EP1221962A2 - Inhibiteurs de l'activite de proteasome pour favoriser la croissance osseuse et la pousse des cheveux - Google Patents
Inhibiteurs de l'activite de proteasome pour favoriser la croissance osseuse et la pousse des cheveuxInfo
- Publication number
- EP1221962A2 EP1221962A2 EP00984583A EP00984583A EP1221962A2 EP 1221962 A2 EP1221962 A2 EP 1221962A2 EP 00984583 A EP00984583 A EP 00984583A EP 00984583 A EP00984583 A EP 00984583A EP 1221962 A2 EP1221962 A2 EP 1221962A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- compound
- bone
- activity
- inhibits
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6875—Nucleoproteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06115183A EP1716861A3 (fr) | 1999-10-20 | 2000-10-20 | Inhibiteurs de l'activité de proteasome pour favoriser la croissance osseuse et la pousse des cheveux |
EP04015639A EP1477180A1 (fr) | 1999-10-20 | 2000-10-20 | Inhibiteurs de l'activité de proteasome pour favoriser la croissance osseuse et la pousse des cheveux |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/421,545 US6902721B1 (en) | 1998-07-10 | 1999-10-20 | Inhibitors of proteasomal activity for stimulating bone growth |
US421545 | 1999-10-20 | ||
US558973 | 2000-04-25 | ||
US09/558,973 US6884769B1 (en) | 1998-07-10 | 2000-04-25 | Inhibitors of proteasomal activity for stimulating hair growth |
PCT/US2000/041360 WO2001028579A2 (fr) | 1999-10-20 | 2000-10-20 | Inhibiteurs de l'activite de proteasome pour favoriser la croissance osseuse et la pousse des cheveux |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06115183A Division EP1716861A3 (fr) | 1999-10-20 | 2000-10-20 | Inhibiteurs de l'activité de proteasome pour favoriser la croissance osseuse et la pousse des cheveux |
EP04015639A Division EP1477180A1 (fr) | 1999-10-20 | 2000-10-20 | Inhibiteurs de l'activité de proteasome pour favoriser la croissance osseuse et la pousse des cheveux |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1221962A2 true EP1221962A2 (fr) | 2002-07-17 |
Family
ID=27025288
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04015639A Withdrawn EP1477180A1 (fr) | 1999-10-20 | 2000-10-20 | Inhibiteurs de l'activité de proteasome pour favoriser la croissance osseuse et la pousse des cheveux |
EP06115183A Ceased EP1716861A3 (fr) | 1999-10-20 | 2000-10-20 | Inhibiteurs de l'activité de proteasome pour favoriser la croissance osseuse et la pousse des cheveux |
EP00984583A Withdrawn EP1221962A2 (fr) | 1999-10-20 | 2000-10-20 | Inhibiteurs de l'activite de proteasome pour favoriser la croissance osseuse et la pousse des cheveux |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP04015639A Withdrawn EP1477180A1 (fr) | 1999-10-20 | 2000-10-20 | Inhibiteurs de l'activité de proteasome pour favoriser la croissance osseuse et la pousse des cheveux |
EP06115183A Ceased EP1716861A3 (fr) | 1999-10-20 | 2000-10-20 | Inhibiteurs de l'activité de proteasome pour favoriser la croissance osseuse et la pousse des cheveux |
Country Status (5)
Country | Link |
---|---|
EP (3) | EP1477180A1 (fr) |
JP (2) | JP2003528039A (fr) |
AU (1) | AU784304B2 (fr) |
CA (1) | CA2385958A1 (fr) |
WO (1) | WO2001028579A2 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8631534B2 (en) | 2006-06-08 | 2014-01-21 | Dr. Fresh, Llc | Toothbrush |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011195590A (ja) * | 1999-10-20 | 2011-10-06 | Osteoscreen Inc | 骨および毛成長を刺激するためのプロテアソーム活性のインヒビター |
US7223745B2 (en) | 2003-08-14 | 2007-05-29 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
US7576206B2 (en) | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
WO2005046584A2 (fr) * | 2003-11-05 | 2005-05-26 | Osteoscreen, Inc. | Stimulation de la croissance des cheveux par les flavanoides du ginkgo biloba |
SG152239A1 (en) | 2004-04-15 | 2009-05-29 | Proteolix Inc | Compounds for proteasome enzyme inhibition |
US7232818B2 (en) | 2004-04-15 | 2007-06-19 | Proteolix, Inc. | Compounds for enzyme inhibition |
CN101006098B (zh) * | 2004-04-15 | 2014-10-29 | 欧尼斯治疗公司 | 用于抑制蛋白酶体酶的化合物 |
US8198270B2 (en) | 2004-04-15 | 2012-06-12 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
PT2030981E (pt) * | 2004-05-10 | 2014-10-14 | Onyx Therapeutics Inc | Compostos para inibição da enzima proteassoma |
CN101044157B (zh) * | 2004-08-06 | 2011-07-13 | 普罗特奥里克斯公司 | 用于抑制蛋白酶体的化合物 |
US20060088471A1 (en) * | 2004-10-20 | 2006-04-27 | Proteolix, Inc. | Compounds for enzyme inhibition |
JP4990155B2 (ja) * | 2004-12-07 | 2012-08-01 | プロテオリックス, インコーポレイテッド | プロテアソームを阻害するための組成物 |
AU2012261655C1 (en) * | 2004-12-07 | 2016-06-23 | Onyx Therapeutics, Inc. | Composition for proteasome inhibition |
CN1315869C (zh) * | 2004-12-13 | 2007-05-16 | 首都医科大学 | 具有抗骨质疏松作用的雌激素-rgd肽缀合物及在医学中的应用 |
US7468383B2 (en) | 2005-02-11 | 2008-12-23 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
CN105237621A (zh) | 2005-11-09 | 2016-01-13 | 欧尼斯治疗公司 | 用于酶抑制的化合物 |
US20070167510A1 (en) * | 2006-01-13 | 2007-07-19 | Suzanne Lentzsch | Methods for inhibiting osteoclastogenesis |
GB0605450D0 (en) * | 2006-03-17 | 2006-04-26 | Intercytex Ltd | Cell co-culture |
EP2041158B1 (fr) | 2006-06-19 | 2013-04-17 | Onyx Therapeutics, Inc. | Peptide epoxycetones destinees a l'inhibition de proteasome |
US8921340B2 (en) | 2006-11-17 | 2014-12-30 | Trustees Of Dartmouth College | Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions |
WO2008064132A2 (fr) * | 2006-11-17 | 2008-05-29 | Trustees Of Dartmouth College | Triterpénoïdes synthétiques et bis-énones tricycliques pour une utilisation dans la stimulation de croissance osseuse et cartilagineuse |
CL2008002966A1 (es) | 2007-10-04 | 2010-06-25 | Onyx Therapeutics Inc | Compuesto tetrapeptido ceto-epoxido cristalino; sal citrato cristalina del compuesto; metodos de preparacion; compuesto intermediario cristalino; metodo de preparacion; y uso para tratar cancer, enfermedad autoinmune, afeccion relacionada con trasplante, enfermedad neurodegenerativa, afeccion asociada con fibrosis, entre otros. |
EA035100B1 (ru) | 2008-10-21 | 2020-04-28 | Оникс Терапьютикс, Инк. | Комбинированная терапия с применением пептид эпоксикетонов |
TWI504598B (zh) | 2009-03-20 | 2015-10-21 | Onyx Therapeutics Inc | 結晶性三肽環氧酮蛋白酶抑制劑 |
WO2011060179A1 (fr) | 2009-11-13 | 2011-05-19 | Onyx Therapeutics, Inc | Utilisation de peptides epoxycetones pour la suppression de la metastase |
CN102725300B (zh) | 2009-12-22 | 2015-03-11 | 赛福伦公司 | 蛋白酶体抑制剂及其制备、纯化、和应用的方法 |
US9359398B2 (en) | 2010-03-01 | 2016-06-07 | Onyx Therapeutics, Inc. | Compounds for immunoproteasome inhibition |
WO2013009923A1 (fr) * | 2011-07-13 | 2013-01-17 | Creighton University | Procédés de favorisation de la croissance de neurones |
US8921419B2 (en) | 2012-05-08 | 2014-12-30 | Trustees Of Dartmouth College | Triterpenoids and compositions containing the same |
UY34897A (es) | 2012-07-09 | 2014-01-31 | Onyx Therapeutics Inc | Profarmacos de inhibidores peptidicos de expoxi cetona proteasa |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0597697A (ja) * | 1991-10-02 | 1993-04-20 | Lion Corp | 歯槽骨再生剤 |
US5942494A (en) * | 1995-10-06 | 1999-08-24 | The Trustees Of Columbia University In The City Of New York | Stimulation of gene expression and synthesis of heat shock protein 72/73 (HSP 70) |
EP0944312B9 (fr) * | 1996-12-13 | 2006-07-05 | ZymoGenetics, Inc. | Compositions visant a stimuler la croissance osseuse et methodes afferentes |
US6462019B1 (en) * | 1998-07-10 | 2002-10-08 | Osteoscreen, Inc. | Inhibitors of proteasomal activity and production for stimulating bone growth |
-
2000
- 2000-10-20 JP JP2001531407A patent/JP2003528039A/ja not_active Withdrawn
- 2000-10-20 CA CA002385958A patent/CA2385958A1/fr not_active Abandoned
- 2000-10-20 AU AU21183/01A patent/AU784304B2/en not_active Ceased
- 2000-10-20 EP EP04015639A patent/EP1477180A1/fr not_active Withdrawn
- 2000-10-20 EP EP06115183A patent/EP1716861A3/fr not_active Ceased
- 2000-10-20 EP EP00984583A patent/EP1221962A2/fr not_active Withdrawn
- 2000-10-20 WO PCT/US2000/041360 patent/WO2001028579A2/fr not_active Application Discontinuation
-
2007
- 2007-08-02 JP JP2007202377A patent/JP2007297408A/ja active Pending
Non-Patent Citations (2)
Title |
---|
None * |
See also references of WO0128579A3 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8631534B2 (en) | 2006-06-08 | 2014-01-21 | Dr. Fresh, Llc | Toothbrush |
Also Published As
Publication number | Publication date |
---|---|
WO2001028579A2 (fr) | 2001-04-26 |
WO2001028579A3 (fr) | 2001-09-20 |
EP1716861A3 (fr) | 2007-08-29 |
AU2118301A (en) | 2001-04-30 |
EP1477180A1 (fr) | 2004-11-17 |
JP2007297408A (ja) | 2007-11-15 |
JP2003528039A (ja) | 2003-09-24 |
CA2385958A1 (fr) | 2001-04-26 |
AU784304B2 (en) | 2006-03-09 |
EP1716861A2 (fr) | 2006-11-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20020429 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
17Q | First examination report despatched |
Effective date: 20031028 |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: ROSSINI, G. Inventor name: MUNDY, GREGORY, R. Inventor name: GARRETT, ROSS, I. |
|
17Q | First examination report despatched |
Effective date: 20050707 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20070321 |