EP1105144A1 - Composition and method for eliminating undigested fat and reducing cholesterol in the human body - Google Patents

Composition and method for eliminating undigested fat and reducing cholesterol in the human body

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Publication number
EP1105144A1
EP1105144A1 EP98943227A EP98943227A EP1105144A1 EP 1105144 A1 EP1105144 A1 EP 1105144A1 EP 98943227 A EP98943227 A EP 98943227A EP 98943227 A EP98943227 A EP 98943227A EP 1105144 A1 EP1105144 A1 EP 1105144A1
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EP
European Patent Office
Prior art keywords
composition
generally
weight
amount
human
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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EP98943227A
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German (de)
French (fr)
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EP1105144A4 (en
Inventor
Jose A. Diaz
Eduardo M. Naranjo
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Individual
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Individual
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Priority claimed from PCT/US1998/017074 external-priority patent/WO2000010586A1/en
Publication of EP1105144A1 publication Critical patent/EP1105144A1/en
Publication of EP1105144A4 publication Critical patent/EP1105144A4/en
Withdrawn legal-status Critical Current

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Definitions

  • the present invention relates to a chemical composition for mgestion by humans and a method for aiding weight loss and reducing cholesterol levels m humans. More in particular, the chemical composition of the present invention is intended for mgestion by a human prior to eating a meal and will aid m the absorption and binding of undigested fat to at least one fibrous agent for rapid and natural elimination from the human body.
  • a healthy body automatically secretes lipase, an enzyme that accelerates synthesis of fats, i.e., breaking down the fat molecule.
  • lipase an enzyme that accelerates synthesis of fats, i.e., breaking down the fat molecule.
  • the majority of all fats in foods are present "triglyce ⁇ de form", which the body seeks to break down by removing the glycerol molecule from the triglycende and thereby, release the free fatty acids. Once this occurs, the body is well on its way to absorbing the fat and likely, storing same instead of utilizing it for energy.
  • any such product or method would permit the a person to eat the foods that they most like, while not being as mindful about the amount of fats contained therein, and further, would prevent the body from absorbing the fat such foods once they have been eaten Any such product and method would also ideally aid the body rapid elimination of the ingested fats m a safe, comfortable and natural manner. In turn, the rapid elimination of fats subsequent to mgestion and yet prior to digestion would have a highly beneficial effect in preventing the build-up or accumulation of harmful cholesterol.
  • the present invention is designed to satisfy these and other needs which remain m the art and is believed to represent a significant advance in improving a person's health not only by facilitating weight loss but also the reduction of harmful cholesterol in humans, by means of the rapid elimination of fat from the human body.
  • the present invention is directed to a novel chemical composition intended for mgestion by humans and a method which aids with weight loss and in reducing cholesterol m humans .
  • the chemical composition of the present invention when the chemical composition of the present invention is ingested by a human prior to eating a meal, the composition acts to absorb and bind undigested fat to a fibrous agent so as to promote its rapid elimination from the human body.
  • the novel composition is moisture activated such that it remains inert and can be formed into capsules, preferably conveniently sized for mgestion by a human, and will remain inert until it comes into contact with bodily secretions whether water or other liquid.
  • the chemical composition of the present invention comprises a mixture of an amount of at least one fibrous agent, such as psyllium, at generally about 80% to 83% by weight, and amount of glucosamine, preferably glucosamine HCL, at generally about 8% to 10% by weight, and an amount of glucomannan generally about 5% to 6% by weight, and an amount of apple pectin generally about 2% by weight, and finally, also preferably an amount of stearic acid generally about 1% or 2% by weight of the composition.
  • fibrous agent such as psyllium
  • the chemical composition comprises at least one fibrous agent, preferably psyllium, at generally between 48% and 52% by weight, and an amount of glucosamine, preferably glucosamine HCL, at generally between 38% and 42% by weight, and an amount of glucomannan at generally between 5% and 6% by weight, and an amount of fruit or vegetable derived pectin, such as apple pectin, at generally about 2% by weight, and finally, preferably also an amount of stearic acid at generally between 1% and 2% by weight of the composition.
  • the chemical composition comprises a mixture of an amount of at least one fibrous agent, such as psyllium, at generally about 85% by weight, and an amount of glucosamine, also preferably glucosamine
  • HCL HCL
  • glucomannan at generally about 5% and 6% by weight
  • fruit or vegetable derived pectin such as apple pectin
  • stearic acid generally between 1% and 2% by weight of the composition.
  • a method for using the chemical composition comprises the steps of forming a capsule of generally about five hundred milligrams (500mg) which contains the chemical composition of the first and second preferred embodiments, and having a human ingest at least one of said capsules, preferably with about eight ounces of water about fifteen minutes or twenty minutes before each meal.
  • the method for using the chemical composition for reducing cholesterol comprises the steps of forming a single dose capsule of preferably about seven hundred milligrams (700 mg) which contains the chemical composition of the third preferred embodiment, described above, and having a human ingest at least four of such capsules, preferably with about eight ounces of water between fifteen and twenty minutes prior to each meal.
  • this alternative preferred method includes having a human ingest substantially about twenty-eight hundred milligrams (2800 mg) of the composition before each meal, and contemplates three meals per day, which is believed to offer compelling results reducing the cholesterol levels of a human following the steps of the method. These results would only be enhanced if a diet low fatty foods and a regimen of regular exercise were also followed.
  • a primary object of the present invention is to provide a convenient and effective means for aiding weight loss m a human which safely affects only the fat portion of foods ingested by the human without affecting metabolism.
  • Another primary object of the present invention is to provide a chemical composition and method of treatment which serve as convenient and effective means for reducing the quantity of fat digested and/or absorbed by the human body, thereby aiding m a significant reduction of harmful cholesterol and the build-up or collection of cholesterol deposits the cardio-vascular system.
  • Yet another primary object of the present invention is to provide a chemical composition which seeks out, attaches and binds undigested fat ingested by a human to a fibrous agent, forming an undigestible mass which can easily and rapidly be eliminated from the human ' s body.
  • a feature of the chemical composition according to the present invention is that moisture activated and therefore, is inert and can be formed into and stored as conveniently sized capsules until being ingested by a human and activated by coming into contact with bodily secretions whether water or other liquid.
  • Yet another object of the present invention is to provide a chemical composition which includes a blend of fibrous material for aiding the human body m rapid elimination of waste.
  • a feature of the present invention in the form of one 500 milligram capsule is that it can absorb at least five times its own weight of undigested fats.
  • the present invention is directed towards a chemical composition and method of treatment utilizing the chemical composition which acts to absorb and bind undigested fat and rapidly eliminate the fat through the normal passage of waste from the human body prior to digestion or absorption of the fat.
  • the present invention is also directed to a method of significantly reducing the production and cardio-vascular build-up of harmful cholesterol humans .
  • the chemical composition of the present invention primarily comprises at least one fibrous agent to act both as a vehicle for absorbing fat and as a medium for allowing a human to feel full.
  • the fibrous agent used is psyllium and comprises generally between 80% and 90% by weight of the composition.
  • psyllium comprises generally about or between 80% to 83% by weight of the composition
  • m another alternative embodiment, intended to aid with reducing cholesterol, the psyllium comprises generally about 84% - 85% by weight of the composition.
  • the chemical composition comprises generally between 48% and 52% by weight of psyllium, and more preferably, about fifty percent (50%) of psyllium.
  • composition of the present invention may additionally comprise one or more other fibrous agents, which may be in addition to psyllium.
  • other fibrous agents may be utilized, which are very fibrous materials.
  • Other fibrous agents may also be utilized, as described more fully below.
  • composition of the present invention preferably also comprises glucosamine, a material derived from deacetylated shellfish shells or chitin.
  • Chitin is known in the art as a naturally occurring polysaccharide
  • glucosamine may be obtained from chitin by hydrolysis.
  • glucosamine salts and compounds derived from a monomer of chitin namely, N-acetyl-D- glucosamine (GlcN Ac) which is represented by the general formula:
  • glucosamine hydrochloride acetylated glucosamines, and/or D-glucosamine .
  • glucosamine HCL and/or glucosamine hydrochloride will be utilized and will comprise m a first preferred embodiment, generally between eight and ten percent (8% to 10%) by weight of the composition.
  • the amount of glucosamine or glucosamine HCL m the chemical composition will generally between 38% and 42% by weight, and ideally, about forty percent (40%) by weight of the composition.
  • the amount of glucosamine or glucosamine HCL m the chemical composition will generally be about six or seven percent (6% - 7%) by weight of the composition.
  • the use of glucosamine hydrochloride in the composition offers an additional side benefit in that it has been shown to be an efficacious alternative to corticosteroid treatment of enteritis and colonitis.
  • glucosamine HCL is an ion, or molecule having a negative charge, and which therefore, attracts and binds with certain molecules of food.
  • a beta- alkylglycoside of N-acetyl-D-glucosamme may be utilized, which is represented by the general formula:
  • the composition may comprise chitosan, instead of glucosamine, m amounts similar to those described above with respect to glucosamine and/or glucosamine HCL.
  • Chitosan is formed by dunking the chitin, m its white powder form, in a concentrated sodium hydroxide solution heated to above 135 degrees Celsius to remove one of chitin' s side groups, i.e., to hydrolyze the N-acetyl linkage, such that chitosan results, which can be more readily dissolved.
  • Chitosan which is represented by the general formula:
  • the chemical composition comprises, in addition to psyllium and glucosamine or glucosamine HCL, a quantity of glucomannan -- also known as Konjak or Konjac Root -- which serves the purpose of providing lubrication and as well as providing an additional fibrous agent to the composition.
  • glucomannan comprises generally about 5% to 6% by weight of the composition.
  • the chemical composition preferably also comprises a pectin derived from fruits or succulent vegetables which serves the purpose of providing an additional fibrous agent to the composition so as to aid the user with feeling "full".
  • an apple pectin is used to form the composition which ideally, comprises generally about 2% by weight of the composition.
  • the chemical composition also comprises a saturated fatty acid such as stearic acid, which serves the purpose of permitting the capsule containing the composition to be smooth and/or of facilitating the formation of the capsule containing the inventive composition.
  • a saturated fatty acid such as stearic acid
  • the stearic acid utilized will comprise generally about 1% or 2% by weight of the composition.
  • the psyllium, glucosamine HCL, glucomannan, apple pectin and stearic acid are mixed together in powder form, although a granular form might also be suitable, and result in a mixture which is inert until it comes into contact with water, or another liquid such as is produced by the human body during digestion.
  • the present invention can be formed into capsules for being easily packaged and stored. Additionally, the material used to form the encasement of the capsule will be inert and upon coming into contact with water or other liquid, will begin to break down and permit both the release and activation of the chemical composition.
  • Capsules also have the advantage of dissolving m a shorter period of time, thereby exposing the chemical composition to ingested fat in a shorter amount of time after mgestion.
  • Single doses of the composition could also be formed, however, into pills which would simply require mgestion by humans at a longer period of time before meals are consumed.
  • the capsules containing the chemical composition according to the present invention may be packaged into bottles containing 50, 60, 75, 80, 100 or more capsules, and may include a small, separately wrapped quantity of a drying agent, such as a silica gel in order to assume a dry storage environment desirable for preserving the inertness of the composition until use.
  • the chemical composition of the present invention will be formed into capsules containing generally about 500 milligrams of the chemical composition m the following amounts: generally about 80% or 83% by weight of psyllium; generally about 8% or 10% by weight of glucosamine HCL; generally about 5% or 6% by weight of glucomannan; generally about 2% by weight of apple pectm; and generally about 1% or 2% by weight of stearic acid.
  • the chemical composition will also be formed into capsules containing generally about 500 milligrams of the chemical composition m the following amounts: generally about fifty percent (50%) by weight of psyllium, generally about forty percent (40%) by weight of glucosamine, preferably glucosamine HCL, generally between 5% and 6% by weight of glucomannan, and generally about 2% by weight of fruit or vegetable derived pectm, such as apple pectm, and generally about 1% or 2% by weight of stearic acid.
  • psyllium generally about forty percent (40%) by weight of glucosamine, preferably glucosamine HCL, generally between 5% and 6% by weight of glucomannan, and generally about 2% by weight of fruit or vegetable derived pectm, such as apple pectm, and generally about 1% or 2% by weight of stearic acid.
  • glucosamine HCL generally between 5% and 6% by weight of glucomannan
  • a capsule containing about 500 milligrams has a size and overall dimension which is readily suited for being comfortably swallowed by a person, although the capsule could be formed to be contain less or more of the chemical composition (with ratios of the composition similar to that disclosed herein) , and thereby be somewhat larger or smaller, and still function for being ingested by a person.
  • Testing experiments with the above described chemical composition have demonstrated the ability to absorb at least five (5) times its own weight of undigested fats. For instance, m one experiment 70 milliliters of water was placed in an appropriately sized test tube along with 10 grams (10,000mg) of wheat germ oil and 100 milligrams of lecithin. This mixture was shaken vigorously for about 10 seconds.
  • the chemical composition of the present invention seeks out and binds with fat ingested by a human prior to its being absorbed into the body, and as has been explained, binds them to a fibrous agent so as to aid the person in feeling "full” and further, to permit rapid elimination by the human body.
  • one preferred method of the present invention comprises the steps of forming a capsule of generally about 500 milligrams with the chemical composition and having the human mgest at least one of the 500 milligram capsules with generally about eight ounces of water generally about fifteen to twenty minutes before a meal.
  • the human will mgest two of the capsules before each meal, but may mgest up to about four of the capsules (2000 milligrams) if the meal to be eaten is especially large and/or has a particularly high fat content.
  • each capsule Upon being ingested by a human, each capsule begins to disintegrate and releases or otherwise facilitates activation of the chemical composition contained therein in typically, generally about thirty (30) minutes, and often less time.
  • the present invention will be formed into capsules containing generally about seven hundred milligrams (700 mgs) of the chemical composition in the following amounts: generally about 85% by weight of psyllium; generally about 6% by weight of glucosamine HCL; generally about 6% by weight of glucomannan; generally about 2% by weight of apple pectin; and generally about 1% by weight of stearic acid.
  • a capsule containing about 700 milligrams has a size and overall dimension which is readily suited for being comfortably swallowed by a person in quantities corresponding to recommended doses.
  • the capsule could be formed to contain less or more of the chemical composition (with ratios of the composition similar to that disclosed therein) , and thereby be somewhat larger or smaller, and still be adequate for ingestion by a person.
  • This alternative embodiment of the chemical composition lends itself to a method for reducing cholesterol, which will now be described.
  • another preferred method of the present invention comprises the steps of forming a capsule of generally about 700 milligrams with the chemical composition and having the human ingest at least four of the 700 milligram capsules with generally about eight ounces of water about fifteen to twenty minutes before a meal. Ideally however, the human will ingest four of the capsules before each meal, with three meals per day being eaten.
  • the intake of psyllium with each capsule is generally about six hundred milligrams (600 mgs) or multiplying by four, twenty-four hundred milligrams (2400 mgs) per meal, and if three meals a day are eaten, the intake would then be seventy-two hundred milligrams (7200 mgs) of psyllium per day, which amount has been shown to significantly aid with reducing cholesterol. From the foregoing, it should be clear that the human may ingest more than four such capsules, e.g., up to about six or more of the capsules if the meal to be eaten is especially large and/or has a particularly high fat content.
  • each capsule Upon being ingested by a human, each capsule also begins to disintegrate and releases or otherwise facilitates activation of the chemical composition contained therein in typically, generally about thirty (30) minutes, and often less time.

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  • Medicines Containing Plant Substances (AREA)
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Abstract

A moisture activated composition is provided for ingestion by humans to aid in absorbing and binding undigested fat for rapid elimination from the human body. In a first preferred embodiment the composition comprises at least one fibrous agent, such as psyllium, in an amount of generally about 80 % by weight of the composition, an amount of glucosamine HCL generally about 10 % by weight of the composition, and amount of glucomannan, apple pectin, and stearic acid forming the other generally about 10 % by weight of the composition. In an alternative embodiment intended to achieve more rapid weight loss, the composition comprises a mixture of an amount of at least one fibrous agent, such as psyllium, at generally between 50 % by weight, an amount of glucosamine HCL at generally between 40 % by weight, an amount of glucomannan generally between 5 % and 6 % by weight, an amount of fruit or vegetable derived pectin such as apple pectin generally about 2 % by weight and an amount of stearic acid generally between 1 % and 2 % by weight of the composition. Finally, in an alternative embodiment, intended more for reducing cholesterol, the chemical composition preferably comprises at least one fibrous agent, such as psyllium, in an amount of generally about 85 % by weight of the composition, an amount of glucosamine HCL generally about 6 % by weight of the composition, and amounts of glucomannan, apple pectin, and stearic acid forming the other generally about 10 % by weight of the composition.

Description

Description
COMPOSITION AND METHOD FOR ELIMINATING UNDIGESTED FAT AND REDUCING CHOLESTEROL IN THE HUMAN BODY
BACKGROUND OF THE INVENTION Field of the Invention
The present invention relates to a chemical composition for mgestion by humans and a method for aiding weight loss and reducing cholesterol levels m humans. More in particular, the chemical composition of the present invention is intended for mgestion by a human prior to eating a meal and will aid m the absorption and binding of undigested fat to at least one fibrous agent for rapid and natural elimination from the human body.
Description of the Related Art
In this day and age, many people's lifestyles have become less physically active. A natural result of a sedentary lifestyle is the tendency to gam weight, which is further compounded by the modern day tendency of many people to consume food which has a high fat content. Indeed, it is commonly thought that many people are now over-weight or at least moderately obese, and such individuals typically suffer from certain health problems associated with such conditions, at least at some later point life, if not sooner than expected. Due to this trend, countless efforts have been made to help people control their weigh . As a few examples, many have proclaimed to have won the "battle of the bulge" with a specific diet program or a particular exercise program. Others have explored hypnosis and other mechanisms for controlling the appetite of an individual. Others m the scientific arena have formulated sugar substitutes and are pursuing fat substitutes as methods to reduce the caloric intake of an individual without hopefully, sacrificing the taste of otherwise highly fattening foods. While these efforts are generally capable of aiding many in their fight to lose weight and establish a healthier life style, many such attempts are generally ineffective or simply not practical. For example, some good meaning souls have tried m earnest to follow a particular diet plan but eventually, deviate from the plan because of lack of will-power to continue a given program for weeks or months at a time. This is equally true of those who try hypnosis and similar weight-loss gimmicks. Finally, some view sugar substitutes as being tasteless or worse, as carrying an intolerable health risk, given that some studies have linked them to carcinogens and/or the formation of brain tumors. It has been appreciated recent years that the fat content of foods which people eat are a major culprit behind human weight ga . For example, regardless of the type of fat present a food product, fat has the highest caloric value per gram -- about 9 large calories per gram -- of any food group. It is understood that the body tends to store fat for future use, rather than to utilize its immediately, and this factor helps lead to weight- gain. However, it has also been appreciated recent years that there is a connection between the amount of fat stored in the body and the level of cholesterol in the body, with a diet high m fat likely to lead to high cholesterol levels. As cholesterol has been implicated as a factor m arteriosclerosis or hardening of the arteries, the risk for heart disease and/or a heart attack is elevated when a diet high fat is followed. Unfortunately, fat also makes many food items more tasty -- whether butter on bread, dressings on salads, sour cream on potatoes, or frosting on cake - - and are therefore, difficult to eliminate entirely from one's diet. Thus, fat usually finds its way into the body. Once it does so, a healthy body automatically secretes lipase, an enzyme that accelerates synthesis of fats, i.e., breaking down the fat molecule. The majority of all fats in foods are present "triglyceπde form", which the body seeks to break down by removing the glycerol molecule from the triglycende and thereby, release the free fatty acids. Once this occurs, the body is well on its way to absorbing the fat and likely, storing same instead of utilizing it for energy.
From the foregoing, it will be understood that there remains an appreciable need m the art for a product and attendant safe and easy method of treatment which facilitates a person's efforts to lose weight and to control the accumulation of harmful cholesterol . Any such product and method should be capable of aiding a person accomplishing these goals, without relying exclusively on a person's having sufficient will-power to maintain a strict diet and/or a rigorous exercise program. In addition, any such product and method should not interfere with the taste of foods. Ideally, any such product or method would permit the a person to eat the foods that they most like, while not being as mindful about the amount of fats contained therein, and further, would prevent the body from absorbing the fat such foods once they have been eaten Any such product and method would also ideally aid the body rapid elimination of the ingested fats m a safe, comfortable and natural manner. In turn, the rapid elimination of fats subsequent to mgestion and yet prior to digestion would have a highly beneficial effect in preventing the build-up or accumulation of harmful cholesterol. The present invention is designed to satisfy these and other needs which remain m the art and is believed to represent a significant advance in improving a person's health not only by facilitating weight loss but also the reduction of harmful cholesterol in humans, by means of the rapid elimination of fat from the human body.
SUMMARY OF THE INVENTION
The present invention is directed to a novel chemical composition intended for mgestion by humans and a method which aids with weight loss and in reducing cholesterol m humans . In particular, when the chemical composition of the present invention is ingested by a human prior to eating a meal, the composition acts to absorb and bind undigested fat to a fibrous agent so as to promote its rapid elimination from the human body. In accordance with this invention, the novel composition is moisture activated such that it remains inert and can be formed into capsules, preferably conveniently sized for mgestion by a human, and will remain inert until it comes into contact with bodily secretions whether water or other liquid.
In a first preferred embodiment, the chemical composition of the present invention comprises a mixture of an amount of at least one fibrous agent, such as psyllium, at generally about 80% to 83% by weight, and amount of glucosamine, preferably glucosamine HCL, at generally about 8% to 10% by weight, and an amount of glucomannan generally about 5% to 6% by weight, and an amount of apple pectin generally about 2% by weight, and finally, also preferably an amount of stearic acid generally about 1% or 2% by weight of the composition. In a second, alternative preferred embodiment, intended to more significantly aid with weight loss, the chemical composition comprises at least one fibrous agent, preferably psyllium, at generally between 48% and 52% by weight, and an amount of glucosamine, preferably glucosamine HCL, at generally between 38% and 42% by weight, and an amount of glucomannan at generally between 5% and 6% by weight, and an amount of fruit or vegetable derived pectin, such as apple pectin, at generally about 2% by weight, and finally, preferably also an amount of stearic acid at generally between 1% and 2% by weight of the composition. In a third and alternative preferred embodiment, intended more for reducing cholesterol levels m humans, the chemical composition comprises a mixture of an amount of at least one fibrous agent, such as psyllium, at generally about 85% by weight, and an amount of glucosamine, also preferably glucosamine
HCL, at generally about 6% or 7% by weight, and an amount of glucomannan at generally about 5% and 6% by weight, and an amount of fruit or vegetable derived pectin, such as apple pectin, at generally about 2% by weight, and finally, also preferably an amount of stearic acid generally between 1% and 2% by weight of the composition. Upon contact with moisture, the chemical composition of these embodiments begins to break down and becomes activated. Once activated, the composition acts quickly, usually within 30 seconds to seek and attach itself to undigested fats such as oils and the like, and typically, withm about 2 minutes will form a small mass of undigestible fibrous material. Additionally, a method for using the chemical composition is also described which one embodiment, comprises the steps of forming a capsule of generally about five hundred milligrams (500mg) which contains the chemical composition of the first and second preferred embodiments, and having a human ingest at least one of said capsules, preferably with about eight ounces of water about fifteen minutes or twenty minutes before each meal. In an alternative embodiment, the method for using the chemical composition for reducing cholesterol comprises the steps of forming a single dose capsule of preferably about seven hundred milligrams (700 mg) which contains the chemical composition of the third preferred embodiment, described above, and having a human ingest at least four of such capsules, preferably with about eight ounces of water between fifteen and twenty minutes prior to each meal. While the size of the individual single dose capsule may vary, this alternative preferred method includes having a human ingest substantially about twenty-eight hundred milligrams (2800 mg) of the composition before each meal, and contemplates three meals per day, which is believed to offer compelling results reducing the cholesterol levels of a human following the steps of the method. These results would only be enhanced if a diet low fatty foods and a regimen of regular exercise were also followed.
A primary object of the present invention is to provide a convenient and effective means for aiding weight loss m a human which safely affects only the fat portion of foods ingested by the human without affecting metabolism.
Another primary object of the present invention is to provide a chemical composition and method of treatment which serve as convenient and effective means for reducing the quantity of fat digested and/or absorbed by the human body, thereby aiding m a significant reduction of harmful cholesterol and the build-up or collection of cholesterol deposits the cardio-vascular system. Yet another primary object of the present invention is to provide a chemical composition which seeks out, attaches and binds undigested fat ingested by a human to a fibrous agent, forming an undigestible mass which can easily and rapidly be eliminated from the human ' s body.
A feature of the chemical composition according to the present invention is that moisture activated and therefore, is inert and can be formed into and stored as conveniently sized capsules until being ingested by a human and activated by coming into contact with bodily secretions whether water or other liquid.
Yet another object of the present invention is to provide a chemical composition which includes a blend of fibrous material for aiding the human body m rapid elimination of waste. A feature of the present invention in the form of one 500 milligram capsule is that it can absorb at least five times its own weight of undigested fats.
These and other objects, features and advantages of the present invention will become readily apparent from the detailed description, which follows.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT
The present invention is directed towards a chemical composition and method of treatment utilizing the chemical composition which acts to absorb and bind undigested fat and rapidly eliminate the fat through the normal passage of waste from the human body prior to digestion or absorption of the fat. As a result of substantially reducing fat absorption, the present invention is also directed to a method of significantly reducing the production and cardio-vascular build-up of harmful cholesterol humans .
The chemical composition of the present invention primarily comprises at least one fibrous agent to act both as a vehicle for absorbing fat and as a medium for allowing a human to feel full. Preferably, the fibrous agent used is psyllium and comprises generally between 80% and 90% by weight of the composition. In the first preferred embodiment, psyllium comprises generally about or between 80% to 83% by weight of the composition, and m another alternative embodiment, intended to aid with reducing cholesterol, the psyllium comprises generally about 84% - 85% by weight of the composition. In an alternative preferred embodiment, intended to more significantly aid with weight loss, the chemical composition comprises generally between 48% and 52% by weight of psyllium, and more preferably, about fifty percent (50%) of psyllium. In these and other embodiments, the composition of the present invention may additionally comprise one or more other fibrous agents, which may be in addition to psyllium. For example, plantago ovata seed mucilage or the cover or husks of psyllium seeds may be utilized, which are very fibrous materials. Other fibrous agents may also be utilized, as described more fully below.
In addition to the fibrous agent psyllium, the composition of the present invention preferably also comprises glucosamine, a material derived from deacetylated shellfish shells or chitin.
Chitin is known in the art as a naturally occurring polysaccharide
-- a polymer or long molecules consisting of sugar molecules strung together as shown by the general formula:
Chitin, which can be obtained from crab, lobster or shrimp shells by dissolving the shells' calcium carbonate and then removing protein fragments, leaving behind chitin as a white powder, normally cycles through the environment, decomposing naturally into its hydrogen, carbon, nitrogen and oxygen building blocks. In one embodiment of the invention, glucosamine may be obtained from chitin by hydrolysis. Preferably, glucosamine salts and compounds derived from a monomer of chitin, namely, N-acetyl-D- glucosamine (GlcN Ac) which is represented by the general formula:
will be utilized such as, for example, glucosamine hydrochloride, acetylated glucosamines, and/or D-glucosamine . In a most preferred embodiment , glucosamine HCL and/or glucosamine hydrochloride will be utilized and will comprise m a first preferred embodiment, generally between eight and ten percent (8% to 10%) by weight of the composition. In the alternative preferred embodiment intended for more rapid weight loss, the amount of glucosamine or glucosamine HCL m the chemical composition will generally between 38% and 42% by weight, and ideally, about forty percent (40%) by weight of the composition. In a third preferred embodiment, intended to aid w th reducing cholesterol, the amount of glucosamine or glucosamine HCL m the chemical composition will generally be about six or seven percent (6% - 7%) by weight of the composition. The use of glucosamine hydrochloride in the composition offers an additional side benefit in that it has been shown to be an efficacious alternative to corticosteroid treatment of enteritis and colonitis. It will be understood by those of ordinary skill in the art that as a derivative of chitosan, which has an ability to chelate various metal ions because of its hydroxy and ammo groups act as electron donors, glucosamine HCL is an ion, or molecule having a negative charge, and which therefore, attracts and binds with certain molecules of food. In an alternative embodiment, a beta- alkylglycoside of N-acetyl-D-glucosamme may be utilized, which is represented by the general formula:
3 and is believed to effectively increase the ability of one's digestive tract to handle substantial quantities of lactose. In yet another alternative embodiment, the composition may comprise chitosan, instead of glucosamine, m amounts similar to those described above with respect to glucosamine and/or glucosamine HCL. Chitosan is formed by dunking the chitin, m its white powder form, in a concentrated sodium hydroxide solution heated to above 135 degrees Celsius to remove one of chitin' s side groups, i.e., to hydrolyze the N-acetyl linkage, such that chitosan results, which can be more readily dissolved. Chitosan, which is represented by the general formula:
also has the ability to act as a coagulant, i.e., to attract and bind with certain molecules such as amino acids and proteins.
In the preferred embodiments of the present invention, the chemical composition comprises, in addition to psyllium and glucosamine or glucosamine HCL, a quantity of glucomannan -- also known as Konjak or Konjac Root -- which serves the purpose of providing lubrication and as well as providing an additional fibrous agent to the composition. In all of the preferred embodiments, glucomannan comprises generally about 5% to 6% by weight of the composition. In addition, the chemical composition preferably also comprises a pectin derived from fruits or succulent vegetables which serves the purpose of providing an additional fibrous agent to the composition so as to aid the user with feeling "full". Most preferably, an apple pectin is used to form the composition which ideally, comprises generally about 2% by weight of the composition. Finally, in the preferred embodiment, the chemical composition also comprises a saturated fatty acid such as stearic acid, which serves the purpose of permitting the capsule containing the composition to be smooth and/or of facilitating the formation of the capsule containing the inventive composition. Ideally, the stearic acid utilized will comprise generally about 1% or 2% by weight of the composition.
In all of the preferred embodiments, the psyllium, glucosamine HCL, glucomannan, apple pectin and stearic acid are mixed together in powder form, although a granular form might also be suitable, and result in a mixture which is inert until it comes into contact with water, or another liquid such as is produced by the human body during digestion. Thus, m a most preferred embodiment, the present invention can be formed into capsules for being easily packaged and stored. Additionally, the material used to form the encasement of the capsule will be inert and upon coming into contact with water or other liquid, will begin to break down and permit both the release and activation of the chemical composition. Capsules also have the advantage of dissolving m a shorter period of time, thereby exposing the chemical composition to ingested fat in a shorter amount of time after mgestion. Single doses of the composition could also be formed, however, into pills which would simply require mgestion by humans at a longer period of time before meals are consumed. If desired, the capsules containing the chemical composition according to the present invention may be packaged into bottles containing 50, 60, 75, 80, 100 or more capsules, and may include a small, separately wrapped quantity of a drying agent, such as a silica gel in order to assume a dry storage environment desirable for preserving the inertness of the composition until use.
In a first preferred embodiment, the chemical composition of the present invention will be formed into capsules containing generally about 500 milligrams of the chemical composition m the following amounts: generally about 80% or 83% by weight of psyllium; generally about 8% or 10% by weight of glucosamine HCL; generally about 5% or 6% by weight of glucomannan; generally about 2% by weight of apple pectm; and generally about 1% or 2% by weight of stearic acid. In a second preferred embodiment, intended to more significantly aid with weight loss, the chemical composition will also be formed into capsules containing generally about 500 milligrams of the chemical composition m the following amounts: generally about fifty percent (50%) by weight of psyllium, generally about forty percent (40%) by weight of glucosamine, preferably glucosamine HCL, generally between 5% and 6% by weight of glucomannan, and generally about 2% by weight of fruit or vegetable derived pectm, such as apple pectm, and generally about 1% or 2% by weight of stearic acid. It will be appreciated that a capsule containing about 500 milligrams has a size and overall dimension which is readily suited for being comfortably swallowed by a person, although the capsule could be formed to be contain less or more of the chemical composition (with ratios of the composition similar to that disclosed herein) , and thereby be somewhat larger or smaller, and still function for being ingested by a person. Testing experiments with the above described chemical composition have demonstrated the ability to absorb at least five (5) times its own weight of undigested fats. For instance, m one experiment 70 milliliters of water was placed in an appropriately sized test tube along with 10 grams (10,000mg) of wheat germ oil and 100 milligrams of lecithin. This mixture was shaken vigorously for about 10 seconds. Next, 1 gram or 1000 milligrams of the chemical composition according to the present invention (two capsules of 500 mg each) were added and again, the mixture was shaken vigorously for about 10 seconds. After several minutes, the mixture was observed as having approximately fifty percent (50%) of fat (oil layer) gone, i.e., much of the fat was no longer visible but instead had become bound with the fibrous agent of the composition so as to form an undigestible mass. In addition, the chemical composition of the present invention lends itself to a method of aiding human weight loss, which will now be described. In particular, the chemical composition of the present invention seeks out and binds with fat ingested by a human prior to its being absorbed into the body, and as has been explained, binds them to a fibrous agent so as to aid the person in feeling "full" and further, to permit rapid elimination by the human body. Accordingly, one preferred method of the present invention comprises the steps of forming a capsule of generally about 500 milligrams with the chemical composition and having the human mgest at least one of the 500 milligram capsules with generally about eight ounces of water generally about fifteen to twenty minutes before a meal. Ideally, the human will mgest two of the capsules before each meal, but may mgest up to about four of the capsules (2000 milligrams) if the meal to be eaten is especially large and/or has a particularly high fat content. Upon being ingested by a human, each capsule begins to disintegrate and releases or otherwise facilitates activation of the chemical composition contained therein in typically, generally about thirty (30) minutes, and often less time. In a preferred form of the method there is an additional step of having the human ingest generally about eight ounces of water upon waking up in the morning, and ideally, there is an additional step of having the human ingest generally about eight ounces of water between meals. In an alternative preferred embodiment, intended more for reducing cholesterol in humans, the present invention will be formed into capsules containing generally about seven hundred milligrams (700 mgs) of the chemical composition in the following amounts: generally about 85% by weight of psyllium; generally about 6% by weight of glucosamine HCL; generally about 6% by weight of glucomannan; generally about 2% by weight of apple pectin; and generally about 1% by weight of stearic acid. Similarly, a capsule containing about 700 milligrams has a size and overall dimension which is readily suited for being comfortably swallowed by a person in quantities corresponding to recommended doses. However, the capsule could be formed to contain less or more of the chemical composition (with ratios of the composition similar to that disclosed therein) , and thereby be somewhat larger or smaller, and still be adequate for ingestion by a person. This alternative embodiment of the chemical composition lends itself to a method for reducing cholesterol, which will now be described. Thus, another preferred method of the present invention comprises the steps of forming a capsule of generally about 700 milligrams with the chemical composition and having the human ingest at least four of the 700 milligram capsules with generally about eight ounces of water about fifteen to twenty minutes before a meal. Ideally however, the human will ingest four of the capsules before each meal, with three meals per day being eaten. Thus, the intake of psyllium with each capsule is generally about six hundred milligrams (600 mgs) or multiplying by four, twenty-four hundred milligrams (2400 mgs) per meal, and if three meals a day are eaten, the intake would then be seventy-two hundred milligrams (7200 mgs) of psyllium per day, which amount has been shown to significantly aid with reducing cholesterol. From the foregoing, it should be clear that the human may ingest more than four such capsules, e.g., up to about six or more of the capsules if the meal to be eaten is especially large and/or has a particularly high fat content. Upon being ingested by a human, each capsule also begins to disintegrate and releases or otherwise facilitates activation of the chemical composition contained therein in typically, generally about thirty (30) minutes, and often less time. In a preferred form of the method there is an additional step of having the human ingest generally about eight ounces of water upon waking upon in the morning, and ideally, there is an additional step of having the human ingest about eight ounces of water between meals.
Since many modifications, variations and changes in detail can be made to the described preferred embodiment of the invention, it is intended that all matters in the foregoing description be interpreted as illustrative and not in a limiting sense. Thus, the scope of the invention should be determined by the appended claims and their legal equivalents. Now that the invention has been described,

Claims

Claims
1. A chemical composition for mgestion by a human at mealtimes, which aids absorbing and binding undigested fat for rapid elimination from the human's body, said composition comprising: a) an amount of a fibrous agent generally about 83% by weight of said composition; b) an amount of glucosamine HCL generally about 8% by weight of said composition; c) an amount of glucomannan generally about 6% by weight of said composition; d) an amount of apple pectm generally about 2% by weight of said composition; and e) an amount of stearic acid generally about 1% by weight of said composition.
2. A chemical composition as recited m claim 1, wherein said fibrous agent comprises psyllium.
3. A chemical composition as recited claim 1, wherein said composition is formed into a capsule of 500 milligrams.
4. A chemical composition for mgestion by a human at mealtimes, which aids m absorbing and binding undigested fat for rapid elimination from the human's body, said composition containing : a) an amount of fibrous agent generally about 80% by weight of said composition; b) an amount of glucosamine generally about 8% to 10% by weight of said composition; c) an amount of glucomannan generally about 5% by weight of said composition; d) an amount of apple pect generally about 2% by weight of said composition; and e) an amount of stearic acid generally about 2% by weight of said composition
5. A chemical composition as recited m claim 4, wherein said fibrous agent comprises psyllium.
6. A method of absorbing and binding undigested fat ingested by a human and for rapidly eliminating same from the human, said method comprising the steps of: a) forming a capsule of generally about 500 milligrams with a chemical composition comprising: i) an amount of psyllium generally about 83% by weight of said composition; ii) an amount of glucosamine HCL generally about 8% by weight of said composition; iii) an amount of glucomannan generally about 6% by weight of said composition; iv) an amount of apple pectin generally about 2% by weight of said composition; and v) an amount of stearic acid generally about 1% by weight of said composition; and b) having the human ingest at least one of said capsules with generally about eight ounces of water generally about fifteen minutes before a meal.
7. A method as recited in claim 6, wherein the human ingests two of said capsules before each meal, three times a day.
8. A method as recited in claim 6, wherein the human ingests four of said capsules.
9. A method as recited in claim 6, further comprising the step of having the human ingest generally about eight ounces of water upon waking up in the morning .
10. A method as recited in claim 6, further comprising the step of having the human ingest generally about eight ounces of water between meals.
11. A chemical composition designed for the reduction of cholesterol in the human body, said composition comprising: a) an amount of psyllium in quantities generally between 84% and 85% by weight of said composition; b) an amount of glucosamine HCL generally between 6% and 7% by weight of said composition; c) an amount of glucomannan generally about 5% and 6% by weight of said composition, and d) an amount of fruit or vegetable derived pectin generally about 2% by weight of said composition.
12. A method of reducing cholesterol in the human body, said method comprising the steps of: a) forming a single dose of generally about 700 milligrams with a chemical composition comprising: i) an amount of psyllium in quantities generally between 84% and 85% by weight of said composition, ii) an amount of glycocyamine HCL generally between 6% and 7% by weight of said composition, iii) an amount of glucomannan generally between 5% and 6% by weight of said composition, iv) an amount of apple pectin generally about
2% by weight of said composition, and b) having the human ingest at least one of said single doses with generally about eight ounces of water generally about fifteen minutes before a meal.
13. A method as recited in claim 12, wherein the human ingests four of said single doses before each meal, three times a day.
14. A method as recited in claim 13, wherein the single dose is a capsule.
15. A chemical composition designed to be ingested for the rapid elimination of fat from the human body, prior to digestion, said composition comprising: a) an amount of psyllium of substantially about 50% by weight of said composition, b) an amount of glucosamine HCL substantially about
40% by weight of said composition, c) an amount of glucomannan substantially about of 6% by weight of said composition, and d) an amount of apple pectin substantially above 2% by weight of said composition.
16. A chemical composition as resided in claim 15 comprising a single dose defined by a capsule of substantially 500 milligrams .
17. A chemical composition as resided in claim 16 further comprising an amount of stearic acid generally between 1% and 2% by weight of said composition.
18. A chemical composition designed for the rapid elimination of fat from the human body prior to digestion, said composition comprising: a) an amount of psyllium generally about 50% by weight of said composition, b) an amount of chitosan generally about 40% by weight of said composition, c) an amount of glucomannan generally between 5% to 6% by weight of said composition, and d) an amount of apple pectin generally about 1% to 2% by weight of said composition.
19. A method of rapidly eliminating fat from the human body prior to digestion, said method comprising the steps of: a) forming a single dose of 500 milligrams of a chemical composition comprising: i) an amount of psyllium generally about 48% to 52% by weight of said composition, ii) an about of glucosamine HCL generally about 38% to 42% by weight of said composition, iii) an amount of glucomannan generally between 5% to 6% by weight of said composition, and iv) an amount of apple peccant generally about 1% to 2% by weight of said composition, b) having a human ingest at least two of said single doses prior to a meal .
EP98943227A 1998-08-18 1998-08-18 Composition and method for eliminating undigested fat and reducing cholesterol in the human body Withdrawn EP1105144A4 (en)

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WO2005072750A1 (en) * 2004-01-30 2005-08-11 Otsuka Pharmaceutical Co., Ltd. Composition for inhibting dietary lipid absorption

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