EP1251829A4 - Electrospun pharmaceutical compositions - Google Patents

Electrospun pharmaceutical compositions

Info

Publication number
EP1251829A4
EP1251829A4 EP01903299A EP01903299A EP1251829A4 EP 1251829 A4 EP1251829 A4 EP 1251829A4 EP 01903299 A EP01903299 A EP 01903299A EP 01903299 A EP01903299 A EP 01903299A EP 1251829 A4 EP1251829 A4 EP 1251829A4
Authority
EP
European Patent Office
Prior art keywords
pharmaceutical compositions
electrospun
electrospun pharmaceutical
compositions
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01903299A
Other languages
German (de)
French (fr)
Other versions
EP1251829A1 (en
Inventor
Francis Ignatious
John M Baldoni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP1251829A1 publication Critical patent/EP1251829A1/en
Publication of EP1251829A4 publication Critical patent/EP1251829A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0015—Electro-spinning characterised by the initial state of the material
    • D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
    • D01D5/0038—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion the fibre formed by solvent evaporation, i.e. dry electro-spinning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0015—Electro-spinning characterised by the initial state of the material
    • D01D5/0023—Electro-spinning characterised by the initial state of the material the material being a polymer melt
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F1/00—General methods for the manufacture of artificial filaments or the like
    • D01F1/02—Addition of substances to the spinning solution or to the melt
    • D01F1/10—Other agents for modifying properties
EP01903299A 2000-01-28 2001-01-25 Electrospun pharmaceutical compositions Withdrawn EP1251829A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17868200P 2000-01-28 2000-01-28
US178682P 2000-01-28
PCT/US2001/002399 WO2001054667A1 (en) 2000-01-28 2001-01-25 Electrospun pharmaceutical compositions

Publications (2)

Publication Number Publication Date
EP1251829A1 EP1251829A1 (en) 2002-10-30
EP1251829A4 true EP1251829A4 (en) 2009-05-06

Family

ID=22653497

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01903299A Withdrawn EP1251829A4 (en) 2000-01-28 2001-01-25 Electrospun pharmaceutical compositions

Country Status (18)

Country Link
EP (1) EP1251829A4 (en)
JP (1) JP2003521493A (en)
KR (1) KR100806412B1 (en)
CN (1) CN1223340C (en)
AR (1) AR028204A1 (en)
AU (1) AU772830B2 (en)
BR (1) BR0107869A (en)
CA (1) CA2396640A1 (en)
HU (1) HUP0301130A3 (en)
IL (1) IL150642A0 (en)
MX (1) MXPA02007298A (en)
MY (1) MY129356A (en)
NO (1) NO20023338L (en)
NZ (1) NZ519992A (en)
PL (1) PL356924A1 (en)
TW (1) TWI289061B (en)
WO (1) WO2001054667A1 (en)
ZA (1) ZA200205989B (en)

Families Citing this family (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9910505D0 (en) 1999-05-06 1999-07-07 Electrosols Ltd A method and apparatus for manufacturing consumable tablets
EP1333808B1 (en) * 2000-10-18 2012-07-25 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed composition used in drug delivery and cell encapsulation
JP4485124B2 (en) * 2000-11-17 2010-06-16 ヴァージニア コモンウェルス ユニバーシティ インテレクチュアル プロパティー ファンデーション Electroprocessed collagen
JP2010163435A (en) * 2000-11-17 2010-07-29 Virginia Commonwealth Univ Intellectual Property Foundation Electroprocessed collagen
EP1377421A4 (en) * 2001-03-20 2004-05-26 Nicast Ltd Polymer fiber tubular structure having improved kinking resistance
US6685956B2 (en) * 2001-05-16 2004-02-03 The Research Foundation At State University Of New York Biodegradable and/or bioabsorbable fibrous articles and methods for using the articles for medical applications
GB0123951D0 (en) * 2001-10-05 2001-11-28 Glaxo Group Ltd Therapies for treating respiratory diseases
JP2005523262A (en) 2002-02-01 2005-08-04 ファイザー・プロダクツ・インク Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming substances
KR100549140B1 (en) * 2002-03-26 2006-02-03 이 아이 듀폰 디 네모아 앤드 캄파니 A electro-blown spinning process of preparing for the nanofiber web
AU2003228460A1 (en) 2002-04-04 2003-10-27 The University Of Akron Non-woven fiber assemblies
US8367570B2 (en) 2002-04-04 2013-02-05 The University Of Akron Mechanically strong absorbent non-woven fibrous mats
WO2003087443A1 (en) * 2002-04-11 2003-10-23 Secant Medical, Inc. Covering process using electrospinning of very small fibers
TW200410714A (en) * 2002-08-07 2004-07-01 Smithkline Beecham Corp Electrospun amorphous pharmaceutical compositions
US20060083784A1 (en) * 2002-08-07 2006-04-20 Smithkline Beecham Corporation Amorphous pharmaceutical compositions
WO2004062697A2 (en) 2003-01-07 2004-07-29 Tufts University Silk fibroin materials and use thereof
JP2007501218A (en) 2003-08-04 2007-01-25 ファイザー・プロダクツ・インク Pharmaceutical composition of adsorbate of amorphous drug and lipophilic microphase-forming substance
CA2548376A1 (en) 2003-12-31 2005-07-21 Pfizer Products Inc. Solid compositions of low-solubility drugs and poloxamers
JP4526851B2 (en) * 2004-03-31 2010-08-18 明彦 谷岡 Polysaccharide nanoscale fibers and compacts
WO2006006746A1 (en) * 2004-07-09 2006-01-19 Hak-Yong Kim Polymer particles, and a method for manufacturing the same
CN100577720C (en) * 2005-03-21 2010-01-06 中国科学院化学研究所 Biodegradable and absorb polymer nano fibrous membrane materials and method for making and purposes
JP2006299459A (en) * 2005-04-20 2006-11-02 National Institute For Materials Science Method for producing biodegradable polymer nonwoven fabric tube
CN1300393C (en) * 2005-07-01 2007-02-14 中国科学院长春应用化学研究所 Preparation method of ultrafine fiber medical agent type emulsion electro spinning fiber
US20090107495A1 (en) * 2005-07-21 2009-04-30 National Institute For Materials Science Device for inhalation of medicine
JP4787585B2 (en) * 2005-09-29 2011-10-05 帝人株式会社 Manufacturing method of fiber structure by electrostatic spinning method
CN100556399C (en) * 2005-12-23 2009-11-04 中国科学院广州化学研究所 A kind of intestine target medicinal controlled release fiber and preparation method thereof
US8367112B2 (en) * 2006-02-28 2013-02-05 Alkermes Pharma Ireland Limited Nanoparticulate carverdilol formulations
KR100824719B1 (en) * 2006-09-04 2008-04-24 주식회사 아모메디 Bio-degradable food-packing materials consisting of starch-contained nonwoven-nanofabrics and preparation methods therefor
EP2271301A4 (en) 2008-03-27 2014-07-02 Agigma Inc Methods and compositions for the delivery of agents
ES2640162T3 (en) 2008-04-16 2017-11-02 The Procter & Gamble Company Composition for non-foaming personal hygiene in the form of an article
JP2011530661A (en) 2008-08-08 2011-12-22 ビーエーエスエフ ソシエタス・ヨーロピア Active ingredient-containing fiber surface structure with controlled release of active ingredient, its use and method for its production
WO2010015419A2 (en) 2008-08-08 2010-02-11 Basf Se Continuous fiber layer comprising an active substance on the basis of bio-polymers, the use thereof, and method for the production thereof
CN101721751B (en) * 2008-10-10 2013-01-02 张阳德 Human tissue engineering support loaded with controlled-release cell growth factor and provided with hollow silicon dioxide ball with kernel and preparation method and applications thereof
US20100291182A1 (en) * 2009-01-21 2010-11-18 Arsenal Medical, Inc. Drug-Loaded Fibers
KR101065255B1 (en) * 2009-02-13 2011-09-16 김근형 New drug delivery system using electrospinning of biodegradable polymers
CN101559242B (en) * 2009-05-22 2015-07-29 广州迈普再生医学科技有限公司 A kind of can simultaneously as the nano artificial cerebral dura mater and preparation method thereof of drug controlled release system
WO2011029777A1 (en) 2009-09-11 2011-03-17 Basf Se Methods for producing coated polymer fibers
WO2011072009A1 (en) 2009-12-08 2011-06-16 The Procter & Gamble Company A porous, dissolvable solid substrate and surface resident coating comprising matrix microspheres
WO2011103152A1 (en) 2010-02-16 2011-08-25 The Procter & Gamble Company A porous, dissolvable solid substrate and surface resident coating comprising a zync pyrithione
CN101816627B (en) * 2010-04-16 2012-03-07 浙江大学 Synergistic treatment type multi-material sustained-release eye drop and preparation method
WO2012003316A1 (en) 2010-07-02 2012-01-05 The Procter & Gamble Company Process for making films from nonwoven webs
RU2541949C2 (en) 2010-07-02 2015-02-20 Дзе Проктер Энд Гэмбл Компани Filaments, containing active agent, non-woven cloths and methods of obtaining them
CA2803621C (en) * 2010-07-02 2015-01-06 The Procter & Gamble Company Filaments comprising a non-perfume active agent nonwoven webs and methods for making same
WO2012003351A2 (en) 2010-07-02 2012-01-05 The Procter & Gamble Company Web material and method for making same
US20180163325A1 (en) 2016-12-09 2018-06-14 Robert Wayne Glenn, Jr. Dissolvable fibrous web structure article comprising active agents
EP2588064B1 (en) * 2010-07-02 2020-03-11 The Procter and Gamble Company Dissolvable fibrous web structure article comprising active agents
RU2613316C1 (en) * 2010-07-02 2017-03-15 Дзе Проктер Энд Гэмбл Компани Methods of medical active agent delivery by injection of individual health articles containing filament
CN103025930B (en) 2010-07-02 2014-11-12 宝洁公司 Method for delivering an active agent
RU2012154298A (en) * 2010-07-02 2014-08-10 Дзе Проктер Энд Гэмбл Компани FILAMENTS CONTAINING SUITABLE FOR RECEPTION INSIDE ACTIVE AGENTS, NONWOVEN CLOTHES AND METHODS FOR THEIR MANUFACTURE
CN101915797B (en) * 2010-07-27 2011-09-28 北京师范大学 Method for preparing electrostatic spinning immobilized laccase electrode
WO2012070028A1 (en) * 2010-11-26 2012-05-31 University Of The Witwatersrand, Johannesburg A pharmaceutical dosage form
WO2012084427A1 (en) 2010-12-22 2012-06-28 Unilever Nv Compositions comprising structured non-aqueous liquid phase
WO2012084441A1 (en) 2010-12-22 2012-06-28 Unilever Nv Compositions in the form of fibres
CZ201124A3 (en) 2011-01-17 2012-06-13 Elmarco S.R.O. Carrier for oromucosal, especially sublingual application of physiologically active compounds
CN102251317B (en) * 2011-05-18 2013-01-16 东华大学 Preparation method of electrospun fibers with controllable drug release
WO2013124869A2 (en) * 2012-02-21 2013-08-29 Amrita Vishwa Vidyapeetham University The art, method,manner process and system of fibrous bio-degradable polymeric wafers for the local delivery of therapeutic agents in combinations
CN102631715A (en) * 2012-05-04 2012-08-15 江南大学 Preparation method of anti-coagulation nano fiber membrane
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US20180193209A1 (en) * 2015-07-07 2018-07-12 Singapore Health Services Pte Ltd. A polymer product and preparation therof
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4043331A (en) * 1974-08-05 1977-08-23 Imperial Chemical Industries Limited Fibrillar product of electrostatically spun organic material
WO1988008298A1 (en) * 1987-04-20 1988-11-03 Fuisz Richard C Rapidly dissoluble medicinal dosage unit and method of manufacture
WO2001027365A1 (en) * 1999-10-08 2001-04-19 The University Of Akron Electrospun fibers and an apparatus therefor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5567439A (en) * 1994-06-14 1996-10-22 Fuisz Technologies Ltd. Delivery of controlled-release systems(s)
US5736152A (en) * 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
US5869098A (en) * 1997-08-20 1999-02-09 Fuisz Technologies Ltd. Fast-dissolving comestible units formed under high-speed/high-pressure conditions
US5980941A (en) * 1997-08-20 1999-11-09 Fuisz Technologies Ltd. Self-binding shearform compositions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4043331A (en) * 1974-08-05 1977-08-23 Imperial Chemical Industries Limited Fibrillar product of electrostatically spun organic material
WO1988008298A1 (en) * 1987-04-20 1988-11-03 Fuisz Richard C Rapidly dissoluble medicinal dosage unit and method of manufacture
WO2001027365A1 (en) * 1999-10-08 2001-04-19 The University Of Akron Electrospun fibers and an apparatus therefor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0154667A1 *

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