EP1221963A4 - Methoden zur hemmung der osteoclastogenese - Google Patents

Methoden zur hemmung der osteoclastogenese

Info

Publication number
EP1221963A4
EP1221963A4 EP00953710A EP00953710A EP1221963A4 EP 1221963 A4 EP1221963 A4 EP 1221963A4 EP 00953710 A EP00953710 A EP 00953710A EP 00953710 A EP00953710 A EP 00953710A EP 1221963 A4 EP1221963 A4 EP 1221963A4
Authority
EP
European Patent Office
Prior art keywords
methods
inhibiting osteoclastogenesis
osteoclastogenesis
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00953710A
Other languages
English (en)
French (fr)
Other versions
EP1221963A1 (de
Inventor
Kazuhiro Aoki
William Carle Horne
Roland Baron
Mark I Greene
Ramachandran Murali
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
University of Pennsylvania Penn
Original Assignee
Yale University
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yale University, University of Pennsylvania Penn filed Critical Yale University
Publication of EP1221963A1 publication Critical patent/EP1221963A1/de
Publication of EP1221963A4 publication Critical patent/EP1221963A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP00953710A 1999-07-28 2000-07-28 Methoden zur hemmung der osteoclastogenese Withdrawn EP1221963A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14609099P 1999-07-28 1999-07-28
US146090P 1999-07-28
PCT/US2000/020510 WO2001008699A1 (en) 1999-07-28 2000-07-28 Methods of inhibiting osteoclastogenesis

Publications (2)

Publication Number Publication Date
EP1221963A1 EP1221963A1 (de) 2002-07-17
EP1221963A4 true EP1221963A4 (de) 2006-03-22

Family

ID=22515815

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00953710A Withdrawn EP1221963A4 (de) 1999-07-28 2000-07-28 Methoden zur hemmung der osteoclastogenese

Country Status (5)

Country Link
EP (1) EP1221963A4 (de)
JP (1) JP2003505514A (de)
AU (1) AU777634B2 (de)
CA (1) CA2380009A1 (de)
WO (1) WO2001008699A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6673771B1 (en) 1999-07-28 2004-01-06 The Trustees Of The University Of Pennsylvania Methods of inhibiting osteoclast activity
EP1207873B1 (de) * 1999-07-28 2009-11-18 The Trustees Of The University Of Pennsylvania Methoden zur hemmung der aktivität der osteoklasten
ES2208145T3 (es) 2000-09-22 2007-12-16 Immunex Corporation Ensayos de seleccion para agonistas o antagonistas del receptor activador de nf-kb.
JPWO2003000286A1 (ja) * 2001-06-22 2004-10-07 第一サントリーファーマ株式会社 好酸球増多性疾患治療薬
DK2684888T3 (da) * 2011-03-09 2019-08-19 Jitsubo Co Ltd Nye tværbundne peptider indeholdende ikke-peptid-tværbundet struktur, fremgangsmåde til syntetisering af tværbundne peptider og ny organisk forbindelse anvendt i fremgangsmåden
JP2014101274A (ja) * 2011-03-09 2014-06-05 Jitsubo Co Ltd 新規な架橋構造を含むｔｎｆレセプターループペプチドの模倣ペプチドを用いた医薬組成物
CA2967123A1 (en) 2014-11-14 2016-05-19 Probiocon Gmbh Rankl-specific agent for treating metastatic disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998053842A1 (en) * 1997-05-30 1998-12-03 The Trustees Of The University Of Pennsylvania Tumor necrosis factor receptor-derived peptide analogues
WO2001008677A1 (en) * 1999-07-28 2001-02-08 The Trustees Of The University Of Pennsylvania Methods of inhibiting osteoclast activity

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5470952A (en) * 1993-10-20 1995-11-28 Regeneron Pharmaceuticals, Inc. CNTF and IL-6 antagonists
US5770565A (en) * 1994-04-13 1998-06-23 La Jolla Cancer Research Center Peptides for reducing or inhibiting bone resorption
US5955425A (en) * 1996-08-02 1999-09-21 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
AU693478B2 (en) * 1994-11-10 1998-07-02 Metabolic Pharmaceuticals Limited Treatment of obesity
DE19629816A1 (de) * 1996-07-24 1998-01-29 Hoechst Ag Neue Cycloalkyl-Derivate als Inhibitoren der Knochenresorption und Vitronectinrezeptor-Antagonisten
JP4122061B2 (ja) * 1996-08-02 2008-07-23 ナショナル リサーチ カウンシル オブ カナダ 骨粗鬆症の治寮のための副甲状腺ホルモン類似体
WO1998028423A2 (en) * 1996-12-20 1998-07-02 Board Of Regents, The University Of Texas System Compositions and methods of use for osteoclast inhibitory factors
GB9703109D0 (en) * 1997-02-14 1997-04-02 Smith & Nephew Compositions
WO1999012567A1 (en) * 1997-09-10 1999-03-18 Uab Research Foundation Regulation of osteoclast formation by inhibition of osteoblastic stem cell factor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998053842A1 (en) * 1997-05-30 1998-12-03 The Trustees Of The University Of Pennsylvania Tumor necrosis factor receptor-derived peptide analogues
WO2001008677A1 (en) * 1999-07-28 2001-02-08 The Trustees Of The University Of Pennsylvania Methods of inhibiting osteoclast activity

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MIZUNO ET AL: "Severe Osteoporosis in Mice Lacking Osteoclastogenesis Inhibitory Factor/Osteoprotegerin", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 247, no. 3, 29 June 1998 (1998-06-29), pages 610 - 615, XP005300950, ISSN: 0006-291X, DOI: 10.1006/BBRC.1998.8697 *
See also references of WO0108699A1 *
SIMONET W ET AL: "Osteoprotegerin: a novel secreted protein involved in the regulation of bone density", CELL, CELL PRESS, US, no. 89, 18 April 1997 (1997-04-18), pages 309 - 319, XP002077048, ISSN: 0092-8674, DOI: 10.1016/S0092-8674(00)80209-3 *
TAKASAKI W ET AL: "STRUCTURE-BASED DESIGN AND CHARACTERIZATION OF EXOCYCLIC PEPTIDOMIMETICS THAT INHIBIT TNFALPHA BINDING TO ITS RECEPTOR", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 15, no. 12, November 1997 (1997-11-01), pages 1266 - 1270, XP001179759, ISSN: 1087-0156 *

Also Published As

Publication number Publication date
CA2380009A1 (en) 2001-02-08
JP2003505514A (ja) 2003-02-12
AU777634B2 (en) 2004-10-28
WO2001008699A1 (en) 2001-02-08
EP1221963A1 (de) 2002-07-17
AU6611100A (en) 2001-02-19

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Legal Events

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Owner name: YALE UNIVERSITY

A4 Supplementary search report drawn up and despatched

Effective date: 20060206

RIC1 Information provided on ipc code assigned before grant

Ipc: A61P 19/10 20060101ALI20060131BHEP

Ipc: A61K 38/16 20060101ALI20060131BHEP

Ipc: A61P 19/02 20060101ALI20060131BHEP

Ipc: A61K 38/12 20060101AFI20010213BHEP

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17Q First examination report despatched

Effective date: 20070619

RAP1 Party data changed (applicant data changed or rights of an application transferred)

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Owner name: YALE UNIVERSITY

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