Classifications

• • C—CHEMISTRY; METALLURGY
  • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
  • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
  • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
  • C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
  • C09K11/07—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials having chemically interreactive components, e.g. reactive chemiluminescent compositions
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
  • A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements

Definitions

• the present invention relates to a lighting element used for the photographic or visual examination of all accessible body cavities. either by direct examination, or by endoscopic method, or by laparoscopy, or in gastric cavity, or in oral cavity, and the use of a chemiluminescent composition for this lighting element.
• the element is, among other things, suitable for screening for vaginal precancerous lesions, either of the cervix or of the uterus itself. It is based, in association with a photographic or visual examination, on the use of a small container in the form of a bulb or pocket filled with a liquid emitting chemiluminescent light attached to the exploration instrument used by the medical examiner.
• a blue-emitting peroxyoxalate chemiluminescent solution is used in the lighting element, to which 10 "1 to 10 ⁇ 2 percent by weight of naphthalimide fluorescent dye" Violett F-570 "from BASF (Ludwigshaven, Germany) are added. ).
• the components according to the invention are advantageously arranged either, as is the case in various prior arts in the field of chemiluminescent lighting - in a container or cylindrical bulb made of flexible translucent plastic, or even in a flexible film pocket of translucent plastic.
• the element thus formed can then advantageously be attached, at the time of the examination, to the medical exploration instrument, speculum in the case of exploration of the hysteroscope vagina in the case of exploration of the uterus.
• This fixation is convenient, but one can however conceive that the lighting element is independent: it can for example be attached to a rod integral with the objective, in the case of photographic examination.
• the use of the lighting element in cylindrical form is particularly indicated in the case of an examination inside the uterus, and the use of an element in the form of a plastic film pocket, flatter and wider appearance, is more suitable for lining the blades of the vaginal exploration speculum, for example by adhesion using a double-sided sticker.
• the user To initiate the chemiluminescent reaction, the user, according to a scheme particularly well known in the prior art, must cause the components contained in the lighting element to mix, for example by breaking, from outside the element , an internal glass ampoule filled with one of the reagents concerned and surrounded by the other reagent (s).
• the light which is created at this instant is emitted in the very light blue color, and this in a very intense manner at the start, then gradually dimming to extinguish after a time of 15 to 30 minutes.
• the activating solution which consists of a solution of hydrogen peroxide added with an alkaline salt, and have this bulb in the solution of oxalate to activate; or do the opposite.
• the subject of the present invention is also the development of several new variants of activating solutions which contribute to making the lighting obtained particularly efficient. For this purpose, an amount of 0.1 to 1% by weight of one or more of the alkaline acid salts is incorporated as catalysts, in a solution of hydrogen peroxide titrating 2.5% to 5% by volume. following:
• Potassium trichlorosalicylate has been shown to be particularly effective.
• the potassium metal can be
• the examining physician m ⁇ performs, during the first minutes of intense lighting, either a photographic or video shot, or a visual diagnosis.
• a lighting element according to the invention which has been given a tubular shape of 65 mm long and about 9.5 mm in diameter, made of translucent polyethylene, for a vaginal diagnostic examination.
• the element is attached to the upper blade of the speculum by a double-sided sticker.
• the mucous membranes are washed in a conventional manner before the examination using dilute acetic acid.
• the shooting as well as the examination with the naked eye and the examination with a magnifying glass, are carried out within 6 minutes of ignition and the immediately subsequent introduction into the vagina of the speculum furnished with the illuminating element.
• Dissolution is obtained by stirring the components for 1 hour at 150 ° C under nitrogen purge.
• an activating solution B is prepared, by mixing, with cold stirring, the following components:
• activator solution B 0.4 ml of activator solution B is placed in a thin-walled, sealed glass ampoule, 45 mm long and 6 mm in diameter, and placed together with 1.2 ml of solution A, in the tubular polyethylene lighting element.
• the doctor slightly folds the polyethylene bulb, which causes the internal glass bulb to break, and the components to mix. A very clear blue light appears.
• the doctor makes a judgment on the visibility of the lesions, both on the photographic test and on visual examination, and makes the comparison with the same examinations carried out both in incandescent electric light, and with the element "Speculite" (TM ) above.
• Example I The procedure is as for Example I, but by reducing, in the activating solution, the dose of potassium trichlorosalicylate from 4 g to 2 g, and by adding 2 g of potassium 5-chlorosalicylate.
• Example II The procedure is as in Example II, here again reducing the dose of potassium trichlorosalicylate to 2 g and adding 2 g of 5-chlorosalicylate.

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• Chemical & Material Sciences (AREA)
• Chemical Kinetics & Catalysis (AREA)
• General Chemical & Material Sciences (AREA)
• Engineering & Computer Science (AREA)
• Materials Engineering (AREA)
• Organic Chemistry (AREA)
• Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Applications Claiming Priority (3)

Publications (1)

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• 1998
  • 1998-09-29 EP EP98946171A patent/EP1018927A1/de not_active Withdrawn
  • 1998-09-29 AU AU93329/98A patent/AU9332998A/en not_active Abandoned
  • 1998-09-29 WO PCT/BE1998/000144 patent/WO1999016342A1/fr not_active Application Discontinuation

Non-Patent Citations (1)

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