ES2408697T3 - Ampoules containing an injectable liquid - Google Patents
Ampoules containing an injectable liquid Download PDFInfo
- Publication number
- ES2408697T3 ES2408697T3 ES98949359T ES98949359T ES2408697T3 ES 2408697 T3 ES2408697 T3 ES 2408697T3 ES 98949359 T ES98949359 T ES 98949359T ES 98949359 T ES98949359 T ES 98949359T ES 2408697 T3 ES2408697 T3 ES 2408697T3
- Authority
- ES
- Spain
- Prior art keywords
- liquid
- vial
- cavity
- serves
- retention
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
- B65D1/09—Ampoules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
- A61J1/065—Rigid ampoules, e.g. glass ampoules
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Ceramic Engineering (AREA)
- Mechanical Engineering (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Water Treatment By Sorption (AREA)
Abstract
Una ampolla (1) que contiene un líquido (2) para su inyección y que tiene: una parte de fondo (5) que sirve como una retención para los contaminantes en partículas sólidas precipitados (9); y una parte de pared lateral (6) parecida a una cavidad que, cuando la ampolla (1) se inclina, sirve como un sumidero de líquido, por lo cual el líquido (2) esencialmente libre de contaminantes se puede extraer de la ampolla (1), caracterizada porque la parte de pared lateral parecida a una cavidad está formada por una constricción circunferencial (3) en forma de V practicada en la pared lateral de la ampolla (1).An ampoule (1) containing a liquid (2) for injection and having: a bottom portion (5) serving as a retainer for precipitated solid particulate contaminants (9); and a cavity-like sidewall portion (6) which, when the ampule (1) is tilted, serves as a liquid sump, whereby essentially contaminant-free liquid (2) can be drawn from the ampule ( 1), characterized in that the cavity-like part of the lateral wall is formed by a V-shaped circumferential constriction (3) made in the lateral wall of the blister (1).
Description
Ampollas que contienen un líquido inyectable. Ampoules containing an injectable liquid.
Campo de la invención. Field of the invention.
La presente invención pertenece al campo de las ampollas que contienen un líquido inyectable. The present invention belongs to the field of ampoules containing an injectable liquid.
Las ampollas se usan comúnmente como envases primarios para fármacos líquidos y otros fluidos. Después de llenarla, la ampolla se cierra herméticamente para que el contenido no interaccione con el ambiente. El vidrio es el material preferido para la fabricación de las ampollas debido a su inercia química que minimiza su interacción con el contenido. Los intentos para reemplazar el vidrio con otros materiales, tales como plástico, en la fabricación de ampollas han fracasado debido a las fugas, al coste o a interacciones de estos materiales con el contenido. Blisters are commonly used as primary containers for liquid drugs and other fluids. After filling, the vial is closed tightly so that the content does not interact with the environment. Glass is the preferred material for the manufacture of ampoules due to its chemical inertia that minimizes its interaction with the content. Attempts to replace glass with other materials, such as plastic, in the manufacture of ampoules have failed due to leaks, cost or interactions of these materials with the content.
Una ampolla de vidrio se abre rompiéndola en una constricción situada en el fondo de su vástago. El vidrio de la región de la constricción se podría debilitar a priori o bien debilitarse ad hoc con ayuda de un instrumento como una lima, con el fin de facilitar su apertura. Invariablemente, las partículas de vidrio se albergan desde el borde cortante al contenido durante la apertura. Las partículas de pequeño tamaño son capaces de penetrar a través de la abertura de una aguja de jeringuilla durante la extracción de líquido de la ampolla, y de ese modo podría ser peligroso cuando el contenido se inyecte en una persona. A glass ampoule is opened by breaking it into a constriction located at the bottom of its stem. The glass of the constriction region could be weakened a priori or weakened ad hoc with the help of an instrument such as a file, in order to facilitate its opening. Invariably, the glass particles are housed from the cutting edge to the contents during opening. Small particles are able to penetrate through the opening of a syringe needle during fluid removal from the vial, and thus could be dangerous when the content is injected into a person.
El D1 296 18 100 divulga una ampolla con una parte de fondo, cóncava y arqueada, y una restricción circunferencial. D1 296 18 100 discloses a blister with a bottom, concave and arched, and a circumferential restriction.
Compendio de la invención. Compendium of the invention.
El objeto de la presente invención es proveer una ampolla según la reivindicación 1 que contiene un líquido para su inyección que tiene una retención para la recogida de los contaminantes en partículas. The object of the present invention is to provide a vial according to claim 1 containing a liquid for injection that has a retention for the collection of particulate contaminants.
Según la presente invención, se provee una ampolla que tiene un fondo o parte inferior formado por una constricción circunferencial en forma de V practicada en la pared lateral de la ampolla que sirve como una retención para los contaminantes en partículas sólidas precipitados y una parte de pared lateral parecida a una cavidad que sirve como un sumidero de líquido cuando la ampolla se inclina, por lo cual se puede extraer de la ampolla el líquido esencialmente libre de contaminante. According to the present invention, a blister is provided having a bottom or bottom formed by a V-shaped circumferential constriction practiced on the side wall of the blister that serves as a retention for contaminants in precipitated solid particles and a wall part side resembling a cavity that serves as a liquid sump when the vial is tilted, whereby the essentially contaminant-free liquid can be removed from the vial.
Las partículas contenidas en la retención se separan del grueso de líquido contenido en la ampolla de tal manera que el líquido se podría aspirar en una jeringuilla libre de partículas. Por tanto, se han reducido o limitado sustancialmente los riesgos anteriormente indicados que plantean estos contaminantes. The particles contained in the retention are separated from the bulk of liquid contained in the vial so that the liquid could be aspirated into a particle-free syringe. Therefore, the aforementioned risks posed by these pollutants have been substantially reduced or limited.
Descripción de los dibujos. Description of the drawings.
A continuación se describe la invención con referencia a los siguientes dibujos, en los que: The invention is described below with reference to the following drawings, in which:
La figura 1 presenta un dibujo a escala ampliada de la ampolla de la presente invención; Figure 1 presents an enlarged drawing of the vial of the present invention;
La figura 2 muestra el método de apertura de la ampolla de la figura 1; Figure 2 shows the method of opening the ampoule of Figure 1;
La figura 3 muestra la extracción del contenido de la ampolla de la figura 1 después de abrirla (ampolla pequeña); y Figure 3 shows the removal of the contents of the ampoule of Figure 1 after opening it (small vial); Y
La figura 4 muestra la extracción del contenido de la ampolla de la figura 1 después de abrirla (ampolla de mayor Figure 4 shows the removal of the contents of the blister of Figure 1 after opening (larger blister
tamaño ≥ 10 ml.) size ≥ 10 ml.)
Descripción detallada de una realización específica. Detailed description of a specific embodiment.
La figura 1 muestra, una ampolla 1 herméticamente cerrada según la presente invención que contiene un líquido 2 para su inyección. La ampolla 1 está formada con el fin de que posea una constricción circunferencial 3 en forma de V en un punto muy próximo a su pared de fondo 4, dividiéndose entre una retención 5 y una cavidad circunferencial 6 y una segunda constricción circunferencial 7 en la parte inferior o fondo de su vástago 8. Figure 1 shows, a tightly sealed vial 1 according to the present invention containing a liquid 2 for injection. The ampoule 1 is formed so that it has a circumferential constriction 3 in the form of V at a point very close to its bottom wall 4, dividing between a retention 5 and a circumferential cavity 6 and a second circumferential constriction 7 in the part bottom or bottom of its stem 8.
La figura 2 muestra que la ampolla de la figura 1 se ha abierto mediante la aplicación de un par de torsión a su vástago 8, causando que el vástago se rompa en la constricción 7. Figure 2 shows that the vial of Figure 1 has been opened by applying a torque to its rod 8, causing the rod to break at constriction 7.
La figura 3 muestra la ampolla y el vástago 8 separado después de la apertura. La ampolla se mantiene inclinada para que los contaminantes en partículas 9, tales como partículas de vidrio contenidas en el líquido 2 procedentes de los bordes cortantes 10 y 11 durante la apertura de la ampolla y que se hayan sedimentado a través del líquido 2, se recojan en la retención 5 formada entre la constricción 3 y el fondo 4. Para extraer el líquido de la ampolla 1 en una jeringuilla 12, se inserta la aguja 13 de jeringuilla de tal manera que su punta esté situada en la cavidad 6, que en el estado inclinado sirve como un sumidero de líquido. En esta configuración, el líquido 2 se aspira al interior de la jeringuilla, mientras que las partículas 9 contenidas en la retención 5 no se aspiran a la aguja de la jeringuilla, y por consiguiente el líquido aspirado al interior de la jeringuilla 12 está exento de partículas que permanecen en la retención 5 junto con un volumen insignificantemente pequeño de líquido 2. Figure 3 shows the blister and the stem 8 separated after opening. The vial is kept tilted so that particulate contaminants 9, such as glass particles contained in the liquid 2 from the cutting edges 10 and 11 during the opening of the vial and that have settled through the liquid 2, are collected in the retention 5 formed between the constriction 3 and the bottom 4. To extract the liquid from the ampoule 1 in a syringe 12, the syringe needle 13 is inserted so that its tip is located in the cavity 6, which in the Inclined state serves as a liquid sump. In this configuration, the liquid 2 is aspirated into the syringe, while the particles 9 contained in the retention 5 are not aspirated to the syringe needle, and therefore the liquid aspirated into the syringe 12 is free of particles that remain in the retention 5 together with an insignificantly small volume of liquid 2.
Claims (1)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93534297A | 1997-09-22 | 1997-09-22 | |
US935342 | 1997-09-22 | ||
PCT/US1998/019377 WO1999015096A1 (en) | 1997-09-22 | 1998-09-17 | Ampoules holding an injectable liquid |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2408697T3 true ES2408697T3 (en) | 2013-06-21 |
Family
ID=25466945
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98949359T Expired - Lifetime ES2408697T3 (en) | 1997-09-22 | 1998-09-17 | Ampoules containing an injectable liquid |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1022991B1 (en) |
AU (1) | AU9569798A (en) |
CY (1) | CY1113957T1 (en) |
DK (1) | DK1022991T3 (en) |
ES (1) | ES2408697T3 (en) |
PT (1) | PT1022991E (en) |
SI (1) | SI1022991T1 (en) |
WO (1) | WO1999015096A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101341897B1 (en) | 2012-07-10 | 2013-12-16 | 대한약품공업 주식회사 | Plastic ampul |
KR101761570B1 (en) * | 2017-01-19 | 2017-07-26 | 주식회사 네스필러피케이지 | Plastic ampule |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1744947A (en) * | 1928-10-17 | 1930-01-28 | Owen J Bowman | Bottle |
US1770093A (en) * | 1929-02-15 | 1930-07-08 | Cream Separator Bottle Inc | Milk bottle |
US2494456A (en) * | 1946-03-18 | 1950-01-10 | Kathleen S Still | Container |
US2644599A (en) * | 1951-04-24 | 1953-07-07 | Royden A Blunt | Bottle |
US3198194A (en) * | 1963-05-13 | 1965-08-03 | Upjohn Co | Admixing storage container with means preventing inadvertent removal of closure means |
US3674028A (en) * | 1969-06-04 | 1972-07-04 | Ims Ltd | Multi-mix |
DE29618100U1 (en) * | 1996-10-18 | 1997-01-23 | Buender Glas Gmbh | ampoule |
-
1998
- 1998-09-17 WO PCT/US1998/019377 patent/WO1999015096A1/en active Application Filing
- 1998-09-17 EP EP98949359A patent/EP1022991B1/en not_active Expired - Lifetime
- 1998-09-17 AU AU95697/98A patent/AU9569798A/en not_active Abandoned
- 1998-09-17 PT PT09894935T patent/PT1022991E/en unknown
- 1998-09-17 ES ES98949359T patent/ES2408697T3/en not_active Expired - Lifetime
- 1998-09-17 SI SI9830938T patent/SI1022991T1/en unknown
- 1998-09-17 DK DK98949359.8T patent/DK1022991T3/en active
-
2013
- 2013-04-25 CY CY20131100340T patent/CY1113957T1/en unknown
Also Published As
Publication number | Publication date |
---|---|
SI1022991T1 (en) | 2013-07-31 |
DK1022991T3 (en) | 2013-04-29 |
WO1999015096A1 (en) | 1999-04-01 |
EP1022991A1 (en) | 2000-08-02 |
PT1022991E (en) | 2013-05-06 |
CY1113957T1 (en) | 2016-07-27 |
EP1022991A4 (en) | 2004-04-07 |
EP1022991B1 (en) | 2013-02-13 |
AU9569798A (en) | 1999-04-12 |
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