EP1189632A4 - Vaccin a combinaison de proteines de surface pneumococciques - Google Patents

Vaccin a combinaison de proteines de surface pneumococciques

Info

Publication number
EP1189632A4
EP1189632A4 EP00947640A EP00947640A EP1189632A4 EP 1189632 A4 EP1189632 A4 EP 1189632A4 EP 00947640 A EP00947640 A EP 00947640A EP 00947640 A EP00947640 A EP 00947640A EP 1189632 A4 EP1189632 A4 EP 1189632A4
Authority
EP
European Patent Office
Prior art keywords
surface protein
combination vaccine
protein combination
pneumococcal surface
pneumococcal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00947640A
Other languages
German (de)
English (en)
Other versions
EP1189632A1 (fr
Inventor
Robert C Huebner
Jacquelyn S Sampson
George M Carlone
Edwin Ades
David E Briles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur SA
UAB Research Foundation
Sanofi Pasteur Inc
Centers of Disease Control and Prevention CDC
Original Assignee
Aventis Pasteur SA
UAB Research Foundation
Centers of Disease Control and Prevention CDC
Aventis Pasteur Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pasteur SA, UAB Research Foundation, Centers of Disease Control and Prevention CDC, Aventis Pasteur Inc filed Critical Aventis Pasteur SA
Publication of EP1189632A1 publication Critical patent/EP1189632A1/fr
Publication of EP1189632A4 publication Critical patent/EP1189632A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP00947640A 1999-06-10 2000-06-09 Vaccin a combinaison de proteines de surface pneumococciques Withdrawn EP1189632A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13842299P 1999-06-10 1999-06-10
US138422P 1999-06-10
US58783300A 2000-06-06 2000-06-06
US587833 2000-06-06
PCT/US2000/040176 WO2000076541A1 (fr) 1999-06-10 2000-06-09 Vaccin a combinaison de proteines de surface pneumococciques

Publications (2)

Publication Number Publication Date
EP1189632A1 EP1189632A1 (fr) 2002-03-27
EP1189632A4 true EP1189632A4 (fr) 2002-08-21

Family

ID=26836182

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00947640A Withdrawn EP1189632A4 (fr) 1999-06-10 2000-06-09 Vaccin a combinaison de proteines de surface pneumococciques

Country Status (7)

Country Link
EP (1) EP1189632A4 (fr)
JP (1) JP2003519089A (fr)
AU (1) AU6121000A (fr)
BR (1) BR0011478A (fr)
CA (1) CA2379327A1 (fr)
MX (1) MXPA01012721A (fr)
WO (1) WO2000076541A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7078042B2 (en) * 1995-09-15 2006-07-18 Uab Research Foundation Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor
GB0022742D0 (en) * 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
EP1477802A1 (fr) * 2003-05-16 2004-11-17 Erasmus Universiteit Rotterdam Procédé de selection et de fabrication des constituents du vaccine, et leur utilisation en vaccines
JP5081243B2 (ja) * 2006-08-17 2012-11-28 ザ ユーエービー リサーチ ファウンデーション 肺炎球菌抗原を被検体における肺炎球菌性肺炎の指標とする方法
RU2510281C2 (ru) * 2012-06-22 2014-03-27 Общество с ограниченной ответственностью "Эпитоп" (ООО "Эпитоп") ВАКЦИНА ПРОТИВ ПНЕВМОНИИ, ВЫЗЫВАЕМОЙ Streptococcus pneumoniae, НА ОСНОВЕ ГИБРИДНОГО БЕЛКА
GB201318170D0 (en) * 2013-10-14 2013-11-27 Univ Edinburgh Proteins with Diagnostic and Therapeutic Uses
KR101627285B1 (ko) * 2014-06-05 2016-06-07 한국생명공학연구원 ＰｓｐＡ를 유효성분으로 포함하는 퇴행성 뇌질환의 예방 또는 치료용 약학 조성물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014318A1 (fr) * 1992-12-24 1994-07-07 Medimmune, Inc. Procedes de protection contre le streptococcus pneumoniae a l'aide de mycobacteries transformees
WO1999053940A1 (fr) * 1998-04-23 1999-10-28 Uab Research Foundation Proteine de surface pneumococcique c(pspc), regions epitopes et selection de souches d'une telle proteine, et utilisations correspondantes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854416A (en) * 1991-11-14 1998-12-29 The United States Of America As Represented By The Department Of Health And Human Services Streptococcus pneumoniae 37-KDA surface adhesin a protein and nucleic acids coding therefor
CA2326408A1 (fr) * 1998-03-02 1999-09-10 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Peptides epitopes immunogenes contre l'infection par streptococcus pneumoniae

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014318A1 (fr) * 1992-12-24 1994-07-07 Medimmune, Inc. Procedes de protection contre le streptococcus pneumoniae a l'aide de mycobacteries transformees
WO1999053940A1 (fr) * 1998-04-23 1999-10-28 Uab Research Foundation Proteine de surface pneumococcique c(pspc), regions epitopes et selection de souches d'une telle proteine, et utilisations correspondantes

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BRILES D E ET AL: "Pneumococcal diversity: considerations for new vaccine strategies with emphasis on pneumococcal surface protein A (PspA).", CLINICAL MICROBIOLOGY REVIEWS. UNITED STATES OCT 1998, vol. 11, no. 4, October 1998 (1998-10-01), pages 645 - 657, XP000946754, ISSN: 0893-8512 *
BRILES D E ET AL: "PSPA AND PSPC: THEIR POTENTIAL FOR USE AS PNEUMOCOCCAL VACCINES", MICROBIAL DRUG RESISTANCE, LIEBERT, US, vol. 3, no. 4, 1997, pages 401 - 408, XP000946756, ISSN: 1076-6294 *
BRILES D E ET AL: "PspA, a protection-eliciting pneumococcal protein: immunogenicity of isolated native PspA in mice", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 14, no. 9, 1 June 1996 (1996-06-01), pages 858 - 867, XP004057611, ISSN: 0264-410X *
BRILES D E ET AL: "The potential for using protein vaccines to protect against otitis media caused by Streptococcus pneumoniae", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 19, 8 December 2000 (2000-12-08), pages S87 - S95, XP004227955, ISSN: 0264-410X *
BROOKS-WALTER A ET AL: "The pspC gene encodes a second pneumococcal surface protein homologous to the gene encoding the protection-eliciting PspA protein of Streptococcus pneumoniae.", ABSTRACTS OF THE GENERAL MEETING OF THE AMERICAN SOCIETY FOR, vol. 97, 1997, 97th General Meeting of the American Society for Microbiology;Miami Beach, Florida, USA; May 4-8, 1997, 1997, pages 35, XP001083844, ISSN: 1060-2011 *
MCDANIEL L S ET AL: "IMMUNIZATION WITH A PLASMID EXPRESSING PNEUMOCOCCAL SURFACE PROTEIN A (PSPA) CAN ELICIT PROTECTION AGAINST FATAL INFECTION WITH STREPTOCOCCUS PNEUMONIAE", GENE THERAPY, MACMILLAN PRESS LTD., BASINGSTOKE, GB, no. 4, April 1997 (1997-04-01), pages 375 - 377, XP001068798, ISSN: 0969-7128 *
SAMPSON ET AL: "Limited Diversity of Streptococcus pneumoniae psaA among Pneumococcal Vaccine Serotypes", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, US, vol. 65, no. 5, May 1997 (1997-05-01), pages 1967 - 1971, XP002108304, ISSN: 0019-9567 *
SAMPSON J S ET AL: "CLONING AND NUCLEOTIDE SEQUENCE ANALYSIS OF PSAA, THE STREPTOCOCCUSPNEUMONIAE GENE ENCODING A 37-KILODALTON PROTEIN HOMOLOGOUS TO PREVIOUSLY REPORTED STREPTOCOCCUS S. ADHESINS", INFECTION AND IMMUNITY, AMERICAN SOCIETY FOR MICROBIOLOGY. WASHINGTON, US, vol. 62, no. 1, 1994, pages 319 - 324, XP000749404, ISSN: 0019-9567 *
See also references of WO0076541A1 *
THARPE ET AL: "Purification and seroreactivity of pneumococcal surface adhesin A (PsaA)", CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 3, no. 2, March 1996 (1996-03-01), pages 227 - 229, XP002109329, ISSN: 1071-412X *

Also Published As

Publication number Publication date
EP1189632A1 (fr) 2002-03-27
WO2000076541A1 (fr) 2000-12-21
BR0011478A (pt) 2002-03-19
JP2003519089A (ja) 2003-06-17
CA2379327A1 (fr) 2000-12-21
AU6121000A (en) 2001-01-02
MXPA01012721A (es) 2004-10-14

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