EP1119416A1 - Centrifuge and method for operating said centrifuge - Google Patents

Centrifuge and method for operating said centrifuge

Info

Publication number
EP1119416A1
EP1119416A1 EP99947433A EP99947433A EP1119416A1 EP 1119416 A1 EP1119416 A1 EP 1119416A1 EP 99947433 A EP99947433 A EP 99947433A EP 99947433 A EP99947433 A EP 99947433A EP 1119416 A1 EP1119416 A1 EP 1119416A1
Authority
EP
European Patent Office
Prior art keywords
centrifuge
bag
container
wall
centrifuge according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP99947433A
Other languages
German (de)
French (fr)
Other versions
EP1119416B1 (en
Inventor
Wilfried Mackel
Werner Kohlstette
Thomas Kleimann
Willi Niemerg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GEA Mechanical Equipment GmbH
Original Assignee
Westfalia Separator GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Westfalia Separator GmbH filed Critical Westfalia Separator GmbH
Publication of EP1119416A1 publication Critical patent/EP1119416A1/en
Application granted granted Critical
Publication of EP1119416B1 publication Critical patent/EP1119416B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B11/00—Feeding, charging, or discharging bowls
    • B04B11/04—Periodical feeding or discharging; Control arrangements therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B11/00—Feeding, charging, or discharging bowls
    • B04B11/04—Periodical feeding or discharging; Control arrangements therefor
    • B04B11/05—Base discharge
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B7/00—Elements of centrifuges
    • B04B7/02—Casings; Lids

Definitions

  • the present invention relates to a centrifuge according to the preamble of claim 1 and a method for operating the centrifuge according to the preamble of claim 12.
  • a generic centrifuge is known from US 5,328,441.
  • the liquid is first drained from the centrifuge drum and then the solid is peeled out of the centrifuge drum by means of a device specially designed for this purpose.
  • the solids are collected underneath the centrifuge drum in an undetectable way.
  • a centrifuge of the type described above is used in the pharmaceutical sector, for example for the extraction of solids from human blood and or for the production of insulin
  • handling appears problematic in view of the increasingly stringent hygiene requirements in recent times.
  • manual handling of the solids discharge leads to losses, which reduces the yield of the solids extraction.
  • solids are obtained from blood, there is a particularly high level of interest in the loss-free solids extraction.
  • the invention aims to provide a centrifuge and a method for operating the centrifuge with which a largely loss-free extraction of solids from a centrifugal material such as blood can be achieved with an increased hygiene standard.
  • the invention achieves this aim with regard to the centrifuge by the subject matter of claim 1 and with regard to the method for operating the centrifuge by the subject matter of claim 12.
  • the invention is characterized in that a container is provided for collecting part of the constituents released by the centrifuge, in particular the solid, a bag for holding the solids from the centrifuge drum being inserted into the container .
  • a container is provided for collecting part of the constituents released by the centrifuge, in particular the solid, a bag for holding the solids from the centrifuge drum being inserted into the container .
  • the interior of the bag is preferably connected to the space surrounding the bag via a pressure-equalizing hose and / or pipeline, which preferably opens into the interior of the bag in the vicinity of the axis of rotation of the centrifuge drum.
  • a pressure-equalizing hose and / or pipeline which preferably opens into the interior of the bag in the vicinity of the axis of rotation of the centrifuge drum.
  • the air surrounding the drum also rotates due to the friction surfaces of the drum. This rotation creates an increase in pressure from the inside (axis of rotation) to the outside due to the centrifugal forces.
  • the space in the inner region - that is, in the region of the axis of rotation - is connected to the ambient pressure, an overpressure occurs in the outer region of the interior of the bag.
  • the bag is "stretched” and pressed against the surrounding walls, so that it is particularly problem-free Filling the bag is possible.
  • the hose or pipeline is preferably guided from the interior of the bag into the space between the exterior of the bag and the inner wall of the container. If the pressure in the container is reduced during spinning in order to carry out the spinning process in a vacuum, the pressure drop created by the rotation of the drum is sufficient to open the bag. The low pressure also facilitates the sterile handling of the centrifuge.
  • the hose or pipeline is provided with a shut-off valve.
  • the valve is closed in order to prevent the solids from coming into contact with the ambient air when the pressure in the container increases after a spinning process.
  • Figure 1 is a schematic, partially sectioned view of a centrifuge according to the invention.
  • FIG. 2 shows a partially sectioned view of a further centrifuge according to the invention in the operating position changed compared to FIG. 1 when welding a bag filled with solid matter.
  • FIG. 1 shows a centrifuge 1 with a housing 3, on which the drive unit 5 of a centrifuge drum 7 is arranged.
  • Lines 9 enable a centrifugal material such as blood to be fed into and removed from the centrifuge drum 7, which is to be separated into the liquid and solid components therein.
  • the centrifuge drum 7 projects into a container 11 which is arranged on the underside of the housing 3 and which has a cylindrical container section 13 which is closed at the bottom in a cup-like manner and can be attached to an upper container closure 15 in a pressure-tight manner.
  • the container end 15 has a stepped ring 17, on the outer wall of which, when the container 11 is closed, the inner wall of the opening area of the cup-like container section 13 rests, with the stepped ring 17 and the undersidenic container section 13, a sealing ring 19 is arranged.
  • the container end 15 is completed by a sealing ring 21 located inside the ring -17 with an inflatable sealing chamber 23 which, when inflated, bears against the inner wall of the stepped ring 17 and by an insert ring 25 for the sealing ring 21 located on the inner wall
  • the centrifugal material is produced for the separator drum by a pipeline 26 which runs through the lower wall of the housing 3a.
  • the space enclosed by the lower and upper container sections 13, 15 can be evacuated with the aid of a pump (not shown here) so that the actual spinning process can take place under negative pressure.
  • a cylindrical jacket 27 which extends to near the bottom of the container section 13, which essentially runs parallel to the outer wall of the container section 13 and is formed with a double wall 27a, 27b, between the A space 29 through which rinsing liquid can flow is formed in the walls 27a and 27b and can be supplied via a feed line 31 and a discharge line (not shown here) can be derived.
  • a film-like plastic tube 33 which lies above the sealing ring 21 in a ring-like receiving space 35 and from there down into the container section 13 can be pulled.
  • the lower container section 13 is first lowered using a suitable lifting device (not shown here) (see FIG. 2), the plastic tube 33 being pulled downward out of the receiving space 35. Then the plastic tube 33 is underneath the jacket 27 and above the container Section 13 pressed together and welded in two closely adjacent areas, for example line-like (arrows a and b), so that a lower seal for an upper plastic bag a and an upper seal for a lower bag 37b is formed. The two bags 37a and 37b are now separated from each other in the area of arrow c. Furthermore, after the lower bag 37b has been removed from the lower container section 13, the lower container section is raised and passed over the ring 17 in a pressure-tight manner.
  • a suitable lifting device not shown here
  • the centrifuge drum protruding into the upper bag opening ensuring a pressure drop inside the bag during its rotation. Since the interior of the bag 37a, in which the centrifuge drum rotates, is also connected to the intermediate space 41 between the outer wall of the bag and the inner wall of the container 11 by means of a hose and pipeline 39, near the axis of rotation of the drum, the bag settles when the drum rotates to the walls surrounding it. The solids therefore get into the interior of the bag without any problems during spinning. Damage to the bag is safely avoided.
  • the pressure in the container is increased and the lower container section is lowered, whereupon the bag walls are welded and severed, after which a new spinning cycle can be started.
  • the solids are obtained sterile and with a very high yield.
  • the hose and pipeline 39 can be provided with a shut-off valve 43 in order to close off the solids in the bag 37 against the ambient air.
  • the hose and pipe run from the inner wall of the conical section 25b of the insert ring 25 through the housing 3, then through a ring 45 below the housing 3 and through the ring 17 engaging in the ring 45 to the intermediate space 41.
  • Container 11 lower container section 13 upper container end 15 stepped ring 17th

Landscapes

  • Centrifugal Separators (AREA)
  • External Artificial Organs (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

A centrifuge, comprising: a centrifuge basket for separating a fed substance to be centrifuged into different constituents; a receptacle surrounding a portion of the basket; a bag insertable into the receptacle, the bag having an exterior wall and an interior for catching at least a portion of the constituents delivered by the centrifuge basket; a space surrounding the bag; and wherein the interior of the bag near an axis of rotation of the centrifuge basket is connected by a hose with the space surrounding the bag. A method of operating the centrifuge including the steps of mounting the receptacle, feeding the substance to be centrifuged, rotating the centrifuge basket and catching solids in the bag while separating the solids and liquid.

Description

Bechreibung Description
Zentrifuge und Verfahren zum Betreiben der ZentrifugeCentrifuge and method for operating the centrifuge
Die vorliegende Erfindung betrifft eine Zentrifuge nach dem Oberbegriff des Anspruches 1 sowie ein Verfahren zum Betreiben der Zentrifuge nach dem Oberbegriff des Anspruches 12.The present invention relates to a centrifuge according to the preamble of claim 1 and a method for operating the centrifuge according to the preamble of claim 12.
Eine gattungsgemäße Zentrifuge ist aus der US 5,328,441 bekannt. Beim Betreiben der in dieser Schrift dargestellten Zentrifuge wird nach dem Abschleudern der Feststoffe aus dem Schleudergut zunächst die Flüssigkeit aus der Zentrifugentrommel abgelassen und anschließend mittels einer speziell zu diesem Zweck ausgelegten Einrichtung der Feststoff aus der Zentrifugentrommel herausgeschält. Die Feststoffe werden unterhalb der Zentrifugentrommel in nicht erkennbarer Weise aufgefangen.A generic centrifuge is known from US 5,328,441. When operating the centrifuge shown in this document, after the solids have been spun out of the centrifuged material, the liquid is first drained from the centrifuge drum and then the solid is peeled out of the centrifuge drum by means of a device specially designed for this purpose. The solids are collected underneath the centrifuge drum in an undetectable way.
Wird eine Zentrifuge der vorstehend beschriebenen Art im pharmazeutischen Bereich, beispielsweise zur Gewinnung von Feststoffen aus Humanblut und oder zur Insulinherstellung eingesetzt, ergibt sich das Problem einer möglichst hygienischen bzw. möglichst sterilen Handhabung der von der Zentrifugentrommel abgegebenen Feststoffe. Zwar ist es möglich, die Feststoffe "manuell" aus der Zentrifuge bzw. aus einem unterhalb der Zentrifuge angeordneten Behälter zu entnehmen. Eine derartige Handhabung erscheint allerdings in Hinsicht auf die in neuerer Zeit immer weiter verschärften Hygieneanforderungen als problematisch. Darüber hinaus besteht das Problem, daß bei einer manuellen Handhabung des Feststoffaus- trages mit Verlusten zu rechnen ist, was die Ausbeute der Feststoffgewinnung herabsetzt. Gerade bei der Gewinnung von Feststoffen aus Blut ist das Interesse an einer möglichst verlustfreien Feststoffgewinnung aber besonders hoch.If a centrifuge of the type described above is used in the pharmaceutical sector, for example for the extraction of solids from human blood and or for the production of insulin, the problem arises of handling the solids discharged from the centrifuge drum as hygienically or as sterile as possible. It is possible to remove the solids "manually" from the centrifuge or from a container arranged below the centrifuge. However, such handling appears problematic in view of the increasingly stringent hygiene requirements in recent times. In addition, there is the problem that manual handling of the solids discharge leads to losses, which reduces the yield of the solids extraction. Especially when solids are obtained from blood, there is a particularly high level of interest in the loss-free solids extraction.
Die Erfindung zielt daher gegenüber dem gattungsgemäßen Stand der Technik darauf ab, eine Zentrifuge sowie ein Verfahren zum Betreiben der Zentrifuge zu schaffen, mit welchen eine weitgehend verlustfreie Feststoffgewinnung aus einem Schleudergut wie Blut bei einem erhöhten Hygienestandard realisierbar ist.-Compared to the generic prior art, the invention therefore aims to provide a centrifuge and a method for operating the centrifuge with which a largely loss-free extraction of solids from a centrifugal material such as blood can be achieved with an increased hygiene standard.
Die Erfindung erreicht dieses Ziel in Hinblick auf die Zentrifuge durch den Gegenstand des Anspruches 1 und in Hinblick auf das Verfahren zum Betreiben der Zentrifuge durch den Gegenstand des Anspruches 12.The invention achieves this aim with regard to the centrifuge by the subject matter of claim 1 and with regard to the method for operating the centrifuge by the subject matter of claim 12.
Gegenüber dem Stand der Technik zeichnet sich die Erfindung dadurch aus, daß ein Behältnis zum Auffangen eines Teiles der von der Zentrifuge abgegebenen Bestandteile, insbeson- dere des Feststoffes, vorgesehen ist, wobei in das Behältnis ein Beutel zur Aufnahme der von der Zentrifugentrommel Feststoffe eingesetzt ist. Durch das Auffangen der Feststoffe in dem in das Behältnis eingesetzten Beutel ist eine weitgehend sterile Handhabung der Feststoffe möglich, denn der Beutel braucht nach einem Füll- bzw. Schleudervorgang lediglich mitsamt seinem Inhalt aus dem Behältnis genommen zu werden. Feststoffverluste beim Entleeren des Behältnisses werden vermieden.Compared to the prior art, the invention is characterized in that a container is provided for collecting part of the constituents released by the centrifuge, in particular the solid, a bag for holding the solids from the centrifuge drum being inserted into the container . By collecting the solids in the bag inserted into the container, a largely sterile handling of the solids is possible, because after a filling or spinning process the bag only needs to be removed from the container together with its contents. Loss of solids when emptying the container is avoided.
Vorzugsweise ist der Innenraum des Beutels über eine druckausgleichende Schlauch- und/oder Rohrleitung mit dem den Beutel umgebenden Raum verbunden, welche vorzugsweise in der Nähe der Rotationsachse der Zentrifugentrommel in das Beutelinnere mündet. In dem Raum unterhalb der Zentrifugentrommel rotiert aufgrund der Reibflächen der Trommel auch die Luft mit, welche die Trommel umgibt. Diese Drehung erzeugt aufgrund der Zentrifugalkräfte einen Druckanstieg von innen (Drehachse) nach außen. Da zudem der Raum in inneren Bereich - also im Bereich der Rotationsachse - an den Umgebungsdruck angeschlossen ist, tritt im Außenbereich des Inneren des Beutels ein Überdruck auf Dadurch wird der Beutel "aufgespannt" und an die ihn umgebenden Wandungen gedrückt, so daß ein besonders problemloses Befüllen des Beutels möglich ist.The interior of the bag is preferably connected to the space surrounding the bag via a pressure-equalizing hose and / or pipeline, which preferably opens into the interior of the bag in the vicinity of the axis of rotation of the centrifuge drum. In the space below the centrifuge drum, the air surrounding the drum also rotates due to the friction surfaces of the drum. This rotation creates an increase in pressure from the inside (axis of rotation) to the outside due to the centrifugal forces. Since, in addition, the space in the inner region - that is, in the region of the axis of rotation - is connected to the ambient pressure, an overpressure occurs in the outer region of the interior of the bag. As a result, the bag is "stretched" and pressed against the surrounding walls, so that it is particularly problem-free Filling the bag is possible.
Vorzugsweise ist die Schlauch- oder Rohrleitung vom Innenraum des Beutels in den Zwischenraum zwischen dem Beuteläußeren und der Innenwandung des Behältnisses geführt. Wird jetzt im Behälter beim Schleudern der Druck abgesenkt, um den Schleudervorgang im Vakuum durchzuführen, reicht das durch die Rotation der Trommel erzeugte Druckgefälle dazu aus, den Beutel aufzuspannen. Der niedrige Druck erleichtert darüber hinaus die sterile Handhabung des Schleudergutes.The hose or pipeline is preferably guided from the interior of the bag into the space between the exterior of the bag and the inner wall of the container. If the pressure in the container is reduced during spinning in order to carry out the spinning process in a vacuum, the pressure drop created by the rotation of the drum is sufficient to open the bag. The low pressure also facilitates the sterile handling of the centrifuge.
Bei einer weiteren besonders bevorzugten Ausführungsform der Erfindung ist die Schlauch- oder Rohrleitung mit einem Absperrventil versehen. Das Ventil wird geschlossen, um einen Kontakt der Feststoffe mit der Umgebungsluft beim Erhöhen des Druckes im Behälter nach einem Schleudervorgang zu vermeiden.In a further particularly preferred embodiment of the invention, the hose or pipeline is provided with a shut-off valve. The valve is closed in order to prevent the solids from coming into contact with the ambient air when the pressure in the container increases after a spinning process.
Weitere vorteilhafte Ausgestaltungen der Erfindung sind den übrigen Unteransprüchen zu entnehmen.Further advantageous embodiments of the invention can be found in the remaining subclaims.
Nachfolgend wird die Erfindung unter Bezug auf die Zeichnung anhand von Ausführungsbeispielen näher beschrieben. Es zeigt:The invention is described in more detail below with reference to the drawing using exemplary embodiments. It shows:
Fig. 1 eine schematische, teilgeschnittene Ansicht einer erfindungsgemäßen Zentrifuge; undFigure 1 is a schematic, partially sectioned view of a centrifuge according to the invention. and
Fig. 2 eine teilgeschnittene Ansicht einer weiteren erfindungsgemäßen Zentrifuge in gegenüber Fig. 1 veränderter Betriebsstellung beim Verschweißen eines mit Fest- stoff gefüllten Beutels.FIG. 2 shows a partially sectioned view of a further centrifuge according to the invention in the operating position changed compared to FIG. 1 when welding a bag filled with solid matter.
Fig. 1 zeigt eine Zentrifuge 1 mit einem Gehäuse 3, auf dem die Antriebseinheit 5 einer Zentrifugentrommel 7 angeordnet ist. Leitungen 9 ermöglichen die Zu- und Abfuhr eines Schleudergutes wie Blut in die Zentrifugentrommel 7, welches in dieser in die Bestandteile Flüssigkeit und Feststoffe getrennt werden soll.1 shows a centrifuge 1 with a housing 3, on which the drive unit 5 of a centrifuge drum 7 is arranged. Lines 9 enable a centrifugal material such as blood to be fed into and removed from the centrifuge drum 7, which is to be separated into the liquid and solid components therein.
Die Zentrifugentrommel 7 ragt in einen an der Unterseite des Gehäuses 3 angeordneten Behälter 11, welcher einen zylindrischen, nach unten becherartig abgeschlossenenBehälterab- schnitt 13 aufweist, der druckdicht an einem oberen Behälterabschluß 15 anbringbar ist. Der Behälterabschluß 15 weist einen gestuften Ring 17 auf, an dessen Aussenwandung im geschlossenen Zustand des Behälters 11 die Innenwandung des Öffhungsbereiches des becherartigen Behälterabschnittes 13 anliegt, wobei zwischen dem gestuften Ring 17 und dem un- teren Behälterabschnitt 13 ein Dichtring 19 angeordnet ist. Der Behälterabschluß 15 wird komplettiert durch einen innen zum Ring -17 liegenden Dichtring 21 mit einer aufpumpbaren Dichtkammer 23, die sich im aufgepumpten Zustand an die Innenwandung des gestuften Ringes 17 anlegt und durch einen an der Innenwandung des Dichtring 21 liegenden Einsatz- ring 25 für die Separatortrommel 7, der einen unteren zylindrischen Abschnitt 25a, einen sich daran nach oben anschließenden, sich konisch verjüngenden Abschnitt 25b und einen oberen zylindrischen Abschnitt 25c umfaßt, welcher oben an der unteren Wandung 3a des Gehäuses 3 anliegt, die den Behälter 11 nach oben abdeckt. Durch eine durch die untere Wandung des Gehäuses 3a geführte Rohrleitung 26 wird der Separatortrommel das Schleu- dergut hergestellt.The centrifuge drum 7 projects into a container 11 which is arranged on the underside of the housing 3 and which has a cylindrical container section 13 which is closed at the bottom in a cup-like manner and can be attached to an upper container closure 15 in a pressure-tight manner. The container end 15 has a stepped ring 17, on the outer wall of which, when the container 11 is closed, the inner wall of the opening area of the cup-like container section 13 rests, with the stepped ring 17 and the underside teren container section 13, a sealing ring 19 is arranged. The container end 15 is completed by a sealing ring 21 located inside the ring -17 with an inflatable sealing chamber 23 which, when inflated, bears against the inner wall of the stepped ring 17 and by an insert ring 25 for the sealing ring 21 located on the inner wall Separator drum 7, which comprises a lower cylindrical section 25a, an adjoining upwardly, conically tapering section 25b and an upper cylindrical section 25c, which abuts against the lower wall 3a of the housing 3, which covers the container 11 upwards. The centrifugal material is produced for the separator drum by a pipeline 26 which runs through the lower wall of the housing 3a.
Der von den unteren und oberen Behälterabschnitten 13, 15 umschlossene Raum kann Mithilfe einer (hier nicht abgebildeten) Pumpe evakuiert werden, so daß der eigentliche Schleudervorgang unter Unterdruck erfolgen kann.The space enclosed by the lower and upper container sections 13, 15 can be evacuated with the aid of a pump (not shown here) so that the actual spinning process can take place under negative pressure.
An dem unteren Teil der Innenwandung des gestuften Ringes 15 liegt ein sich bis nahe zum Boden des Behälterabschnittes 13 erstreckender zylindrischer Mantel 27 an, der imwesentli- chen parallel zur Außenwandung des Behälterabschnittes 13 verläuft und mit einer Doppelwandung 27a, 27b ausgebildet ist, wobei zwischen den Wänden 27a und 27b ein von Spül- flüssigkeit durchströmbarer Raum 29 ausgebildet wird, welche über eine Zuleitung 31 zugeführt und eine (hier nicht dargestellte) Ableitung abgeleitet werden kann.On the lower part of the inner wall of the stepped ring 15 there is a cylindrical jacket 27 which extends to near the bottom of the container section 13, which essentially runs parallel to the outer wall of the container section 13 and is formed with a double wall 27a, 27b, between the A space 29 through which rinsing liquid can flow is formed in the walls 27a and 27b and can be supplied via a feed line 31 and a discharge line (not shown here) can be derived.
Zwischen der Dichtkammer 23 und der Innenwandung des gestuften Ringes 17 sowie der sich daran nach unten hin anschließenden Innenwandung des Mantels 27 liegt ringsum ein folienartiger Kunststoffschlauch 33, der oberhalb des Dichtringes 21 in einem ringartigen Auf ahmeraum 35 liegt und von dort nach unten in den Behälterabschnitt 13 gezogen werden kann.Between the sealing chamber 23 and the inner wall of the stepped ring 17 and the inner wall of the jacket 27 adjoining it downward is a film-like plastic tube 33 which lies above the sealing ring 21 in a ring-like receiving space 35 and from there down into the container section 13 can be pulled.
Vor dem Start eines Schleudervorganges wird zunächst der untere Behälterabschnitt 13 mit- tels einer dazu geeigneten (hier nicht dargestellten) Hebevorrichtung abgesenkt (siehe Fig. 2) wobei der Kunststoffschlauch 33 aus dem Aufhahmeraum 35 nach unten gezogen wird. Dann wird der Kunststoffschlauch 33 unterhalb des Mantels 27 und oberhalb des Behälterab- Schnittes 13 zusammengedrückt und in zwei eng nebeneinander liegenden Bereichen beispielsweise linienartig verschweißt (Pfeile a und b), so daß ein unterer Abschluß für einen oberen Kunststoffbeutel a und ein oberer Abschluß für einen unteren Beutel 37b gebildet wird. Die beiden Beutel 37a und 37b werden nun im Bereich des Pfeiles c voneinander getrennt. Nachdem ferner der untere Beutel 37b aus dem unteren Behälterabschnitt 13 herausgenommen wurde, wird der untere Behälterabschnitt angehoben und druckdicht über den Ring 17 geführt.Before the start of a spinning process, the lower container section 13 is first lowered using a suitable lifting device (not shown here) (see FIG. 2), the plastic tube 33 being pulled downward out of the receiving space 35. Then the plastic tube 33 is underneath the jacket 27 and above the container Section 13 pressed together and welded in two closely adjacent areas, for example line-like (arrows a and b), so that a lower seal for an upper plastic bag a and an upper seal for a lower bag 37b is formed. The two bags 37a and 37b are now separated from each other in the area of arrow c. Furthermore, after the lower bag 37b has been removed from the lower container section 13, the lower container section is raised and passed over the ring 17 in a pressure-tight manner.
Nach dem Absenken des Druckes im Behälter 11 wird der eigentliche Schleudervorgang ge- startet, wobei die in die obere Beutelöffnung ragende Zentrifugentrommel während ihrer Rotation für ein Druckgefälle im inneren des Beutels sorgt. Da der Innenraum des Beutels 37a, in dem die Zentrifugentrommel rotiert, nahe der Rotationsachse der Trommel zudem mittels einer Schlauch- und Rohrleitung 39 mit dem Zwischenraum 41 zwischen der Beutelaußenwand und der Innenwandung des Behältnisses 11 verbunden ist, legt sich der Beutel bei Drehungen der Trommel an die ihn umgebenden Wandungen. Der Feststoff gelangt daher während des Schleuderns völlig problemlos in das Beutelinnere. Beschädigungen des Beutels werden sicher vermieden. Nach dem Ablassen der Flüssigkeit und nach dem Entleeren der Trommel bzw. dann, wenn der Beutel genügend mit Feststoffen gefüllt ist, wird der Druck im Behälter erhöht und der untere Behälterabschnitt abgesenkt, woraufhin die Beutelwan- düngen verschweißt und durchtrennt werden, wonach ein neuer Schleuderzyklus gestartet werden kann. Mit Hilfe der Beutel 37 erfolgt die Feststoffgewinnung steril und mit sehr hoher Ausbeute.After the pressure in the container 11 has been reduced, the actual spinning process is started, the centrifuge drum protruding into the upper bag opening ensuring a pressure drop inside the bag during its rotation. Since the interior of the bag 37a, in which the centrifuge drum rotates, is also connected to the intermediate space 41 between the outer wall of the bag and the inner wall of the container 11 by means of a hose and pipeline 39, near the axis of rotation of the drum, the bag settles when the drum rotates to the walls surrounding it. The solids therefore get into the interior of the bag without any problems during spinning. Damage to the bag is safely avoided. After draining the liquid and emptying the drum or when the bag is sufficiently filled with solids, the pressure in the container is increased and the lower container section is lowered, whereupon the bag walls are welded and severed, after which a new spinning cycle can be started. With the aid of the bags 37, the solids are obtained sterile and with a very high yield.
Wie in Fig. 2 dargestellt, kann die Schlauch- und Rohrleitung 39 mit einem Absperrventil 43 versehen werden, um die Feststoffe im Beutel 37 gegen die Umgebungsluft abzuschließen. Nach Fig. 2 verläuft die Schlauch- und Rohrleitung von der Innenwandung des konischen Abschnittes 25b des Einsatzringes 25 durch das Gehäuse 3, daran anschließend durch einen unterhalb des Gehäuses 3 liegenden Ring 45 sowie durch den in den Ring 45 eingreifenden Ring 17 zum Zwischenraum 41. BezugszeichenAs shown in FIG. 2, the hose and pipeline 39 can be provided with a shut-off valve 43 in order to close off the solids in the bag 37 against the ambient air. 2, the hose and pipe run from the inner wall of the conical section 25b of the insert ring 25 through the housing 3, then through a ring 45 below the housing 3 and through the ring 17 engaging in the ring 45 to the intermediate space 41. Reference numerals
Zentrifuge 1Centrifuge 1
Gehäuse 3 Antriebseinheit 5Housing 3 drive unit 5
Zentri fugentrommel 7Centrifugal drum 7
Leitungen 9Lines 9
Behälter 11 unterer Behälterabschnitt 13 oberer Behälterabschluß 15 gestufter Ring 17Container 11 lower container section 13 upper container end 15 stepped ring 17th
Dichtring 19Sealing ring 19
Dichtring 21 auφumpbare Dichtkammer 23 Einsatzring 25Sealing ring 21 inflatable sealing chamber 23 insert ring 25
Rohrleitung 26 zylindrischer Mantel 27Pipe 26 cylindrical jacket 27
Doppelwandung 27a,27bDouble wall 27a, 27b
Raum 29 Zuleitung 31Room 29 supply line 31
Kunststoffschlauch 33Plastic hose 33
Aufnahmeraum 35Recording room 35
Beutel 37a,bPouch 37a, b
Schlauch- und Rohrleitung 39 Zwischenraum 41Hose and pipeline 39 gap 41
Absperrventil 43Shut-off valve 43
Ring 45 Ring 45

Claims

Patentansprüche claims
1. Zentrifuge mit einer Zentrifugentrommel (7) zur Trennung eines zugeführten Schleudergutes, insbesondere Blut, in unterschiedliche Bestandteile, insbesondere in Flüssig- keit und Feststoff, gekennzeichnet durch ein Behältnis (11), in das ein Beutel (37) zum Auffangen wenigstens eines Teiles der von der Zentrifugentrommel (7) abgegebenen Bestandteile, insbesondere des Feststoffes, eingesetzt ist.1. Centrifuge with a centrifuge drum (7) for separating a centrifuged material, in particular blood, into different components, in particular in liquid and solid, characterized by a container (11) into which a bag (37) for collecting at least one part the components released by the centrifuge drum (7), in particular the solid, is used.
2. Zentrifuge nach Anspruch 1, dadurch gekennzeichnet, daß das Innere des Beutels (37) an der oder nahe zur Rotationsachse der Zentrifugentrommel (7) über eine Schlauch- und/oder Rohrleitung (39) mit dem den Beutel (37) umgebenden Raum (41) verbunden ist.2. Centrifuge according to claim 1, characterized in that the inside of the bag (37) on or near to the axis of rotation of the centrifuge drum (7) via a hose and / or pipe (39) with the space surrounding the bag (37) ( 41) is connected.
3. Zentrifuge nach Anspruch 2, dadurch gekennzeichnet, daß die Schlauch- und/oder Rohrleitung (39) vom Inneren des Beutels in den Zwischenraum (41) zwischen der3. Centrifuge according to claim 2, characterized in that the hose and / or pipe (39) from the inside of the bag into the space (41) between the
Außenwandung des Beutels (37) und der Innenwandung des Behältnisses (11) geführt ist.The outer wall of the bag (37) and the inner wall of the container (11) is guided.
4. Zentrifuge nach Anspruch 2 oder 3, dadurch gekennzeichnet, daß die Schlauch-oder Rohrleitung (39) mit einem Absperrventil (43) versehen ist.4. Centrifuge according to claim 2 or 3, characterized in that the hose or pipe (39) is provided with a shut-off valve (43).
5. Zentrifuge nach einem der vorstehenden Ansprüche, dadurch gekennzeichnet, daß das Behältnis (11) einen unteren Behälterabschnitt (13) aufweist, der druckdicht an einem oberen Behälterabschluß (15) anbringbar ist, wobei die Zentrifugentrommel (7) vom oberen Behälterabschluß (15) in das Innere des Behältnisses (11) sowie in eine obere5. Centrifuge according to one of the preceding claims, characterized in that the container (11) has a lower container section (13) which can be attached in a pressure-tight manner to an upper container closure (15), the centrifuge drum (7) from the upper container closure (15) into the interior of the container (11) and into an upper one
Öffnung des Beutels (37) ragt.The opening of the bag (37) protrudes.
6. Zentrifuge nach einem der vorstehenden Ansprüche, dadurch gekennzeichnet, daß das Behältnis (11) mit einem sich im wesentlichen parallel zu seiner Außenwandung ver- laufenden ringartigen Mantel (27) versehen ist. 6. Centrifuge according to one of the preceding claims, characterized in that the container (11) is provided with a ring-like jacket (27) extending essentially parallel to its outer wall.
7. Zentrifuge nach einem der vorstehenden Ansprüche, dadurch gekennzeichnet, daß der Mantel (27) eine Doppelwandung aufweist, welche von Kühlflüssigkeit durchströmbar ist.7. Centrifuge according to one of the preceding claims, characterized in that the jacket (27) has a double wall through which cooling liquid can flow.
8. Zentrifuge nach einem der vorstehenden Ansprüche, gekennzeichnet durch einen ringförmigen Auf ahmeraum zur Aufnahme eines Kunststoffschlauches (33), aus dem durch Abtrennen von Schlauchabschnitten und Verschließen der offenen Enden der Schlauchabschnitte die Kunststoffbeutel (37) bildbar sind.8. Centrifuge according to one of the preceding claims, characterized by an annular on receiving space for receiving a plastic tube (33), from which the plastic bags (37) can be formed by separating tube sections and closing the open ends of the tube sections.
9. Zentrifuge nach einem der vorstehenden Ansprüche, gekennzeichnet durch eine Verschlußeinrichtung, die zum Verschließen der Schlauchabschnittes in zwei nebeneinander liegenden Bereichen ausgelegt ist.9. Centrifuge according to one of the preceding claims, characterized by a closure device which is designed to close the tube section in two adjacent areas.
10. Zentrifuge nach einem der vorstehenden Ansprüche, gekennzeichnet durch eine Pumpe zur Erzeugung eines Unterdruckes im Behältnis (11).10. Centrifuge according to one of the preceding claims, characterized by a pump for generating a negative pressure in the container (11).
11. Zentrifuge nach einem der vorstehenden Ansprüche, gekennzeichnet durch einen Dichtring (21) mit aufpumpbarer Dichtkammer (23), mit welcher der Kunststoffschlauch (33) an die Innenwandung des Mantels (27) anpreßbar ist.11. Centrifuge according to one of the preceding claims, characterized by a sealing ring (21) with an inflatable sealing chamber (23) with which the plastic tube (33) can be pressed onto the inner wall of the jacket (27).
12. Verfahren zum Betreiben einer Zentrifuge, insbesondere zum Betreiben einer Zentrifuge mit den Merkmalen von wenigstens einem der vorstehenden Ansprüche, dadurch gekennzeichnet, daß bei der Trennung von Feststoffen und Flüssigkeit die Feststoffe in einem geschlossenen Beutel aufgefangen werden.12. A method for operating a centrifuge, in particular for operating a centrifuge with the features of at least one of the preceding claims, characterized in that the solids are collected in a closed bag when separating solids and liquid.
13. Verfahren nach Anspruch 12, dadurch gekennzeichnet, daß bei der Trennung durch Rotation der Zentrifugentrommel im Beutelinnenraum ein Druckgefälle von außen nach innen erzeugt wird, welches den Beutel aufspannt. 13. The method according to claim 12, characterized in that in the separation by rotation of the centrifuge drum in the bag interior, a pressure drop is generated from the outside in, which spans the bag.
EP99947433A 1998-10-09 1999-09-29 Centrifuge and method for operating said centrifuge Expired - Lifetime EP1119416B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19846535A DE19846535C2 (en) 1998-10-09 1998-10-09 centrifuge
DE19846535 1998-10-09
PCT/EP1999/007211 WO2000021679A1 (en) 1998-10-09 1999-09-29 Centrifuge and method for operating said centrifuge

Publications (2)

Publication Number Publication Date
EP1119416A1 true EP1119416A1 (en) 2001-08-01
EP1119416B1 EP1119416B1 (en) 2003-04-16

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US (1) US6530871B1 (en)
EP (1) EP1119416B1 (en)
JP (1) JP3842972B2 (en)
AT (1) ATE237407T1 (en)
DE (2) DE19846535C2 (en)
DK (1) DK1119416T3 (en)
ES (1) ES2192079T3 (en)
NO (1) NO315503B1 (en)
WO (1) WO2000021679A1 (en)

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JP3842972B2 (en) 2006-11-08
ES2192079T3 (en) 2003-09-16
ATE237407T1 (en) 2003-05-15
NO315503B1 (en) 2003-09-15
EP1119416B1 (en) 2003-04-16
DE19846535C2 (en) 2000-12-07
JP2002527224A (en) 2002-08-27
NO20011750D0 (en) 2001-04-06
DK1119416T3 (en) 2003-08-04
DE59905101D1 (en) 2003-05-22
US6530871B1 (en) 2003-03-11
DE19846535A1 (en) 2000-04-20
NO20011750L (en) 2001-04-06
WO2000021679A1 (en) 2000-04-20

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