EP1225866A4 - Methode und zusammensetzungen zur behandlung von atemwegserkrankungen - Google Patents

Methode und zusammensetzungen zur behandlung von atemwegserkrankungen

Info

Publication number
EP1225866A4
EP1225866A4 EP00975533A EP00975533A EP1225866A4 EP 1225866 A4 EP1225866 A4 EP 1225866A4 EP 00975533 A EP00975533 A EP 00975533A EP 00975533 A EP00975533 A EP 00975533A EP 1225866 A4 EP1225866 A4 EP 1225866A4
Authority
EP
European Patent Office
Prior art keywords
compositions
pulmonary diseases
treating pulmonary
treating
diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00975533A
Other languages
English (en)
French (fr)
Other versions
EP1225866A2 (de
Inventor
Peter N Goodfellow
Richard Nieman
Theodore J Torphy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP1225866A2 publication Critical patent/EP1225866A2/de
Publication of EP1225866A4 publication Critical patent/EP1225866A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP00975533A 1999-11-02 2000-11-01 Methode und zusammensetzungen zur behandlung von atemwegserkrankungen Withdrawn EP1225866A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16315899P 1999-11-02 1999-11-02
US163158P 1999-11-02
PCT/US2000/030113 WO2001032127A2 (en) 1999-11-02 2000-11-01 Method and compositions for treating pulmonary diseases

Publications (2)

Publication Number Publication Date
EP1225866A2 EP1225866A2 (de) 2002-07-31
EP1225866A4 true EP1225866A4 (de) 2004-04-21

Family

ID=22588737

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00975533A Withdrawn EP1225866A4 (de) 1999-11-02 2000-11-01 Methode und zusammensetzungen zur behandlung von atemwegserkrankungen

Country Status (29)

Country Link
EP (1) EP1225866A4 (de)
JP (1) JP2003513028A (de)
KR (1) KR20020057988A (de)
CN (1) CN1387404A (de)
AP (1) AP2002002496A0 (de)
AR (1) AR029189A1 (de)
AU (1) AU1357501A (de)
BG (1) BG106748A (de)
BR (1) BR0015270A (de)
CA (1) CA2388333A1 (de)
CO (1) CO5261512A1 (de)
CZ (1) CZ20021512A3 (de)
DZ (1) DZ3225A1 (de)
EA (1) EA200200518A1 (de)
EC (1) ECSP003747A (de)
HK (1) HK1049107A1 (de)
HU (1) HUP0203152A3 (de)
IL (1) IL149367A0 (de)
MA (1) MA26841A1 (de)
MX (1) MXPA02004350A (de)
NO (1) NO20022057L (de)
OA (1) OA12076A (de)
PE (1) PE20011005A1 (de)
PL (1) PL355261A1 (de)
SK (1) SK7592002A3 (de)
TR (1) TR200201211T2 (de)
TW (1) TWI242431B (de)
WO (1) WO2001032127A2 (de)
ZA (1) ZA200203435B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100496607C (zh) * 2001-09-19 2009-06-10 尼科梅德有限责任公司 Nsaid与pde-4抑制剂的并用药物
CA2462525A1 (en) * 2001-10-31 2003-05-08 Merck Patent Gesellschaft Mit Beschraenkter Haftung Type 4 phosphodiesterase inhibitors and uses thereof
UA82323C2 (uk) * 2002-08-09 2008-04-10 Меда Фарма Гмбх & Ко. Кг Нова комбінація глюкокортикоїду та pde-інгібітору для лікування респіраторних захворювань, алергічних захворювань, астми та хронічних обструктивних легеневих захворювань
TW200410923A (en) * 2002-10-17 2004-07-01 Ono Pharmaceutical Co Therapeutic agent for chronic obstructive pulmonary disease
US20060199789A1 (en) * 2003-03-31 2006-09-07 Kyowa Hakko Kogyo Co., Ltd. medical composition
US20050026883A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
JPWO2006041121A1 (ja) * 2004-10-13 2008-05-15 協和醗酵工業株式会社 慢性皮膚疾患の治療および/または予防剤
EP1948167A1 (de) * 2005-10-19 2008-07-30 Ranbaxy Laboratories, Ltd. Zusammensetzungen von phosphodiesterase-typ-iv-hemmern
MY187036A (en) 2010-01-05 2021-08-27 Microdose Therapeutx Inc Inhalation device and method
WO2015063669A1 (en) 2013-10-30 2015-05-07 Wockhardt Limited Pharmaceutical compositions comprising combination of roflumilast and acebrophylline or pharmaceutically acceptable salts thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000139A1 (en) * 1993-06-18 1995-01-05 Smithkline Beecham Corporation Compounds
DE4332041A1 (de) * 1993-09-21 1995-03-23 Rentschler Arzneimittel Verwendung von Pentoxifyllin zur Behandlung granulomatöser und fibrosierender Lungenerkrankungen

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE44995A1 (es) * 1994-01-27 1995-12-18 Schering Corp Furoato de mometasona para el tratamiento de las enfermedades pulmonares y de las vias respiratorias
SE9801368D0 (sv) * 1998-04-20 1998-04-20 Astra Ab New use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000139A1 (en) * 1993-06-18 1995-01-05 Smithkline Beecham Corporation Compounds
DE4332041A1 (de) * 1993-09-21 1995-03-23 Rentschler Arzneimittel Verwendung von Pentoxifyllin zur Behandlung granulomatöser und fibrosierender Lungenerkrankungen

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MURDOCH R ET AL: "The addition of SB 207499 (ARIFLO), a novel and selective PDE4 inhibitor, to oral prednisolone, is safe and well tolerated", EUROPEAN RESPIRATORY JOURNAL, vol. 12, no. SUPPL. 28, September 1998 (1998-09-01), European Respiratory Society Annual Congress;Geneva, Switzerland; September 19-23, 1998, pages 362S, XP009026674, ISSN: 0903-1936 *
NORMAN P: "PDE4 inhibitors 1999", EXPERT OPINION ON THERAPEUTIC PATENTS 1999 UNITED KINGDOM, vol. 9, no. 8, 1999, pages 1101 - 1118, XP001058161, ISSN: 1354-3776 *
SILVESTRE J ET AL: "SB-207499. Antiasthmatic/antiinflammatory phosphodiesterase IV inhibitor", DRUGS OF THE FUTURE 1998 SPAIN, vol. 23, no. 6, 1998, pages 607 - 615, XP000981875, ISSN: 0377-8282 *
TORPHY T J ET AL: "ARIFLO (SB 207499), A SECOND GENERATION PHOSPHODIESTERASE 4 INHIBITOR FOR THE TREATMENT OF ASTHMA AND COPD: FROM CONCEPT TO CLINIC", PULMONARY PHARMACOLOGY AND THERAPEUTICS, ACADEMIC PRESS, NEW YORK, NY, US, vol. 12, no. 2, 1999, pages 131 - 135, XP001155797, ISSN: 1094-5539 *

Also Published As

Publication number Publication date
JP2003513028A (ja) 2003-04-08
SK7592002A3 (en) 2002-11-06
CZ20021512A3 (cs) 2003-04-16
HUP0203152A3 (en) 2004-06-28
DZ3225A1 (fr) 2001-05-10
EA200200518A1 (ru) 2002-10-31
MXPA02004350A (es) 2002-11-07
TWI242431B (en) 2005-11-01
ECSP003747A (es) 2002-05-23
CO5261512A1 (es) 2003-03-31
WO2001032127A3 (en) 2001-12-06
KR20020057988A (ko) 2002-07-12
BG106748A (en) 2003-02-28
NO20022057L (no) 2002-06-27
MA26841A1 (fr) 2004-12-20
PL355261A1 (en) 2004-04-05
CN1387404A (zh) 2002-12-25
IL149367A0 (en) 2002-11-10
WO2001032127A2 (en) 2001-05-10
EP1225866A2 (de) 2002-07-31
ZA200203435B (en) 2003-06-25
CA2388333A1 (en) 2001-05-10
AR029189A1 (es) 2003-06-18
AU1357501A (en) 2001-05-14
HUP0203152A2 (hu) 2003-01-28
TR200201211T2 (tr) 2002-08-21
AP2002002496A0 (en) 2002-06-30
NO20022057D0 (no) 2002-04-30
BR0015270A (pt) 2002-06-18
PE20011005A1 (es) 2001-09-28
OA12076A (en) 2006-05-04
HK1049107A1 (zh) 2003-05-02

Similar Documents

Publication Publication Date Title
WO2003011274A3 (en) Use of a pde4 inhibitor in combination with an anticholinergic agent for the treatment of pulmonary disease such as asthma
MY126544A (en) Therapies for treating pulmonary diseases
EP1602370A3 (de) Synergistische Kombinationen enthaltend einen Renininhibitor für kardiovaskulären Erkrankungen
WO2003000241A3 (de) Neue arzneimittelkompositionen auf der basis von anticholinergika; corticosteroiden und betamimetika zur behandlung von entzündlichen und/oder obstruktiven atemwegserkrankungen
WO2004078144A3 (en) Diphenylethylene compounds and uses thereof
WO2004021989A3 (en) Imidazolopyridines and methods of making and using the same
AU2001271973A1 (en) Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
AU2001278852A1 (en) Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
WO2004078712A3 (en) Isoquinoline derivatives and methods of use thereof
IS6444A (is) Pýrimidín karboxamíð nytsamleg sem latar á PDE4 samsætuensím
NO20060328L (no) Kombinasjon av mGluR2-antagonist og ACHE-inhibitor for behandiing av akutt og/eller kronisk neurologiske forstyrrelser
BR0009446A (pt) Composto, processo para preparar o mesmo, composição uso de um composto, e, métodos para o tratamento ou a prevenção de uma doença em um mamìfero, para o tratamento ou a prevenção de asma em um mamìfero e para o tratamento ou a prevenção de doença pulmonar obstrutiva crÈnica em um mamìfero
WO2001032127A3 (en) Method and compositions for treating pulmonary diseases
WO2004043456A8 (en) Cholesterol absorption inhibitors for the treatment of demyelination
WO2005011614A8 (en) Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-ige antibody for treatment of asthma or chronic obstructive pulmonary disease
IL165378A0 (en) Nebulizer formulations of dehydroepiandrosterone and methods of treating asthma or chronic obstructive pulmonary disease using compositions thereof
WO1999012933A3 (en) Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase
MXPA03011702A (es) Composicion que comprende un inhibidor de fosodiesterasa 4 y un antagonista de receptor h1 y el uso de los mismos para la elaboracion de un medicamento para el tratamiento de enfermedades respiratorias.
WO2003039464A3 (en) Antimuscarinic aerosol
WO2002017894A3 (en) Pharmaceutical formulation of salmeterol and fluticasone propionate
WO2006015970A3 (en) Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
AU2003272945A1 (en) Composition for preventing/treating the expression of clinical symptom in disease caused by mitochondrial dysfunction
WO2005011608A3 (en) PHARMACEUTICAL COMPOSITION COMPRISING A NON-GLUCOCORTICOID STEROID AND A cAMP INHIBITOR
WO2005011604A3 (en) Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease
HUP0102388A3 (en) Use of diazepinoindole derivatives for the preparation of pharmaceutical composition treating chronic obstructive pulmonary disease

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20020521

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Free format text: AL;LT;LV;MK;RO;SI PAYMENT 20020521

RIC1 Information provided on ipc code assigned before grant

Free format text: 7A 01N 43/36 A, 7A 61K 31/40 B, 7A 61K 31/56 B

A4 Supplementary search report drawn up and despatched

Effective date: 20040304

RIC1 Information provided on ipc code assigned before grant

Ipc: 7A 61K 31:44 O

Ipc: 7A 61K 31/575 K

Ipc: 7A 61K 31/575 M

Ipc: 7A 61K 31:44 N

Ipc: 7A 61K 31:275 K

Ipc: 7A 61P 11/00 B

Ipc: 7A 61K 31/575 A

Ipc: 7A 61K 31/4439 B

Ipc: 7A 61K 31:4439 L

Ipc: 7A 61K 31/44 B

Ipc: 7A 61K 31/58 L

Ipc: 7A 61K 31/58 J

Ipc: 7A 61K 31:4439 M

Ipc: 7A 61K 31/58 N

Ipc: 7A 61K 31/58 B

Ipc: 7A 61K 31:275 J

Ipc: 7A 61K 31/275 B

Ipc: 7A 61K 31/575 O

17Q First examination report despatched

Effective date: 20070111

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20070523

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1049107

Country of ref document: HK