EP1273914A4 - Hypotenseurs - Google Patents

Hypotenseurs

Info

Publication number
EP1273914A4
EP1273914A4 EP01919831A EP01919831A EP1273914A4 EP 1273914 A4 EP1273914 A4 EP 1273914A4 EP 01919831 A EP01919831 A EP 01919831A EP 01919831 A EP01919831 A EP 01919831A EP 1273914 A4 EP1273914 A4 EP 1273914A4
Authority
EP
European Patent Office
Prior art keywords
hypotensors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP01919831A
Other languages
German (de)
English (en)
Other versions
EP1273914A1 (fr
Inventor
Yuichi Ishida
Fumiaki Suzuki
Kazuo Murakami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ProteinExpress Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP1273914A1 publication Critical patent/EP1273914A1/fr
Publication of EP1273914A4 publication Critical patent/EP1273914A4/fr
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • C12N9/6486—Renin (3.4.23.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/23—Aspartic endopeptidases (3.4.23)
    • C12Y304/23015—Renin (3.4.23.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96472—Aspartic endopeptidases (3.4.23)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP01919831A 2000-04-10 2001-04-09 Hypotenseurs Ceased EP1273914A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000108670 2000-04-10
JP2000108670 2000-04-10
PCT/JP2001/003034 WO2001077673A1 (fr) 2000-04-10 2001-04-09 Hypotenseurs

Publications (2)

Publication Number Publication Date
EP1273914A1 EP1273914A1 (fr) 2003-01-08
EP1273914A4 true EP1273914A4 (fr) 2004-08-25

Family

ID=18621470

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01919831A Ceased EP1273914A4 (fr) 2000-04-10 2001-04-09 Hypotenseurs

Country Status (9)

Country Link
US (2) US6900020B2 (fr)
EP (1) EP1273914A4 (fr)
KR (1) KR100775980B1 (fr)
CN (1) CN1311238C (fr)
AU (2) AU4686401A (fr)
CA (1) CA2404644A1 (fr)
EA (1) EA005310B1 (fr)
MX (1) MXPA02010028A (fr)
WO (1) WO2001077673A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2004073740A1 (ja) * 2003-02-20 2006-06-01 雄一 石田 組織内アンジオテンシンｉｉ産生亢進制御剤並びに動脈硬化症、心・脳血管疾患及び／若しくは糖尿病合併症の発症予防又は治療剤
JPWO2006132245A1 (ja) * 2005-06-06 2009-01-08 株式会社プロテイン・エクスプレス 腫瘍増殖抑制剤
WO2010091182A2 (fr) * 2009-02-04 2010-08-12 Molecular Innovations Procédés pour cribler des agents candidats pour la modulation de la prorénine et de la rénine, tests de détection de la prorénine, et anticorps qu'ils emploient
US9586995B2 (en) 2012-09-19 2017-03-07 University Of Utah Research Foundation Compositions and methods of use for (pro)renin receptor
US9573976B2 (en) * 2012-09-19 2017-02-21 University Of Utah Research Foundation Antagonist for (pro)renin receptor for the treatment of hypertension and diabetes
WO2014047194A1 (fr) * 2012-09-19 2014-03-27 Feng Yumei Antagoniste du récepteur de la (pro)rénine pour le traitement de l'hypertension et du diabète
US10780143B2 (en) 2012-09-19 2020-09-22 University Of Utah Research Foundation Compositions and methods of use for (pro)renin receptor antagonists
EP3537152B1 (fr) * 2016-10-21 2023-06-14 Fujirebio Inc. Méthode d'immunoessai permettant de déterminer une concentration de rénine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3939747A1 (de) * 1989-06-09 1990-12-13 Bayer Ag Renininhibitorische peptide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
EP0410278B1 (fr) * 1989-07-25 1994-01-19 Hoechst Aktiengesellschaft Dérivés aminooligohydroxy inhibiteurs de la rénine
TW209870B (fr) * 1990-01-18 1993-07-21 Pfizer
JP3271157B2 (ja) 1997-04-07 2002-04-02 常盤化学工業株式会社 新規な抗体、それを含むレニン活性物質及びそれを用いたプロレニン測定試薬
DK1023067T4 (da) * 1997-10-17 2011-12-12 Ark Therapeutics Ltd Anvendelse af inhibitorer af renin-angiotensin-systemet til behandling af hypoxi eller svækket metabolisk funktion
JP3271159B2 (ja) * 1998-10-13 2002-04-02 常盤化学工業株式会社 レニン活性物質

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ATLAS S A ET AL: "IMMUNOLOGICAL EVIDENCE THAT INACTIVE RENIN IS PRORENIN", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 132, no. 3, 1985, pages 1038 - 1045, XP009032809, ISSN: 0006-291X *
COHEN P ET AL: "New monoclonal antibodies directed against the propart segment of human prorenin as a tool for the exploration of prorenin conformation", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 184, no. 1, 17 July 1995 (1995-07-17), pages 91 - 100, XP004021006, ISSN: 0022-1759 *
ISHIZUKA Y ET AL: "CHARACTERIZATION OF MONOCLONAL ANTIBODIES AGAINST HUMAN PRORENIN PROFRAGMENT AND IDENTIFICATION OF ACTIVE PRORENINS IN PLASMA", JOURNAL OF BIOCHEMISTRY (TOKYO), vol. 106, no. 3, 1989, pages 430 - 435, XP009032812, ISSN: 0021-924X *
See also references of WO0177673A1 *

Also Published As

Publication number Publication date
CN1311238C (zh) 2007-04-18
US7361637B2 (en) 2008-04-22
AU2001246864B2 (en) 2006-07-27
CN1436305A (zh) 2003-08-13
AU4686401A (en) 2001-10-23
US20050203021A1 (en) 2005-09-15
US20030165999A1 (en) 2003-09-04
MXPA02010028A (es) 2004-08-19
KR20020097217A (ko) 2002-12-31
US6900020B2 (en) 2005-05-31
EA005310B1 (ru) 2004-12-30
EP1273914A1 (fr) 2003-01-08
EA200201072A1 (ru) 2003-06-26
CA2404644A1 (fr) 2001-10-18
WO2001077673A1 (fr) 2001-10-18
KR100775980B1 (ko) 2007-11-16

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Legal Events

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Effective date: 20041126

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Owner name: PROTEIN EXPRESS CO., LTD.

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Effective date: 20100215