EP1386153A2 - Sondes a photoaffinite pour l'oxazolidinone, modes d'utilisation et composes associes - Google Patents

Sondes a photoaffinite pour l'oxazolidinone, modes d'utilisation et composes associes

Info

Publication number
EP1386153A2
EP1386153A2 EP01993282A EP01993282A EP1386153A2 EP 1386153 A2 EP1386153 A2 EP 1386153A2 EP 01993282 A EP01993282 A EP 01993282A EP 01993282 A EP01993282 A EP 01993282A EP 1386153 A2 EP1386153 A2 EP 1386153A2
Authority
EP
European Patent Office
Prior art keywords
probe
biological target
methyl
oxo
photoaffinity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01993282A
Other languages
German (de)
English (en)
Inventor
Gerard R. Colca
William Gerald Mcdonald
Dean L. Shinabarger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Publication of EP1386153A2 publication Critical patent/EP1386153A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9446—Antibacterials

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention se rapporte à de nouvelles méthodes permettant d'identifier des cibles biologiques de composés présentant une activité antimicrobienne. Cette invention concerne également de nouvelles méthodes permettant d'identifier des composés pouvant présenter une activité antimicrobienne.
EP01993282A 2000-12-15 2001-12-14 Sondes a photoaffinite pour l'oxazolidinone, modes d'utilisation et composes associes Withdrawn EP1386153A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25605300P 2000-12-15 2000-12-15
US256053P 2000-12-15
PCT/US2001/048455 WO2002056013A2 (fr) 2000-12-15 2001-12-14 Sondes a photoaffinite pour l'oxazolidinone, modes d'utilisation et composes associes

Publications (1)

Publication Number Publication Date
EP1386153A2 true EP1386153A2 (fr) 2004-02-04

Family

ID=22970924

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01993282A Withdrawn EP1386153A2 (fr) 2000-12-15 2001-12-14 Sondes a photoaffinite pour l'oxazolidinone, modes d'utilisation et composes associes

Country Status (5)

Country Link
EP (1) EP1386153A2 (fr)
JP (1) JP2004537265A (fr)
AU (1) AU2002245127A1 (fr)
CA (1) CA2432162A1 (fr)
WO (1) WO2002056013A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1443930A1 (fr) 2001-10-25 2004-08-11 AstraZeneca AB Derives d'isoxazoline utilises en tant qu'agents antimicrobiens
EP1892530A1 (fr) * 2006-08-25 2008-02-27 Boehringer Ingelheim Pharma GmbH & Co. KG Procédé de détermination de l'activité de transport d'une protéine de transport
WO2008046584A2 (fr) * 2006-10-16 2008-04-24 Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften Facteur lepa utilisé en tant que cible pour des agents antibactériens
WO2023215497A1 (fr) * 2022-05-04 2023-11-09 Promega Corporation Composés photoactivables et leurs utilisations

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002048139A2 (fr) * 2000-12-15 2002-06-20 Pharmacia & Upjohn Company Sonde de photo-affinite a base d'oxazolidinone

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002048139A2 (fr) * 2000-12-15 2002-06-20 Pharmacia & Upjohn Company Sonde de photo-affinite a base d'oxazolidinone

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO02056013A3 *

Also Published As

Publication number Publication date
CA2432162A1 (fr) 2002-07-18
JP2004537265A (ja) 2004-12-16
WO2002056013A3 (fr) 2003-11-06
WO2002056013A2 (fr) 2002-07-18
AU2002245127A1 (en) 2002-07-24

Similar Documents

Publication Publication Date Title
US8835476B2 (en) Synthesis of novel antimicrobials
JP5733760B2 (ja) 蛍光発生分子および標的核酸検出方法
EP1386153A2 (fr) Sondes a photoaffinite pour l'oxazolidinone, modes d'utilisation et composes associes
Chaparian et al. Hierarchical transcriptional control of the LuxR quorum-sensing regulon of Vibrio harveyi
Kuboyama et al. Stoichiometry-focused 18F-labeling of alkyne-substituted oligodeoxynucleotides using azido ([18F] fluoromethyl) benzenes by Cu-catalyzed Huisgen reaction
US20150321164A1 (en) Method for synthesizing and screening lead compound and reagent testing kit
Vo et al. Design of multimodal small molecules targeting miRNAs biogenesis: Synthesis and in vitro evaluation
CN110308124A (zh) 含有苯并噻唑类化合物的荧光探针在检测细菌信使分子c-di-GMP中的应用
US6861433B2 (en) Oxazolidinone photoaffinity probes
Sadeghzadeh et al. Development and radiosynthesis of the first 18F‐labeled inhibitor of monocarboxylate transporters (MCTs)
CN114524792A (zh) 具有抗菌增敏活性的双芳基衍生物及其在抗菌中的应用
CN102516141B (zh) 五羟色胺转运体显像剂[18f]-fpbm的标记方法
Park et al. Role of the C (5)− C (5a) Exomethylene Group in Bicyclomycin: Synthesis, Structure, and Biochemical and Biological Properties
CN111170895B (zh) 一种2-羟基胍类化合物及其制备方法
CN112898285A (zh) 含三氟甲基双噁唑类化合物及其合成方法和在抗癌药物中的应用
JP4011937B2 (ja) ミスマッチ検出分子
Braga et al. Synthesis of new 1, 2, 4-oxadiazoles carrying (1'S, 2'S)-t-butyloxycarbonyl-1-amino-2-methyl-1-butyl and (1'S)-t-butyloxycarbonyl-1'-amino-1'-ethyl groups at C-5
JP2002535680A (ja) 延長因子ｐ活性モジュレーターのアッセイ方法
Venkatachalam et al. Challenges in the automated synthesis of [18F]-1-fluoroethyl tryptophan: Formation of both O-and N-alkylated products
TWI373468B (en) Method for preparation of amido pyrazole
Singh et al. Synthesis, Antitubercular Activity, Molecular Modeling and Docking Studies of Novel Thiazolidin-4-One Linked Dinitrobenzamide Derivatives
Seo et al. Development of PRPK Directed Phthalimides
WO2020246616A1 (fr) Sonde fluorescente pour la détection de l'activité de l'enpp
JP2005221394A (ja) フォトアフィニティービーズ、アフィニティー吸着体及び標的物質の分離・精製方法
JPH10104230A (ja) 核酸等の検出方法，並びに標識物質及び検出物質

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20030625

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: PHARMACIA & UPJOHN COMPANY LLC

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: PHARMACIA & UPJOHN COMPANY LLC

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20060930