ZA973571B - Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2,6-di-alkyl-4-silyl-phenols. - Google Patents

Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2,6-di-alkyl-4-silyl-phenols.

Info

Publication number
ZA973571B
ZA973571B ZA9703571A ZA973571A ZA973571B ZA 973571 B ZA973571 B ZA 973571B ZA 9703571 A ZA9703571 A ZA 9703571A ZA 973571 A ZA973571 A ZA 973571A ZA 973571 B ZA973571 B ZA 973571B
Authority
ZA
South Africa
Prior art keywords
silyl
phenols
alkyl
inflammatory diseases
cell adhesion
Prior art date
Application number
ZA9703571A
Inventor
Paul S Wright
Steven J Busch
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of ZA973571B publication Critical patent/ZA973571B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials
ZA9703571A 1996-04-30 1997-04-24 Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2,6-di-alkyl-4-silyl-phenols. ZA973571B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64147496A 1996-04-30 1996-04-30

Publications (1)

Publication Number Publication Date
ZA973571B true ZA973571B (en) 1997-10-30

Family

ID=24572554

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9703571A ZA973571B (en) 1996-04-30 1997-04-24 Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2,6-di-alkyl-4-silyl-phenols.

Country Status (12)

Country Link
EP (1) EP0910384A1 (en)
JP (2) JP2000509070A (en)
KR (1) KR20000065102A (en)
CN (1) CN1216921A (en)
AR (1) AR006891A1 (en)
AU (1) AU2209097A (en)
BR (1) BR9709189A (en)
CA (1) CA2252869A1 (en)
IL (1) IL126744A0 (en)
NO (1) NO985040L (en)
WO (1) WO1997040837A1 (en)
ZA (1) ZA973571B (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
EP0996623A1 (en) * 1997-06-25 2000-05-03 Hoechst Marion Roussel, Inc. 2,6-DI-t-BUTYL-4- (DIMETHYL-4-METHOXYPHENYLSILYL) -METHYLOXY]PHENOL AND 2,6-DI-t-BUTYL-4- (DIMETHYL-2-METHOXY-PHENYLSILYL) -METHYLOXY]PHENOL
US6632810B2 (en) 2001-06-29 2003-10-14 Kowa Co., Ltd. Cyclic diamine compound with condensed-ring groups
US6509329B1 (en) 2001-06-29 2003-01-21 Kowa Co., Ltd. Cyclic diamine compound with 6-membered ring groups
US6472386B1 (en) 2001-06-29 2002-10-29 Kowa Co., Ltd. Cyclic diamine compound with 5-membered ring groups
US6432957B1 (en) 2001-06-29 2002-08-13 Kowa Co., Ltd. Piperazine derivative
US6552188B2 (en) 2001-06-29 2003-04-22 Kowa Co., Ltd. Unsymmetrical cyclic diamine compound
US6605620B1 (en) 2001-08-30 2003-08-12 Kowa Co., Ltd. Cyclic amine compounds and pharmaceutical composition containing the same
US6867221B2 (en) 2001-08-30 2005-03-15 Kowa Co., Ltd. Cyclic amine compounds and pharmaceutical composition containing the same
US6395753B1 (en) 2001-08-30 2002-05-28 Kowa Co., Ltd. Cyclic amine compounds and pharmaceutical composition containing the same
AU2002363318B2 (en) * 2001-10-25 2008-09-11 Atherogenics, Inc. Compounds and methods for treating transplant rejection
JP2007509054A (en) * 2003-10-17 2007-04-12 アミリン・ファーマシューティカルズ，インコーポレイテッド Silylphenol promotes vascular health
CN1325478C (en) * 2004-04-01 2007-07-11 复旦大学 Nano structured organic photoelectric material, and preparation method

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4670421A (en) * 1982-07-12 1987-06-02 American Cyanamid Company Antiatherosclerotic silanes
US5155250A (en) * 1990-07-05 1992-10-13 Merrell Dow Pharmaceuticals Inc. 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents
US5380747A (en) * 1992-10-30 1995-01-10 Emory University Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
US5608095A (en) * 1996-04-30 1997-03-04 Hoechst Marion Roussel, Inc. Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents

Also Published As

Publication number Publication date
JP2008088183A (en) 2008-04-17
CA2252869A1 (en) 1997-11-06
IL126744A0 (en) 1999-08-17
KR20000065102A (en) 2000-11-06
WO1997040837A1 (en) 1997-11-06
AR006891A1 (en) 1999-09-29
NO985040D0 (en) 1998-10-29
BR9709189A (en) 1999-08-10
AU2209097A (en) 1997-11-19
CN1216921A (en) 1999-05-19
JP2000509070A (en) 2000-07-18
EP0910384A1 (en) 1999-04-28
NO985040L (en) 1998-10-29

Similar Documents

Publication Publication Date Title
ZA983451B (en) Substituted imidazoles useful in the treatment of inflammatory diseases.
GR3036364T3 (en) Compositions and methods for treating or preventing inflammatory diseases
AU5116399A (en) A method of determining and treating the health of a crop
EP0681845A3 (en) Polymer composite implant and method of making the same.
ZA961927B (en) Method of treating cardiac inflammatory disease.
ZA93811B (en) Methods of treating inflammatory dermatoses.
AU3223997A (en) Indwelling magnetically-actuated urinary catheter, and method of its construction
AU5558096A (en) Dual curve ablation catheter and method
EP0643196A3 (en) Consolidatable particulate material and well treatment method.
DE69730483D1 (en) Reduced cross-section catheter
ZA973237B (en) Introducers and assemblies.
ZA967513B (en) Method of treating insulin resistance.
ZA964439B (en) Methods for inhibiting vascular smooth muscle cell migration.
ZA973571B (en) Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2,6-di-alkyl-4-silyl-phenols.
ZA991220B (en) Method of treating heart failure.
ZA991053B (en) Method and composition for treatment of inflammatory conditions.
ZA978918B (en) Metal surface treatment.
ZA966038B (en) Hard composite and method of making the same.
ZA975510B (en) Method for increasing the anti-wettability of a body, body treated in this way and applications thereof.
ZA968990B (en) Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases.
ZA971566B (en) Method of treating leather with pmphoteric polymers.
IL132389A0 (en) Method and composition for treating chronic progressive vascular scarring diseases
ZA973843B (en) Treatment of asthma with TNFR-lg.
ZA965346B (en) Methods of treating neuropeptide Y-associated conditions.
EP0888780A4 (en) Treatment composition for contact lenses and method for treating contact lenses with the same