EP1189944A1 - G-protein gekoppelter rezeptor axor16 - Google Patents
G-protein gekoppelter rezeptor axor16Info
- Publication number
- EP1189944A1 EP1189944A1 EP00942952A EP00942952A EP1189944A1 EP 1189944 A1 EP1189944 A1 EP 1189944A1 EP 00942952 A EP00942952 A EP 00942952A EP 00942952 A EP00942952 A EP 00942952A EP 1189944 A1 EP1189944 A1 EP 1189944A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- polypeptide
- polynucleotide
- sequence
- seq
- isolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
Definitions
- the marker sequence is a hexa-histidine peptide, as provided in the pQE vector (Qiagen, Inc.) and descnbed in Gentz et al, Proc Natl Acad Sci USA (1989) 86:821-824, or is an HA tag.
- the polynucleotide may also contain non-codmg 5' and 3' sequences, such as transc ⁇ bed, non-translated sequences, splicing and polyadenylation signals, ⁇ bosome bmdmg sites and sequences that stabilize mRNA
- the present invention relates to a diagonostic kit comprising:
- PCRs result m 93 scores indicating the presence or absence of the PCR product of the gene of interest. These scores are compared with scores created using PCR products from genomic sequences of known location. This comparison is conducted at http://www.genome.wi.mit.edu/.
- the gene of the present invention maps to human chromosome l lql2.2.
- the polynucleotide sequences of the present invention are also valuable tools for tissue expression studies. Such studies allow the determination of expression patterns of polynucleotides of the present invention which may give an indication as to the expression patterns of the encoded polypeptides m tissues, by detecting the mRNAs that encode them.
- Isolated means altered “by the hand of man” from its natural state, i e , if it occurs in nature, it has been changed or removed from its original environment, or both
- a polynucleotide or a polypeptide naturally present in a living organism is not “isolated,” but the same polynucleotide or polypeptide separated from the coexisting materials of its natural state is “isolated”, as the term is employed herein
- a polynucleotide or polypeptide that is introduced mto an organism by transformation, genetic manipulation or by any other recombinant method is "isolated” even if it is still present in said organism, which organism may be living or non-hvmg.
- BESTFLT and GAP may be used to determine the % identity between two polynucleotides and the % identity and the % similanty between two polypeptide sequences.
- BESTFrf uses the "local homology" algorithm of Smith and Waterman (J Mol Biol, 147,195-197, 1981, Advances in Applied Mathematics, 2, 482- 489, 1981) and finds the best single region of similarity between two sequences.
- BESTFIT is more suited to companng two polynucleotide or two polypeptide sequences that are dissimilar in length, the program assuming that the shorter sequence represents a portion of the longer.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33710599A | 1999-06-21 | 1999-06-21 | |
PCT/US2000/016869 WO2000078809A1 (en) | 1999-06-21 | 2000-06-19 | Axor16, a g protein coupled receptor |
US337105 | 2003-01-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1189944A1 true EP1189944A1 (de) | 2002-03-27 |
EP1189944A4 EP1189944A4 (de) | 2002-09-11 |
Family
ID=23319152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP00942952A Withdrawn EP1189944A4 (de) | 1999-06-21 | 2000-06-19 | G-protein gekoppelter rezeptor axor16 |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP1189944A4 (de) |
WO (1) | WO2000078809A1 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2391868A1 (en) * | 1999-08-27 | 2001-03-08 | Takeda Chemical Industries, Ltd. | Novel g protein-coupled receptor protein and dna thereof |
AU2001269013A1 (en) * | 2000-05-18 | 2001-11-26 | Bayer Aktiengesellschaft | Human galanin receptor-like g protein coupled receptor |
AU2001271838A1 (en) * | 2000-07-06 | 2002-01-21 | Bayer Corporation | Human neuropeptide y-like g protein-coupled receptor |
AU2002222681A1 (en) * | 2000-12-19 | 2002-07-01 | Takeda Chemical Industries Ltd. | Novel transmembrane receptor-like proteins and dnas thereof |
EP1436328A2 (de) * | 2001-10-19 | 2004-07-14 | Paradigm Therapeutics Limited | G-protein gekoppelter rezeptor |
MXPA04009959A (es) * | 2002-04-12 | 2004-12-13 | Schering Corp | Ligandos del receptor acoplado a la proteina g y metodos. |
WO2004022086A1 (ja) * | 2002-09-02 | 2004-03-18 | Takeda Pharmaceutical Company Limited | 副腎皮質ホルモン分泌調節剤 |
WO2006039256A1 (en) * | 2004-09-29 | 2006-04-13 | Glaxo Group Limited | Use of gpr103 agonists for modulating feeding behaviour |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000011015A1 (en) * | 1998-08-24 | 2000-03-02 | Alphagene, Inc. | Secreted proteins and polynucleotides encoding them |
WO2000022131A2 (en) * | 1998-10-13 | 2000-04-20 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human g protein-coupled receptors |
WO2000031258A2 (en) * | 1998-11-20 | 2000-06-02 | Arena Pharmaceuticals, Inc. | Human orphan g protein-coupled receptors |
-
2000
- 2000-06-19 WO PCT/US2000/016869 patent/WO2000078809A1/en not_active Application Discontinuation
- 2000-06-19 EP EP00942952A patent/EP1189944A4/de not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000011015A1 (en) * | 1998-08-24 | 2000-03-02 | Alphagene, Inc. | Secreted proteins and polynucleotides encoding them |
WO2000022131A2 (en) * | 1998-10-13 | 2000-04-20 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human g protein-coupled receptors |
WO2000031258A2 (en) * | 1998-11-20 | 2000-06-02 | Arena Pharmaceuticals, Inc. | Human orphan g protein-coupled receptors |
Non-Patent Citations (2)
Title |
---|
ARVIDSSON ANN-KRISTIN ET AL: "Cloning of a neuropeptide Y/peptide YY receptor from the Atlantic cod: The Yb receptor." REGULATORY PEPTIDES, vol. 75-76, 1997, pages 39-43, XP002203031 ISSN: 0167-0115 * |
See also references of WO0078809A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP1189944A4 (de) | 2002-09-11 |
WO2000078809A1 (en) | 2000-12-28 |
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Legal Events
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
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Effective date: 20011221 |
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Inventor name: ELSHOURBAGY, NABIL Inventor name: SHABON, USMAN |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20020731 |
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18D | Application deemed to be withdrawn |
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