcohol is evaporated and the particles of Zein are separated and dried. This process is technically heavy and does not make it possible to encapsulate all the active agents according in particular to their solubilities.
- the present invention proposes to overcome the drawbacks of the prior art, and in particular to solve the problems of bio-availability and stability of active substances so as to finally make possible and effective by oral or topical route their release in the human or animal organism.
- the subject of the present invention is a composition for dietetic or cosmetic use based on at least one plant polymer containing immobilized active principles capable of being obtained by blocking the activity of water in the gel of the polymer. by adding and mixing depressant or osmosis products.
- composition for dietetic or cosmetic use based on plant polymers such as plant prolamins contains active ingredients which are introduced into the polymer gel.
- Another subject of the invention relates to a process for the preparation of such a dietetic or cosmetic composition consisting in: a) gelling the polymer according to known techniques b) incorporate the active ingredient (s) into the hydroalcoholic gel prepared in a) c) block the activity of the water by addition to the osmosis gel to have an Aw value less than or equal to 0.7. d) dry at low temperature, if necessary until a dry powder is obtained.
- Such a method also makes it possible to obtain a composition in which the active ingredients are preserved and immobilized very quickly.
- the invention also relates to the use of the dietetic or cosmetic composition as described above, in formulation for combating the effects of oxidative stress.
- the invention relates to the use of the composition as described above as a human or veterinary drug.
- the composition for dietetic or cosmetic use contains vegetable polymers such as vegetable prolamins and active principles which are introduced into the polymer gel. This is generally obtained by a solvent containing a high proportion of water and ethyl alcohol. The techniques are known to those skilled in the art.
- the water activity in the polymer gel is blocked by adding and mixing depressant or osmosis products, such as sugars, for example.
- osmosis or depressants most of the sugars such as dextrose, sucrose.
- sugars such as dextrose, sucrose.
- Liquids are able to be added by their PAw blocking capacity, there may be mentioned glycerol, alcohol.
- the level of blocking according to the invention of the water activity (Aw) in the prolamine gel used is preferably fixed at a value less than or equal to 0.7.
- the blocking of the water activity can be obtained at this value by adding depressant or osmosis products to the polymer gel in quantities of between 1.5 and 15 times the amount of water by weight contained in the polymer gel. , for example.
- Aw equal to or less than 0.7 there is no appearance or development of molds, yeasts, bacteria.
- the dietary and cosmetic composition according to the invention may contain active ingredients chosen from the group of trace elements, that of enzymes, that of enzymes, and that of vitamins.
- this dietary and cosmetic composition comprises and immobilizes antioxidants of enzymatic origins such as catalase, superoxydismutase (SOD) or peroxidase alone, together or in combination.
- antioxidants of enzymatic origins such as catalase, superoxydismutase (SOD) or peroxidase alone, together or in combination.
- the way of proceeding in order to obtain the composition consists in this case of: a) gelling the prolamine polymer according to the known existing technique, b) incorporating the active agent into the hydroalcoholic gel prepared in a), c) blocking the activity of water by addition to the osmosis gel such as anhydrous dextrose. d) dry at low temperature to obtain a powder, if necessary.
- compositions thus stabilized resides in the intimate dispersion by kneading of the gel in the mass of pulverulent substances provided by the depressants. This procedure makes it possible to create hydrophobic micro-particles of prolamines, which incorporate the active ingredients.
- the powder obtained (c) can be very easily dispersed in water by disintegrating quickly while retaining the active particles enclosing the active agents in suspension. Similarly, such a suspension allows particles of active ingredients to be introduced into cosmetic compositions.
- Example 1 Nutraceutical formulation for a 500 mg tablet
- a fine powder is obtained by drying at room temperature, which is compressed.
- the depressant consists of a percentage mixture of: 23% sucrose, 16% dextrose, 5% sorbitol, 5% sodium chloride, 1% citric acid and 50% ethyl alcohol.
- the amount of depressants represents one tenth of the amount of water in the gel prepared as in Example 1.
- Example 3 In Vivo Tests with the Powder Obtained in Example 1
- a yogurt is added in an amount of 80 mg of powder.
- Example 1 During the preparation of an anti-aging cream, 2% of powder is added as in Example 1.
- Example 6 Clinical study showing the bioavailability of SOD on exercise dogs:
- the aim of the study is to compare different modes of administration of an enzymatic complex with antioxidant activity on dogs by evaluating and measuring their biological effects.
- a pack of 24 Siberian Husky dogs living in the same kennel and undergoing quantifiable physical training receiving the same basic food (Iam's 30/20) are randomized into 3 groups of 8 animals.
- Group 3 Supplementation with the same amount of enzyme complex as for group 2 but vectorized according to the invention and example 1, at a rate of 100 mg per day (lot 3)
- a jugular venous blood sample according to standardized conditions at 9 hours in the morning and on an empty stomach is carried out on each dog.
- control batch 1 or placebo
- batch 2 supplemented by the antioxidant enzyme complex alone.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Dermatology (AREA)
- Food Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0101624 | 2001-02-07 | ||
| FR0101624A FR2820323B1 (fr) | 2001-02-07 | 2001-02-07 | Composition dietetique et cosmetique a base de polymeres vegetaux immobilisant des actifs |
| PCT/FR2002/000462 WO2002062394A2 (fr) | 2001-02-07 | 2002-02-06 | Composition a base de polymeres vegetaux immobilisant des actifs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP1406663A2 true EP1406663A2 (de) | 2004-04-14 |
Family
ID=8859707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP02703667A Withdrawn EP1406663A2 (de) | 2001-02-07 | 2002-02-06 | Pflanzliche polymerzusammensetzung mit immobilisierten wirkstoffen |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP1406663A2 (de) |
| FR (1) | FR2820323B1 (de) |
| WO (1) | WO2002062394A2 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2836827B1 (fr) * | 2002-03-07 | 2010-10-01 | Innoform Sa | Composition dietetique et cosmetique a base de polymeres naturels reticules immobilisant des actifs |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR412208A (fr) * | 1909-03-05 | 1910-07-07 | Siemens Et Cie Soc Geb | Procédé de fabrication de corps moulés réfractaires au feu et aux acides |
| US3092553A (en) * | 1959-01-30 | 1963-06-04 | Jr Carl E Fisher | Pharmaceutical preparations and method and apparatus for making same |
| CH437995A (de) * | 1963-11-01 | 1967-06-15 | Hoffmann La Roche | Verfahren zur Gewinnung von lipophile Substanzen enthaltenden Präparaten |
| EP0434760B1 (de) * | 1988-09-19 | 1994-01-12 | Opta Food Ingredients, Inc. | Hydrophobe proteinmikroteilchen und verfahren zur herstellung |
| ATE133856T1 (de) * | 1989-11-06 | 1996-02-15 | Alkermes Inc | Herstellungsverfahren für proteinmikrosphären |
| US5271961A (en) * | 1989-11-06 | 1993-12-21 | Alkermes Controlled Therapeutics, Inc. | Method for producing protein microspheres |
| FR2729296B1 (fr) * | 1995-01-12 | 1997-03-28 | Europlanaire | Compositions pharmaceutiques comprenant une superoxyde dismutase |
| ATE254909T1 (de) * | 1995-03-29 | 2003-12-15 | Shionogi & Co | Gelatinkapsel mit eingestellter wasseraktivität |
| FR2759288A1 (fr) * | 1997-02-12 | 1998-08-14 | Gredeco Groupe De Rech En Derm | Nouveau gel a base de gliadine |
-
2001
- 2001-02-07 FR FR0101624A patent/FR2820323B1/fr not_active Expired - Fee Related
-
2002
- 2002-02-06 EP EP02703667A patent/EP1406663A2/de not_active Withdrawn
- 2002-02-06 WO PCT/FR2002/000462 patent/WO2002062394A2/fr not_active Application Discontinuation
Non-Patent Citations (1)
| Title |
|---|
| See references of WO02062394A2 * |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2820323B1 (fr) | 2004-10-08 |
| WO2002062394A2 (fr) | 2002-08-15 |
| FR2820323A1 (fr) | 2002-08-09 |
| WO2002062394A3 (fr) | 2002-11-28 |
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