EP1149022B1 - Behälter mit in abstand angebrachtem etikett - Google Patents

Behälter mit in abstand angebrachtem etikett Download PDF

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Publication number
EP1149022B1
EP1149022B1 EP00906223A EP00906223A EP1149022B1 EP 1149022 B1 EP1149022 B1 EP 1149022B1 EP 00906223 A EP00906223 A EP 00906223A EP 00906223 A EP00906223 A EP 00906223A EP 1149022 B1 EP1149022 B1 EP 1149022B1
Authority
EP
European Patent Office
Prior art keywords
wall
container
product according
label
walls
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP00906223A
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English (en)
French (fr)
Other versions
EP1149022A1 (de
Inventor
Harry Smithkline Beecham Flewitt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of EP1149022A1 publication Critical patent/EP1149022A1/de
Application granted granted Critical
Publication of EP1149022B1 publication Critical patent/EP1149022B1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Rigid or semi-rigid containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material or by deep-drawing operations performed on sheet material
    • B65D1/40—Details of walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Rigid or semi-rigid containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material or by deep-drawing operations performed on sheet material
    • B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
    • B65D1/0223—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D23/00—Details of bottles or jars not otherwise provided for
    • B65D23/12—Means for the attachment of smaller articles
    • B65D23/14—Means for the attachment of smaller articles of tags, labels, cards, coupons, decorations or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants

Definitions

  • This invention relates to containers and in particular to containers with plastics material walls whose contents can undesirably permeate through the container walls or which are sensitive to ingress of material through the container walls.
  • the invention relates to such containers when used for medicaments.
  • Labels e.g. polyethylene, polypropylene, polyethyleneterphthalate, containers are commonly used to contain medicaments. If a label or shrink sleeve is applied to the outer wall of such a container the adhesive which binds the label or sleeve onto the container surface or alternatively the printing ink which is used when information is printed directly onto the container surface may permeate through the wall thereby contaminating the contents of the container, potentially leading to harmful effects.
  • label used hereinafter, unless specifically distinguished, includes labels attached by an adhesive, shrink sleeves and matter printed directly onto a container wall.
  • the content of the container is a medicament
  • Such trials can be expensive and time-consuming.
  • New adhesives, printing inks or plastics materials may have to be sought which do not give rise to the problem discussed above, although this approach is both time consuming and expensive, particularly if clinical trials are required to prove that the new adhesive or ink does not cause contamination of the contents.
  • the contents of such a plastic walled container, particularly solvents may permeate through the walls and may have a deleterious effect on a label on the outer surface of the container e.g. causing a label fixed by adhesive to become detached or to discolour the printing ink.
  • Materials for container walls which are non-permeable are known, in particular glass and metal, but these have the disadvantage of fragility and cost.
  • US 4367821 discloses a container in which a label is attached to an external skirt spaced apart from a container wall, but possible contents for the container, or the problems caused by label material permeating through the container wall, are not contemplated.
  • a product comprising a double walled container is disclosed in document WO-A-9 711 003.
  • the container construction of the invention enables the contents of the container to be directly enclosed by the inner wall, and to be in contact with the inner surface of the inner wall, yet not being vulnerable to contamination by label material such as adhesives or printing ink applied to the outer wall, should this material be liable to permeate through the outer wall. Consequently the adhesive or ink cannot contaminate the contents by penetration of the wall, and vice versa the content cannot penetrate the wall and affect the label.
  • label material such as adhesives or printing ink applied to the outer wall
  • the internal cavity may be directly enclosed by parts of the outer wall and may be in contact with the outer wall, but the label need not be applied to the outer surface of these parts of the outer wall, but only to those parts of the outer wall the inner surface of which is not in contact with the contents.
  • the outer wall of the container may comprise a skirt portion attached to, e.g. integral with or fitted onto, the inner wall, and having a skirt part spaced apart from the inner wall.
  • This skirt portion may be an upper skirt for example surrounding an upper part of the inner wall.
  • the inner wall may comprise the upper part of the body and may include the mouth opening of the container, for example, the inner wall may define and surround the rim of the mouth opening of the container.
  • the skirt portion may alternatively be a lower skirt surrounding the lower part, e.g. the bottom of the container body.
  • the container may have both upper and lower skirts.
  • the label may be attached to the outer surface of the skirt part, whether an upper or lower skirt, or both upper and lower skirts at a place where the skirt part is spaced apart from the inner wall.
  • the upper or lower skirt portion may have a label fixed to its outer surface by adhesive or alternatively information may be printed directly onto the skirt portion.
  • the abovementioned upper and lower skirts may depend from a part of the body wall which directly encloses the contents of the container i.e. so that the contents of the container are in direct contact with the inner surface of this part of the body wall, but are not in contact with the inner surface of the upper and/or lower skirt portion.
  • the container may be of any shape appropriate for its intended use, for example generally cylindrical, e.g. bottle shaped.
  • the term "cylindrical” as used herein includes true cylinders i.e. a shape having straight longitudinal sides and a circular cross section, with the longitudinal axis of the cylinder passing through the centre of the circular section, and also distorted cylinders, e.g. shapes with convex bulging longitudinal sides e.g. "barrel" shapes, shapes with concave sides, i.e. wider at the cylinder ends than at a waist.
  • the term “cylinder” includes such shapes with oval or oblate circular cross section.
  • the upper and lower skirts may also be of generally cylindrical shape e.g. of substantially the same cross sectional shape as the container.
  • the container is provided with upper or lower skirts these may be made integrally with the container body or may be separately fitted to the container body, for example by welding or a physical connection such as a snap fit.
  • the container of the invention may for example be of multi-part construction, e.g. in lower and upper container parts which fit together with a seal which does not allow leakage or contamination of the contents, and such lower and upper container parts may comprise respective lower and upper inner and outer wall parts of the container which fit together when the upper and lower container parts are fitted together. In such a construction the respective upper and lower wall parts may both fit together with such a seal.
  • the container of this invention may be made of conventional plastics, e.g. polyethylene, polypropylene or polyethyleneterphthalate.
  • Suitable wall thicknesses for the inner wall may be ca. 1 - 2 mm, and for the outer wall ca. 1 - 2.5 mm.
  • the inner wall may benefit from protection from the outer wall and may consequently be relatively thin.
  • the container of the invention is suitable for a wide variety of medicament contents, particularly fluids such as liquid, gel, cream or paste medicaments i.e. which incorporate a solvent vehicle.
  • medicaments may for example be suitable for topical applications or for applications to selected parts of the body e.g. a nasal medicament.
  • Such medicaments may be applied as a spray, droplet or surface smear to such a selected part of the body.
  • examples of such medicaments are liquid formulations based on known pharmaceutically acceptable oily vehicles such as monoglycerides, such as mono-olein and mono-linolein, phospholipids such as phosphatidyl cholines, and galactolipids such as glyceryl diglycerides.
  • such monoglycerides may be long-chain fatty acid monoglycerides, optionally also containing a long-chain digylyceride.
  • Such mono- and di- glycerides may for example be blends of different long-chain fatty acid mono- and di- glycerides.
  • Examples of such fatty acid monoglycerides include glycerol mono-oleate, glycerol monopalmitate and glycerol monostearate.
  • Suitable commercially available examples of such products include those available under the trade names MYVEROL, such as MYVEROL, MYVATEX, MYVAPLEX and GMORPHIC 80 respectively.
  • ARLACEL 186 which in addition to glycerol mono-oleate includes propylene glycol.
  • the major fatty acid component is a C 18 saturated, mono-unsaturated or polyunsaturated fatty acid.
  • Such oily vehicle based medicaments may also include fatty acid triglycerides, typically a vegetable oil, for example as diluents with the above-mentioned fatty acid monoglycerides. Examples of such include coconut oil, e.g. fractionated coconut oil. Commercially available examples of such triglyceride diluent materials include caprylic / capric triglyceride (Tricaprylin).
  • Examples of such materials which are commercially available include those available under the trade names MYRITOL, CAPTEX and MIGLYOL.
  • Examples of such oily vehicles are for example disclosed in WO98/14189A (SmithKline Beecham PLC) the contents of which are included herein by way of reference.
  • the container of the invention is suitable for use with a wide range of active compounds dissolved or dispersed in such a vehicle.
  • a particular example of such an active compound is the compound the antibiotic Mupirocin (Pseudomonic acid, "BactrobanTM ”) typically in the form of calcium mupirocin.
  • mupirocin formulation suitable for use as a nasopharyngeal spray formulation is also disclosed in WO98/14189A, typically comprising fractionated coconut oil (i.e. medium chain length triglycerides) e.g. the commercial product MIGLYOL, glycerol mono-oleate e.g. the commercial product MYVEROL 18-99, powdered lemon juice flavour, and micronised calcium mupirocin.
  • the container of the invention is for example provided for, or containing, such a formulation.
  • the container may be otherwise generally conventional and also provided with a suitable closure means for its mouth opening such as a snap fit or screw threaded cap.
  • the container may further comprise delivery means to deliver fluid contents to for example a nozzle, comprised by the mouth opening of the container, such as a feed tube leading from the mouth opening to the vicinity of the bottom of the container.
  • delivery means may comprise for example a pump, typically of a known type used to pump liquid medicaments, such as an air lift pump, leading to an outlet for the medicament such as a spray nozzle.
  • the container may be a nasal spray container provided with means to deliver its medicament content to the nasal area of a user.
  • the container may be made by conventional methods such as blow moulding or injection moulding.
  • Another aspect of the invention provides moulds for making containers of the present invention and furthermore a process e.g. an injection moulding or blow moulding process using such moulds for making the container of the invention.
  • Figs. 1 shows a container which forms not part of the invention and only Fig. 2 shows a container of the invention.
  • the container comprises a bottle-shaped container 11 of generally cylindrical shape with a generally conical bottom with its concave side toward the interior of the container, defined by a container wall 12.
  • the container 11 is provided with pairs of spaced apart inner and outer walls, being a lower pair of inner 13 and outer 14 walls and an upper pair of inner 15 and outer 16 walls.
  • the outer wall of each of these pairs 13, 14 and 15, 16 respectively is in the form of a lower skirt portion 17 and an upper skirt portion 18.
  • the lower skirt portion 17 depends from the container wall 12 and surrounds the conical bottom of the container 11. This conical bottom consequently comprises the inner wall 13.
  • a label 19 is attached by adhesive to the outer surface of the outer wall 14.
  • An upper skirt portion 18 extends from the container wall 12 and also has a label 19 applied to it by adhesive.
  • Liquid contents 110 are within the container wall 12.
  • the label 19 By locating the label 19 only on the outer wall 14 of the lower skirt 17 and/or the upper skirt 18, and not on an outer surface of the container wall 12 of which the inner surface is in contact with the contents 110, the liquid contents 110 and label 19 are consequently not facing each other on opposite sides of the same region of container wall 12. Therefore adhesive from the label 19 cannot permeate through the container wall 12 and contaminate the contents 110 and vice versa the contents 110 cannot leak through container wall 12 and affect the label 19.
  • the lower skirt portion 17 is made integrally with the container wall 12 and integrally joins the container wall at its upper extremity.
  • the upper skirt portion 18 is made separately and is fitted to the upper part of the container wall 12 by a snap fit fitting at 111.
  • the lower skirt 17 may be made separately and fitted to the container 11 or the upper skirt 18 may be made integrally with the container 11.
  • the container 11 is provided with a mouth opening 112 which has a rim defined by the upper part of the inner wall 15 of the container wall 12.
  • the container 11 is also provided with a delivery means 113 (generally) comprising a nozzle 114 and a feed tube 115.
  • the nozzle 114 fits tightly onto the mouth opening 112 of the container by a snap fitting.
  • the feed tube 115 reaches down toward the lowest part of the conical bottom of the container and feeds liquid to the nozzle 114 from the body 11 in a known manner for example via a pump mechanism 116 or by making the container wall 12 of compressible material and squeezing the container.
  • the container 11 is closed by a closure 117 cover. As shown in the sectional view Fig. 1B about the line B-B the container 11 is oval in cross section.
  • a container of the invention which comprises a lower part container 21 (overall) which has a base wall 22 and lower part side walls 23, 24 extending upwardly from the base wall toward an upper mouth opening 25 of the container 21.
  • the side walls 23, 24 are a continuous double wall comprising spaced apart inner 23 and outer 24 walls extending from the base wall 22 to the height of the mouth opening 25.
  • the inner 23 and outer 24 are substantially cylindrical (as seen in Fig. 2B having an oval cross section, and are substantially concentric and coaxial.
  • the base wall 22 is a continuous base wall linking the inner 23 and outer 24 walls and closing the space 26 between them.
  • the container construction of the invention enables contents (not shown) in the internal cavity 27 of the container to be directly enclosed by the inner wall 23, and to be in contact with the inner surface of the inner wall 23, yet not being vulnerable to contamination by label materials 28 such as adhesives or printing ink applied to the outer wall 24.
  • the internal cavity 27 is also directly enclosed by the base wall 22 where this forms a part of the outer wall 24, but the label is not applied to the outer surface of the base wall 22.
  • the container 21 is made of polypropylene and the inner wall is ca. 1 - 1.5 mm thick, and the outer wall ca. 1.5 - 2.0 mm thick.
  • the volume of the internal cavity 27 is ca 10 - 25 ml in the example illustrated.
  • the container 21 is suitable for a liquid medicament which incorporates a solvent vehicle, such as the oily vehicles described above.
  • the container 21 is a nasal spray dispenser.
  • the container is provided with a pump 29 (generally), typically an air lift pump, to deliver liquid contents to a nozzle 210, via a feed tube leading from the mouth opening to the vicinity of the bottom of the container.
  • the pump 29 is provided as part of an upper part assembly 212 (generally), including upper part inner and outer walls respectively 23A and 24A, and provided with fittings 213A enabling it to fit by a push action onto the lower part container 21 at corresponding fittings 213B, and to be retained thereon by a friction and snap fit.
  • the fitting together of the fittings 213A and 213B form a seal which prevents leakage and contamination of the contents in the cavity 27.
  • the nozzle 210 is covered by a cover closure 214 such that the feed tube 211 fits into the cavity 27 and reaches down to a point near its bottom. As shown in the half sectional view Fig. 2B about the line B-B the container 21 is oval in cross section.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Ceramic Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Glass Compositions (AREA)
  • Rigid Containers With Two Or More Constituent Elements (AREA)
  • Containers Having Bodies Formed In One Piece (AREA)

Claims (15)

  1. Produkt, das einen doppelwandigen Behälter (21) aufweist, der eine Bodenwand (22) und Seitenwände (23,24) aufweist, die sich von der Bodenwand (22) nach oben zu einer oberen Mundöffnung (25) des Behälters erstrecken, und die Seitenwände (23,24) liegen in der Form einer Doppelwand vor, die voneinander beabstandete innere (23) und äußere (24) Wände aufweist, die aus Kunststoffmaterial bestehen, wobei ein Etikett (28) auf der Außenfläche der äußeren Wand (24) angeordnet ist, wobei der Körper (21) einen inneren Hohlraum (27) aufweist, der einen Medikamenteninhalt enthält und mindestens teilweise durch die innere Wand (23) gebunden ist, dadurch gekennzeichnet, daß die Bodenwand (22) eine durchgehende Bodenwand (22) ist, die die inneren und äußeren Wände (23,24) verbindet und den Raum (26) zwischen ihnen abschließt.
  2. Produkt nach Anspruch 1, dadurch gekennzeichnet, daß der innere Hohlraum (27) durch Teile der äußeren Wand (24) direkt umschlossen ist und in Kontakt mit der äußeren Wand (24) steht, das Etikett (28) jedoch auf ein Teil der äußeren Wand (24) aufgebracht ist, deren Innenfläche nicht in Kontakt mit dem Inhalt steht.
  3. Produkt nach Anspruch 1 oder 2, dadurch gekennzeichnet, daß die Seitenwände (23,24) in der Form einer durchgehenden Doppelwand (23,24) vorliegen, die sich über die gesamte Höhe des inneren Hohlraums (27) von der Bodenwand (22) zur Mundöffnung (25) erstreckt.
  4. Produkt nach einem der vorhergehenden Ansprüche, gekennzeichnet durch im wesentlichen zylindrische innere und äußere Wände (23,24), die im wesentlichen konzentrisch und koaxial verlaufen.
  5. Produkt nach einem der vorhergehenden Ansprüche, gekennzeichnet durch untere (21) und obere (212) Behälterteile, die mit einer Dichtung (213A,213B) zusammenpassen, die kein Austreten oder keine Verunreinigung des Inhalt zuläßt, wobei solche unteren und oberen Behälterteile (21,212) jeweilige untere (23,24) und obere (23A,24A) innere und äußere Wandteile des Behälters aufweisen, die zusammenpassen, wenn die oberen (23A,24A) und unteren (23,24) Behälterteile zusammengefügt werden.
  6. Produkt nach einem der vorhergehenden Ansprüche, das aus Kunststoffmaterial besteht und eine Dicke der inneren Wand (23) von ca. 1 - 2 mm und eine Dicke der äußeren Wand von ca. 1 - 2,5 mm aufweist.
  7. Produkt nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß der Medikamenteninhalt eine Flüssigkeit ist, die ein Lösungsmittelvehikel enthält.
  8. Produkt nach Anspruch 7, dadurch gekennzeichnet, daß das Lösungsmittelvehikel ein pharmazeutisch brauchbares Ölvehikel ist.
  9. Produkt nach Anspruch 8 dadurch gekennzeichnet, daß das Ölvehikel ein Monoglycerid, Phospholipid oder ein Galactolipid ist.
  10. Produkt nach Anspruch 9, dadurch gekennzeichnet, daß das Ölvehikel aus Glycerolmonooleat, Glycerolmonopalmitat und Glycerolmonostearat ausgewählt wird.
  11. Produkt nach Anspruch 8, 9 oder 10, dadurch gekennzeichnet, daß es ein langkettiges Diglycerid enthält.
  12. Produkt nach einem der Ansprüche 9 bis 10, das ein Fettsäuretriglycerid enthält.
  13. Produkt nach Anspruch 12, dadurch gekennzeichnet, daß das Fettsäuretriglycerid Octansäure-/Decansäuretriglycerid (Tricaprylin) ist.
  14. Produkt nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß das Medikamenteninhalt Calcium-Mupirocin, fraktioniertes Kokosnußöl, und Glycerolmonooleat ist.
  15. Produkt nach einem der vorhergehenden Ansprüche, das ein Nasenspray-Behälter (21) ist, der mit Einrichtungen (29, 210) versehen ist, um seinen Medikamenteninhalt an den Nasenbereich eines Benutzers abzugeben.
EP00906223A 1999-02-02 2000-01-26 Behälter mit in abstand angebrachtem etikett Expired - Lifetime EP1149022B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9902138 1999-02-02
GBGB9902138.8A GB9902138D0 (en) 1999-02-02 1999-02-02 Container
PCT/EP2000/000559 WO2000046109A1 (en) 1999-02-02 2000-01-26 Container with spaced apart label

Publications (2)

Publication Number Publication Date
EP1149022A1 EP1149022A1 (de) 2001-10-31
EP1149022B1 true EP1149022B1 (de) 2003-04-16

Family

ID=10846846

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00906223A Expired - Lifetime EP1149022B1 (de) 1999-02-02 2000-01-26 Behälter mit in abstand angebrachtem etikett

Country Status (7)

Country Link
EP (1) EP1149022B1 (de)
JP (1) JP2002536252A (de)
AT (1) ATE237511T1 (de)
DE (1) DE60002162T2 (de)
ES (1) ES2197075T3 (de)
GB (1) GB9902138D0 (de)
WO (1) WO2000046109A1 (de)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4367821A (en) 1980-09-12 1983-01-11 Hercules Incorporated Paint pail with depending skirt for label attachment
WO1996030266A1 (en) * 1995-03-28 1996-10-03 Gautam Mahajan Plastic container with cup shaped integral base stand
EP0846011A1 (de) * 1995-08-18 1998-06-10 Pharmasol Limited Spitzvorrichtung
GB9519196D0 (en) * 1995-09-20 1995-11-22 Jaycare Ltd Improvements relating to packaging containers
CH692038A5 (it) * 1996-07-25 2002-01-15 Thewi Holding B V Bottiglia con corpo termicamente schermato.
WO1998014189A1 (en) 1996-10-01 1998-04-09 Smithkline Beecham Corporation Use of mupirocin for the manufacture of a medicament for the treatment of bacterial infections associated with colonisation of the nasopharynx by pathogenic organisms

Also Published As

Publication number Publication date
EP1149022A1 (de) 2001-10-31
DE60002162T2 (de) 2004-02-19
WO2000046109A1 (en) 2000-08-10
JP2002536252A (ja) 2002-10-29
ATE237511T1 (de) 2003-05-15
DE60002162D1 (de) 2003-05-22
ES2197075T3 (es) 2004-01-01
GB9902138D0 (en) 1999-03-24

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