EP1191964B1 - Procede et systeme de production d'une aiguille en plastique - Google Patents

Procede et systeme de production d'une aiguille en plastique Download PDF

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Publication number
EP1191964B1
EP1191964B1 EP00931035A EP00931035A EP1191964B1 EP 1191964 B1 EP1191964 B1 EP 1191964B1 EP 00931035 A EP00931035 A EP 00931035A EP 00931035 A EP00931035 A EP 00931035A EP 1191964 B1 EP1191964 B1 EP 1191964B1
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EP
European Patent Office
Prior art keywords
melt
needle
mould cavity
feed system
plastic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP00931035A
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German (de)
English (en)
Other versions
EP1191964A1 (fr
Inventor
Soren Jensen
Mogens Papsoe
Poul E. Nielsen
Henrik E. Hansen
Anne Sorensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
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Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Priority to EP05010723A priority Critical patent/EP1595563A1/fr
Publication of EP1191964A1 publication Critical patent/EP1191964A1/fr
Application granted granted Critical
Publication of EP1191964B1 publication Critical patent/EP1191964B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/26—Moulds
    • B29C45/261—Moulds having tubular mould cavities
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/46—Means for plasticising or homogenising the moulding material or forcing it into the mould
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/26—Moulds
    • B29C45/27—Sprue channels ; Runner channels or runner nozzles
    • B29C45/2701—Details not specific to hot or cold runner channels
    • B29C45/2708—Gates
    • B29C2045/2714—Gates elongated, e.g. film-like, annular
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0079—Liquid crystals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7544—Injection needles, syringes

Definitions

  • This invention relates to a method for producing a needle of plastic and a system for the same, in particular a needle for medical purposes.
  • Needles or cannulas for medical purposes such as injections of medicine, have been produced in various sizes depending on their intended use.
  • medicine to be injected frequently such as several times a day, it is preferred to use the thinnest possible needle taking into account the viscosity of the medicine to be injected.
  • Diabetics injecting insulin several times a day would preferably use a very thin needle, such as from gauge 26 to gauge 30, in order to reduce the pain as well as reduce the tissue damage resulting from each injection.
  • the term "thin” refers to the diameter of the needle in question.
  • gauge 8 corresponds to 4.19 mm
  • gauge 30 corresponds to 0.30 mm, for example.
  • the very thin needles have usually been made from metal. Like many other medical articles it is of interest to produce the needles of a plastic material.
  • EP 452 595 discloses a method for producing a plastic medical tubing, such as a catheter, wherein a liquid crystalline polymer has been shear-thinned to such a viscosity allowing the melt to flow into and fill a mould.
  • the plastic tubings produced have a gauge size of from 8 to 26, preferably from 14 to 20.
  • the shear-thinning is provided by passing the plastic melt through an orifice before the melt reaches the mould.
  • the patent describes a method for preparing the tubing by extruding the shear-thinned polymer into a mould, and describes further that the polymer melt may be forced under pressure through the orifice and thence directly into the mould.
  • WO 90/00960 concerns a method for producing thin walled tubes by injection moulding, which tubes are suitable for use as indwelling vein cannulae.
  • the method involves a mould with a core, which core is centred during injection moulding by a sleeve.
  • the sleeve is pushed forward by the material being injected whereby the sleeve slides in a controlled way towards the mould end.
  • the sleeve movement is controlled by adjusting the injection pressure and speed of the material.
  • WO 94/20279 discloses a method for manufacturing a needle in which an orifice of the needle is formed by pressing in a fluid, such as a gas, through a center-channel of the mould. Forming of an orifice by use of a mandrel is mentioned briefly including the statement 'Moulding around such long, small diameter mandrels is very difficult and not suited to mass production'. No relevant processing parameter values or feasible dimensions of needles produced by the mandrel method are disclosed.
  • Injection moulding systems are often used for the production of large amount of articles.
  • Injection moulding is a periodical process, in which a plastic granulate is being homogenized and melted by heating as well as by mechanical working.
  • the plastic melt is injected into a mould cavity.
  • the mould cavity has a temperature which is controlled to be lower than the melting point of the plastic.
  • the melt injected into the mould cavity will solidify from the wall of the mould cavity to the centre of the article.
  • a screw may be used to the mechanical working of the melt as well as to introduce the melt into the mould cavity at a certain injection speed.
  • the screw movement or injection stroke is normally set to 1 to 4 times of the diameter of the screw.
  • shot volume is meant the amount of melt necessary to at least fill the mould cavity to obtain a needle of predetermined dimensions.
  • needles or cannulas of this diameter having an inner diameter is very thin-walled, a wall thickness of approximately 0.10-0.18 mm. This provides the problem of introducing the melt into the mould cavity in such a short time, that "freezing” of the melt is avoided.
  • freezing is meant that the melt solidifies rapidly due to the small thickness of the material. In case melt freezes in the first part of the mould cavity, the melt will not be able to fill the entire mould cavity and thereby a needle of predetermined dimensions will not be obtained.
  • the needles or cannulas are furthermore having a very large UD ratio (wherein L is the length, and D is the diameter of the article) which further provides the problem of not only requiring a small shot volume but also of filling the "long" mould cavity as compared to a small diameter.
  • L is the length
  • D is the diameter of the article
  • One aspect of the invention relates to a method for producing a plastic needle, which needle has two ends, wherein at least the outer diameter of one end is less than 0.50 mm, said needle further having a longitudinal lumen extending between two openings of the needle, in a moulding system having an assembly comprising a feed system and a mould cavity, said method comprising the following steps:
  • the moulding system 1 may be any injection moulding system suitable for injection moulding of small articles.
  • Fig. 1 is shown a schematic view of a injection moulding system 1.
  • the system 1 comprises a granulate reservoir 2, which reservoir 2 contains the plastic in a solid phase.
  • the granulate is at the bottom 3 of the reservoir 2 lead through a feed tube 4 into a chamber 5.
  • the chamber 5 comprises a screw 6, which screw 6 is rotated by a driving shaft 7 connected to a motor 8.
  • An instrument for measuring pressure 9 is connected to the chamber 5 in front of the screw 6, for monitoring the pressure building by the screw 6.
  • the screw 6 rotates the granulate is led towards the entrance of an assembly 10.
  • the granulate is being heated and becomes a plastic melt.
  • the temperature is monitored by a temperature sensor 11.
  • the temperature of the assembly 10 is monitored by a temperature sensor 12 and is controlled to be from 50 to 350 °C, preferably from 120 to 140 °C according to the material used in the moulding process.
  • the flow length of the melt in the assembly 10 is optimal in relation to the strength of the produced needle.
  • the assembly 10 is shown schematic in Fig. 2.
  • the assembly 10 comprises in this embodiment a mould cavity 13 and a feed system 14.
  • the melt from the chamber 5 is introduced into the feed system 14. From the feed system 14 the melt is introduced radially into the mould cavity 13. In the feed system 14 the melt pressure is gradually increased before the melt enters the mould cavity 13.
  • the pressure is increased due to the distance the melt has to flow.
  • the matter is that the pressure is increased due to the flow resistance of the melt.
  • the pressure is furthermore increased by decreasing the diameter of the feed system 14.
  • the feed system 14 comprises a first cylindrical part 15 having a first diameter and a second cylindrical part 16 having a second diameter, smaller than the first diameter.
  • the first cylindrical part 15 is separated from the second cylindrical part 16 by a conical part 17.
  • the melt pressure in this embodiment is already increased from the start of the feed system 14 and afterwards increased gradually by the passage of the melt through the feed system 14 due to the distance the melt has to flow as well as due to the decreasing of the diameter of the feed system 14.
  • the melt pressure is increased sufficiently so the high energy reserve in the melt is ensured.
  • the melt pressure can be transferred to the flow front of the melt in approximately 1 msec.
  • Fig. 3 is the mould cavity 13 shown separated from a ring gate 18, the function of the ring gate 18 will be explained more fully below.
  • the melt is in this embodiment introduced radially from the feed system 14 into the ring gate 18 in respect to the melt flow in the mould cavity 13.
  • the mould cavity 13 comprises a first part 19 having a first diameter and a second part 20 with a second diameter smaller than the first diameter.
  • the first part 19 is separated from the second part 20 by a conical part 21.
  • the diameter of the second part 20 corresponds to the outer diameter of the needle and is less than 0.50 mm.
  • a wire 22 is substantially centred in the mould cavity 13 for forming the lumen in the needle.
  • the wire 22 is fixed and extends through the mould cavity 13 and further through the ring gate 18.
  • the melt flows equally around the wire during moulding and the lumen is formed in the centre of the needle.
  • Fig. 4 another embodiment of the feed system 14 according to the invention is shown.
  • the feed system 14 has in this embodiment a first diameter D entrance at the entrance to the feed system 14 and a second diameter D exit at the exit of the feed system 14.
  • the diameter of the feed system 14 is in this embodiment gradually decreasing along the entire length L feed system , so the feed system 14 exhibits a conical geometry.
  • Fig. 5 is the feed system 14 shown in the same way as in Fig. 2.
  • the feed system 14 is having two cylindrical parts separated by conical parts.
  • the first cylindrical part 15 is having a diameter corresponding to the diameter D en -trance at the entrance to the feed system 14.
  • the second cylindrical part 16 is having a diameter D middle , which diameter D middle is smaller than the diameter D entrance .
  • the diameter corresponds to the diameter D exit , which diameter corresponds to the entrance of the mould cavity.
  • the first cylindrical part 15 is separated from the second cylindrical part 16 by a first conical part 17.
  • the second cylindrical part 16 is further separated from the mould cavity by a second conical part 23.
  • the diameter of the feed system 14 is in this embodiment decreased in steps along its entire length L feed system .
  • Fig. 6 is a schematic sectional view of the ring gate 18 shown.
  • the arrow B indicates the main melt flow direction in the feed system.
  • the melt is introduced radially into the ring gate 18 (indicated by arrow B) with respect to the melt flow in the mould cavity (indicated by arrow A).
  • a first part 24 of the ring gate 18, where the melt is introduced, is formed with a large volume around the circumference of the ring gate 18, whereby the melt is forced to flow firstly along the circumference of the first part 24 filling the large volume with melt before entering a second part 25 of the ring gate 18.
  • the melt flows in direction of arrow A.
  • the second part 25 of the ring gate 18 is designed with an elongated conical geometry to avoid any sudden changes in geometry that otherwise could lead to melt stop.
  • Fig. 7 a schematic sectional view of a plastic needle 26 is shown.
  • the needle 26 is having a longitudinal lumen 27 extending between one opening 28 at a first end 29 of the needle 26 and a second opening 30 at a second end 31.
  • Fig. 8 shows a sectional view of the vertical section A-A of the needle 26.
  • the needle 26 is round and has an outer diameter D needle as well as an inner diameter D lumen .
  • a plastic needle being produced according to the invention having an outer diameter of 0.40 mm and a length of 8.00 mm.
  • the needle is further having a lumen with a diameter of 0.16 mm.
  • the wall of the needle is in this embodiment 0.12 mm.
  • the plastic melt used is a liquid crystalline polymer, which is a random copolymer comprising 73% hydroxybenzoic acid and 27 % hydroxynaphtoic acid.
  • the needle is being produced in an injecting moulding system having an assembly comprising a feed system, a ring gate as well as a mould cavity.
  • the screw used in the injecting moulding system has a 15 mm screw.
  • the injection moulding system is set to introduce approximately 2.6 ccm of melt into the feed system with an injection speed of 3 ccm/sec.
  • the temperature of the assembly is controlled to 130 - 140 °C.
  • the geometrical form of the feed system is as follows, an entrance diameter of 4.00 mm, a first cylindrical part with a diameter of 2.50 mm for distance of 449.00 mm, a second cylindrical part with a diameter on 1.60 mm for a distance of 10.00 mm, separated by a conical part for a distance of 10.00 mm.
  • the diagram in Fig. 9 shows an abscissa and an ordinate. At the abscissa the time is indicated as seconds, and at the ordinate the pressure is indicated as MPa.
  • the diagram shows the melt pressure at the entrance to the feed system as function of the time during filling of the assembly. In the diagram it is shown, that the pressure is being increased gradually for about a second during the melts passage of the feed system. At about 1 sec on the abscissa, the pressure have a high increase due to the small diameter of the mould cavity. The high pressure in the melt will due to the energy reserve be transferred to the flow front of the melt, so the entire mould cavity will be filled before the melt starts to solidify.
  • the pressure of the melt will be increased during passage of the feed system, so the energy reserve in the melt will be sufficient to fill the entire mould cavity in approximately 1 msec. Accordingly, the produced needle will obtain the predetermined size as mentioned before.

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  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Moulds For Moulding Plastics Or The Like (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Injection Moulding Of Plastics Or The Like (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Materials For Medical Uses (AREA)

Claims (13)

  1. Système (1) pour fabriquer une aiguille en matière plastique creuse, laquelle aiguille possède deux extrémités, et dans laquelle au moins le diamètre extérieur d'une extrémité est inférieur à 0,50 mm, ladite aiguille comportant en outre une lumière longitudinale qui s'étend entre deux ouvertures de l'aiguille, ledit système (1) possédant un ensemble (10) comprenant un système d'alimentation (14) et une cavité de moule (13), et dans lequel un insert (22) correspond à la lumière de l'aiguille pour la formation de la lumière dans l'aiguille, et comprenant en outre
    des moyens pour introduire une masse fondue de matière plastique dans le système d'alimentation (14),
    ledit système d'alimentation (14) étant agencé de manière à accroítre graduellement la pression de la masse fondue pendant le passage de la masse fondue à l'intérieur du système d'alimentation (14), et
    des moyens pour transférer la masse fondue dans la cavité de moule (13) de sorte que la masse fondue remplit pour l'essentiel la cavité de moule (13) en un intervalle de temps de 0,1 à 10 ms, de préférence de 1 à 2 ms.
  2. Système (1) selon la revendication 1, dans lequel le système d'alimentation (14) possède au moins en partie une forme conique.
  3. Système (1) selon la revendication 1, dans lequel le système d'alimentation (14) comprend des parties cylindriques ayant différents diamètres, séparées par des parties coniques.
  4. Système (1) selon l'une quelconque des revendications 1 à 3, dans lequel une porte annulaire (18) est disposée en avant de la cavité de moule (13), la masse fondue étant introduite dans la porte annulaire (8) avant de pénétrer dans la cavité de moule (13).
  5. Système (1) selon la revendication 4, dans lequel la porte annulaire (18) possède une forme conique.
  6. Système (1) selon la revendication 4 ou 5, dans lequel la masse fondue de matière plastique est introduite radialement dans la porte annulaire (18).
  7. Système (1) selon l'une quelconque des revendications 1 à 6, dans lequel le système d'alimentation (4) et la cavité de moule (13) sont adaptés pour présenter une température dans la gamme de 50 à 350°C, de préférence de 120 à 140°C.
  8. Système (1) selon la revendication 1, dans lequel l'insert est un fil (22) sensiblement centré dans la cavité de moule (13).
  9. Système (1) selon la revendication 8, dans lequel des moyens sont prévus pour retirer le fil (22) après le moulage.
  10. Procédé pour fabriquer une aiguille en matière plastique, laquelle aiguille possède deux extrémités, et au moins le diamètre extérieur d'une extrémité étant inférieur à 0,50 mm, ladite aiguille comportant en outre une lumière longitudinale s'étendant entre deux ouvertures de l'aiguille, dans un système de moulage (1) selon la revendication 1, ledit procédé comprenant les étapes suivantes consistant à:
    introduire une matière plastique dans le système d'alimentation (14),
    augmenter graduellement la pression de la masse fondue pendant le passage de la masse fondue à travers le système d'alimentation (14),
    faire passer la masse fondue dans la cavité de moule (13), la masse fondue remplissant sensiblement la cavité de moule (13) en un intervalle de temps de 0,1 à 10 ms,
    faire refroidir la masse fondue dans la cavité de moule (13), ce qui a pour effet que la masse fondue se solidifie pour former une aiguille, et
    retirer l'aiguille de la cavité de moule (13).
  11. Procédé selon la revendication 10, selon lequel la cavité de moule (13) est remplie sensiblement en un intervalle de temps de 1 à 2 ms.
  12. Procédé selon l'une quelconque des revendications 10 ou 11, selon lequel la masse fondue est introduite dans le système d'alimentation (14) à une cadence de 0,10 à 100 cm3/s, de préférence de 1 à 10 cm3/s.
  13. Procédé selon l'une quelconque des revendications 10, 11 ou 12, selon lequel la température du moule va de 50 à 350°C, de préférence de 120 à 140°C.
EP00931035A 1999-05-28 2000-05-26 Procede et systeme de production d'une aiguille en plastique Expired - Lifetime EP1191964B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05010723A EP1595563A1 (fr) 1999-05-28 2000-05-26 Aiguille en plastique et procédé et système de production d'une aiguille en plastique

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK76099 1999-05-28
DKPA199900760 1999-05-28
PCT/DK2000/000286 WO2000072901A1 (fr) 1999-05-28 2000-05-26 Procede et systeme de production d'une aiguille en plastique

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP05010723A Division EP1595563A1 (fr) 1999-05-28 2000-05-26 Aiguille en plastique et procédé et système de production d'une aiguille en plastique

Publications (2)

Publication Number Publication Date
EP1191964A1 EP1191964A1 (fr) 2002-04-03
EP1191964B1 true EP1191964B1 (fr) 2005-05-25

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EP05010723A Ceased EP1595563A1 (fr) 1999-05-28 2000-05-26 Aiguille en plastique et procédé et système de production d'une aiguille en plastique
EP00931035A Expired - Lifetime EP1191964B1 (fr) 1999-05-28 2000-05-26 Procede et systeme de production d'une aiguille en plastique

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EP05010723A Ceased EP1595563A1 (fr) 1999-05-28 2000-05-26 Aiguille en plastique et procédé et système de production d'une aiguille en plastique

Country Status (7)

Country Link
US (2) US6767496B1 (fr)
EP (2) EP1595563A1 (fr)
JP (1) JP2003517345A (fr)
AT (1) ATE296130T1 (fr)
AU (1) AU4910800A (fr)
DE (1) DE60015974T2 (fr)
WO (1) WO2000072901A1 (fr)

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WO2005023327A1 (fr) 2003-09-11 2005-03-17 Seft Holding Sa Aiguille en plastique et dispositifs comportant cette aiguille
WO2005032348A2 (fr) 2003-10-03 2005-04-14 Applied Medical Resources Corporation Obturateur optique sans lame
EP1682326B1 (fr) * 2003-11-14 2008-08-13 Unomedical A/S Procede et moule de moulage par injection d'un catheter, catheter et son usage
US7431876B2 (en) * 2003-11-14 2008-10-07 Unomedical A/S Injection moulding of a catheter
EP3175804B1 (fr) 2004-06-29 2018-09-26 Applied Medical Resources Corporation Instrument chirurgical optique à insufflation
US7794644B2 (en) * 2005-10-05 2010-09-14 Applied Medical Resources Corporation Thin-walled optical obturator
AU2007303069B2 (en) 2006-10-06 2013-03-21 Applied Medical Resources Corporation Visual insufflation port
EP2357014A1 (fr) 2010-03-17 2011-08-17 Solvay Advanced Polymers, L.L.C. Aiguilles améliorées fabriquées à partir d'un matériau plastique particulier
US8742064B2 (en) * 2007-10-23 2014-06-03 Solvay Advanced Polymers, L.L.C. Medical tubings made of a polymer material
US9265899B2 (en) 2008-01-25 2016-02-23 Applied Medical Resources Corporation Insufflating access system
US7938800B2 (en) * 2008-05-13 2011-05-10 Lawrence R. Koh and Nina Merrell-Koh Needleshield assembly and methods of use
AU2009296212B2 (en) 2008-09-29 2015-02-05 Applied Medical Resources Corporation First-entry trocar system
US9339956B2 (en) 2009-12-18 2016-05-17 3M Innovative Properties Company Molding thermotropic liquid crystalline polymers
EP2547383B1 (fr) 2010-03-17 2018-07-18 Solvay Specialty Polymers USA, L.L.C. Aiguilles améliorées fabriquées à partir d'un matériau plastique particulier
EP2646218B1 (fr) * 2010-12-02 2016-04-06 3M Innovative Properties Company Micro-aiguilles de polymère cristallin liquide
WO2012151276A2 (fr) 2011-05-02 2012-11-08 Applied Medical Resources Corporation Orifice d'accès chirurgical universel peu encombrant
CA3172877A1 (fr) * 2011-09-12 2013-03-21 James B. Wolff Systeme et procede pour creer un effet venturi au sein d'un orifice
CN110834405A (zh) * 2018-08-17 2020-02-25 伊森医药科技(上海)有限公司 一种塑料注射针的制作工艺及其产品

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WO2000072901A1 (fr) 2000-12-07
EP1191964A1 (fr) 2002-04-03
AU4910800A (en) 2000-12-18
EP1595563A1 (fr) 2005-11-16
DE60015974T2 (de) 2006-05-04
DE60015974D1 (de) 2005-12-15
US6767496B1 (en) 2004-07-27
US20040199127A1 (en) 2004-10-07
ATE296130T1 (de) 2005-06-15
JP2003517345A (ja) 2003-05-27

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