EP1095002A4 - Method of vitamin production - Google Patents

Method of vitamin production

Info

Publication number
EP1095002A4
EP1095002A4 EP99932295A EP99932295A EP1095002A4 EP 1095002 A4 EP1095002 A4 EP 1095002A4 EP 99932295 A EP99932295 A EP 99932295A EP 99932295 A EP99932295 A EP 99932295A EP 1095002 A4 EP1095002 A4 EP 1095002A4
Authority
EP
European Patent Office
Prior art keywords
geranylgeraniol
microorganism
farnesol
vitamin production
phosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99932295A
Other languages
German (de)
French (fr)
Other versions
EP1095002A1 (en
Inventor
James R Millis
Gabriel G Saucy
Julie Maurina-Brunker
Thomas W Mcmullin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DCV Inc
Original Assignee
DCV Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DCV Inc filed Critical DCV Inc
Priority to EP10180179.3A priority Critical patent/EP2305825B1/en
Priority to EP08003596A priority patent/EP1947189B1/en
Priority to EP09004155A priority patent/EP2100963B1/en
Priority to DK08003596.7T priority patent/DK1947189T3/en
Publication of EP1095002A1 publication Critical patent/EP1095002A1/en
Publication of EP1095002A4 publication Critical patent/EP1095002A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01Q—ANTENNAS, i.e. RADIO AERIALS
    • H01Q1/00—Details of, or arrangements associated with, antennas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

The invention relates to methods for producing farnesol or geranylgeraniol comprising: (a) culturing a microorganism in a fermentation medium to produce a product selected from the group consisting of farnesyl phosphate and farnesol or geranylgeranyl phosphate and geranylgeraniol, wherein the action of squalene synthase of said microorganism is reduced; and (b) recovering said product.
EP99932295A 1998-07-06 1999-07-06 Method of vitamin production Withdrawn EP1095002A4 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP10180179.3A EP2305825B1 (en) 1998-07-06 1999-07-06 Method of vitamin production
EP08003596A EP1947189B1 (en) 1998-07-06 1999-07-06 Method of vitamin production
EP09004155A EP2100963B1 (en) 1998-07-06 1999-07-06 Method of vitamin production
DK08003596.7T DK1947189T3 (en) 1998-07-06 1999-07-06 Process for Vitamin Preparation

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US9196498P 1998-07-06 1998-07-06
US9198398P 1998-07-06 1998-07-06
US9195198P 1998-07-06 1998-07-06
US91951P 1998-07-06
US91964P 1998-07-06
US91983P 1998-07-06
PCT/US1999/015264 WO2000001650A1 (en) 1998-07-06 1999-07-06 Method of vitamin production

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP08003596A Division EP1947189B1 (en) 1998-07-06 1999-07-06 Method of vitamin production
EP10180179.3A Division EP2305825B1 (en) 1998-07-06 1999-07-06 Method of vitamin production

Publications (2)

Publication Number Publication Date
EP1095002A1 EP1095002A1 (en) 2001-05-02
EP1095002A4 true EP1095002A4 (en) 2005-08-03

Family

ID=27377004

Family Applications (3)

Application Number Title Priority Date Filing Date
EP09004155A Expired - Lifetime EP2100963B1 (en) 1998-07-06 1999-07-06 Method of vitamin production
EP08003596A Expired - Lifetime EP1947189B1 (en) 1998-07-06 1999-07-06 Method of vitamin production
EP99932295A Withdrawn EP1095002A4 (en) 1998-07-06 1999-07-06 Method of vitamin production

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EP09004155A Expired - Lifetime EP2100963B1 (en) 1998-07-06 1999-07-06 Method of vitamin production
EP08003596A Expired - Lifetime EP1947189B1 (en) 1998-07-06 1999-07-06 Method of vitamin production

Country Status (11)

Country Link
EP (3) EP2100963B1 (en)
JP (1) JP4579415B2 (en)
CN (1) CN1330621A (en)
AT (2) ATE490332T1 (en)
AU (1) AU4863099A (en)
CA (2) CA2331343C (en)
DE (1) DE69943009D1 (en)
DK (3) DK2100963T3 (en)
ES (2) ES2534937T3 (en)
MX (2) MX276941B (en)
WO (1) WO2000001650A1 (en)

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AU776316B2 (en) 1999-04-15 2004-09-02 Monsanto Company Nucleic acid sequences to proteins involved in tocopherol synthesis
EP1260590B1 (en) * 2000-03-02 2007-02-14 TOUDAI TLO, Ltd. Method of screening substance specifically inhibiting non-mevalonate pathway
US6872815B1 (en) 2000-10-14 2005-03-29 Calgene Llc Nucleic acid sequences to proteins involved in tocopherol synthesis
US20030033626A1 (en) 2000-07-31 2003-02-13 Hahn Frederick M. Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
AU9052201A (en) 2000-08-07 2002-02-18 Monsanto Technology Llc Methyl-d-erythritol phosphate pathway genes
JP2002253284A (en) * 2000-12-28 2002-09-10 Toyota Motor Corp Method for producing geranylgeraniol and analogous compound thereof by microorganism
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JP3894119B2 (en) * 2000-12-28 2007-03-14 トヨタ自動車株式会社 Method for producing prenyl alcohol
JP3838033B2 (en) * 2000-12-28 2006-10-25 トヨタ自動車株式会社 Method for producing prenyl alcohol
WO2002053747A1 (en) * 2000-12-28 2002-07-11 Toyota Jidosha Kabushiki Kaisha Process for producing prenyl alcohol
JP2003088368A (en) * 2001-09-18 2003-03-25 Toyota Motor Corp Method for producing prenyl alcohol
CN1568141B (en) 2001-05-09 2014-05-07 孟山都技术有限公司 TYRA gene and its application
US7161061B2 (en) 2001-05-09 2007-01-09 Monsanto Technology Llc Metabolite transporters
ES2311613T3 (en) * 2001-06-06 2009-02-16 Dsm Ip Assets B.V. IMPROVED PRODUCTION OF ISOPRENOIDS.
WO2003016482A2 (en) 2001-08-17 2003-02-27 Monsanto Technology Llc Methyltransferase genes and uses thereof
BR0213499A (en) 2001-10-25 2004-11-03 Monsanto Technology Llc Aromatic methyltransferases and their use
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Also Published As

Publication number Publication date
DE69943009D1 (en) 2011-01-13
CA2331343A1 (en) 2000-01-13
ATE537265T1 (en) 2011-12-15
ATE490332T1 (en) 2010-12-15
CA2831321A1 (en) 2000-01-13
DK1947189T3 (en) 2011-03-14
JP4579415B2 (en) 2010-11-10
EP1947189A3 (en) 2008-10-08
MX219130B (en) 2004-02-10
CA2331343C (en) 2014-01-14
MXPA01000216A (en) 2002-10-17
EP1947189A2 (en) 2008-07-23
EP2100963A1 (en) 2009-09-16
ES2379212T3 (en) 2012-04-23
DK2305825T3 (en) 2015-03-02
MX276941B (en) 2010-06-28
AU4863099A (en) 2000-01-24
EP1095002A1 (en) 2001-05-02
DK2100963T3 (en) 2012-04-02
WO2000001650A1 (en) 2000-01-13
EP1947189B1 (en) 2010-12-01
ES2534937T3 (en) 2015-04-30
CA2831321C (en) 2018-05-15
JP2002519049A (en) 2002-07-02
CN1330621A (en) 2002-01-09
EP2100963B1 (en) 2011-12-14

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