EP1383473A2 - Preparations cosmetiques et dermatologiques renfermant un extrait de houblon ou de houblon-malt et leur utilisation pour la reduction de la secretion de sebum cutane - Google Patents

Preparations cosmetiques et dermatologiques renfermant un extrait de houblon ou de houblon-malt et leur utilisation pour la reduction de la secretion de sebum cutane

Info

Publication number
EP1383473A2
EP1383473A2 EP02740431A EP02740431A EP1383473A2 EP 1383473 A2 EP1383473 A2 EP 1383473A2 EP 02740431 A EP02740431 A EP 02740431A EP 02740431 A EP02740431 A EP 02740431A EP 1383473 A2 EP1383473 A2 EP 1383473A2
Authority
EP
European Patent Office
Prior art keywords
hop
skin
sebum
cosmetic
malt extract
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02740431A
Other languages
German (de)
English (en)
Inventor
Stefan Gallinat
Andreas Herpens
Helga Biergiesser
Kirsten Venzke
Franz STÄB
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of EP1383473A2 publication Critical patent/EP1383473A2/fr
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/008—Preparations for oily skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/008—Preparations for oily hair

Definitions

  • the present invention relates to the use of topical preparations for reducing sebum production, for maintaining normal sebum homeostasis, for removing sebum from the skin, in particular for removing and clarifying comedones, for preventing comedone formation, for reducing pore size, for prophylaxis and for treatment seborrhea and blemished skin, for the treatment of mild forms of acne as well as against oily hair and dandruff.
  • Sebum is the secretion of the sebum gland. Sebaceous glands are bulges of the follicular epithelium and therefore part of the follicle with which they form a functional unit. They are holocrine glands, which means that the entire glandular cell is largely converted into the sebum secretion. The cells of the sebum gland, which are constantly renewed from below, become fat and disintegrate, and the skin sebum thus formed is emptied onto the surface of the skin through the follicle openings.
  • This surface film is an emulsion, which can be a water-in-oil or an oil-in-water emulsion. It has the function to keep the skin surface supple and to regulate the water content of the deep-lying skin layers. With good hydration of the sebum, the water content is at least 10 to 20% by weight and the sebum is hydrophilic. If the hydrophilic-hpophile balance of the surface film is no longer present and the water content drops, this is how the sebum changes and becomes hydrophobic. The outflow of sebum from the sebaceous gland and follicle is obstructed. Skin sebum stagnates in the follicular mouths, which can then lead to comedones and inflammation of the follicles
  • comedone formation can have various causes.
  • external influences such as incorrect cleaning habits and incorrect care, comedogenic substances in cosmetics, weather influences, alkaline soaps, harsh detergents.
  • An increased sebum gland secretion and the formation of comedones can also develop through genetic factors and hormonal influences
  • comedones, inflammation, pre-acne and acne with their after-effects can result
  • non-soap surfactants in the form of washing creams or washing lotions are mainly used for skin cleansing.
  • These syndets do not form lime soaps, but treatment with highly surface-active agents has an effect on them
  • Skin has a stronger degreasing and drying effect than soap
  • the more frequently soap and surfactant-containing products are used on the skin the clearer are their adverse effects, namely degreasing and drying out the skin by destroying the hy dro-lipid film in the foreground Almost always, the reduction of the comedones leads to a lowering of the water content in the upper layers of the skin and to a firm formation of concrements in the sebaceous glands, which in turn can induce inflammation.
  • the lowering of the moisture content of the skin is, however, for a caring removal of the Comedones counterproductive
  • Seborrhea is an increased function of the sebaceous glands due to predisposition. Both the scalp and facial skin appear greasy. The composition of seborrhoeic sebum is different from that of normal sebum. There are 3 stages of seborrhea development. 1 Simple seborrhea. Light cases, greasy after 8 days
  • Irreversible form is irreversible. Seborrhea, in which the hair looks bathed in fat after just one day The excessive secretion of the sebaceous glands can be triggered by, among other things, androgenetic disorders and has an aesthetic disadvantage on the overall appearance of the hair. This disorder can also be the cause of hair loss. Its precursor is the seborrhoeic condition of the scalp. Vegetative disorders and improper care can do this Skin condition and hair condition worsen Even with seborrhea, hair can be dry even due to keratin build-up. Dry, damaged hair is often caused by external stress such as sun or chemical treatments. Too hot blow drying or improper care of damaged hair can cause damage to lead
  • the causes of oily hair are in the human body and are caused by hormones.
  • Each hair has its own sebum gland that produces fat (sebum, sebum).
  • Sebum production is hormonally controlled and, depending on the hormone sensitivity of the sebum gland, it can cause an overuse - or come underproduction
  • the sebum itself has the function of keeping the scalp supple.It arrives from the sebum gland on the scalp and only later the hairline where it is normally absorbed by the hair shaft and remains invisible. In a sebum production the hair shaft is no longer able to do so It is visible as a greasy film on the hair. The result is streaky, greasy shiny hair
  • the treatment of seborrhea includes regular and thorough head washing with special shampoos, which can be carried out as often as necessary.
  • the wash should be combined with a massage in the connective tissue, because it empties sebum glands more, which delays re-greasing
  • the object of the present invention is to provide a preparation which does not have the disadvantages of the known and previously used agents, which has a sebum-reducing, fat-regulating and nourishing effect at the same time, removes the already existing comedones without irritation, degreasing and drying out effectively prevents the skin, which brings homeostasis of sebum secretion to a normal state, prevents the formation of comedones and the development of inflammatory skin symptoms, causes a reduction in pore size and is effective in the prophylaxis before and treatment of acne, as well as existing skin inflammation is improved and equivalent cares for the skin
  • This object is achieved by the use of a hop or Hop-malt extract for the preparation of preparations for reducing the production of sebum dissolved.
  • the active ingredients used according to the invention prevent the formation of seborrheic phenomena, in particular greasy hair, but also dandruff, and to eliminate existing seborrheic phenomena, in particular greasy hair, but also dandruff.
  • a method for the prophylaxis against and treatment of impure skin for reducing the pore size, mild forms of acne, inflammatory skin conditions or seborrheic symptoms, in particular oily hair and / or dandruff, is characterized in that the active ingredients used according to the invention are characterized in that a suitable cosmetic or dermatological carrier to be brought into contact with the area affected by increased sebum production.
  • a further preferred embodiment of the present invention are therefore formulations to be used against dandruff, for example antidandruff shampoos.
  • the active ingredients are preferably used in cosmetic or dermatological compositions with a content of 0.0005-50.0% by weight, in particular 0.01-20.0% by weight, based on the total weight of the composition, being preferred.
  • the compositions advantageously contain 0.02-10.0% by weight, particularly preferably 0.02-5.0% by weight of the active ingredients used according to the invention, very particularly advantageously 0.1-3.0% by weight, each based on the total weight of the composition.
  • agents which act against sebum for example selected from the group of starch phosphate, cyclodextrin, sodium um maize starch octylene succinate, silica-dimethyl silylate, hydroxypropyl distarch phosphate, tapioca dextrin, aluminum Starch octylene succinate, acrylate copolymer, magnesium carbonate, maize starch, aluminum starch octylene succinate, kaolin, nylon (eg nylon 6/12), bentonite, sodium silicoaluminate, boron nitride, silica, mica + titanium dioxide.
  • the active compounds according to the invention for. B. as a so-called solid lipid nanoparts with the help of melted waxes, which, among other things, but not exclusively, can be selected from the group of ester waxes, triglyceride waxes or hydrocarbon waxes.
  • the active ingredients used according to the invention can be incorporated into common cosmetic or dermatological formulations without difficulty, advantageously in pump sprays, aerosol sprays, creams, ointments, tinctures, lotions, sticks, washing products and the like.
  • active substances used according to the invention with other active substances, for example with other antimicrobial, antimycotic or antiviral substances.
  • compositions according to the invention can be buffered.
  • a pH range from 3.0 to 9.0 is advantageous. It is particularly favorable to choose the pH in a range from 4.0 to 6.5.
  • the cosmetic and / or dermatological formulations according to the invention can be composed as usual and can be used to treat the skin and / or the hair in the sense of a dermatological treatment or a treatment in the sense of nourishing cosmetics. They can also be used in make-up products in decorative cosmetics
  • the cosmetic and / or dermatological formulations according to the invention are applied to the skin and / or the hair in a sufficient amount in the manner customary for cosmetics and dermatics
  • the antioxidants are advantageously selected from the group consisting of amino acids (eg glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (eg urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-carnosine, L-carnosine and its derivatives (eg anserine), carotenoids, carotenes (eg ⁇ -carotene, ⁇ -carotene, lycopene, phytoene) and their derivatives, lipoic acid and its derivatives (eg dihydro-ponic acid), aurothioglucose, Propylthiouracil and other thiols (e.g.
  • amino acids eg glycine, histidine, tyrosine, tryptophan
  • imidazoles eg urocanic acid
  • peptides such as D, L-carnosine, D-carnosine, L-
  • thioredoxin glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl) , Oleyl, ⁇ -linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and their derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and sulfoximine compounds ( z. B.
  • Buthioninsulfoximine Homocyste- insulfoximin, Buthioninsulfone, Penta-, Hexa-, Heptathi oninsulfoximine
  • very low contractual doses e.g. pmol to ⁇ mol / kg
  • also (metal) chelators e.g. ⁇ -hydroxy fatty acids, palmitic acid, phytic acid, lactofer n
  • ⁇ -hydroxy acids e.g.
  • citric acid citric acid, lactic acid, Malic acid
  • tetrahydrocurcumin humic acid
  • bile acid bile extracts
  • bihrubin biliverdin
  • EDTA EDTA
  • EGTA EGTA
  • unsaturated fatty acids and their derivatives e.g. ⁇ -linolenic acid, linoleic acid, oleic acid
  • folic acid and their derivatives unsaturated fatty acids and their derivatives (e.g. ⁇ -linolenic acid, linoleic acid, oleic acid), folic acid and their derivatives, alanine diacetic acid, polylaphenol diacid, poly Catechins, vitamin C and derivatives (e.g. ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (e.g.
  • vitamin E acetate vitamin E acetate
  • coniferyl benzoate of benzoic resin ruthenic acid and its derivatives, ferulic acid and its derivatives, Butylhydroxyto-toluene, butylhydroxyanisole, nordihydroguajakharzsaure, nordihydroguajaretsaure, tri- hydroxybutyrophenone, uric acid and its derivatives, mannose and its derivatives, zinc and its derivatives (eg ZnO, ZnSO 4 ) selenium and its derivatives (eg selenium methionine), stilbenes and their derivatives (eg stilbene oxide, trans-stilbene oxide) and the derivatives suitable according to the invention (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids) of these active substances
  • the amount of the antioxidants (one or more compounds) in the preparations is preferably 0.001 to 30% by weight, particularly preferably 0.05 to 20% by weight, in particular 1 to 10% by weight, based on the total weight of the preparation
  • the prophylaxis or the cosmetic or dermatological treatment with the active ingredient used according to the invention or with the cosmetic or topical dermatological preparations with an effective content of active ingredient used according to the invention is carried out in the customary manner, in such a way that the active ingredient used according to the invention or the cosmetic or topical dermatological preparations with an effective content of active ingredient used according to the invention is applied to the affected skin areas
  • the active ingredient used according to the invention can advantageously be incorporated into conventional cosmetic and dermatological preparations, which can be in various forms.
  • they can be a solution, an emulsion of the water-in-oil (W / O) type or of the oil-in type.
  • Emulsions according to the invention in the sense of the present invention are advantageous and contain, for example, fats, oils, waxes and / or other fatty substances, as well as water and one or more emulsifiers such as them commonly used for such a type of formulation
  • Medical topical compositions in the sense of the present invention generally contain one or more medicaments in an effective concentration.
  • medicaments in an effective concentration.
  • Preparations according to the invention can therefore advantageously contain substances which absorb UV radiation in the UVB range, the total amount of filter substances e.g. 0.1% by weight to 30% by weight, preferably 0.5 to 10% by weight, in particular 1 to 6% by weight, based on the total weight of the preparations.
  • the total amount of filter substances e.g. 0.1% by weight to 30% by weight, preferably 0.5 to 10% by weight, in particular 1 to 6% by weight, based on the total weight of the preparations.
  • the UVB filters can be oil-soluble or water-soluble.
  • oil-soluble substances e.g. to call:
  • 3-benzylidene camphor and its derivatives for example 3- (4-methylbenzylidene) camphor, 4-aminobenzoic acid derivatives, preferably 4- (dimethylamino) benzoic acid (2-ethylhexyl) ester, 4- (dimethylamino) benzoic acid amyl ester;
  • Esters of cinnamic acid preferably 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-methoxycinnamic acid isopentyl ester;
  • esters of salicylic acid preferably salicylic acid (2-ethylhexyl) ester, salicylic acid (4-isopropylbenzyl) ester, salicylic acid homomethyl ester;
  • benzophenone preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone;
  • Esters of benzalmalonic acid preferably 4-methoxybenzalmalonic acid di (2-ethylhexyl) ester;
  • 2-phenylbenzimidazole-5-sulfonic acid and its salts e.g. Sodium, potassium or triethanolammonium salts
  • Sulfonic acid derivatives of benzophenones preferably 2-hydroxy-4-methoxy-benzophenone-5-sulfonic acid and their salts;
  • Sulfonic acid derivatives of 3-benzylidene camphor e.g. 4- (2-oxo-3-bornylidenemethyl) benzenesulfonic acid, 2-methyl-5- (2-pxo-3-bornylidenemethyl) sulfonic acid and their salts.
  • UVB filters which can be used according to the invention, is of course not intended to be limiting.
  • UVA filters in the preparations according to the invention, which are usually contained in cosmetic and / or dermatological preparations.
  • Such filter substances are preferably derivatives of dibenzoylmethane, in particular 1- (4'-tert-butylphenyl) -3- (4'-methoxyphenyl) propane-1, 3-dione and 1-phenyl-3- (4'-isopropylphenyl) propane-1,3-dione. Preparations containing these combinations are also the subject of the invention.
  • the same amounts of UVA filter substances that were mentioned for UVB filter substances can be used.
  • Cosmetic and / or dermatological preparations in the sense of the present invention can also contain inorganic pigments which are usually used in cosmetics. Metics to protect the skin from UV rays are used. These are oxides of titanium, zinc, iron, zirconium, silicon, manganese, aluminum, cerium and mixtures thereof, and modifications in which the oxides are the active agents are particularly preferred the pigments are based on titanium dioxide. The amounts mentioned for the above combinations can be used
  • the cosmetic and dermatological preparations used in accordance with the invention can contain cosmetic active ingredients, auxiliaries and / or additives of the kind normally used in such preparations, for example antioxidants, preservatives, bactericides, perfumes, substances for preventing foaming, dyes, pigments , which have a coloring effect, thickeners, surface-active substances, emulsifiers, softening, moisturizing and / or moisturizing substances, fats, oils, waxes or other usual components of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic Solvents or silicon derivatives
  • the cosmetic or dermatological preparation in the sense of the present invention is a solution or emulsion or dispersion, solvents can be used
  • Oils such as Tnglyce ⁇ de the Cap ⁇ n- or the caprylic acid, but preferably castor oil, fats, waxes and other natural and synthetic fatty substances, preferably esters of fatty acids with alcohols of low C number, for example with isopropanol, propylene glycol or Glycenn, or esters of Fatty alcohols with low C number alkane acids or with fatty acids,
  • Alcohols, diols or polyols of low C number, and their ethers preferably ethanol, isopropanol, propylene glycol, glycene, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or
  • the oil phase of the emulsions, oleogels or hydrodispersions or lipodispersions for the purposes of the present invention is advantageously selected from the group of esters from saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 3 to 30 carbon atoms, from the group of esters of aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 3 to 30 carbon atoms.
  • ester oils can then advantageously be chosen from the group of isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononylisononanoate, 2-ethyl-2-ethylhexyl, ethyl-2-ethylhexyl, ethyl-2-ethylhexyl 2- octyldodecyl palmitate, oleyl oleate, olerlerucate, erucyl oleate, erucylerucate as well as synthetic, semi-synthetic and natural mixtures of such esters, for example jojoba oil.
  • the oil phase can advantageously be selected from the group of branched and unbranched hydrocarbons and waxes, the silicone oils, the dialkyl ethers, the group of saturated or unsaturated, branched or unbranched alcohols, and also the fatty acid triglycerides, especially the triglycne esters of saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 8 to 24, in particular 12 - 18 carbon atoms.
  • the fatty acid triglycerides can, for example, advantageously be selected from the group of synthetic, semisynthetic and natural oils, e.g. Olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil and the like.
  • any mixtures of such oil and wax components can also be used advantageously for the purposes of the present invention. It may also be advantageous to use waxes, for example cetyl palmitate, as the sole lipid component of the oil phase.
  • the oil phase is advantageously selected from the group consisting of 2-ethylhexyl isostearate, octyldecanol, isotridecyl isononanoate, isoeicosane, 2-ethylhexyl cocoate, C 12 . 15 alkyl benzoate, caprylic capric acid triglyceride, dicaprylyl ether.
  • hydrocarbons paraffin oil, squalane and squalene are advantageously used in the context of the present invention.
  • the oil phase can advantageously also contain cyclic or linear silicone oils or consist entirely of such oils, although it is preferred to use an additional content of other oil phase components in addition to the silicone oil or the silicone oils.
  • Cyclomethicone (octamethylcyclotetrasiloxane) is advantageously used as the silicone oil to be used according to the invention.
  • other silicone oils can also be used advantageously for the purposes of the present invention, for example hexamethylcyclotrisiloxane, polydimethylsiloxane, poly (methylphenylsiloxane).
  • the aqueous phase of the preparations according to the invention advantageously advantageously contains alcohols, diols or polyols of low C number, and also their ethers, preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether , Diethylenglykolmonomethyl- or -monoethylether and analogous products, furthermore low C-number alcohols, eg Ethanol, isopropanol, 1, 2-propanediol, glycerol and in particular one or more thickeners, which one or more can advantageously be selected from the group consisting of silicon dioxide, aluminum silicates, polysaccharides or their derivatives, e.g.
  • Hyaluronic acid, xanthan gum, hydroxypropyl methyl cellulose particularly advantageously from the group of polyacrylates, preferably a polyacrylate from the group of so-called carbopols, for example carbopoles of types 980, 981, 1382, 2984, 5984, each individually or in combination.
  • carbopols for example carbopoles of types 980, 981, 1382, 2984, 5984, each individually or in combination.
  • Gels used according to the invention usually contain alcohols of low C number, for example ethanol, isopropanol, 1, 2-propanediol, glycerol and water or an oil mentioned above in the presence of a thickener which is used in the case of oily alcoholic len is preferably silicon dioxide or an aluminum silicate, in the case of aqueous-alcoholic or alcoholic gels it is preferably a polyacrylate.
  • alcohols of low C number for example ethanol, isopropanol, 1, 2-propanediol, glycerol and water or an oil mentioned above in the presence of a thickener which is used in the case of oily alcoholic len is preferably silicon dioxide or an aluminum silicate, in the case of aqueous-alcoholic or alcoholic gels it is preferably a polyacrylate.
  • Fixed pens contain e.g. natural or synthetic waxes, fatty alcohols or fatty acid esters.
  • liquid oils for example paraffin oils, castor oil, isopropyl myristate
  • semi-solid components for example petroleum jelly, lanolin
  • solid components for example beeswax, ceresin and microcrystallines
  • Waxes or ozokerite for example beeswax, ceresin and microcrystallines
  • high-melting waxes e.g. carnauba wax, candelilla wax
  • Suitable blowing agents for cosmetic and / or dermatological preparations which can be sprayed from aerosol containers for the purposes of the present invention are the customary known volatile, liquefied blowing agents, for example hydrocarbons (propane, butane, isobutane), which can be used alone or in a mixture with one another. Compressed air can also be used advantageously.
  • hydrocarbons propane, butane, isobutane
  • Cosmetic preparations in the sense of the present invention can also be present as gels which, in addition to an effective content of the active ingredient according to the invention and solvents usually used for this purpose, preferably water, and also organic thickeners, for example gum arabic, xanthan gum, sodium alginate, cellulose derivatives, preferably methyl cellulose, Hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose or inorganic thickeners, e.g. B. aluminum silicates such as bentonite, or a mixture of polyethylene glycol and polyethylene glycol stearate or distearate.
  • organic thickeners for example gum arabic, xanthan gum, sodium alginate, cellulose derivatives, preferably methyl cellulose, Hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose or inorganic thickeners, e.g. B. aluminum silicates such as benton
  • the thickener is contained in the gel, for example, in an amount between 0.1 and 30% by weight, preferably between 0.5 and 15% by weight.
  • the following examples are intended to illustrate the embodiment of the present invention. The information always refers to% by weight, unless other information is given.

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Abstract

La présente invention concerne l'utilisation d'un extrait de houblon ou de houblon-malt dans la production de préparations servant à réduire la production de sébum et/ou à régler une homéostasie de sébum normale et servant à prévenir et à traiter l'acné, les peaux à imperfections, les cheveux gras et les pellicules.
EP02740431A 2001-03-23 2002-03-21 Preparations cosmetiques et dermatologiques renfermant un extrait de houblon ou de houblon-malt et leur utilisation pour la reduction de la secretion de sebum cutane Withdrawn EP1383473A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10114304 2001-03-23
DE10114304A DE10114304A1 (de) 2001-03-23 2001-03-23 Kosmetische und dermatologische Zubereitungen mit einem Gehalt an Hopfen bzw. Hopfen-Malz-Extrakt und Verwendung eines Hopfen- bzw. Hopfen-Malz-Extraktes zur Herstellung kosmetischer und dermatologischer Zubereitungen zur Reduktion des Sebumgehaltes der Haut
PCT/EP2002/003178 WO2002076410A2 (fr) 2001-03-23 2002-03-21 Preparations cosmetiques et dermatologiques renfermant un extrait de houblon ou de houblon-malt et utilisation d'un extrait de houblon ou de houblon-malt dans la production de preparations cosmetiques et dermatologiques servant a reduire la secretion de sebum cutane

Publications (1)

Publication Number Publication Date
EP1383473A2 true EP1383473A2 (fr) 2004-01-28

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EP02740431A Withdrawn EP1383473A2 (fr) 2001-03-23 2002-03-21 Preparations cosmetiques et dermatologiques renfermant un extrait de houblon ou de houblon-malt et leur utilisation pour la reduction de la secretion de sebum cutane

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US (1) US20040141938A1 (fr)
EP (1) EP1383473A2 (fr)
DE (1) DE10114304A1 (fr)
WO (1) WO2002076410A2 (fr)

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WO2002076410A3 (fr) 2003-09-25
WO2002076410A2 (fr) 2002-10-03
DE10114304A1 (de) 2002-10-02
US20040141938A1 (en) 2004-07-22

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