JP2021058669A - Injection preparation storing container, container with injection preparation, usage for container with injection preparation and method for storing injection preparation in injection preparation storing container - Google Patents

Abstract

To provide an injection preparation storing container that eliminates the need of additionally fitting a structure for checking opening and can maintain quality of sanitary inside a container until when injection preparation is sucked.SOLUTION: An injection preparation storing container includes: a container body 11 having an insertion surface 13 for an injection needle at one side and an opening on the other side; a protective cover 12 for covering the insertion surface of the container body; and a connection part 15 for connecting the protective cover to the container body. The insertion surface can be penetrated with an injection needle, while the opening on the other side can be hermetically sealed. The connection part is crushed when the protective cover is removed so as to expose the insertion surface to the outside.SELECTED DRAWING: Figure 1

Description

The present invention relates to a container for storing an injection, a container containing an injection, a method for using the container containing an injection, and a method for storing an injection in the container for storing an injection.

Containers for storing or transporting injections are required to maintain a stable sealed state. As such a container, an ampoule bottle or a vial bottle made of glass or plastic is usually used (see, for example, Patent Document 1).

Further, for the purpose of ensuring safety, such a container is required to have a structure that allows easy identification of opened and unopened containers. For example, in the case of Japan, there is a provision in Article 219 of the Pharmaceutical Affairs Law Enforcement Regulations.

For example, in a vial, after an injection is injected into the container body through the opening of the container body, the cap is fitted into the opening of the container body to seal the bottle, and then shrink as a structure for confirming opening. A label is wrapped or a virgin seal is attached. When using vials, they can be peeled off to confirm opening.

On the other hand, in an ampoule bottle, after the injection is injected into the container body through the opening of the container body, the opening of the container body is heat-sealed and sealed. When using an ampoule bottle, a part of the container is cut out in advance to form an injection needle insertion port, so that the opening can be confirmed.

Jikkai Sho 61-159933

By the way, in the vial, after the injection is injected and sealed, a shrink label is wrapped or a virgin seal is attached as a structure for confirming opening. That is, since the structure for confirming the opening is attached separately from the sealing work, it takes time and effort in manufacturing. Further, since the structure for confirming the opening is attached after the sealing work, the work for attaching the structure for confirming the opening is performed not by the manufacturer of the vial but by the manufacturer of the container containing the injection. Therefore, the manufacturer of the container containing an injection needs to separately prepare not only the equipment for injecting the injection and sealing, but also the equipment for attaching the structure for confirming the opening, which is a heavy burden. ..

On the other hand, in the ampoule bottle, since the structure for confirming the opening is automatically created at the same time as the sealing work of the injection, it does not require any manufacturing effort, but by cutting out a part of the container in advance before inserting the injection needle. , The inside of the container is opened to the outside air. Therefore, there is also a problem that the quality of hygiene in the container deteriorates between the time when a part of the container is cut off and the time when the injection needle is inserted and the injection is sucked.

The present invention has been devised in order to effectively solve the above problems by paying attention to the above problems. An object of the present invention is to provide a container for storing an injection, which does not require a separate structure for confirming opening and can maintain the hygienic quality in the container until the time when the injection is aspirated. It is in. Another object of the present invention is to provide a container containing an injection using such a container for storing an injection.

The container for storing an injection of the present invention
A container body that has an injection needle insertion surface on one side and opens on the other side,
A protective cover that covers the insertion surface of the container body,
A connecting portion that connects the protective cover and the container body,
With
The insertion surface is piercable by an injection needle.
The opening on the other side can be sealed and
The connecting portion is broken when the protective cover is removed so that the insertion surface is exposed.
In the injection container for storing the injection of the present invention, the opening on the other side may be sealed in a state where the wall surfaces constituting the opening on the other side are in close contact with each other.
In the injection container of the present invention, the wall surface forming the opening on the other side may be the same thickness or thin as the surrounding portion.
In the injection container for storing the injection of the present invention, the insertion surface may be reinforced by reinforcing ribs provided on the inner peripheral surface of the end of the container body on the insertion surface side.
The container for storing an injection of the present invention further includes a second connecting portion for connecting the protective cover and the container body, and the protective cover is oriented away from the insertion surface with the second connecting portion as a hinge axis. May be rotatable.
In the container for storing injections of the present invention, an inclined portion that narrows the volume inside the container body as it approaches the insertion surface is provided on the inner peripheral surface of the end portion of the container body on the insertion surface side. May be good.
The container containing the injection of the present invention
A container body that has an injection needle insertion surface on one side and opens on the other side,
A protective cover that covers the insertion surface of the container body,
A connecting portion that connects the protective cover and the container body,
Have,
The insertion surface is piercable by an injection needle.
The opening on the other side can be sealed and
The connecting portion is destroyed when the protective cover is removed so that the insertion surface is exposed, and an injection storage container.
The injection stored in the container body of the injection storage container and
With
The opening on the other side of the container body is sealed.
The present invention is the method of using the above-mentioned container containing an injection.
A step of removing the protective cover to expose the insertion surface while breaking the connecting portion, and a step of exposing the insertion surface.
A step is provided in which an injection needle is pierced into the insertion surface from the outside of the container body to suck the injection.
The present invention includes a container body having an injection needle insertion surface on one side and an opening on the other side.
A protective cover that covers the insertion surface of the container body,
A connecting portion that connects the protective cover and the container body,
Have,
The insertion surface is piercable by an injection needle.
The opening on the other side can be sealed and
The connecting portion is a method of storing an injection in an injection storage container, which is destroyed when the protective cover is removed so that the insertion surface is exposed.
A step of injecting an injection into the container body through the opening on the other side of the container body,
The step of sealing the opening on the other side of the container body and
To be equipped.

According to the present invention, it is not necessary to separately attach a structure for confirming opening, and the quality of hygiene in the container can be maintained until the time when the injection is aspirated.

FIG. 1 is a cross-sectional view showing a three-dimensional injection container according to an embodiment of the present invention. FIG. 2 is an enlarged and three-dimensional cross-sectional view of a part of the injection storage container of FIG. FIG. 3 is a cross-sectional view taken along the line AA of the injection storage container of FIG. FIG. 4 is a three-dimensional cross-sectional view showing a container containing an injection using the container for storing the injection of FIG. 1. FIG. 5 is a diagram for explaining a step of removing the protective cover to expose the insertion surface in the container containing the injection of FIG. 4. FIG. 6 is a diagram for explaining a step of sucking the injection from the container containing the injection of FIG. FIG. 7 is a cross-sectional view corresponding to FIG. 2 and is a view for explaining an embodiment in which the insertion surface is reinforced by the reinforcing ribs. FIG. 8 is a cross-sectional view corresponding to FIG. 2, and is a diagram for explaining an embodiment in which a stopper is provided on the ceiling portion of the container body.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. In the drawings attached to the present specification, the scale, aspect ratio, etc. are appropriately changed from those of the actual product and exaggerated for the convenience of easy understanding of the illustration.

FIG. 1 is a cross-sectional view showing a three-dimensional injection container according to an embodiment of the present invention. FIG. 2 is an enlarged and three-dimensional cross-sectional view of a part of the injection storage container of FIG. FIG. 3 is a cross-sectional view taken along the line AA of the injection storage container of FIG.

As shown in FIGS. 1 to 3, the injection storage container 10 according to the present embodiment has a container body 11 having an injection needle insertion surface 13 on one side and an opening on the other side, and insertion of the container body 11. A protective cover 12 that covers the surface 13 and a connecting portion 15 that connects the protective cover 12 and the container body 11 are provided.

Of these, the container body 11 has a substantially cylindrical body portion and a ceiling portion 11b that closes one end of the body portion. An injection needle insertion surface 13 is provided on the ceiling portion 11b that closes one end of the body portion, and an opening 14 is provided on the other end of the body portion.

The axial length of the container body 11 is, for example, 30 mm to 40 mm, and the diameter of the container body 11 is, for example, 10 mm to 20 mm.

The opening 14 on the other side of the container body 11 can be sealed. It is preferable that the opening 14 on the other side of the container body 11 can be sealed in a state where the wall surfaces 11a constituting the opening 14 on the other side are in close contact with each other. In this case, since the container body 11 can be sealed without fitting the cap into the opening 14, the container body 11 can be sealed stably every time, and the sealed state can be stably maintained even if there is vibration such as transportation. it can. Further, in this case, the number of parts is reduced. Examples of the sealing in a state where the wall surfaces 11a constituting the opening 14 on the other side are in close contact with each other include sealing with a heat seal and sealing with an adhesive. In order to facilitate sealing in a state where the wall surfaces 11a forming the other side opening 14 are in close contact with each other, the wall surface 11a forming the other side opening 14 of the container body 11 is a peripheral portion, that is, the wall surface. It is preferable that the thickness is the same as or thinner than the portion adjacent to the ceiling portion 11b side with respect to 11a. Specifically, for example, the thickness T3 of the wall surface 11a forming the opening 14 of the body of the container body 11 is 0.5 mm, and the thickness T2 of the other part of the body is 1.5 mm. ..

Further, in the illustrated example, the insertion surface 13 of the container body 11 is thinner than the peripheral portion thereof, so that the injection needle can easily penetrate the container body 11. The thickness T1 of the insertion surface 13 is, for example, 0.7 mm. (Review Note: The drawing shows the container looking down from diagonally above, and the dome-shaped lines at the locations indicated by symbols 12 and 13 indicate the contour lines on the back side.)

As shown in FIGS. 1 and 2, the insertion surface 13 of the container body 11 is covered with a protective cover 12 to ensure hygiene.

In the illustrated example, the protective cover 12 has a substantially disk shape and is positioned on the outer side of the container body 11 so as to face the insertion surface 13. The diameter of the protective cover 12 is about the same as the diameter of the ceiling portion 11b of the container body 11, for example, 10 mm to 20 mm. A flange portion 12a that projects outward in the radial direction is provided on a part of the outer edge portion of the protective cover 12 in the circumferential direction.

As shown in FIG. 2, the protective cover 12 and the container body 11 are connected by a connecting portion 15 and a second connecting portion 16.

More specifically, the connecting portion 15 and the second connecting portion 16 are provided so as to be sandwiched between the peripheral edge portion surrounding the insertion surface 13 and the peripheral edge portion of the protective cover 12 in the ceiling portion 11b of the container body 11, respectively. ing. As a result, the connecting portion 15 and the second connecting portion 16 do not protrude outward, and the occupied space during storage and transportation becomes compact. Further, as shown in FIG. 3, the connecting portion 15 is positioned at an angle position corresponding to the flange portion 12a in the circumferential direction, and the second connecting portion 16 is 180 ° with the connecting portion 15 in the circumferential direction. It is positioned at a distant angle position.

In the illustrated example, the connecting portion 15 and the second connecting portion 16 each have a rectangular cross section, and the length of one side of the cross section is, for example, 0.3 mm to 1.0 mm.

Of these, the connecting portion 15 can be destroyed when the protective cover 12 is removed so that the insertion surface 13 is exposed. On the other hand, the second connecting portion 16 functions as a hinge shaft when the protective cover 12 is removed so that the insertion surface 13 is exposed.

In the illustrated example, the connecting portion 15 is formed with a "neck" in a part in the axial direction, and the strength against the tensile force in the axial direction is reduced. Therefore, as shown in FIG. 5, when an upward external force is applied to the flange portion 12a of the protective cover 12, the protective cover 12 is rotated in a direction away from the insertion surface 13 with the second connecting portion 16 as a hinge axis. A tensile force in the axial direction is applied to the connecting portion 15, and the connecting portion 15 is destroyed at the "necked" portion.

Further, in the illustrated example, the second connecting portion 16 also has a "neck" formed in a part in the axial direction, and the protective cover 12 is oriented away from the insertion surface 13 with the second connecting portion 16 as a hinge axis. When rotated, the second connecting portion 16 is adapted to be easily curved or bent at the "neck" portion. The cross-sectional area of the "neck" of the second connecting portion 16 is preferably larger than the cross-sectional area of the "neck" of the connecting portion 15. In this case, when the protective cover 12 is rotated with the second connecting portion 16 as a hinge axis in a direction away from the insertion surface 13, it is possible to prevent the second connecting portion 16 from being undesirably broken.

In the present embodiment, as shown in FIG. 2, the volume inside the container body 11 is reduced as it approaches the insertion surface 13 on the inner peripheral surface of the end portion of the body of the container body 11 on the insertion surface 13 side. An inclined portion 17 is provided. In the illustrated example, the inclined portion 17 is provided in a ring shape along the circumferential direction so as to define a conical accommodation space inside the inclined portion 17. The inner diameter of the end portion on the insertion surface 13 side of the accommodation space defined by the inclined portion 17 is smaller than the inner diameter of the end portion on the other side.

The injection container 10 having the above configuration can be manufactured integrally, that is, as one part, for example, by injection molding of a resin using a split mold. A transparent resin is preferably used as the material of the injection container 10, and specifically, for example, polyethylene (PE), polypropylene (PP), cycloolefin polymer (COP), or the like is used. Since the injection container 10 is injection-molded as one part, the number of parts is reduced and the parts can be easily managed at the time of manufacturing.

In the present embodiment, the injection container 10 is manufactured integrally by injection molding of a resin using a split mold, that is, as one part, but the present invention is not limited to this, and for example, The container body 11 and the protective cover 12 may be injection-molded separately, that is, as two parts, and the protective cover 12 injection-molded into the separate body may be adhesively fixed to the ceiling portion 11b of the container body 11 with an adhesive. In this case, the solidified adhesive may form the connecting portion 15.

Next, the injection container 20 using the injection storage container 10 as described above will be described.

FIG. 4 is a schematic side view showing a container 20 containing an injection according to the present embodiment.

As shown in FIG. 4, the container 20 containing an injection according to the present embodiment includes an injection storage container 10 and an injection 21 stored in the container body 11 of the injection storage container 10. The opening 14 on the other side of the container body 11 is sealed by, for example, a heat seal in a state where the wall surfaces 11a constituting the opening 14 on the other side are in close contact with each other. Reference numeral 18 in FIG. 4 indicates a heat-sealed portion.

The volume of the injection 21 stored in the container body 11 is, for example, 1 ml to 2 ml. The type of injection 21 is not particularly limited, but for example, an injection preservative solution containing dendritic cells is assumed.

Next, a method for manufacturing such an injection-containing container 20, that is, a method for storing the injection 21 in the injection storage container 10 will be described.

First, the injection storage container 10 as shown in FIG. 1 is prepared, and the opening 14 of the container body 11 is directed upward.

Next, the injection 21 is injected into the inside of the container body 11 through the opening 14 with the opening 14 of the container body 11 facing upward. In order to prevent the injection 21 from being thermally denatured by the heat seal described later, the liquid level of the injection 21 injected into the container body 11 is separated from the wall surface forming the opening 14 of the container body 11 by about 25 mm. It is preferable to be located.

Next, with the opening 14 of the container body 11 facing upward, the opening 14 of the container body 11 is sealed with, for example, a heat seal in a state where the wall surfaces 11a constituting the opening 14 on the other side are in close contact with each other. To.

Next, a method of using such a container 20 containing an injection will be described.

First, a container 20 containing an injection agent containing the injection agent 21 is prepared. The insertion surface 13 of the injection needle in the injection container 20 is covered with the protective cover 12 and kept clean.

Next, as shown in FIG. 5, an upward external force is applied to the flange portion 12a of the protective cover 12, and the protective cover 12 is rotated in a direction away from the insertion surface 13 with the second connecting portion 16 as a hinge axis. Then, the insertion surface 13 is exposed to the outside. At this time, the second connecting portion 16 is curved or bent at the "necked" portion, and an axial pulling force is applied to the connecting portion 15, and the connecting portion 15 is broken at the "necked" portion.

By breaking the connecting portion 15, it is possible to easily identify that the container 20 may have been used, that is, it is possible to confirm the opening.

Further, since the second connecting portion 16 is curved without being broken, the protective cover 12 remains connected without being separated from the container main body 11. As a result, it is possible to prevent the separated protective cover 12 from falling and cluttering the site.

Next, as shown in FIG. 6, the injection needle 23 of the syringe 22 is pierced into the insertion surface 13 from the outside of the container body 11 with the insertion surface 13 of the container body 11 facing downward, and the injection needle 23 is inserted. The tip of the needle is immersed in the injection 21 stored in the container body 11. Then, the piston 24 of the syringe 22 is pulled to form a negative pressure inside the syringe 25, so that the injection agent 21 is sucked from the container body 11 through the injection needle 23 into the inside of the syringe 25.

In the present embodiment, since the inclined portion 17 that narrows the volume in the container body 11 as it approaches the insertion surface 13 is provided, when the amount of the injection 21 in the container body 11 decreases, the corner portion or the like is provided. It is possible to suppress the formation of a liquid pool and the inability to aspirate, and to reliably aspirate the desired amount of the injection 21.

According to the present embodiment as described above, there is a possibility that the container 20 has been used because the connecting portion 15 is broken when the protective cover 12 is removed so that the insertion surface 13 is exposed. Can be easily identified. Therefore, unlike a vial, there is no need to wrap a shrink label or affix a virgin seal as a structure for confirming opening, and there is no manufacturing effort.

Further, according to the present embodiment, since the insertion surface 13 through which the injection needle 23 can easily penetrate is provided on one side of the container body 11, the injection surface 13 of the container body 11 is injected when the injection is sucked. The injection 21 can be sucked by directly piercing the needle 23. As a result, unlike an ampoule bottle, it is not necessary to cut out a part of the container to open the inside of the container to the outside air, and it is possible to maintain the hygienic quality inside the container until the time when the injection is aspirated.

It is possible to make various changes to the above-described embodiment.

For example, as shown in FIG. 7, the insertion surface 13 of the injection needle may be reinforced by a reinforcing rib 31 provided on the inner peripheral surface of the end portion of the container body 11 on the insertion surface 13 side. In the illustrated example, four reinforcing ribs 31 are provided in the container main body 11 at intervals of 90 ° with respect to the circumferential direction, and the wall thickness of each reinforcing rib 31 is 1.0 mm. The reinforcing rib 31 is injection-molded integrally with other parts of the container body 11. The insertion surface 13 is thinner than the surrounding portion, but by being reinforced by the reinforcing ribs 31 in this way, the injection needle 23 can be easily penetrated at the time of suction of the injection agent, and at the time of storage and transportation. It is possible to improve the strength as a structure.

Further, as shown in FIG. 8, a stopper 32 may be provided on the ceiling portion 11b of the container body 11 so as to project outward. In this case, when the injection needle 23 is pierced into the insertion surface 13 from the outside of the container body 11, the tip of the stopper 32 comes into contact with the end of the syringe 25, thereby restricting further insertion of the injection needle 23. It is possible to prevent the tip of the injection needle 23 from breaking through the heat-sealed portion 18 of the container body 11.

Further, in the above-described embodiment, the opening 14 on the other side of the container body 11 can be sealed in a state where the wall surfaces 11a constituting the opening 14 on the other side are in close contact with each other, but the present invention is not limited to this. For example, the container body 11 may be hermetically sealed by fitting a cap into the opening 14 on the other side. In this case, it is not necessary for the manufacturer of the container containing the injection to prepare special equipment for heat sealing, for example, and the burden is reduced.

Further, in the above-described embodiment, the container body 11 and the protective cover 12 are connected by the connecting portion 15 and the second connecting portion 16, but the present invention is not limited to this, and the second connecting portion 16 is omitted to form the container. The main body 11 and the protective cover 12 may be connected only by the connecting portion 15. In this case, since the protective cover 12 is separated from the container body 11 when the insertion surface 13 is exposed, the protective cover 12 is inserted when the injection needle 23 is pierced into the downwardly facing insertion surface 13 as shown in FIG. Is prevented from hanging from the container body 11 and interfering with the injection needle 23. Further, a plurality of connecting portions 15 may be provided at intervals in the circumferential direction, or may be provided in a ring shape along the circumferential direction. If the insertion surface 13 is provided in a ring shape along the circumferential direction, the hygiene of the insertion surface 13 can be more reliably maintained.

10 Syringe storage container 11 Container body 11a Wall surface 11b that constitutes the opening Ceiling part 12 Protective cover 12a Flange part 13 Insertion surface 14 Opening 15 Connecting part 16 Second connecting part 17 Inclined part 18 Heat-sealed part 20 Contains injection Container 21 Injection 22 Syringe 23 Injection needle 24 Piston 25 Syringe 31 Reinforcing rib 32 Stopper

Claims (1)

A container body that has an injection needle insertion surface on one side and opens on the other side,
A protective cover that covers the insertion surface of the container body,
A connecting portion that connects the protective cover and the container body,
With
The insertion surface is piercable by an injection needle.
The opening on the other side can be sealed and
The connecting portion is a container for storing an injection, which is broken when the protective cover is removed so that the insertion surface is exposed.

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