EP1352072A4 - Formulierungen für die zuführung von nukleinsäuren - Google Patents
Formulierungen für die zuführung von nukleinsäurenInfo
- Publication number
- EP1352072A4 EP1352072A4 EP02713428A EP02713428A EP1352072A4 EP 1352072 A4 EP1352072 A4 EP 1352072A4 EP 02713428 A EP02713428 A EP 02713428A EP 02713428 A EP02713428 A EP 02713428A EP 1352072 A4 EP1352072 A4 EP 1352072A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- nucleic acid
- acid delivery
- delivery formulations
- formulations
- nucleic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
- A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
- A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26221901P | 2001-01-17 | 2001-01-17 | |
US262219P | 2001-01-17 | ||
US27025601P | 2001-02-20 | 2001-02-20 | |
US270256P | 2001-02-20 | ||
US30048401P | 2001-06-22 | 2001-06-22 | |
US300484P | 2001-06-22 | ||
PCT/US2002/001379 WO2002057424A2 (en) | 2001-01-17 | 2002-01-17 | Nucleic acid delivery formulations |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1352072A2 EP1352072A2 (de) | 2003-10-15 |
EP1352072A4 true EP1352072A4 (de) | 2004-09-01 |
Family
ID=27401491
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02713428A Withdrawn EP1352072A4 (de) | 2001-01-17 | 2002-01-17 | Formulierungen für die zuführung von nukleinsäuren |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1352072A4 (de) |
JP (1) | JP2004521109A (de) |
CA (1) | CA2435287A1 (de) |
WO (1) | WO2002057424A2 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7375096B1 (en) | 1998-12-04 | 2008-05-20 | California Institute Of Technology | Method of preparing a supramolecular complex containing a therapeutic agent and a multi-dimensional polymer network |
WO2003070905A2 (en) * | 2002-02-15 | 2003-08-28 | Zycos, Inc. | Electroporation methods for introducing bioactive agents into cells |
PT1534340E (pt) | 2002-09-06 | 2012-03-13 | Cerulean Pharma Inc | Polímeros à base de ciclodextrina para a administração de medicamentos ligados por ligação covalente |
CN101415443A (zh) * | 2003-10-23 | 2009-04-22 | 阿尔扎公司 | 涂覆微喷射体的稳定dna组合物 |
US20080095822A1 (en) * | 2004-11-16 | 2008-04-24 | Universite De Liege | Active Substance Delivery System Comprising A Hydrogel Atrix And Microcarriers |
JP2010516625A (ja) | 2007-01-24 | 2010-05-20 | インサート セラピューティクス, インコーポレイテッド | 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート |
WO2012144560A1 (ja) * | 2011-04-19 | 2012-10-26 | 国立大学法人京都大学 | 自己ゲル化核酸 |
WO2014055493A1 (en) | 2012-10-02 | 2014-04-10 | Cerulean Pharma Inc. | Methods and systems for polymer precipitation and generation of particles |
US11452759B2 (en) * | 2015-01-19 | 2022-09-27 | Technion Research & Development Foundation Limited | Ubiquitin ligase KPC1 promotes processing of P105 NF-κB1 to p50, eliciting strong tumor suppression |
KR101637883B1 (ko) * | 2015-09-30 | 2016-07-21 | 선바이오(주) | 폴리에틸렌글리콜 수화젤 주사제 |
KR101666792B1 (ko) * | 2016-02-05 | 2016-10-17 | 주식회사 파마리서치프로덕트 | 핵산 및 키토산을 포함하는 온도감응성 하이드로겔 조성물 |
CN111333878B (zh) * | 2019-05-23 | 2020-11-10 | 吾奇生物医疗科技(镇江)有限公司 | 一种双交联壳聚糖水凝胶及其制备方法和应用 |
CN109134855B (zh) * | 2018-07-23 | 2021-03-23 | 安徽大学 | 一种酸敏感的聚酰胺胺的阳离子聚合物poeamam及其制备方法和应用 |
CN113683780B (zh) * | 2021-09-15 | 2022-07-05 | 广州医科大学 | 具有穿膜活性和细胞核定位功能的抗血清、低细胞毒性的聚氨基酸类基因递送载体材料 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0987029A1 (de) * | 1998-08-28 | 2000-03-22 | Transgene S.A. | Verwendung eines kationischen Polymer zur Herstellung von Nukleinsäure-Komplexe und verwandte Zusammensetzungen |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3940316A1 (de) * | 1989-12-06 | 1991-06-13 | Bollig & Kemper | Waessrige dispersionen von vernetzten polymermikroteilchen |
US5534259A (en) * | 1993-07-08 | 1996-07-09 | Liposome Technology, Inc. | Polymer compound and coated particle composition |
US5972707A (en) * | 1994-06-27 | 1999-10-26 | The Johns Hopkins University | Gene delivery system |
US6132765A (en) * | 1996-04-12 | 2000-10-17 | Uroteq Inc. | Drug delivery via therapeutic hydrogels |
EP0932390A1 (de) * | 1996-10-11 | 1999-08-04 | Sequus Pharmaceuticals, Inc. | Therapeutische liposomenzusammensetzung und verfahren |
ES2198057T3 (es) * | 1997-06-30 | 2004-01-16 | Ciba Specialty Chemicals Water Treatments Limited | Materiales polimericos y su utilizacion. |
-
2002
- 2002-01-17 EP EP02713428A patent/EP1352072A4/de not_active Withdrawn
- 2002-01-17 WO PCT/US2002/001379 patent/WO2002057424A2/en active Application Filing
- 2002-01-17 CA CA002435287A patent/CA2435287A1/en not_active Abandoned
- 2002-01-17 JP JP2002558478A patent/JP2004521109A/ja active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0987029A1 (de) * | 1998-08-28 | 2000-03-22 | Transgene S.A. | Verwendung eines kationischen Polymer zur Herstellung von Nukleinsäure-Komplexe und verwandte Zusammensetzungen |
Non-Patent Citations (2)
Title |
---|
KABANOV A V ET AL: "DNA COMPLEXES WITH POLYCATIONS FOR THE DELIVERY OF GENETIC MATERIALINTO CELLS", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 6, no. 1, 1995, pages 7 - 20, XP000494803, ISSN: 1043-1802 * |
MATTSON G ET AL: "A practical approach to crosslinking.", MOLECULAR BIOLOGY REPORTS. APR 1993, vol. 17, no. 3, April 1993 (1993-04-01), pages 167 - 183, XP009033258, ISSN: 0301-4851 * |
Also Published As
Publication number | Publication date |
---|---|
EP1352072A2 (de) | 2003-10-15 |
WO2002057424A3 (en) | 2002-10-03 |
JP2004521109A (ja) | 2004-07-15 |
CA2435287A1 (en) | 2002-07-25 |
WO2002057424A2 (en) | 2002-07-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20030728 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20040719 |
|
17Q | First examination report despatched |
Effective date: 20070126 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20070807 |