EP1226108A4 - Diaryl-enynes - Google Patents

Diaryl-enynes

Info

Publication number
EP1226108A4
EP1226108A4 EP00976775A EP00976775A EP1226108A4 EP 1226108 A4 EP1226108 A4 EP 1226108A4 EP 00976775 A EP00976775 A EP 00976775A EP 00976775 A EP00976775 A EP 00976775A EP 1226108 A4 EP1226108 A4 EP 1226108A4
Authority
EP
European Patent Office
Prior art keywords
enynes
diaryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00976775A
Other languages
German (de)
French (fr)
Other versions
EP1226108A1 (en
Inventor
Ian Egle
Jennifer Frey
Methvin Isaac
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire NPS Pharmaceuticals Inc
Original Assignee
NPS Allelix Corp Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NPS Allelix Corp Canada filed Critical NPS Allelix Corp Canada
Publication of EP1226108A1 publication Critical patent/EP1226108A1/en
Publication of EP1226108A4 publication Critical patent/EP1226108A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Confectionery (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Furan Compounds (AREA)
EP00976775A 1999-11-01 2000-11-01 Diaryl-enynes Withdrawn EP1226108A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US431022 1995-04-28
US43102299A 1999-11-01 1999-11-01
PCT/US2000/030074 WO2001032602A1 (en) 1999-11-01 2000-11-01 Diaryl-enynes

Publications (2)

Publication Number Publication Date
EP1226108A1 EP1226108A1 (en) 2002-07-31
EP1226108A4 true EP1226108A4 (en) 2004-06-16

Family

ID=23710104

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00976775A Withdrawn EP1226108A4 (en) 1999-11-01 2000-11-01 Diaryl-enynes

Country Status (22)

Country Link
EP (1) EP1226108A4 (en)
JP (1) JP2003513063A (en)
KR (1) KR100702717B1 (en)
CN (1) CN100357274C (en)
AU (1) AU780922C (en)
BG (1) BG65275B1 (en)
BR (1) BR0015199A (en)
CA (1) CA2387660A1 (en)
CZ (1) CZ20021545A3 (en)
EA (1) EA004602B1 (en)
EE (1) EE05031B1 (en)
HR (1) HRP20020376A2 (en)
HU (1) HUP0203182A3 (en)
IL (1) IL149347A0 (en)
MX (1) MXPA02004354A (en)
NO (1) NO20021936L (en)
NZ (1) NZ529245A (en)
PL (1) PL355425A1 (en)
SK (1) SK6202002A3 (en)
UA (1) UA73749C2 (en)
WO (1) WO2001032602A1 (en)
ZA (1) ZA200203458B (en)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04225953A (en) * 1990-05-07 1992-08-14 Shionogi & Co Ltd Spiro dibenzosuberane derivative
CA2087449A1 (en) * 1990-08-13 1992-02-14 Joseph L. Roba Use of heterocyclic amino-alcohol compounds for treatment of cns diseases
ES2260773T3 (en) * 1995-12-07 2006-11-01 Daniel C. Javitt TREATMENT OF THE NEGATIVE AND COGNITIVE SYMPTOMS OF THE SCHIZOPHRENIAC ANTAGONISTS OF THE GLYCINE ABSORPTION.
UA52698C2 (en) * 1996-10-04 2003-01-15 Х. Луннбек А/С (3-Alkoxyisoxazol-4-yl)-substituted 2-amino carboxylic acid derivatives
IL138228A0 (en) * 1998-03-06 2001-10-31 Janssen Pharmaceutica Nv Glycine transport inhibitors
SK13092000A3 (en) * 1998-03-06 2001-03-12 Janssen Pharmaceutica N. V. Glycine transport inhibitors
PE20000728A1 (en) * 1998-06-26 2000-08-21 Cocensys Inc HETEROCYCLES 4-BENZYL PIPERIDINE ALKYLSULFOXIDE AND THEIR USE AS SUBTYPE-SELECTIVE NMDA RECEPTOR ANTAGONISTS
US6103743A (en) * 1999-08-06 2000-08-15 Allelix Neuroscience, Inc. Unsaturated amino acid derivatives

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 28 October 1999 (1999-10-28), AVENET P ET AL: "Postsynaptic effects of glycine transport inhibition in the rat spinal cord: A slice patch-clamp study", XP002277465, Database accession no. PREV200000066905 *
See also references of WO0132602A1 *
SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 25, no. 1-2, 1999, 29TH ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE, PART 1; MIAMI BEACH, FLORIDA, USA; OCTOBER 23-28, 1999, pages 165, ISSN: 0190-5295 *

Also Published As

Publication number Publication date
NO20021936L (en) 2002-07-01
EE200200229A (en) 2003-06-16
CN1387507A (en) 2002-12-25
BR0015199A (en) 2002-07-09
MXPA02004354A (en) 2003-10-06
UA73749C2 (en) 2005-09-15
KR100702717B1 (en) 2007-04-03
PL355425A1 (en) 2004-04-19
EA004602B1 (en) 2004-06-24
JP2003513063A (en) 2003-04-08
BG106671A (en) 2003-02-28
CZ20021545A3 (en) 2002-10-16
AU780922B2 (en) 2005-04-28
AU780922C (en) 2005-10-20
HUP0203182A2 (en) 2003-01-28
EA200200521A1 (en) 2002-10-31
AU1450701A (en) 2001-05-14
NO20021936D0 (en) 2002-04-24
ZA200203458B (en) 2003-10-29
IL149347A0 (en) 2002-11-10
KR20020060961A (en) 2002-07-19
CN100357274C (en) 2007-12-26
CA2387660A1 (en) 2001-05-10
EE05031B1 (en) 2008-06-16
BG65275B1 (en) 2007-11-30
EP1226108A1 (en) 2002-07-31
NZ529245A (en) 2005-09-30
WO2001032602A1 (en) 2001-05-10
HRP20020376A2 (en) 2004-02-29
SK6202002A3 (en) 2002-10-08
HUP0203182A3 (en) 2003-04-28

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20020522

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RIN1 Information on inventor provided before grant (corrected)

Inventor name: ISAAC, METHVIN

Inventor name: EGLE, IAN

Inventor name: FREY, JENNIFER

A4 Supplementary search report drawn up and despatched

Effective date: 20040506

RIC1 Information provided on ipc code assigned before grant

Ipc: 7C 07D 333/20 B

Ipc: 7C 07C 323/41 B

Ipc: 7A 61K 31/21 B

Ipc: 7C 07D 307/52 B

Ipc: 7C 07C 229/36 B

Ipc: 7C 07C 229/00 A

17Q First examination report despatched

Effective date: 20041223

R17C First examination report despatched (corrected)

Effective date: 20080827

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: NPS PHARMACEUTICALS, INC.

GRAP Despatch of communication of intention to grant a patent

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STAA Information on the status of an ep patent application or granted ep patent

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Effective date: 20100504