Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/20—Halogens; Compounds thereof
  • A61K8/21—Fluorides; Derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/69—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/11—Encapsulated compositions
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
  • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/73—Polysaccharides
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/73—Polysaccharides
  • A61K8/733—Alginic acid; Salts thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
  • A61K2800/41—Particular ingredients further characterized by their size
  • A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns

Definitions

• This invention relates to ingestable calcium carbonate compositions, a method for
• this invention relates to treated calcium carbonate materials
• Calcium carbonate is used in food products and dietary supplements as well as
• Another factor may be the chemical property such as
• Calcium carbonate as a cleaning abrasive is a commonly used component in
• toothpaste and tooth powders Another component in toothpaste and tooth powders can be any component in toothpaste and tooth powders. Another component in toothpaste and tooth powders can be any component in toothpaste and tooth powders.
• Calcium carbonate can react with fluoride to enhance enamel protection.
• European Patent Application No. 0 219 483 discloses a treated calcium carbonate
• abrasive comprising pulverized calcium carbonate in a liquid dispersion with an alkali
• U.S. Pat. No. 4,357,318 discloses a dentifrice comprising a water soluble
• monofluorophosphate salt as a source of soluble fluoride in a therapeutically effective anti-caries concentration, an effective abrasive amount of calcium carbonate and a dibasic
• alkali metal phosphate said dentifrice being devoid of benzyl alcohol.
• U.S. Pat. No. 3, 930, 305 discloses a dental cream containing an abrasive system
• thickening agent to impart to the dental cream the pasty consistency, body and the non
• cream having a granular textured appearance comprising dispersed non-crystalline
• composition comprising a precipitated amorphous silicon dioxide.
• the abrasive composition when incorporated into toothpaste compositions containing a fluoride
• U.S. Pat. No. 5,939,051 discloses a dentifrice composition, comprising an orally
• U.S. Pat. No. 5,891,448 discloses a two-component system for delayed sustained
• second component is isolated from the reaction with the first component during storage
• the inhibitor produces a delay
• the level of phosphate in the system is less than the concentration needed for significant
• U.S. Pat. No. 5,723,107 discloses a method for fluoridating teeth utilizing a semi-
• the steps include preparing as a first
• component a semi-solid, extrudable dentifrice composition containing a fluoride ion
• the fluoride compound is stable, the vehicle being free of abrasive and surfactant and containing xanthan gum as the major thickening agent and glycerin, sorbitol or
• aqueous dentifrice composition containing a calcium ion releasable compound and an
• abrasive in an aqueous vehicle contains xanthan gum as the major thickening agent and
• the first and second dentifrice are glycerin, sorbitol or mixtures thereof as the humectant.
• multi-component composition is hydrolyzed, and calcium fluoride is precipitated from
• the reactive multi-component composition is a mixture of the reactive multi-component composition.
• the reactive multi-component composition is a mixture of the reactive multi-component composition.
• An object of the present invention is to produce a calcium carbonate particle that
• Another object of the present invention is to provide a process for producing
• a further object of the present invention is to provide calcium carbonate
• the present invention solves the problem of fluoride stability in toothpaste when
• calcium carbonate is used as an abrasive.
• calcium carbonate is
• the present invention is a fluoride compatible surface treated calcium carbonate
• the present invention also solves the problem of chalkiness taste when ingesting
• the present invention also provides enhanced shelf life to material using the
• the present invention relates to a surface treated calcium carbonate particle in
• the ingestible material can be any material for consumption, such as
• presence of a calcium carbonate particle in such material can be for any of a variety of
• Suitable calcium carbonate particles that may be surface treated by the process of
• the present invention include calcium carbonate particles having the morphological forms
• particles may also be synthetically produced precipitated calcium carbonate (PCC) or
• a preferred calcium carbonate particle has a median
• particle size of from about 0.5 to about 30 micrometers, preferably from about 1 to about
• invention is from about 0.5 meters square per gram to about 50 meters square per gram.
• a preferred specific surface area is from about 1 to about 10 meters square per gram.
• the specific surface area of the calcium carbonate is defined herein as the area per unit
• Suitable surface treating agents include fatty acids and polysaccharides.
• fatty acids that are useful in the present invention have the general chemical formula of CH 3 (CH 2 ) x CO 2 H, in which X ranges from about 2 to about 20, more preferably from about 8 to about 20.
• the fatty acid can be saturated or unsaturated. Substitution is
• Preferred fatty acids have the common names of
• the treating level can be affected by the surface area of the calcium carbonate in that as the particle size decreases, the treating level increases.
• Preferred polysaccharides used in the present invention have nine or more units
• monosaccharides C 6 H 12 O 6 linked by glycosidic bonds and include, but are not limited to, gums, starches and mucilages.
• Other preferred polysaccharides that are useful in the present invention may be selected from the group consisting of alginates,
• the treating level increases generally.
• One preferred polysaccharide form is starch. Starches that are useful in the
• present invention may be selected from the group consisting of potato, corn, tapioca,
• the treating level for starches can range from about 0.05 percent to about 20 percent, preferably from about 0.05 percent to about 4
• the treating level is affected by
• the treating level increases.
• Mucilages that are
• the treating level is tragacanth mucilage, yellow or white mustard mucilages and the like.
• mucilages can range from about 0.05 percent to about 20 percent, preferably from
• the treating level is affected by the surface area of the calcium carbonate. What this is possible.
• the treating level increases.
• the fatty acids can be applied to calcium carbonate by
• Dry coating is achieved by adding stearic acid to a dry calcium carbonate
• calcium carbonate is treated with the fatty acid.
• the calcium carbonate of the present invention so treated is particularly suitable for use in mouthwashes, dentifrices, gels,
• An alternative method to dry coating is to wet coat the calcium carbonate.
• coating is achieved by adding a solution or emulsion of fatty acids or polysaccharides
• the calcium carbonate slurry including gums, starches and mucilages to a calcium carbonate slurry.
• carbonate slurry is prepared by synthesizing calcium carbonate in an aqueous
• Another alternative method for treating the calcium carbonate is by adding dry
• carbonate is by adding dry fatty acids or polysaccharides including gums, starches and
• the treated calcium carbonate abrasive of this invention can be used as the sole
• abrasives include water-insoluble sodium or potassium metaphosphates, hydrated or anhydrous dicalcium phosphate, sodium bicarbonate,
• calcium pyrophosphate various forms of silica, zirconium, silicate and the like.
• the total amount of abrasives employed in oral hygiene products can range from
• toothpaste contains from 20 percent to 60 percent by weight of abrasive.
• average particle size preferably ranges from about 2 microns to 20 microns.
• binders binders, humectants, flavoring agents, sweetening agents and water.
• Suitable fluoride compounds can be any of the compounds previously mentioned
• Suitable sudsing agents are generally anionic organic synthetic detergents active
• C 10 -C lg alkyl sulfates such as sodium lauryl sulfate; of sulfonated monoglycerides of fatty acids, such as sodium monoglyceride sulfonates; of fatty acid amides of taurine,
• aliphatic acylamides such as sodium N-lauroyl sarcosinate.
• Suitable binders or thickening agents to provide the desired consistency are, for
• hydroxyethylcellulose sodium carboxymethylcellulose
• natural gums such as
• gum karaya gum arabic
• gum tragacanth colloidal silicates and finely divided silica.
• composition Generally, from 0.5 percent to 5 percent by weight of the composition can be used.
• humectants such as glycerine, sorbitol and other
• Suitable flavoring agents include oil of wintergreen, oil of spearmint, oil of peppermint, oil of clove, oil of sassafras and the like. Saccharin, aspartame, dextrose,
• levulose can be used as sweetening agents.
• XPS X-ray Photoelectron Spectroscopy
• ESCA Electron
• 1.5 percent of the atoms on the surface are fluorine ions that are attached to a sodium
• the Hefferren method measures the Radioactive Dentin Abrasivity (RDA) number, also
• Al Abrasivity Index
• human teeth which are irradiated by a neutron flux.
• the teeth are mounted and brushed
• results are compared to a reference abrasive provided by the American Dental Association (ADA).
• ADA American Dental Association
• Al Abrasivity Index
• polysaccharides xanthan, and carboxymethylcellulose also increase
• Stearic acid and guar gum treated GCC are in the medium abrasive range.

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Epidemiology (AREA)
• Birds (AREA)
• Chemical & Material Sciences (AREA)
• Inorganic Chemistry (AREA)
• Emergency Medicine (AREA)
• Oral & Maxillofacial Surgery (AREA)
• Cosmetics (AREA)

Applications Claiming Priority (1)

Publications (1)

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Family Applications (1)

Country Status (11)

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Family Cites Families (5)

• 2001
  • 2001-04-24 EP EP01930657A patent/EP1383476A1/de not_active Withdrawn
  • 2001-04-24 CN CNA018231802A patent/CN1505501A/zh active Pending
  • 2001-04-24 BR BR0116983-1A patent/BR0116983A/pt not_active IP Right Cessation
  • 2001-04-24 KR KR10-2003-7013800A patent/KR20030090781A/ko not_active Application Discontinuation
  • 2001-04-24 JP JP2002582894A patent/JP2004527539A/ja active Pending
  • 2001-04-24 WO PCT/US2001/013056 patent/WO2002085319A1/en active Application Filing
  • 2001-04-24 CA CA002443747A patent/CA2443747A1/en not_active Abandoned
  • 2001-04-24 PL PL01363310A patent/PL363310A1/xx not_active Application Discontinuation
  • 2001-04-24 SK SK1300-2003A patent/SK13002003A3/sk unknown
• 2003
  • 2003-10-20 TW TW092129009A patent/TW200514574A/zh unknown
  • 2003-10-21 NO NO20034712A patent/NO20034712D0/no not_active Application Discontinuation

Non-Patent Citations (1)

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