EP1073471A4 - METHOD FOR THE TREATMENT OF ENDOTOXEMIA - Google Patents

METHOD FOR THE TREATMENT OF ENDOTOXEMIA

Info

Publication number
EP1073471A4
EP1073471A4 EP99920001A EP99920001A EP1073471A4 EP 1073471 A4 EP1073471 A4 EP 1073471A4 EP 99920001 A EP99920001 A EP 99920001A EP 99920001 A EP99920001 A EP 99920001A EP 1073471 A4 EP1073471 A4 EP 1073471A4
Authority
EP
European Patent Office
Prior art keywords
treating endotoxemia
endotoxemia
treating
lpsd
downregulates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99920001A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP1073471A1 (en
Inventor
Peter M C Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Temple University of Commonwealth System of Higher Education
Original Assignee
Temple University of Commonwealth System of Higher Education
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Temple University of Commonwealth System of Higher Education filed Critical Temple University of Commonwealth System of Higher Education
Publication of EP1073471A1 publication Critical patent/EP1073471A1/en
Publication of EP1073471A4 publication Critical patent/EP1073471A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/05—Triphosphoric monoester hydrolases (3.1.5)
    • C12Y301/05001—Triphosphoric monoester hydrolases (3.1.5) dGTPase (3.1.5.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP99920001A 1998-04-27 1999-04-26 METHOD FOR THE TREATMENT OF ENDOTOXEMIA Withdrawn EP1073471A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8321098P 1998-04-27 1998-04-27
US83210P 1998-04-27
PCT/US1999/008934 WO1999055378A1 (en) 1998-04-27 1999-04-26 Method of treating endotoxemia

Publications (2)

Publication Number Publication Date
EP1073471A1 EP1073471A1 (en) 2001-02-07
EP1073471A4 true EP1073471A4 (en) 2005-06-01

Family

ID=22176885

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99920001A Withdrawn EP1073471A4 (en) 1998-04-27 1999-04-26 METHOD FOR THE TREATMENT OF ENDOTOXEMIA

Country Status (8)

Country Link
EP (1) EP1073471A4 (ko)
JP (1) JP2002512984A (ko)
KR (1) KR20010071185A (ko)
CN (3) CN1213768C (ko)
AU (1) AU768497B2 (ko)
CA (1) CA2330033A1 (ko)
HK (1) HK1039565B (ko)
WO (1) WO1999055378A1 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003020979A1 (en) * 2001-08-31 2003-03-13 Rosetta Inpharmactis Llc. Methods for preparing nucleic acid samples
DK1984021T3 (en) * 2006-01-19 2016-12-05 Res Corp Tech Inc VIABLE non-toxic Gram-negative bacteria
CN101805392B (zh) * 2007-07-10 2012-05-02 中国人民解放军第三军医大学野战外科研究所 能阻断lps与md2结合的抗炎抗菌多肽
CN108603199A (zh) * 2015-12-15 2018-09-28 建新公司 用于治疗粘脂贮积症ii型的腺伴随病毒载体
CN114935654B (zh) * 2022-05-26 2023-09-01 四川大学华西医院 检测样本cd72蛋白的试剂或诊断装置在制备检测脓毒症的试剂或试剂盒中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997004001A1 (en) * 1995-07-21 1997-02-06 Temple University - Of The Commonwealth System Of Higher Education Lipopolysaccharide endotoxin response gene and use thereof in screening agents for anti-endotoxemia activity

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
POLTORAK ALEXANDER ET AL: "Defective LPS signaling in C3H/H3J and C57BL/10ScCr mice: Mutations in Tlr4 gene", SCIENCE (WASHINGTON D C), vol. 282, no. 5396, 11 December 1998 (1998-12-11), pages 2085 - 2088, XP002323220, ISSN: 0036-8075 *
See also references of WO9955378A1 *
VOGEL S N ET AL: "Construction of a BALB/c congenic mouse, C.C3H-Lpsd, that expresses the Lpsd allele: analysis of chromosome 4 markers surrounding the Lps gene.", INFECTION AND IMMUNITY. OCT 1994, vol. 62, no. 10, October 1994 (1994-10-01), pages 4454 - 4459, XP008044993, ISSN: 0019-9567 *

Also Published As

Publication number Publication date
AU768497B2 (en) 2003-12-11
HK1039565B (zh) 2005-10-21
CN1307487A (zh) 2001-08-08
KR20010071185A (ko) 2001-07-28
EP1073471A1 (en) 2001-02-07
CN1840659A (zh) 2006-10-04
WO1999055378A1 (en) 1999-11-04
AU3759499A (en) 1999-11-16
CA2330033A1 (en) 1999-11-04
JP2002512984A (ja) 2002-05-08
CN1213768C (zh) 2005-08-10
CN1990865A (zh) 2007-07-04
HK1039565A1 (en) 2002-05-03

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20001127

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Effective date: 20050415

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20051101