EP1049670A1 - Azetidincarboxamidderivate zur behandlung von zns-erkrankungen - Google Patents
Azetidincarboxamidderivate zur behandlung von zns-erkrankungenInfo
- Publication number
- EP1049670A1 EP1049670A1 EP99901781A EP99901781A EP1049670A1 EP 1049670 A1 EP1049670 A1 EP 1049670A1 EP 99901781 A EP99901781 A EP 99901781A EP 99901781 A EP99901781 A EP 99901781A EP 1049670 A1 EP1049670 A1 EP 1049670A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- azetidine
- compound according
- carboxamide
- compound
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PVXOUGHWLCBJOW-UHFFFAOYSA-N azetidine-1-carboxamide Chemical class NC(=O)N1CCC1 PVXOUGHWLCBJOW-UHFFFAOYSA-N 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 132
- 208000019901 Anxiety disease Diseases 0.000 claims abstract description 23
- 238000011282 treatment Methods 0.000 claims abstract description 22
- 230000036506 anxiety Effects 0.000 claims abstract description 20
- 206010015037 epilepsy Diseases 0.000 claims abstract description 14
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 11
- 125000003118 aryl group Chemical group 0.000 claims abstract description 11
- 238000011321 prophylaxis Methods 0.000 claims abstract description 10
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 4
- 239000001257 hydrogen Substances 0.000 claims abstract description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 3
- -1 4-(trifluoromethyl)phenyl Chemical group 0.000 claims description 39
- 238000000034 method Methods 0.000 claims description 39
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 16
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims description 15
- 206010022437 insomnia Diseases 0.000 claims description 15
- 239000003814 drug Substances 0.000 claims description 12
- 125000001424 substituent group Chemical group 0.000 claims description 11
- 208000002193 Pain Diseases 0.000 claims description 10
- 238000001356 surgical procedure Methods 0.000 claims description 10
- 125000005843 halogen group Chemical group 0.000 claims description 9
- QLKRYLUAPDTMMK-SECBINFHSA-N 3-(4-fluorophenyl)-n-[(2r)-2-hydroxypropyl]azetidine-1-carboxamide Chemical compound C1N(C(=O)NC[C@H](O)C)CC1C1=CC=C(F)C=C1 QLKRYLUAPDTMMK-SECBINFHSA-N 0.000 claims description 7
- 230000001684 chronic effect Effects 0.000 claims description 7
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 7
- 206010021118 Hypotonia Diseases 0.000 claims description 6
- 230000036640 muscle relaxation Effects 0.000 claims description 6
- 125000001624 naphthyl group Chemical group 0.000 claims description 6
- 208000024891 symptom Diseases 0.000 claims description 6
- 206010053164 Alcohol withdrawal syndrome Diseases 0.000 claims description 5
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- 208000005298 acute pain Diseases 0.000 claims description 5
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- 238000004519 manufacturing process Methods 0.000 claims description 5
- 230000004770 neurodegeneration Effects 0.000 claims description 5
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 238000009101 premedication Methods 0.000 claims description 5
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- 201000009032 substance abuse Diseases 0.000 claims description 5
- 231100000736 substance abuse Toxicity 0.000 claims description 5
- 208000011117 substance-related disease Diseases 0.000 claims description 5
- MUQSWQVSMWULTQ-UHFFFAOYSA-N 3-(4-chlorophenyl)-n-prop-2-enylazetidine-1-carboxamide Chemical compound C1=CC(Cl)=CC=C1C1CN(C(=O)NCC=C)C1 MUQSWQVSMWULTQ-UHFFFAOYSA-N 0.000 claims description 4
- XJGZWCYMWKCJFW-UHFFFAOYSA-N 3-(4-chlorophenyl)-n-prop-2-ynylazetidine-1-carboxamide Chemical compound C1=CC(Cl)=CC=C1C1CN(C(=O)NCC#C)C1 XJGZWCYMWKCJFW-UHFFFAOYSA-N 0.000 claims description 4
- QLKRYLUAPDTMMK-VIFPVBQESA-N 3-(4-fluorophenyl)-n-[(2s)-2-hydroxypropyl]azetidine-1-carboxamide Chemical compound C1N(C(=O)NC[C@@H](O)C)CC1C1=CC=C(F)C=C1 QLKRYLUAPDTMMK-VIFPVBQESA-N 0.000 claims description 4
- JREUHGFVPKPLOH-UHFFFAOYSA-N 3-(4-fluorophenyl)-n-prop-2-ynylazetidine-1-carboxamide Chemical compound C1=CC(F)=CC=C1C1CN(C(=O)NCC#C)C1 JREUHGFVPKPLOH-UHFFFAOYSA-N 0.000 claims description 4
- 125000004122 cyclic group Chemical group 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 208000035475 disorder Diseases 0.000 claims description 4
- FYGMYXQRFFXYFI-UHFFFAOYSA-N n-prop-2-ynyl-3-[3-(trifluoromethyl)phenyl]azetidine-1-carboxamide Chemical compound FC(F)(F)C1=CC=CC(C2CN(C2)C(=O)NCC#C)=C1 FYGMYXQRFFXYFI-UHFFFAOYSA-N 0.000 claims description 4
- HOYZULQJHINVJL-SECBINFHSA-N 3-(4-chlorophenyl)-n-[(2r)-2-hydroxypropyl]azetidine-1-carboxamide Chemical compound C1N(C(=O)NC[C@H](O)C)CC1C1=CC=C(Cl)C=C1 HOYZULQJHINVJL-SECBINFHSA-N 0.000 claims description 3
- HUYMODRJYUULAH-UHFFFAOYSA-N 3-(4-fluorophenyl)-n-prop-2-enylazetidine-1-carboxamide Chemical compound C1=CC(F)=CC=C1C1CN(C(=O)NCC=C)C1 HUYMODRJYUULAH-UHFFFAOYSA-N 0.000 claims description 3
- 125000003342 alkenyl group Chemical group 0.000 claims description 3
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 3
- 125000000304 alkynyl group Chemical group 0.000 claims description 3
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 3
- 125000001153 fluoro group Chemical group F* 0.000 claims description 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 3
- UIZDSIWZGBMXHR-UHFFFAOYSA-N n-prop-2-ynyl-3-[4-(trifluoromethyl)phenyl]azetidine-1-carboxamide Chemical compound C1=CC(C(F)(F)F)=CC=C1C1CN(C(=O)NCC#C)C1 UIZDSIWZGBMXHR-UHFFFAOYSA-N 0.000 claims description 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 2
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 claims description 2
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims description 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 1
- JRHGEHVPXIJESH-SECBINFHSA-N n-[(2r)-2-hydroxypropyl]-3-[4-(trifluoromethyl)phenyl]azetidine-1-carboxamide Chemical compound C1N(C(=O)NC[C@H](O)C)CC1C1=CC=C(C(F)(F)F)C=C1 JRHGEHVPXIJESH-SECBINFHSA-N 0.000 claims 1
- 208000015114 central nervous system disease Diseases 0.000 abstract description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 72
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 57
- 239000000243 solution Substances 0.000 description 49
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 44
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 33
- 239000000203 mixture Substances 0.000 description 32
- 229910001868 water Inorganic materials 0.000 description 27
- 206010010904 Convulsion Diseases 0.000 description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 25
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 18
- 239000012267 brine Substances 0.000 description 17
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 17
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 230000000949 anxiolytic effect Effects 0.000 description 15
- 238000012360 testing method Methods 0.000 description 13
- DKIDEFUBRARXTE-UHFFFAOYSA-N 3-mercaptopropanoic acid Chemical compound OC(=O)CCS DKIDEFUBRARXTE-UHFFFAOYSA-N 0.000 description 11
- IYGJPNAEMKBWCF-UHFFFAOYSA-N 1-benzhydryl-3-(4-fluorophenyl)azetidine Chemical compound C1=CC(F)=CC=C1C1CN(C(C=2C=CC=CC=2)C=2C=CC=CC=2)C1 IYGJPNAEMKBWCF-UHFFFAOYSA-N 0.000 description 10
- LKPALSUBQRWDMZ-UHFFFAOYSA-N 1-benzhydryl-3-(4-tert-butylphenyl)azetidine Chemical compound C1=CC(C(C)(C)C)=CC=C1C1CN(C(C=2C=CC=CC=2)C=2C=CC=CC=2)C1 LKPALSUBQRWDMZ-UHFFFAOYSA-N 0.000 description 10
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 10
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 description 9
- HYMUREYQKUJWIQ-UHFFFAOYSA-N 1-benzhydryl-3-[4-(trifluoromethyl)phenyl]azetidine Chemical compound C1=CC(C(F)(F)F)=CC=C1C1CN(C(C=2C=CC=CC=2)C=2C=CC=CC=2)C1 HYMUREYQKUJWIQ-UHFFFAOYSA-N 0.000 description 8
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 8
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 description 8
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 7
- 239000002249 anxiolytic agent Substances 0.000 description 7
- 229940049706 benzodiazepine Drugs 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 7
- 238000003818 flash chromatography Methods 0.000 description 7
- 230000004044 response Effects 0.000 description 7
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- DMDDOOGJRZVTPH-UHFFFAOYSA-N 1-benzhydryl-3-(4-fluorophenyl)azetidin-3-ol Chemical compound C1C(O)(C=2C=CC(F)=CC=2)CN1C(C=1C=CC=CC=1)C1=CC=CC=C1 DMDDOOGJRZVTPH-UHFFFAOYSA-N 0.000 description 6
- VDECBPZVCMSIKK-UHFFFAOYSA-N 1-benzhydryl-3-(4-tert-butylphenyl)-3-chloroazetidine Chemical compound C1=CC(C(C)(C)C)=CC=C1C1(Cl)CN(C(C=2C=CC=CC=2)C=2C=CC=CC=2)C1 VDECBPZVCMSIKK-UHFFFAOYSA-N 0.000 description 6
- UPXXQMBUBSHBEZ-UHFFFAOYSA-N 3-(4-chlorophenyl)azetidine Chemical compound C1=CC(Cl)=CC=C1C1CNC1 UPXXQMBUBSHBEZ-UHFFFAOYSA-N 0.000 description 6
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 6
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 6
- 239000007832 Na2SO4 Substances 0.000 description 6
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 6
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 description 6
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- 229940079593 drug Drugs 0.000 description 6
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- 229910052938 sodium sulfate Inorganic materials 0.000 description 6
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 5
- ZGTCLZWKESFPIE-UHFFFAOYSA-N 1-benzhydryl-3-(3,4-dichlorophenyl)azetidine Chemical compound C1=C(Cl)C(Cl)=CC=C1C1CN(C(C=2C=CC=CC=2)C=2C=CC=CC=2)C1 ZGTCLZWKESFPIE-UHFFFAOYSA-N 0.000 description 5
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- IRPMIKJQQYLTLF-UHFFFAOYSA-N 1-benzhydryl-3-chloro-3-(4-fluorophenyl)azetidine Chemical compound C1=CC(F)=CC=C1C1(Cl)CN(C(C=2C=CC=CC=2)C=2C=CC=CC=2)C1 IRPMIKJQQYLTLF-UHFFFAOYSA-N 0.000 description 5
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- the present invention relates to chemical compounds useful in the treatment of disorders of the central nervous system (CNS), such as anxiety and all forms of epilepsy, particularly in humans.
- CNS central nervous system
- the invention also relates to the use of such compounds, pharmaceutical preparations containing such compounds and to methods of preparing such compounds.
- Anxiety disorders affect an estimated 73 million people world-wide.
- the benzodiazepines have provided the dominant therapy for anxiety over the past three decades and there is no doubt that they are remarkably effective anxiolytics.
- chronic administration of benzodiazepines produces severe dependence liability, withdrawal syndromes, and side effects (sedation, amnesia, muscle relaxation).
- the only non-benzodiazepine anxiolytic that has been launched over the past decade is the 5-HT receptor ligand buspirone (Buspar ® ).
- This drug has had a remarkable commercial success despite being regarded as a weak anxiolytic (compared with the benzodiazepines) and having a long latency to onset of therapeutic action (2-4 weeks).
- buspirone and all related 5-HT IA partial agonists suffer from a dose-limiting side-effect profile comprising nausea, vertigo and endocrine changes.
- the 5-HT 3 receptor antagonists are now discredited as psychotropics: they have a restricted range of activity in functional and anxiety models; they show no convincing anxiolytic effects in the clinic; and they are now accepted only as useful anti-emetics.
- the 5-HT 2A antagonists similarly are regarded as ineffective in terms of psychotropic activity.
- the clinical utility of 5-HT 1A receptor agonists and partial agonists is severely limited by their intrinsically weak action and by the dose-limiting side-effects (vertigo, endocrine changes, nausea) which become more intense as the agonist efficacy of these molecules is increased.
- the selective CCK B receptor antagonists have displayed an unimpressive preclinical profile similar to that of selective 5-HT ligands such as the 5-HT antagonists.
- Serotonergic anxiolytics include the selective serotonin reuptake inhibitors (SSRIs) which, in addition to displaying antidepressant properties, are also effective in anxiety disorders such as panic disorder and obsessive-compulsive disorder.
- SSRIs selective serotonin reuptake inhibitors
- anxiety disorders such as panic disorder and obsessive-compulsive disorder.
- the major drawback with these compounds is the long delay (6-8 weeks) in the onset of clinical improvement following chronic administration.
- US-4956359 and EP-A-0194112 disclose 3-aryloxy and 3-arylthio azetidinecarboxamides and their anti-convulsant and anti-epileptic activity. These compounds, like the benzodiazepines, have low water solubility which leads to difficulties in formulation.
- the presence of an oxygen or sulphur atom, present as a linking atom between the aryl group and the azetidine ring, is a key feature of these compounds since such atoms can undergo hydrogen-bonding interactions with other molecules, affect molecular conformation and increase electron density in the aryl rings.
- R 1 is aryl
- R 2 is hydrogen or alkyl; and pharmaceutically acceptable addition compounds thereof.
- alkyl means a branched or unbranched, cyclic or acyclic, saturated or unsaturated (e.g. alkenyl or alkynyl) hydrocarbyl radical.
- the alkyl group is preferably C ⁇ to C ]2 , more preferably Ci to C 8 (such as methyl, ethyl, propyl, isopropyl butyl, isobutyl, tert-butyl, amyl, isoamyl, hexyl, heptyl, octyl).
- aryl means a mono or bicyclic aromatic group, such as phenyl or naphthyl.
- alkyl and aryl groups may be substituted or unsubstituted. Where substituted, there will generally be 1 to 3 substituents present, preferably 1 or 2 substituents. Substituents may include:
- alkyl aryl, arylalkyl e.g. substituted and unsubstituted phenyl, substituted and unsubstituted benzyl
- halogen atoms and halogen containing groups such as haloalkyl (e.g. trifluoromethyl)
- oxygen containing groups such as alcohols (e.g. hydroxy, hydroxyalkyl, (aryl)(hydroxy)alkyl), ethers (e.g. alkoxy, alkoxyalkyl, aryloxyalkyl), aldehydes (e.g. carboxaldehyde), ketones (e.g.
- alkylcarbonyl alkylcarbonylalkyl, arylcarbonyl, arylalkylcarbonyl, arylcarbonylalkyl
- acids e.g. carboxy, carboxyalkyl
- acid derivatives such as esters
- amides e.g. aminocarbonyl, mono- or dialkylaminocarbonyl, aminocarbonylalkyl, mono- or dialkylaminocarbonylalkyl, arylaminocarbonyl
- nitrogen containing groups such as amines (e.g. amino, mono- or dialkylamino, aminoalkyl, mono- or dialkylaminoalkyl), azides, nitriles (e.g. cyano, cyanoalkyl), nitro; sulphur containing groups such as thiols, thioethers, sulphoxides and sulphones
- alkylthio alkylsulfinyl, alkylsufonyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, arylthio, arylsulfinyl, arylsulfonyl, arylthioalkyl, arylsulfinylalkyl, arylsulfonylalkyl); and
- Preferred substituents include alkyl, aryl, halo, or an halogen-containing group such as trifluoromethyl.
- alkoxy means alkyl-O- and "alkoyl” means alkyl-CO-.
- halogen means a fluorine, chlorine, bromine or iodine radical, preferably a fluorine or chlorine radical.
- the compounds of formula (1) may exist in a number of diastereomeric and/or enantiomeric forms.
- Reference in the present specification to "a compound of formula (1)" is a reference to all stereoisomeric forms of the compound and includes a reference to the unseparated stereoisomers in a mixture, racemic or non-racemic, and to each stereoisomer in its pure form.
- R 1 is a substituted or unsubstituted aryl group selected from phenyl and naphthyl, more preferably R 1 is a substituted phenyl or naphthyl, more preferably R 1 is phenyl or naphthyl having 1 to 3 substituents and most preferably R 1 is phenyl or naphthyl having 1 or 2 substituents.
- R 1 is a mono- or di-substituted phenyl group, preferably a mono-substituted phenyl group.
- R 1 is napthyl, it is preferred that R 1 is 2-naphthyl.
- the preferred substituent groups are selected from halo (preferably fluoro and chloro), trifluoromethyl and tertiary butyl, and more preferably from fluoro, chloro and trifluoromethyl.
- R 1 is a phenyl having 1 substituent
- the phenyl group is preferably para- or meta-substituted.
- R 1 is a phenyl having 2 substituents
- the phenyl group is preferably 2,3-disubstituted, 2,4-disubstiruted, 3,4-disubstituted or 3,5-disubstituted, preferably 3,4- disubstituted.
- R 1 is disubstituted, it is preferred that R 1 is substituted by two halo groups, the same or different, or by one halo group and one trifluoromethyl group. More preferably, R 1 is dichloro-, difluoro-, chloro-fluoro- or fluoro-trifluoromethyl-substituted.
- the R 1 groups are preferably selected from 4-chlorophenyl, 4-fluorophenyl, 4- (trifluoromethyl)phenyl, 3-(trifluoromethyl)phenyl, 3,4-difluorophenyl, 3,4-dichlorophenyl, 3-chloro-4-fluorophenyl, 4-chloro-3-fluorophenyl, 3-fluoro-4-(trifluoromethyl)phenyl, 4- fluoro-3-(trifluoromethyl)phenyl and 3-chloro-5-fluorophenyl.
- R 2 is alkyl, preferably selected from C ⁇ -8 alkyl, more preferably from alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl and unsubstituted saturated cyclic and acyclic hydrocarbyl, and more preferably from propyl, 2-propenyl, 2-propynyl and 2-hydroxypropyl.
- the preferred compounds are: 3-(4-Chlorophenyl)-N-(2-propynyl)azetidine-l- carboxamide, (S)-3-(4-Fluorophenyl)-N-(2-hydroxypropyl)azetidine- 1 -carboxamide, 3-(4- Fluorophenyl)-N-(2-propynyl)azetidine-l -carboxamide, (R)-3-(4-Fluorophenyl)-N-(2- hydroxypropyl)azetidine- 1 -carboxamide, 3-(4-Chlorophenyl)-N-(2-propenyl)azetidine- 1 - carboxamide, (S)-3-(4-(Trifluoromethyl)phenyl)-N-(2-hydroxypropyl)azetidme- 1 - carboxamide, 3-(3-(Trifluoromethyl)phenyl)-N-(2-propynyl)-
- the compounds of the present invention may be used in the treatment (including prophylaxis) of CNS disorders.
- the compounds of the present invention may be used in the treatment (including prophylaxis) of anxiety, epilepsy, insomnia, including travel insomnia and insomnia associated with terminal illness, alcohol withdrawal syndrome, chronic and acute pain, neurodegenerative diseases (for example, senile dementia) and symptoms related to withdrawal from substance abuse.
- the compounds may also be used in the relief of spasticity.
- the compounds of the present invention may also be used in muscle relaxation prior to surgery or surgical manipulation or as pre-medication prior to surgery.
- the compounds are used in the treatment (including prophylaxis) of anxiety or epilepsy.
- Anxiety includes generalised anxiety disorder (GAD), panic disorder, panic disorder plus agoraphobia, simple (specific) phobias (e.g. arachnophobia, performance anxiety such as public speaking), social phobias, post-traumatic stress disorder, anxiety associated with depression, and obsessive compulsive disorder (OCD).
- GAD generalised anxiety disorder
- panic disorder panic disorder plus agoraphobia
- simple (specific) phobias e.g. arachnophobia, performance anxiety such as public speaking
- social phobias e.g. arachnophobia, performance anxiety such as public speaking
- post-traumatic stress disorder e.g. arachnophobia, performance anxiety such as public speaking
- OCD obsessive compulsive disorder
- Epilepsy is a chronic disorder characterised by recurrent seizures.
- Two forms of epilepsy exist - partial and generalised epilepsy - and each type is subdivided into idiopathic (cause unknown) or symptomatic (cause known).
- a compound of the present invention in the manufacture of a medicament for the treatment (including prophylaxis) of CNS disorders, preferably anxiety, epilepsy, insomnia, including travel insomnia and insomnia associated with terminal illness, alcohol withdrawal syndrome, chronic and acute pain, neurodegenerative diseases, symptoms relating to withdrawal from substance abuse or spasticity, and more preferably anxiety or epilepsy.
- CNS disorders preferably anxiety, epilepsy, insomnia, including travel insomnia and insomnia associated with terminal illness, alcohol withdrawal syndrome, chronic and acute pain, neurodegenerative diseases, symptoms relating to withdrawal from substance abuse or spasticity, and more preferably anxiety or epilepsy.
- a compound of the present invention in the manufacture of a medicament for muscle relaxation prior to surgery or surgical manipulation or as pre-medication prior to surgery.
- the invention further provides a method of treatment (including prophylaxis) of CNS disorders, preferably anxiety, epilepsy, insomnia, including travel insomnia and insomnia associated with terminal illness, alcohol withdrawal syndrome, chronic and acute pain, neurodegenerative diseases, symptoms relating to withdrawal from substance abuse and spasticity, and more preferably anxiety or epilepsy, comprising administering to a patient in need of such treatment an effective dose of a compound according to the present invention.
- a method of treatment including prophylaxis of CNS disorders, preferably anxiety, epilepsy, insomnia, including travel insomnia and insomnia associated with terminal illness, alcohol withdrawal syndrome, chronic and acute pain, neurodegenerative diseases, symptoms relating to withdrawal from substance abuse and spasticity, and more preferably anxiety or epilepsy
- the invention further provides a method of muscle relaxation prior to surgery or surgical manipulation or as pre-medication prior to surgery, comprising administering to a patient in need thereof an effective dose of a compound according to the present invention.
- the 3-aryl-3- azetidinol (III) may be formed by treatment of the ketone (II) with an organometallic reagent such as an aryllithium or an arylmagnesium halide.
- Removal of the hydroxyl group to give the 3-arylazetidine (IV) may be effected by several methods including, for example, catalytic hydrogenolysis; treatment with lithium or sodium and ammonia; conversion to the xanthate by treatment with carbon disulphide, methyl iodide and base, followed by tin-mediated reduction; and conversion to the 3-aryl-3-chloroazetidine analogue using an alkylsulfonyl chloride and a base, followed by a reductive dechlorination using sodium, lithium or nickel. Formation of the azetidine (V) is achieved by reaction of (IV) with a suitable nitrogen deprotection agent.
- deprotection may be carried out by either catalytic transfer hydrogenation (e.g. ammonium formate and palladium catalyst) or by treatment with 1-chloroethyl chloroformate followed by methanol.
- the urea (I) is formed by reaction of azetidine (V) with an N-alkylisocyanate or an N-alkylcarbamoyl chloride and a base such as triethylamine or potassium carbonate.
- the urea may be prepared directly from the azetidine (IV) without isolation of an intermediate such as the secondary amine (V).
- azetidine (IV) may be treated with phosgene followed by amine R 2 NH to give urea (I) directly.
- the invention further provides a pharmaceutical composition comprising a compound according to the present invention in combination with a pharmaceutically acceptable carrier or excipient and a method of making such a composition comprising combining a compound according to the present invention with a pharmaceutically acceptable carrier or excipient.
- Compounds of the present invention may be administered in a form suitable for oral use, for example a tablet, capsule, aqueous or oily solution, suspension or emulsion; for topical use including transmucosal and transdermal use, for example a cream, ointment, gel, aqueous or oil solution or suspension, salve, patch or plaster; for nasal use, for a example a snuff, nasal spray or nasal drops; for vaginal or rectal use, for example a suppository; for administration by inhalation, for example a finely divided powder or a liquid aerosol; for sub-lingual or buccal use, for example a tablet or capsule; or for parenteral use (including intravenous, subcutaneous, intramuscular, intravascular or infusion), for example a sterile aqueous or oil solution or suspension.
- the above compositions may be prepared in a conventional manner using conventional excipients, using standard techniques well known to those skilled in the art of pharmacy.
- the compound is administered or
- the compounds of the invention will generally be provided in the form of tablets or capsules or as an aqueous solution or suspension.
- Tablets for oral use may include the active ingredient mixed with pharmaceutically acceptable excipients such as inert diluents, disintegrating agents, binding agents, lubricating agents, sweetening agents, flavouring agents, colouring agents and preservatives.
- suitable inert diluents include sodium and calcium carbonate, sodium and calcium phosphate, and lactose, while corn starch and alginic acid are suitable disintegrating agents.
- Binding agents may include starch and gelatin, while the lubricating agent, if present, will generally be magnesium stearate, stearic acid or talc.
- the tablets may be coated with a material such as glyceryl monostearate or glyceryl distearate, to delay absorption in the gastrointestinal tract.
- Capsules for oral use include hard gelatin capsules in which the active ingredient is mixed with a solid diluent, and soft gelatin capsules wherein the active ingredient is mixed with water or an oil such as peanut oil, liquid paraffin or olive oil.
- the compounds of the invention will generally be provided in sterile aqueous solutions or suspensions, buffered to an appropriate pH and isotonicity.
- Suitable aqueous vehicles include Ringer's solution and isotonic sodium chloride.
- Aqueous suspensions according to the invention may include suspending agents such as cellulose derivatives, sodium alginate, polyvinyl-pyrrolidone and gum tragacanth, and a wetting agent such as lecithin.
- Suitable preservatives for aqueous suspensions include ethyl and n-propyl p-hydroxybenzoate. It will be appreciated that the dosage levels used may vary over quite a wide range depending upon the compound used, the severity of the symptoms exhibited by the patient and the patient's body weight.
- GABA gamma-aminobutyric acid
- the inhibitor of glutamate decarboxylase (GAD), 3- mercaptopropionic acid (3-MPA) was used as the convulsant challenge agent.
- Anticonvulsant effects of test compounds were determined by their abilities to significantly increase the dose of 3-MPA required to initiate a seizure response.
- mice Male albino T/O strain mice (obtained from Tuck) weighing 28-40 g were used in these studies. Animals were assigned randomly to treatment groups and vehicle or test drug (at a dose of 30mg/kg) were administered p.o. to groups of 12 animals 60 min before the administration of a bolus dose of 3-MPA intravenously. Immediately following 3-MPA administration, each mouse was placed individually into a cage for observation. The seizure response of each animal was scored quantally as present or absent (response or non-response) during the 5 min period immediately following 3-MPA administration. A seizure response was defined as the onset of the initial clonic phase of the seizure (abrupt loss of righting reflex accompanied by vocalisation).
- the seizure threshold (in terms of mg/kg i.v. of 3-MPA required to evoke a seizure response) was determined in each treatment group by a sequential up/down method followed by modified probit analysis of the quantal data.
- a range of doses of 3-MPA was prepared (12.5 - 200.0 mg/kg i.v.) increasing by a constant geometric factor ( 3 V2), which was found in pilot studies to generate suitable data for analysis by this method.
- Test compounds were prepared as solutions dissolved in 45% w/v aqueous 2-hydroxypropyl- ⁇ -cyclodextrin in distilled water. 3-MPA was dissolved in isotonic saline and its pH adjusted to 6 using 1M sodium hydroxide solution. Drugs were administered in a dose volume of 10 ml/kg body weight. The test results are shown in Table 1.
- the elevated "zero-maze” is a modification of the elevated plus-maze model of anxiety which incorporates both traditional and novel ethological measures in the analysis of drug effects (Shepherd, J.K., Grewal, S.S., Fletcher, A., Bill, D J. and Dourish, C.T.,. Behavioural and pharmacological characterisation of the elevated "zero-maze” as an animal model of anxiety. Psychopharmacology, 1994, 116, 56-64). Male Sprague-Dawley rats (Charles River) weighing 300-450 gm are used.
- Animals are group-housed (5 per cage; cage size: 40 x 40 x 20 cm) in a temperature-controlled environment (20 ⁇ 2°C), under a 12h light-dark cycle (lights on: 08:00 hours). Food and water are made freely available. Four hours prior to testing, animals are transferred to clean cages and moved to the testing room in order to habituate to the testing environment.
- the maze is comprised of a black Perspex annular platform (105cm diameter, 10cm width) elevated to 65cm above ground level, divided equally into four quadrants. Two opposite quadrants are enclosed by clear red Perspex walls (27cm high) on both the inner and outer edges of the platform, while the remaining two opposite quadrants are surrounded only by a Perspex "lip" (1cm high) which serves as a tactile guide to animals on these open areas.
- the apparatus is divided into octants by splitting each quadrant into equal halves using high contrast white lines.
- the apparatus is illuminated by dim red lighting arranged in such a manner as to provide similar lux levels in both the open and closed quadrants (40-60 lux).
- a video camera connected to a VCR in an adjacent observation room, is mounted overhead in order to record behaviour on the maze for subsequent analysis.
- Chlordiazepoxide hydrochloride [CDP; Sigma Chemical Co. Ltd., Poole] which has previously been shown to display robust anxiolytic-like effects in the zero-maze, serves as positive control.
- Drugs are typically dissolved in a 45% solution of 2-hydroxy-propyl- ⁇ - cyclodextrin, and administered orally by gavage 1 hour prior to zero-maze testing.
- Rats are placed on a closed quadrant and a 5 min test period is recorded on video-tape.
- the maze is cleaned with a 5% methanol/water solution and dried thoroughly between test sessions.
- Five behavioural parameters are scored: [1] percentage of time spent on the open areas; [2] frequency of head dips over the edge of the platform when subjects are located in either the open or the end of the closed quadrants; [3] frequency of stretch-attend postures (SAP) from closed to open quadrants, determined when the subject, on a closed quadrant, exhibits an elongated body posture stretched forward with at least the snout passing over the open/close divide; [4] frequency of rearing; and [5] the number of line crossings. Animals are scored as being in the open area when all four paws were in an open quadrant, and in the closed area only when all four paws passed over the open/closed divide. All testing is carried out between 1100 and 1700 hours.
- An increase in the frequency of head dips is considered to be a measure of anxiolytic activity.
- the compound of example 6 was found to be effective at a dose of 100 mg/Kg.
- the compound (2) was prepared according to the method of Anderson and Lok (J. Org. Chem. 1972, 37, 3953, the disclosure of which is incorporated herein by reference), m.p. 111- 112 °C (lit. m.p. 113 °C).
- reaction mixture was then partitioned between aqueous ammonium acetate solution (50 mL) and diethyl ether (50 mL).
- aqueous ammonium acetate solution 50 mL
- diethyl ether 50 mL
- the aqueous layer was extracted with diethyl ether (3 x 50 mL) and the combined organic extracts were washed (water, brine), dried (Na SO 4 ), filtered and concentrated in vacuo to give the crude product as a pale yellow viscous oil in quantitative yield.
- This compound was prepared from 3 -(4-chlorophenyl- l-(diphenylmethyl)azetidine (6) and propargylamine using the procedure outlined in Example 3, m.p. 160 °C (diethyl ether). Found C, 62.85; H, 5.38; N, 10.89 C 13 H 13 ClN 2 O requires C, 62.78; H, 5.27; N, 11.26%.
- This compound was prepared from compound (3) and 3,4-dichlorophenylmagnesium bromide using the procedure described for compound (4).
- This compound was prepared from compound (26) and propargylamine using the procedure described for compound (12). m.p. 105.5-107.5°C.
- This compound was prepared from compound (3) and 4-(trifluoromethyl)phenylmagnesium bromide using the procedure described for compound (4).
- This compound was prepared from compound (30) using the procedure described for compound (10).
- This compound was prepared from compound (3) and 3-(trifluoromethyl)phenylmagnesium bromide using the procedure described for compound (4).
- This compound was prepared from compound (32) using the procedure described for compound (10).
- This compound was prepared from compound (38) and (T )-l-amino-2-propanol using the procedure described for compound (12). m.p. 81-82°C.
- This compound was prepared from compound (38) and (S)-l-amino-2-propanol using the procedure described for compound (12). m.p. 80-82°C.
- Footnote a IR: 3373, 3316, 2923, 2855, 1639, 1620, 1557, 1488, 1462, 1434, 1378, 1304, 1153, 815 cm “1 .
- Footnote b IR: 3500, 3429, 3346, 3274, 2925, 2854, 1614, 1556, 1466, 1420, 1407, 1052, 824, 536 cm "1 .
- Footnote c IR: 3414, 3320, 3253, 2925, 2855, 1606, 1544, 1492, 1460, 1376, 1316, 1092,
- Footnote d IR: 3340, 3166, 2923, 2854, 1650, 1613, 1493, 1460, 1378, 1303, 1098, 820 cm "1 .
- Footnote e IR: 3310, 2964, 2878, 1632, 1538, 1494, 1482, 1462, 1398, 1328, 1093, 1015,
- Footnote f compound (102) was made by the oxidation of compound (33), by methods known to those skilled in the art.
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SI9930093T SI1049670T1 (en) | 1998-01-23 | 1999-01-22 | Azetidinecarboxamide derivatives for treating cns disorders |
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GBGB9801499.6A GB9801499D0 (en) | 1998-01-23 | 1998-01-23 | Chemical compounds iii |
GB9824458 | 1998-11-06 | ||
GBGB9824458.5A GB9824458D0 (en) | 1998-11-06 | 1998-11-06 | Chemical compounds II |
PCT/GB1999/000223 WO1999037613A1 (en) | 1998-01-23 | 1999-01-22 | Azetidinecarboxamide derivatives for treating cns disorders |
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US (1) | US6831078B1 (de) |
EP (1) | EP1049670B1 (de) |
JP (1) | JP4542264B2 (de) |
AT (1) | ATE220665T1 (de) |
AU (1) | AU2178099A (de) |
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CN115650893B (zh) * | 2022-10-24 | 2024-08-06 | 南通华祥医药科技有限公司 | 一种1-二苯甲基氮杂环丁烷-3-酮的合成方法 |
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GB872447A (en) | 1958-12-23 | 1961-07-12 | Lepetit Spa | 1-carbamyl-3-substituted azetidines |
US4226861A (en) | 1978-04-18 | 1980-10-07 | A. H. Robins Company, Inc. | N-Lower-alkyl 3-phenoxy-1-azetidinecarboxamides |
IL68699A (en) * | 1982-08-19 | 1986-08-31 | Robins Co Inc A H | 3-phenoxy-1-azetidine-carboxamides,their preparation and pharmaceutical compositions containing them |
US4505907A (en) * | 1982-09-02 | 1985-03-19 | A. H. Robins Company, Inc. | N-Formyl and N-hydroxymethyl-3-phenoxy-1-azetidinecarboxamides |
IE58943B1 (en) | 1985-02-28 | 1993-12-01 | Robins Co Inc A H | 3-Aryloxy-azetidine-carboxamides |
US4956359A (en) * | 1985-02-28 | 1990-09-11 | A. H. Robins Company, Inc. | 3-aryloxy and 3-arylthioazetidinecarboxamides as anticonvulsants and antiepileptics |
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DE69902142D1 (de) | 2002-08-22 |
US6831078B1 (en) | 2004-12-14 |
EP1049670B1 (de) | 2002-07-17 |
WO1999037613A1 (en) | 1999-07-29 |
DE69902142T2 (de) | 2003-01-09 |
ES2181387T3 (es) | 2003-02-16 |
DK1049670T3 (da) | 2002-11-11 |
JP2002501046A (ja) | 2002-01-15 |
JP4542264B2 (ja) | 2010-09-08 |
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PT1049670E (pt) | 2002-12-31 |
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