EP1093368A4 - ALPHA KETOOXADIAZOLES CONTAINING INDOL AND TETRAHYDROISOQUINOLINE AS SERINE PROTEASE INHIBITORS - Google Patents
ALPHA KETOOXADIAZOLES CONTAINING INDOL AND TETRAHYDROISOQUINOLINE AS SERINE PROTEASE INHIBITORSInfo
- Publication number
- EP1093368A4 EP1093368A4 EP99927189A EP99927189A EP1093368A4 EP 1093368 A4 EP1093368 A4 EP 1093368A4 EP 99927189 A EP99927189 A EP 99927189A EP 99927189 A EP99927189 A EP 99927189A EP 1093368 A4 EP1093368 A4 EP 1093368A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- oxadiazoles
- tetrahydroisoquinoline
- keto
- indole
- protease inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01200500A EP1114822A3 (en) | 1998-06-03 | 1999-06-03 | Indoles and tetrahydroisoquinolines containing alpha-keto oxadiazoles as serine protease inhibitors |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/089,587 US6100238A (en) | 1994-11-21 | 1998-06-03 | Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors |
1999-05-06 | |||
PCT/US1999/012352 WO1999062514A1 (en) | 1998-06-03 | 1999-06-03 | INDOLE AND TETRAHYDROISOQUINOLINE CONTAINING α-KETO OXADIAZOLES AS SERINE PROTEASE INHIBITORS |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP01200500A Division EP1114822A3 (en) | 1998-06-03 | 1999-06-03 | Indoles and tetrahydroisoquinolines containing alpha-keto oxadiazoles as serine protease inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1093368A1 EP1093368A1 (en) | 2001-04-25 |
EP1093368A4 true EP1093368A4 (en) | 2002-11-13 |
Family
ID=26780737
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99927189A Withdrawn EP1093368A4 (en) | 1998-06-03 | 1999-06-03 | ALPHA KETOOXADIAZOLES CONTAINING INDOL AND TETRAHYDROISOQUINOLINE AS SERINE PROTEASE INHIBITORS |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1093368A4 (ko) |
JP (1) | JP2004517028A (ko) |
KR (1) | KR20010078724A (ko) |
WO (1) | WO1999062514A1 (ko) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2009008493A (es) * | 2007-02-09 | 2009-08-20 | Irm Llc | Compuestos y composiciones como inhibidores de la proteasa activadora de canal. |
EP4031138A1 (en) | 2019-09-17 | 2022-07-27 | Mereo Biopharma 4 Limited | Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease |
AU2021256835A1 (en) | 2020-04-16 | 2022-10-13 | Mereo Biopharma 4 Limited | Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency |
WO2023067103A1 (en) | 2021-10-20 | 2023-04-27 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993020099A2 (en) * | 1992-03-27 | 1993-10-14 | Ferring B.V. | Cck and/or gastrin receptor ligands |
WO1996016080A1 (en) * | 1994-11-21 | 1996-05-30 | Cortech, Inc. | Human neutrophil elastase inhibitors |
-
1999
- 1999-06-03 JP JP2000551770A patent/JP2004517028A/ja not_active Withdrawn
- 1999-06-03 WO PCT/US1999/012352 patent/WO1999062514A1/en not_active Application Discontinuation
- 1999-06-03 KR KR1020007013664A patent/KR20010078724A/ko not_active Application Discontinuation
- 1999-06-03 EP EP99927189A patent/EP1093368A4/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993020099A2 (en) * | 1992-03-27 | 1993-10-14 | Ferring B.V. | Cck and/or gastrin receptor ligands |
WO1996016080A1 (en) * | 1994-11-21 | 1996-05-30 | Cortech, Inc. | Human neutrophil elastase inhibitors |
US5618792A (en) * | 1994-11-21 | 1997-04-08 | Cortech, Inc. | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase |
Non-Patent Citations (1)
Title |
---|
See also references of WO9962514A1 * |
Also Published As
Publication number | Publication date |
---|---|
KR20010078724A (ko) | 2001-08-21 |
WO1999062514A1 (en) | 1999-12-09 |
EP1093368A1 (en) | 2001-04-25 |
JP2004517028A (ja) | 2004-06-10 |
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Legal Events
Date | Code | Title | Description |
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20001228 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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AX | Request for extension of the european patent |
Free format text: AL PAYMENT 20001228;LT PAYMENT 20001228;LV PAYMENT 20001228;MK PAYMENT 20001228;RO PAYMENT 20001228;SI PAYMENT 20001228 |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20020930 |
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AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7C 07D 413/12 A, 7A 61K 31/405 B, 7A 61K 31/41 B, 7A 61K 31/47 B, 7C 07D 217/12 B, 7C 07D 217/16 B, 7C 07D 249/08 B, 7C 07D 271/06 B, 7C 07D 271/10 B |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20051201 |
|
R18D | Application deemed to be withdrawn (corrected) |
Effective date: 20060103 |