EP1100455A1 - Cosmetic and dermatological preparations comprising an effective content of bile acids, their salts and/or their derivatives - Google Patents

Abstract

The invention relates to cosmetic and dermatological preparations comprising an effective content of bile acids, their salts and/or their derivatives, whereby said active ingredients can be provided both individually and in a mixture.

Description

 description

Cosmetic and dermatological preparations with an effective content of bile acids, their salts and / or their derivatives

The present invention relates to cosmetic and dermatological preparations with an effective content of bile acids, their salts and / or their derivatives and the use thereof for strengthening the barrier function of the skin.

The skin is the largest human organ. Among its many functions (for example for heat regulation and as a sensory organ), the barrier function that prevents the skin (and ultimately the entire organism) from drying out is probably the most important. At the same time, the skin acts as a protective device against the penetration and absorption of substances coming from outside. This barrier function is brought about by the epidermis, which as the outermost layer forms the actual protective cover against the environment. At around a tenth of the total thickness, it is also the thinnest layer of the skin.

The epidermis is a stratified tissue in which the outer layer, the horny layer (stratum corneum), is the important part for the barrier function. It is worn away in contact with the environment and is therefore in a constant renewal process, with fine flakes being continuously released to the outside and corneal and lipid material horned from the inside being reproduced.

The skin model of Elias (PM Elias, Structure and Function of the Stratum Corneum Permeability Barrier, Drug Dev. Res. 13, 1988, 97-105), which is recognized by experts today, describes the horny layer as a two-component system, similar to a brick wall ( Brick-mortar model). In this model, the horny cells (corneocytes) correspond to the bricks, the complex lipid membrane in the intercellular spaces corresponds to the mortar. This system essentially represents a physical barrier against hydrophilic substances, but due to its narrow and more-

Q \ USER \ HEINDO-R \ PAT-RS \ 97-179 DOC layered structure is equally difficult for lipophilic substances to pass through. The special structure of the horny layer protects the skin on the one hand and on the other hand stabilizes its own flexibility by binding a defined amount of water.

Mechanical loads such as pressure, impact or shear forces can also be absorbed to an astonishing extent by the horny layer alone or in combination with the deeper skin layers. Greater pressure, torsional or shear forces are passed on to the deeper layers of the skin through the interlocking of the epidermis with the corium.

The regulation of water and moisture content is one of the most important functions of the epidermal lipid membrane. However, it not only has a barrier effect against external chemical and physical influences, but also contributes to the cohesion of the horny layer.

The lipids of the horny layer essentially consist of ceramides, free fatty acids, cholesterol and cholesterol sulfate and are distributed over the entire horny layer. The composition of these lipids is of crucial importance for the intact function of the epidermal barrier and thus for the water impermeability of the skin.

When the skin is cleaned with the help of a simple water bath - without the addition of surfactants - the skin's horny layer swells. The degree of this swelling depends on a. on the duration of the bath and its temperature. At the same time, water-soluble substances are washed off or washed out, e.g. B. water-soluble dirt components, but also the skin's own substances, which are responsible for the water retention capacity of the horny layer. Skin oils are also dissolved and washed out to a certain extent by the skin's own surface-active substances. After initial swelling, this causes the skin to subsequently dry out, which can be significantly enhanced by washing-active additives.

These processes are generally irrelevant for healthy skin, since the protective mechanisms of the skin can easily compensate for such slight disorders of the upper layers of the skin. But already in the case of non-pathological deviations from normal status, e.g. B. by environmental wear and tear or irritation, light damage, aging skin, etc., the protective mechanism on the skin surface is disturbed. In the case of old skin, for example, the regenerative renewal is slowed down, the water-binding capacity of the horny layer in particular diminishing. It therefore becomes inflexible, dry and cracked ("physiologically" dry skin). Barrier damage is the result. The skin becomes susceptible to negative environmental influences such as the invasion of microorganisms, toxins and allergens. As a result, there may even be toxic or allergic skin reactions.

In the case of pathologically dry and sensitive skin, there is a priori barrier damage. Epidermal intercellular lipids appear to be defective or in insufficient quantity or composition. The consequence is increased permeability of the horny layer and inadequate protection of the skin against loss of hygroscopic substances and water.

The barrier effect of the skin can be quantified by determining the transepidermal water loss (TEWL - transepidermal water ioss). This is the evaporation of water from the inside of the body without taking into account the loss of water when sweating. The determination of the TEWL value has proven to be extremely informative and can be used to diagnose cracked or chapped skin, to determine the compatibility of chemically differently structured surfactants and the like.

For the beauty and care of the skin, the water content in the top layer of skin is of the utmost importance. It can be influenced to a limited extent by introducing moisture regulators.

Anionic surfactants, which are generally components of cleaning preparations, can increase the pH value in the horny layer for a long time, which greatly hinders regenerative processes that serve to restore and renew the barrier function of the skin. In this case, a new, often very unfavorable state of equilibrium occurs in the horny layer between regeneration and the loss of essential substances through regular extraction, which significantly affects the external appearance of the skin and the physiological functioning of the horny layer.

Skin care in the sense of the present invention is to be understood primarily as meaning that the natural function of the skin acts as a barrier against environmental influences (e.g. dirt, chemical potassium, microorganisms) and against the loss of the body's own substances (e.g. water, lipids, electrolytes) is strengthened or restored.

Products for the care, treatment and cleaning of dry and stressed skin are known per se. However, their contribution to the regeneration of a physiologically intact, hydrated and smooth horny layer is limited in scope and time.

The effect of ointments and creams on the barrier function and the hydration of the horny layer is based essentially on the covering (occlusion) of the treated skin areas. The ointment or cream is, so to speak, a (second) artificial barrier that is supposed to prevent water loss from the skin. This physical barrier can be removed correspondingly easily, for example with cleaning agents, as a result of which the original, impaired state is reached again. In addition, the skin care effect can decrease with regular treatment. After stopping the application of the product, the skin quickly returns to the condition before the start of treatment. With certain products, the condition of the skin may even temporarily deteriorate. A sustainable product effect is therefore generally not achieved or only to a limited extent.

The effect of some pharmaceutical preparations on the barrier function of the skin even consists in selective barrier damage, which is intended to enable active substances to penetrate into or through the skin into the body. A disturbed appearance of the skin is sometimes accepted as a side effect.

The effect of nourishing cleaning products essentially consists in an efficient regreasing with sebum lipid-like substances. By simultaneously reducing the surfactant content of such preparations, the damage to the horny layer barrier can be further limited.

However, the prior art lacks preparations which have a positive effect on the barrier function and hydration of the horny layer and which strengthen or even restore the physicochemical properties of the horny layer and in particular the lamellae made of intercellular lipids. The object of the present invention was therefore to eliminate the disadvantages of the prior art. In particular, skin-care preparations and preparations for cleaning the skin should be made available which maintain or restore the barrier properties of the skin, especially when the natural regeneration of the skin is insufficient. They should also be suitable for the treatment and prophylaxis of consequential damage to skin drying out, for example fissures or inflammatory or allergic processes or also neurodermatitis. It was also an object of the present invention to provide stable skin-care cosmetic and / or dermatological agents which protect the skin from environmental influences such as sun and wind. In particular, the effect of the preparations should be physiological, quick and sustainable.

These objects are surprisingly and unpredictably achieved for the person skilled in the art by cosmetic and dermatological preparations with an effective content of bile acids, their salts and / or their derivatives, it being possible for the active substances mentioned to be present both individually and in a mixture.

For the purposes of the present invention, “barrier strengthening” or “strengthening the barrier function of the skin” is to be understood in particular to mean the following effect: the active compounds according to the invention interact with the lipids of the horny layer in such a way that the arrangement of these lipids in the horny layer at the molecular level is improved. This means that the natural function of the skin as a barrier against environmental influences and against the loss of the body's own substances is strengthened or restored.

The preparations according to the invention are extremely satisfactory preparations in every respect. It was not foreseeable for the person skilled in the art that the preparations according to the invention

- better maintain or restore the skin's barrier properties,

- counteract dehydration better,

- work better against aging and

- protect the skin better from environmental influences than the preparations of the prior art.

Bile is the exocrine secretion of the liver, the main components of which are water (86.7%), bile acids (9.1%), bile pigments (3%), cholesterol (0.3%) and fatty acids, pro teine and inorganic substances. The function of the bile in the context of fat digestion consists in the emulsification of water-insoluble food components in the intestinal tract and in the conversion of water-insoluble compounds into the resorbable cholic acids. In addition, the bile acids, which occur in the bile as salts, keep the cholesterol in solution and facilitate its excretion. Bile acids are predominantly substituted cholanic acids conjugated with glycine (glycocholic acid) or taurine (taurocholic acid), which have the following structural motif:

Advantageous for the purposes of the present invention are, for example, dehydrocholic acid, which is characterized by the following structure, and its salts:

Also advantageous are lithocholic acid, which is characterized by the following structure, and its salts:

Cholic acid, which is characterized by the following structure, and its salts are also advantageous:

Glycocholic acid, which is characterized by the following structure, and its salts are also advantageous:

Also advantageous are taurolithocholic acid, which is characterized by the following structure, and its salts, in particular its sodium salt:

For the purposes of the present invention, particular preference is given to deoxycholic acid, which is characterized by the following structure, and its salts:

Also particularly preferred are ursodeoxycholic acid (chenodeoxycholic acid), which is characterized by the following structure, and its salts:

Further particularly preferred are taurocholic acid, which is characterized by the following structure, and its salts, in particular its sodium salt:

Also advantageous in the sense of the present invention are the esters and ethers of bile acids, in particular the esters and ethers of the aforementioned bile acids.

Bile acid ethers can be obtained by etherification of at least one of the alcohol functions in the 3-, 7- or 12-position of the cholane ring. Bile acid ethers which are obtainable by etherification of the alcohol function in the 3-position are particularly preferred.

For the purposes of the present invention, bile acid ethers which are obtainable by etherification with ethylene oxide, saturated and / or unsaturated, branched and / or unbranched alcohols having a chain length of 2 to 22 carbon atoms are advantageous.

Bile acid esters can be obtained by esterifying at least one of the alcohol functions in the 3-, 7- or 12-position of the cholane ring and by esterifying the terminal acid functions. Advantageous in the sense of the present invention are bile acid esters, which by esterification with saturated and / or unsaturated, branched and / or unbranched acids with a chain length of 2 to 22 carbon atoms are available.

Also advantageous are bile acid esters which can be obtained by esterifying the terminal acid function with ethylene oxide, saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 2 to 22 carbon atoms.

The salts of bile acids, in particular the alkali and / or alkaline earth metal salts, and the salts of the mono- or divalent cations of elements of the subgroups and of the lanthanides and / or actinides, are also particularly advantageous in the sense of the present invention. Also advantageous are bile acid salts of ammonium (-NH ₃ ), alkanolammonium derivatives with 2 to 9 carbon atoms in total, alkyl or alkenylammonium derivatives with 1 to 22 carbon atoms in total, pyridine, which can be substituted with an alkyl or alkenyl group , which has 1 to 18 carbon atoms, and basic amino acids. The sodium, potassium and / or triethanolamine salts of bile acids are particularly preferred according to the invention.

The cosmetic or dermatological preparations or formulations according to the invention can be composed as usual and can be used for the treatment, care and cleaning of the skin and / or hair and as a make-up product in decorative cosmetics. Correspondingly, depending on their structure, they can be used, for example, as a skin protection cream, cleansing milk, sunscreen lotion, nutritional cream, day or night cream, etc. It may be possible and advantageous to use the preparations according to the invention as the basis for pharmaceutical formulations. The preparations according to the invention contain z. B. 0.001 to 10 wt .-%, preferably 0.01 wt .-% to 1 wt .-%, but especially 0.01 wt .-% to 0.5 wt .-%, each based on the total weight of the preparations on the active substances according to the invention.

Cosmetic and dermatological preparations which are in the form of a sunscreen are also favorable. In addition to one or more active substances according to the invention, these preferably contain at least one UV-A filter substance and / or at least one UV-B filter substance and / or at least one inorganic pigment. However, it is also advantageous for the purposes of the present invention to produce cosmetic and dermatological preparations whose main purpose is not protection against sunlight, but which nevertheless contain UV protection substances. So z. B. usually incorporated into day creams UV-A or UV-B filter substances.

The cosmetic and dermatological preparations according to the invention can contain cosmetic auxiliaries, as are usually used in such preparations, e.g. B. preservatives, bactericides, perfumes, anti-foaming substances, dyes, pigments that have a coloring effect, thickeners, surface-active substances, emulsifiers, softening, moisturizing and / or moisturizing substances, fats, oils, waxes or other common components of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives.

The amounts of cosmetic, dermatological or medical carriers and perfume to be used in each case can easily be determined by a person skilled in the art depending on the type of product in question by simply trying them out.

Preparations for the treatment and care of the skin are particularly preferred.

For use, the cosmetic and dermatological preparations according to the invention are applied to the skin and / or the hair in a sufficient amount in the manner customary for cosmetics.

Cosmetic and dermatological preparations according to the invention can be in various forms. So you can z. B. a solution, an anhydrous preparation, an emulsion or microemulsion of the water-in-oil (W / O) or oil-in-water (O / W) type, a multiple emulsions, for example of the water-in-oil type Oil-in-water (W / O / W), a gel, a solid stick, an ointment or an aerosol. It is also advantageous to present the active compounds according to the invention in encapsulated form, e.g. B. in collagen matrices and other common encapsulation materials, e.g. B. as cellulose encapsulation, encapsulated in gelatin, wax matrices or liposomal. It is also possible and advantageous for the purposes of the present invention to insert the active compounds according to the invention into aqueous systems or surfactant preparations for cleaning the skin and hair.

In particular, the cosmetic and dermatological preparations according to the invention can also contain antioxidants. According to the invention, all the antioxidants suitable or customary for cosmetic and / or dermatological applications can be used as favorable antioxidants.

The antioxidants are advantageously selected from the group consisting of amino acids (e.g. glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (e.g. urocanic acid) and their derivatives, peptides such as D, L-camosine, D-carnosine, L-carnosine and their derivatives (e.g. anserine), carotenoids, carotenes (e.g. α-carotene, ß-carotene, lycopene) and their derivatives, chlorogenic acid and its derivatives, lipoic acid and its derivatives ( e.g. dihydroliponic acid), aurothioglucose, propylthiouracil and other thiols (e.g. thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl , Butyl and lauryl, palmitoyl, oleyl, γ-linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and their derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) as well as sulfoximine compounds (e.g. buthionine sulfoximines, homocysteine sulfoximine, buthioni nsulfones, penta-, hexa-, heptathioninsulfoximine) in very low tolerable doses (e.g. B. pmol to μmol / kg), further (metal) chelators (e.g. α-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), α-hydroxy acids (e.g. crtronic acid, lactic acid, malic acid), humic acid, bile acid, Bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (e.g. γ-linolenic acid, linoleic acid, oleic acid), folic acid and their derivatives, ubiquinone and ubiquinol and their derivatives, vitamin C and derivatives (e.g. B. Ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (e.g. vitamin E acetate), vitamin A and derivatives (vitamin A palmitate) and coniferyl benzoate of benzoin, rutinic acid and its derivatives, α-Glycosylrutin, ferulic acid, furfurylidene glucitol, carnosine, butylated hydroxytoluene, butylated hydroxy anisole, nordihydroguajak resin acid, nordihydroguajaretic acid, trihydroxybutyrophenone, uric acid and its derivatives, mannose and their derivatives, zinc and its derivatives, e.g. Zn 4), selenium and its derivatives (e.g. B. selenomethionine), stilbene and their

Derivatives (e.g. stilbene oxide, trans-stilbene oxide) and the derivatives suitable according to the invention te (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids) of these active ingredients.

The amount of the aforementioned antioxidants (one or more compounds) in the preparations according to the invention is preferably 0.001 to 30% by weight, particularly preferably 0.05-20% by weight, in particular 1-10% by weight, based on the total weight the preparation.

If vitamin E and / or its derivatives represent the antioxidant (s), it is advantageous to choose their respective concentrations from the range of 0.001-10% by weight, based on the total weight of the formulation.

If vitamin A or vitamin A derivatives or carotenes or their derivatives represent the antioxidant or antioxidants, it is advantageous to use their respective concentrations in the range from 0.001-10% by weight, based on the total weight of the formulation, to choose.

The following examples are intended to illustrate the present invention without restricting it. The numerical values in the examples mean percentages by weight, based on the total weight of the respective preparations.

Example recipes:

1. Lecithin fluid

% By weight

Lecithin 5.00

Ursodeoxycholic acid 0.50

Cetearyl alcohol 1.00

Glycerin 3.00

Antioxidants, preservatives, neutralizing agents, q.s. Perfume, dyes

Water ad 100

2. Hvdrodispersion gel

% By weight

Stearyl alcohol 2.00

Behenyl alcohol 2.00

Ceramide 3 0.20

Taurodeoxycholic acid 0.10

Carbopol 0.30

Hydroxyethyl cellulose 0.40

Glycerin 3.00

Panthenol 1, 00

Caprylic / Capric Triglyceride 3.00

Isopropyl palmitate 3.00

Shea Butter 2.00

Antioxidants, preservatives, neutralizing agents, q.s.

Perfume, dyes

Water ad 100 3. Light gel

% By weight

Sucrose stearate 3.00

Cetearyl alcohol 2.00

Deoxycholic acid 0.02

Carbopol 0.50

Glycerin 3.00

Antioxidants, preservatives, neutralizing agents, q.s. Perfume, dyes

Water ad 100

4. O / W cream

% By weight

Sucrose stearate 4.00

Sucroselaurate 2.00

Taurolithocholic acid 0.02

Cetearyl alcohol 3.00

Glycerin 3.00

Dimethicone 2.00

Mineral oil 5.00

Isopropyl palmitate 3.00

Sunflower oil 3.00

Hydrogenated coconut fatty acid glycerides 2.50

Liquorice root extract 2.00

Carbomer 0.20

NaOH 45% 0.10

Antioxidants, preservatives, neutralizing agents, q.s. Perfume, dyes

Water ad 100 5. O / W lotion

% By weight

Stearic acid 1, 50

Sorbitan monostearate 0.50

U rsodeoxycholic acid 0.05

Myristyl alcohol 1.00

Glycerol monostearate 0.50

Paraffin oil, subliquidum 10.00

Dimethicone 1, 00

Octyldodecanol 2.00

Hydrogenated coconut fatty acid glycerides 0.50

Carbomer 0.10

Serine 0.50

Glycerin 5.00

Tocopherol acetate 0.50

Antioxidants, preservatives, neutralizing agents, q.s.

Perfume, dyes

Water ad 100

6. W / O lotion

% By weight

PEG-7 hydrogenated castor oil 4.00

Glycocholic acid 0.01

Beeswax 3.00

Vaseline 4.00

Ozokerite 4.00

Paraffin oil, subliquidum 10.00

Glycerin 5.00

Octyl methoxycinnamate 2.50

Methylbenzylidene camphor 2.50

Tocopherol acetate 1.00

Magnesium sulfate 7 H ₂ O 0.70

Antioxidants, preservatives, neutralizing agents, q.s.

Perfume, dyes

Water ad 100 % By weight

PEG-7 hydrogenated castor oil 4.00

Wool wax alcohol 1, 50

Deoxycholic acid 0.05

Vaseline 9.00

Ozokerite 4.00

Paraffin oil, subliquidum 10.00

Urea 10.00

Magnesium sulfate 7 H ₂ O 0.70

Lactic acid 0.30

Sodium lactate 2.50

Antioxidants, preservatives, neutralizing agents, q.s. Perfume, dyes

Water ad 100

8. Silicone emulsion

% By weight

Dimethicone copolyol 2.00

Cylomethicone 5.00

Dimethicone 3.00

Paraffin oil, subliquidum 8.00

Wheat germ oil 4.00

Dehydrocholic acid 0.02

Glycerin 10.00

Sodium chloride 1.00

Antioxidants, preservatives, neutralizing agents, q.s. Perfume, dyes

Water ad 100 9. Ointment

% By weight

Vaseline 36.00

Ceresin 10.00

Zinc oxide 4.00

Wheat germ oil 20.00

Taurocholic acid 0.02

Antioxidants, preservatives, neutralizing agents, q.s. Perfume, dyes

Paraffin oil ad 100

10. Skin oil

% By weight

Cetyl palmitate 3.00

C12-15 alkyl benzoate 2.00

Polyisobutene 10.00

Squalane 2.00

Ursodeoxycholic acid 0.05

Antioxidants, preservatives, neutralizing agents, q.s. Perfume, dyes

Paraffin oil ad 100

11. Bath oil

% By weight

Paraffin oil 20.00

PEG-40 Hydrogenated castor oil 5.00

Deoxycholic acid 0.50

Antioxidants, preservatives, neutralizing agents, q.s. Perfume, dyes

Soybean oil ad 100 12. Lip care stick

% By weight

Caprylic / Capric triglyceride 25.00

Octyldodecanol 25.00

Ceramide 3 0.50

Ursodeoxycholic acid 0.20

Beeswax 20.00

Cetyl palmitate 8.00

Jojoba oil 5.00

Carnauba wax 4.00

Tocopherol acetate 0.75

Antioxidants, preservatives, neutralizing agents, q.s.

Perfume, dyes

Squalane ad 100

13. Emulsion lip care stick

% By weight

Caprylic / Capric Triglyceride 30.00

Octyldodecanol 20.00

Polyglyceryl-3 dioleate 3.50

Beeswax 10.00

Dehydrocholic acid 0.10

C _{2 (M} o alkyl stearate 5.00

Jojoba oil 5.00

Carnauba wax 2.00

Tocopherol acetate 0.75

Water 5.00

Antioxidants, preservatives, neutralizing agents, q.s. Perfume, dyes

Squalane ad 100 14. Lipstick

% By weight

Caprylic / Capric triglyceride 22.00

Octyldodecanol 22.00

Ursodeoxycholic acid 0.20

PEG-5 soyasterol 0.50

Beeswax hydrolyzate 5.00

Beeswax 15.00

Cetyl palmitate 2.00

Jojoba oil 5.00

Carnauba wax 2.00

Tocopherol acetate 0.75

Color pigments, color lacquers, titanium dioxide q, p.

Antioxidants, preservatives, neutralizing agents, q, s. Perfume, dyes

Squalane ad 100

15. Emulsion makeup

% By weight

Sorbitan monostearate 1.50

Sorbitan monooleate 1.00

Glycerol monostearate 1, 00

Taurocholic acid 0.20

Glyceryl alcoholate 1.00

Paraffin oil, subliquidum 7.00

Octyldodecanol 7.00

Hydrogenated coconut fatty acid glycerides 4.00

Octyl methoxycinnamate 2.00

Butyl methoxydibenzoyl methane 1.00

Carbomer 0.10

Glycerin 5.00

1, 3 butylene glycol 2.00

Tocopherol acetate 1.00

Strength Natriumoctenylsuccinat (Amiogum ^® from the American 2.50

Maize-Products Company / CERSTAR)

Magnesium silicate 1.00

Mica 1, 00

Iron oxides 1, 00

Titanium dioxide 2.50

Talc 5.00

Antioxidants, preservatives, neutralizing agents, q.s.

Perfume, dyes

Water ad 100

16. Haircare products

% By weight

TEA - Cocoyl hydrolyzed collagen 30.00

Monoethanolamine lauryl sulfate 25.00

Almond oil 2.00

PEG-25 Soyasterol 2.00

Deoxycholic acid 0.20

Sodium chloride 1.00

Antioxidants, preservatives, neutralizing agents, q.s. Perfume, dyes

Water ad 100

17.Care shampoo

% By weight

Sodium lauryl sulfate 34.00

Disodium lauryl sulfosuccinate 6.00

Cocoamidopropyl betaine 10.00

Lithocholic acid 0.02

Glycol distearate 5.00

Antioxidants, preservatives, neutralizing agents, q.s. Perfume, dyes

Water ad 100

18. Pumpsprav

% By weight

PEG-40 hydrogenated castor oil 2.00

Glycerin 1, 00

PEG-25 Soyasterol 2.00

Glycocholic acid 0.02

Antioxidants, preservatives, neutralizing agents, q.s. Perfume, dyes

Water ad 100

19. Roll-on emulsion

% By weight

Triceteareth phosphate 0.30

Octyldodecanol 2.00

C1 ₂ -1S alkyl benzoate 2.00

C ₁ 0-30 alkyl acrylate 0.15

Taurolithocholic acid 0.05

Antioxidants, preservatives, neutralizing agents, q.s. Perfume, dyes

Water ad 100

Claims

Claims:

1. Cosmetic and dermatological preparations with an effective content of bile acids, their salts and / or their derivatives, it being possible for the active substances mentioned to be present both individually and in a mixture.

2. Preparations according to claim 1, characterized in that additional cosmetic or dermatological auxiliaries, additives and / or active ingredients are included.

3. Preparations according to one of the preceding claims, characterized in that the content of one or more bile acids, their salts and / or their derivatives in the cosmetic or dermatological preparations from the range 0.001 to 10 wt .-%, preferably 0.01 wt % to 1% by weight, but in particular 0.01% by weight to 0.5% by weight, in each case based on the total weight of the preparations.

4. Preparations according to one of the preceding claims, characterized in that the active ingredient or ingredients are selected from the group deoxycholic acid, ursodeoxycholic acid, taurocholic acid and / or their salts and / or their derivatives.

5. Preparations according to one of the preceding claims, characterized in that the active ingredient or ingredients are selected from the group of esters and ethers of galienic acids.

6. Preparations according to one of the preceding claims, characterized in that the active ingredient or ingredients are selected from the group consisting of the salts of bile acids, in particular the alkali and alkaline earth metal salts, the salts of the mono- or divalent cations of elements of the subgroups and the lanthanides and Actinides, the salts of ammonium (-NH ₃ ), alkanolammonium derivatives with 2 to 9 carbon atoms in total, alkyl and alkenylammonium derivatives with 1 to 22 carbon atoms in total, pyridine, which can be substituted with an alkyl or alkenyl group, the 1st has up to 18 carbon atoms and the salts of basic amino acids.

7. Use of preparations according to one of claims 1 to 6 for strengthening the barrier function of the skin.