EP1189944A1 - Axor16, r cepteur coupl une prot ine g - Google Patents

Axor16, r cepteur coupl une prot ine g

Info

Publication number
EP1189944A1
EP1189944A1 EP00942952A EP00942952A EP1189944A1 EP 1189944 A1 EP1189944 A1 EP 1189944A1 EP 00942952 A EP00942952 A EP 00942952A EP 00942952 A EP00942952 A EP 00942952A EP 1189944 A1 EP1189944 A1 EP 1189944A1
Authority
EP
European Patent Office
Prior art keywords
polypeptide
polynucleotide
sequence
seq
isolated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00942952A
Other languages
German (de)
English (en)
Other versions
EP1189944A4 (fr
Inventor
Nabil Elshourbagy
Usman Shabon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP1189944A1 publication Critical patent/EP1189944A1/fr
Publication of EP1189944A4 publication Critical patent/EP1189944A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Definitions

  • the marker sequence is a hexa-histidine peptide, as provided in the pQE vector (Qiagen, Inc.) and descnbed in Gentz et al, Proc Natl Acad Sci USA (1989) 86:821-824, or is an HA tag.
  • the polynucleotide may also contain non-codmg 5' and 3' sequences, such as transc ⁇ bed, non-translated sequences, splicing and polyadenylation signals, ⁇ bosome bmdmg sites and sequences that stabilize mRNA
  • the present invention relates to a diagonostic kit comprising:
  • PCRs result m 93 scores indicating the presence or absence of the PCR product of the gene of interest. These scores are compared with scores created using PCR products from genomic sequences of known location. This comparison is conducted at http://www.genome.wi.mit.edu/.
  • the gene of the present invention maps to human chromosome l lql2.2.
  • the polynucleotide sequences of the present invention are also valuable tools for tissue expression studies. Such studies allow the determination of expression patterns of polynucleotides of the present invention which may give an indication as to the expression patterns of the encoded polypeptides m tissues, by detecting the mRNAs that encode them.
  • Isolated means altered “by the hand of man” from its natural state, i e , if it occurs in nature, it has been changed or removed from its original environment, or both
  • a polynucleotide or a polypeptide naturally present in a living organism is not “isolated,” but the same polynucleotide or polypeptide separated from the coexisting materials of its natural state is “isolated”, as the term is employed herein
  • a polynucleotide or polypeptide that is introduced mto an organism by transformation, genetic manipulation or by any other recombinant method is "isolated” even if it is still present in said organism, which organism may be living or non-hvmg.
  • BESTFLT and GAP may be used to determine the % identity between two polynucleotides and the % identity and the % similanty between two polypeptide sequences.
  • BESTFrf uses the "local homology" algorithm of Smith and Waterman (J Mol Biol, 147,195-197, 1981, Advances in Applied Mathematics, 2, 482- 489, 1981) and finds the best single region of similarity between two sequences.
  • BESTFIT is more suited to companng two polynucleotide or two polypeptide sequences that are dissimilar in length, the program assuming that the shorter sequence represents a portion of the longer.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Cette invention, qui a trait à des polypeptides et à des polynucléotides d'AXOR16, concerne également des procédés de production de ces polypeptides par le biais de techniques de recombinaison. Elle concerne également des méthodes d'utilisation des polypeptides et des polynucléotides d'AXOR16 dans des doses diagnostiques.
EP00942952A 1999-06-21 2000-06-19 Axor16, r cepteur coupl une prot ine g Withdrawn EP1189944A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33710599A 1999-06-21 1999-06-21
US337105 1999-06-21
PCT/US2000/016869 WO2000078809A1 (fr) 1999-06-21 2000-06-19 Axor16, récepteur couplé à une protéine g

Publications (2)

Publication Number Publication Date
EP1189944A1 true EP1189944A1 (fr) 2002-03-27
EP1189944A4 EP1189944A4 (fr) 2002-09-11

Family

ID=23319152

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00942952A Withdrawn EP1189944A4 (fr) 1999-06-21 2000-06-19 Axor16, r cepteur coupl une prot ine g

Country Status (2)

Country Link
EP (1) EP1189944A4 (fr)
WO (1) WO2000078809A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1207201A4 (fr) * 1999-08-27 2003-03-12 Takeda Chemical Industries Ltd Proteine recepteur couplee a une proteine g et adn correspondant
EP1287021A2 (fr) * 2000-05-18 2003-03-05 Bayer Aktiengesellschaft Regulation du recepteur couple a la proteine g analogue au recepteur de la galanine humaine
US6927041B2 (en) 2000-07-06 2005-08-09 Bayer Corporation Human neuropeptide Y-like G protein-coupled receptor
WO2002050265A1 (fr) * 2000-12-19 2002-06-27 Takeda Chemical Industries, Ltd. Nouvelles proteines transmembranaires du type recepteur et adn correspondants
WO2003033536A2 (fr) * 2001-10-19 2003-04-24 Paradigm Therapeutics Limited Recepteur
MXPA04009959A (es) 2002-04-12 2004-12-13 Schering Corp Ligandos del receptor acoplado a la proteina g y metodos.
AU2003261874A1 (en) * 2002-09-02 2004-03-29 Takeda Pharmaceutical Company Limited Adrenocortical hormone secretion controller
WO2006039256A1 (fr) * 2004-09-29 2006-04-13 Glaxo Group Limited Utilisation d'agonistes du gpr103 pour moduler le comportement alimentaire

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000011015A1 (fr) * 1998-08-24 2000-03-02 Alphagene, Inc. Proteines secretees et polynucleotides codant pour ces proteines
WO2000022131A2 (fr) * 1998-10-13 2000-04-20 Arena Pharmaceuticals, Inc. Recepteurs non-endogenes de la proteine g humaine ayant une activite constitutive
WO2000031258A2 (fr) * 1998-11-20 2000-06-02 Arena Pharmaceuticals, Inc. Recepteurs humains couples a la proteine g orphan

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000011015A1 (fr) * 1998-08-24 2000-03-02 Alphagene, Inc. Proteines secretees et polynucleotides codant pour ces proteines
WO2000022131A2 (fr) * 1998-10-13 2000-04-20 Arena Pharmaceuticals, Inc. Recepteurs non-endogenes de la proteine g humaine ayant une activite constitutive
WO2000031258A2 (fr) * 1998-11-20 2000-06-02 Arena Pharmaceuticals, Inc. Recepteurs humains couples a la proteine g orphan

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ARVIDSSON ANN-KRISTIN ET AL: "Cloning of a neuropeptide Y/peptide YY receptor from the Atlantic cod: The Yb receptor." REGULATORY PEPTIDES, vol. 75-76, 1997, pages 39-43, XP002203031 ISSN: 0167-0115 *
See also references of WO0078809A1 *

Also Published As

Publication number Publication date
WO2000078809A1 (fr) 2000-12-28
EP1189944A4 (fr) 2002-09-11

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