EP1100947A4 - Verfahren zur herstelling von eines antibiotischen wirkstoffs - Google Patents

Verfahren zur herstelling von eines antibiotischen wirkstoffs

Info

Publication number
EP1100947A4
EP1100947A4 EP99938933A EP99938933A EP1100947A4 EP 1100947 A4 EP1100947 A4 EP 1100947A4 EP 99938933 A EP99938933 A EP 99938933A EP 99938933 A EP99938933 A EP 99938933A EP 1100947 A4 EP1100947 A4 EP 1100947A4
Authority
EP
European Patent Office
Prior art keywords
production
antibiotic agent
antibiotic
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99938933A
Other languages
English (en)
French (fr)
Other versions
EP1100947A1 (de
Inventor
Neal C Connors
Leslie A Petersen
David L Hughes
Lisa M Dimichele
Thomas J Novak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1100947A1 publication Critical patent/EP1100947A1/de
Publication of EP1100947A4 publication Critical patent/EP1100947A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP99938933A 1998-08-07 1999-08-04 Verfahren zur herstelling von eines antibiotischen wirkstoffs Withdrawn EP1100947A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9569198P 1998-08-07 1998-08-07
US95691P 1998-08-07
PCT/US1999/017444 WO2000008197A1 (en) 1998-08-07 1999-08-04 Method for the production of an antibiotic agent

Publications (2)

Publication Number Publication Date
EP1100947A1 EP1100947A1 (de) 2001-05-23
EP1100947A4 true EP1100947A4 (de) 2001-09-05

Family

ID=22253174

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99938933A Withdrawn EP1100947A4 (de) 1998-08-07 1999-08-04 Verfahren zur herstelling von eines antibiotischen wirkstoffs

Country Status (4)

Country Link
EP (1) EP1100947A4 (de)
JP (1) JP2003510245A (de)
AU (1) AU5331199A (de)
WO (1) WO2000008197A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696412B1 (en) 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
JP2004525108A (ja) 2000-12-18 2004-08-19 キュービスト ファーマスーティカルズ インコーポレイテッド 精製リポペプチドの調製方法
KR20110011704A (ko) * 2008-06-25 2011-02-08 테바 기오기스제르갸르 자르트쾨렌 뮈쾨되 레스즈베니타르사사그 카스포펀진 불순물 ａ를 함유하지 않는 카스포펀진
CN101928670B (zh) * 2009-09-24 2012-02-22 上海天伟生物制药有限公司 一种抗生素的高产菌株及其制备方法和用途
US8951958B2 (en) 2010-03-29 2015-02-10 Dsm Sinochem Pharmaceuticals Netherlands B.V. Purification of caspofungin intermediates
CN104145021A (zh) * 2012-01-13 2014-11-12 中化帝斯曼制药有限公司荷兰公司 在提高的金属离子浓度下发酵环肽
CN105481952B (zh) * 2014-12-24 2020-12-29 上海天伟生物制药有限公司 一种含氮杂环六肽前体的组合物及其制备方法和用途
CN106755223A (zh) * 2017-01-20 2017-05-31 信泰制药（苏州）有限公司 一种纽莫康定b0的发酵方法
CN107201316B (zh) * 2017-07-14 2020-04-07 海正药业(杭州)有限公司 一种曲霉菌及其生产肺念菌素b0的方法
CN113046250B (zh) * 2019-12-27 2023-01-24 上海医药工业研究院 生产纽莫康定b0的基因工程菌及其制备方法和应用
CN113046251B (zh) * 2019-12-27 2023-01-24 上海医药工业研究院 生产纽莫康定b0的基因工程菌、其制备方法及应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4931352A (en) * 1987-10-07 1990-06-05 Merck & Co., Inc. Antifungal fermentation product
US4968608A (en) * 1987-10-07 1990-11-06 Merck & Co., Inc. Process for antifungal fermentation product
US5021341A (en) * 1990-03-12 1991-06-04 Merck & Co., Inc. Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol
US5049546A (en) * 1990-03-19 1991-09-17 Merck & Co., Inc. Antibiotic agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO0008197A1 *

Also Published As

Publication number Publication date
AU5331199A (en) 2000-02-28
EP1100947A1 (de) 2001-05-23
WO2000008197A1 (en) 2000-02-17
JP2003510245A (ja) 2003-03-18

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