EP1022991B1 - Ampoules holding an injectable liquid - Google Patents

Ampoules holding an injectable liquid Download PDF

Info

Publication number
EP1022991B1
EP1022991B1 EP98949359A EP98949359A EP1022991B1 EP 1022991 B1 EP1022991 B1 EP 1022991B1 EP 98949359 A EP98949359 A EP 98949359A EP 98949359 A EP98949359 A EP 98949359A EP 1022991 B1 EP1022991 B1 EP 1022991B1
Authority
EP
European Patent Office
Prior art keywords
ampoule
liquid
ampoules
holding
trap
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP98949359A
Other languages
German (de)
French (fr)
Other versions
EP1022991A4 (en
EP1022991A1 (en
Inventor
Yosef Ron Oded Shapira
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Priority to SI9830938T priority Critical patent/SI1022991T1/en
Publication of EP1022991A1 publication Critical patent/EP1022991A1/en
Publication of EP1022991A4 publication Critical patent/EP1022991A4/en
Application granted granted Critical
Publication of EP1022991B1 publication Critical patent/EP1022991B1/en
Priority to CY20131100340T priority patent/CY1113957T1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
    • B65D1/09—Ampoules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/065—Rigid ampoules, e.g. glass ampoules

Definitions

  • the present invention is in the field of ampoules holding an injectable liquid
  • Ampoules are commonly used as primary packaging for liquid drugs and other fluids. After filling, the ampoule is hermetically sealed so that the contents do not interact with the environment. Glass is the preferred material for the manufacture of ampoules due to its chemical inertness which minimizes its interaction with the contents. Attempts to replace glass with other materials, such as plastic, in the manufacture of ampoules have failed due to leakage, cost, or interactions of these material with the contents.
  • a glass ampoule is opened by breaking the ampoule at a constriction located at the bottom of its stem.
  • the glass in the region of the constriction may be weakened apriori or be wakened ad hoc with the aid of an instrument such as a tile, in order to facilitate opening.
  • glass particles are shed from the cut edges into the contents during opening. Particles of a small size are able to penetrate via opening of a syringe needle during withdrawal of liquid from the ampoule and thus may be hazardous when the contents are injected into an individual
  • D1 296 18 100 discloses an ampoule with an arched, concave bottom portion and a circumferential restriction.
  • an ampoule having a bottom formed by a V-shaped circumferential constriction in the side wall of the ampoule which serves as a trap for precipitated solid particulate contaminants and a pocket-like side wall portion which serves as a liquid sump when the ampoule is tilted, whereby essentially contaminant free liquid can be withdrawn from the ampoule.
  • Particles in the trap are separate from the bulk of the liquid in the ampoule so that the liquid may be aspirated into a syringe free of particles.
  • the aforementioned hazards posed by these contaminants are thereby substantially reduced or eliminated.
  • Fig. 1 shows, a sealed ampoule 1 according to the present invention containing a liquid 2 for injection.
  • the ampoule 1 is formed so as to possess a V-shaped circumferential constriction 3 close to its bottom wall 4, dividing between a trap 5 and a circumferential pocket 6 and a second circumferential constriction 7 at the bottom of its stem 8.
  • Fig. 2 shows that the ampoule of Fig. 1 is opened by applying a torque to its stem 8, causing the stem to break at the constriction 7.
  • Fig. 3 shows the ampoule and the detached stem 8 after opening.
  • the ampoule is held tilted so that particulate contaminants 9, such as glass particles shed into the liquid 2 from cut edges 10 and 11 during opening of the ampoule and which have sedimented through the liquid 2, collect in the trap 5 formed between the constriction 3 and the bottom 4.
  • the syringe needle 13 is inserted so that its tip lies in pocket 6, which in the tilted state serves as liquid sump.
  • the liquid 2 is aspirated into the syringe while particles 9 in the trap 5 are not drawn into the syringe needle and consequently the liquid aspirated into the syringe 12 is free of particles which remain in the trap 5 together with an insignificantly small volume of liquid 2.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ceramic Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Water Treatment By Sorption (AREA)

Description

    FIELD OF THE INTENTION
  • The present invention is in the field of ampoules holding an injectable liquid,
    • BACKGROUND OF THE INTENTION
  • Ampoules are commonly used as primary packaging for liquid drugs and other fluids. After filling, the ampoule is hermetically sealed so that the contents do not interact with the environment. Glass is the preferred material for the manufacture of ampoules due to its chemical inertness which minimizes its interaction with the contents. Attempts to replace glass with other materials, such as plastic, in the manufacture of ampoules have failed due to leakage, cost, or interactions of these material with the contents.
  • A glass ampoule is opened by breaking the ampoule at a constriction located at the bottom of its stem. The glass in the region of the constriction may be weakened apriori or be wakened ad hoc with the aid of an instrument such as a tile, in order to facilitate opening. Invariably, glass particles are shed from the cut edges into the contents during opening. Particles of a small size are able to penetrate via opening of a syringe needle during withdrawal of liquid from the ampoule and thus may be hazardous when the contents are injected into an individual
  • D1 296 18 100 discloses an ampoule with an arched, concave bottom portion and a circumferential restriction.
    • SUMMARY OF THE INVENTION
  • It is the purpose of the present invention to provide an ampoule according to claim 1 containing a liquid for injection having a trap for the collection of particulate contaminants.
  • In accordance with the present invention an ampoule is provided having a bottom formed by a V-shaped circumferential constriction in the side wall of the ampoule which serves as a trap for precipitated solid particulate contaminants and a pocket-like side wall portion which serves as a liquid sump when the ampoule is tilted, whereby essentially contaminant free liquid can be withdrawn from the ampoule.
  • Particles in the trap are separate from the bulk of the liquid in the ampoule so that the liquid may be aspirated into a syringe free of particles. The aforementioned hazards posed by these contaminants are thereby substantially reduced or eliminated.
    • DESCRIPTION OF THE DRAWINGS
  • The invention will be described with reference to the following drawings in which:
    • Fig. 1 shows a magnified drawing of an ampoule of the present invention;
    • Fig. 2 shows the method of opening the ampoule of Fig. 1;
    • Fig. 3 shows removal of the contents of the ampoule of Fig. 1 after opening (small ampoule); and
    • Fig. 4 shows removal of the contents of the ampoule of Fig. 1 after opening (bigger ampoule ≥ 10 ml.).
    DETAILED DESCRIPTION OF A SPECIFIC EMBODIMENT
  • Fig. 1 shows, a sealed ampoule 1 according to the present invention containing a liquid 2 for injection. The ampoule 1 is formed so as to possess a V-shaped circumferential constriction 3 close to its bottom wall 4, dividing between a trap 5 and a circumferential pocket 6 and a second circumferential constriction 7 at the bottom of its stem 8. Fig. 2 shows that the ampoule of Fig. 1 is opened by applying a torque to its stem 8, causing the stem to break at the constriction 7.
  • Fig. 3 shows the ampoule and the detached stem 8 after opening. The ampoule is held tilted so that particulate contaminants 9, such as glass particles shed into the liquid 2 from cut edges 10 and 11 during opening of the ampoule and which have sedimented through the liquid 2, collect in the trap 5 formed between the constriction 3 and the bottom 4. For withdrawing liquid from the ampoule 1 into a syringe 12, the syringe needle 13 is inserted so that its tip lies in pocket 6, which in the tilted state serves as liquid sump. In this configuration, the liquid 2 is aspirated into the syringe while particles 9 in the trap 5 are not drawn into the syringe needle and consequently the liquid aspirated into the syringe 12 is free of particles which remain in the trap 5 together with an insignificantly small volume of liquid 2.

Claims (1)

  1. An ampoule (1) containing a liquid (2) for injection having:
    a bottom portion (5) serving as trap for precipitated solid particulate contaminants (9); and
    a pocket-tike side wall portion (6), which when the ampoule (1) is tilted serves as a liquid sump,
    whereby essentially contaminant free liquid (2) can be withdrawn from the ampoule (1),
    characterised in that the pocket-tike side wall portion (6) is formed by a V-shaped circumferential constriction (3) in the side wall of the ampoule (1).
EP98949359A 1997-09-22 1998-09-17 Ampoules holding an injectable liquid Expired - Lifetime EP1022991B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI9830938T SI1022991T1 (en) 1997-09-22 1998-09-17 Ampoules holding an injectable liquid
CY20131100340T CY1113957T1 (en) 1997-09-22 2013-04-25 LIQUID CONSERVATION CARPET WITH INJECTION POSSIBILITY

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93534297A 1997-09-22 1997-09-22
US935342 1997-09-22
PCT/US1998/019377 WO1999015096A1 (en) 1997-09-22 1998-09-17 Ampoules holding an injectable liquid

Publications (3)

Publication Number Publication Date
EP1022991A1 EP1022991A1 (en) 2000-08-02
EP1022991A4 EP1022991A4 (en) 2004-04-07
EP1022991B1 true EP1022991B1 (en) 2013-02-13

Family

ID=25466945

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98949359A Expired - Lifetime EP1022991B1 (en) 1997-09-22 1998-09-17 Ampoules holding an injectable liquid

Country Status (8)

Country Link
EP (1) EP1022991B1 (en)
AU (1) AU9569798A (en)
CY (1) CY1113957T1 (en)
DK (1) DK1022991T3 (en)
ES (1) ES2408697T3 (en)
PT (1) PT1022991E (en)
SI (1) SI1022991T1 (en)
WO (1) WO1999015096A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101341897B1 (en) 2012-07-10 2013-12-16 대한약품공업 주식회사 Plastic ampul
KR101761570B1 (en) * 2017-01-19 2017-07-26 주식회사 네스필러피케이지 Plastic ampule

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1744947A (en) * 1928-10-17 1930-01-28 Owen J Bowman Bottle
US1770093A (en) * 1929-02-15 1930-07-08 Cream Separator Bottle Inc Milk bottle
US2494456A (en) * 1946-03-18 1950-01-10 Kathleen S Still Container
US2644599A (en) * 1951-04-24 1953-07-07 Royden A Blunt Bottle
US3198194A (en) * 1963-05-13 1965-08-03 Upjohn Co Admixing storage container with means preventing inadvertent removal of closure means
US3674028A (en) * 1969-06-04 1972-07-04 Ims Ltd Multi-mix
DE29618100U1 (en) * 1996-10-18 1997-01-23 Bünder Glas GmbH, 32257 Bünde ampoule

Also Published As

Publication number Publication date
EP1022991A4 (en) 2004-04-07
PT1022991E (en) 2013-05-06
DK1022991T3 (en) 2013-04-29
SI1022991T1 (en) 2013-07-31
WO1999015096A1 (en) 1999-04-01
ES2408697T3 (en) 2013-06-21
EP1022991A1 (en) 2000-08-02
CY1113957T1 (en) 2016-07-27
AU9569798A (en) 1999-04-12

Similar Documents

Publication Publication Date Title
US11697114B2 (en) Centrifugation method separating serum or plasma from whole blood using a specimen container having a cap to retain blood cells
US5207320A (en) Compartmented mixing device with bead
US5514339A (en) Stopper of analysis test tubes
AU733770B2 (en) Assembly for collecting blood or other body fluids
US5100010A (en) Containment seal assembly
US4863453A (en) Sterile closure device
EP0366826A1 (en) Swab retaining vial cap
JPH0245056A (en) Ampule
WO1993010001A1 (en) Fluid transfer device
EP0728522B1 (en) Blood collection assembly having additive dispensing means and method for sample collection using same
US20130259771A1 (en) High Bias Gel Tube and Process for Making Tube
AU2002240911A1 (en) Closure for a reagent container
AU616828B2 (en) Liquid collecting tube
EP0187820B1 (en) Sealed container with replaceable plug insert
EP1022991B1 (en) Ampoules holding an injectable liquid
JP3342933B2 (en) Complete removal type container and method
US4659024A (en) Ampul opening device
US4254883A (en) Ampul
US20040232152A1 (en) Safety glass break-seal vessel
JP6818259B2 (en) How to use the injection container, the container containing the injection, the container containing the injection, and the method of storing the injection in the container for storing the injection.
JPH06312758A (en) Container lid structure
AU746794B2 (en) Assembly for collecting blood or other body fluids
JP2021058669A (en) Injection preparation storing container, container with injection preparation, usage for container with injection preparation and method for storing injection preparation in injection preparation storing container

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20000417

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL PAYMENT 20000425;LT PAYMENT 20000425;LV PAYMENT 20000425;MK PAYMENT 20000425;RO PAYMENT 20000425;SI PAYMENT 20000425

A4 Supplementary search report drawn up and despatched

Effective date: 20040219

17Q First examination report despatched

Effective date: 20060628

RIC1 Information provided on ipc code assigned before grant

Ipc: A61J 1/06 20060101ALI20120518BHEP

Ipc: B65D 41/00 20060101ALI20120518BHEP

Ipc: A61B 19/00 20060101AFI20120518BHEP

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 596055

Country of ref document: AT

Kind code of ref document: T

Effective date: 20130215

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 69842960

Country of ref document: DE

Effective date: 20130411

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

REG Reference to a national code

Ref country code: PT

Ref legal event code: SC4A

Free format text: AVAILABILITY OF NATIONAL TRANSLATION

Effective date: 20130426

REG Reference to a national code

Ref country code: SE

Ref legal event code: TRGR

REG Reference to a national code

Ref country code: NL

Ref legal event code: T3

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2408697

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20130621

REG Reference to a national code

Ref country code: GR

Ref legal event code: EP

Ref document number: 20130400921

Country of ref document: GR

Effective date: 20130614

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20131114

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 69842960

Country of ref document: DE

Effective date: 20131114

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FI

Payment date: 20160913

Year of fee payment: 19

Ref country code: NL

Payment date: 20160920

Year of fee payment: 19

Ref country code: GB

Payment date: 20160920

Year of fee payment: 19

Ref country code: DE

Payment date: 20160921

Year of fee payment: 19

Ref country code: DK

Payment date: 20160920

Year of fee payment: 19

Ref country code: IE

Payment date: 20160923

Year of fee payment: 19

Ref country code: MC

Payment date: 20160914

Year of fee payment: 19

Ref country code: CH

Payment date: 20160920

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GR

Payment date: 20160921

Year of fee payment: 19

Ref country code: PT

Payment date: 20160915

Year of fee payment: 19

Ref country code: SE

Payment date: 20160920

Year of fee payment: 19

Ref country code: AT

Payment date: 20160921

Year of fee payment: 19

Ref country code: FR

Payment date: 20160921

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: LU

Payment date: 20161005

Year of fee payment: 19

Ref country code: ES

Payment date: 20160916

Year of fee payment: 19

Ref country code: BE

Payment date: 20160920

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20160922

Year of fee payment: 19

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CY

Payment date: 20160908

Year of fee payment: 19

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 69842960

Country of ref document: DE

REG Reference to a national code

Ref country code: LT

Ref legal event code: MM9D

Effective date: 20170917

REG Reference to a national code

Ref country code: DK

Ref legal event code: EBP

Effective date: 20170930

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170917

Ref country code: FI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170917

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: SE

Ref legal event code: EUG

REG Reference to a national code

Ref country code: NL

Ref legal event code: MM

Effective date: 20171001

REG Reference to a national code

Ref country code: AT

Ref legal event code: MM01

Ref document number: 596055

Country of ref document: AT

Kind code of ref document: T

Effective date: 20170917

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20170917

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180319

Ref country code: MC

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20171002

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20170930

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20171001

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170917

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20180531

Ref country code: SI

Ref legal event code: KO00

Effective date: 20180508

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170930

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170930

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170917

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180404

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170917

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170917

Ref country code: GR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180403

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170917

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170930

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20171002

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20181019

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170930

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION

Effective date: 20181003

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170918

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20170918