EP1009431A4 - Human tumor necrosis factor receptor-like 2 (tr2) antibodies - Google Patents

Human tumor necrosis factor receptor-like 2 (tr2) antibodies

Info

Publication number
EP1009431A4
EP1009431A4 EP98922245A EP98922245A EP1009431A4 EP 1009431 A4 EP1009431 A4 EP 1009431A4 EP 98922245 A EP98922245 A EP 98922245A EP 98922245 A EP98922245 A EP 98922245A EP 1009431 A4 EP1009431 A4 EP 1009431A4
Authority
EP
European Patent Office
Prior art keywords
antibodies
necrosis factor
tumor necrosis
factor receptor
human tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98922245A
Other languages
German (de)
French (fr)
Other versions
EP1009431A1 (en
Inventor
Jeremy A Harrop
Stephen D Holmes
Manjula P Reddy
Alemseged Truneh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Ltd
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd, SmithKline Beecham Corp filed Critical SmithKline Beecham Ltd
Publication of EP1009431A1 publication Critical patent/EP1009431A1/en
Publication of EP1009431A4 publication Critical patent/EP1009431A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
EP98922245A 1997-05-12 1998-05-12 Human tumor necrosis factor receptor-like 2 (tr2) antibodies Withdrawn EP1009431A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4624997P 1997-05-12 1997-05-12
US46249P 1997-05-12
PCT/US1998/009744 WO1998051346A1 (en) 1997-05-12 1998-05-12 Human tumor necrosis factor receptor-like 2 (tr2) antibodies

Publications (2)

Publication Number Publication Date
EP1009431A1 EP1009431A1 (en) 2000-06-21
EP1009431A4 true EP1009431A4 (en) 2000-09-27

Family

ID=21942431

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98922245A Withdrawn EP1009431A4 (en) 1997-05-12 1998-05-12 Human tumor necrosis factor receptor-like 2 (tr2) antibodies

Country Status (4)

Country Link
EP (1) EP1009431A4 (en)
JP (1) JP2001524985A (en)
CA (1) CA2290067A1 (en)
WO (1) WO1998051346A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7427492B1 (en) 1995-06-05 2008-09-23 Human Genome Sciences, Inc. Polynucleotides encoding human tumor necrosis factor receptor-like2
US7118742B2 (en) 1997-07-07 2006-10-10 La Jolla Institute For Allergy And Immunology Ligand for herpes simplex virus entry mediator and methods of use
US6140467A (en) * 1997-07-07 2000-10-31 La Jolla Institute For Allergy And Immunology Ligand for herpes simplex virus entry mediator and methods of use
AU3766700A (en) * 1999-03-22 2000-10-09 Human Genome Sciences, Inc. Human tumor necrosis factor receptor-like 2
WO2001079496A2 (en) * 2000-03-13 2001-10-25 La Jolla Institute For Allergy And Immunology Ligand for herpes simplex virus entry mediator and methods of use
ES2352742T3 (en) * 2000-04-12 2011-02-22 La Jolla Institute For Allergy And Immunology BINDING FOR THE SIMPLE HERPES VIRUS INPUT MEDIATOR AND USE PROCEDURES.
WO2003086301A2 (en) * 2002-04-12 2003-10-23 Human Genome Sciences, Inc. Antibodies that specifically bind to tr2
US20100203047A1 (en) * 2007-10-05 2010-08-12 University Of Maryland, Baltimore Novel Compositions And Methods For Stimulating Erythropoiesis In A Mammal

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994009137A1 (en) * 1992-10-15 1994-04-28 Genentech, Inc. Antibodies against type 2 tumor necrosis factor receptor
WO1996034095A1 (en) * 1995-04-27 1996-10-31 Human Genome Sciences, Inc. Human tumor necrosis factor receptors
WO1997004658A1 (en) * 1995-07-28 1997-02-13 Northwestern University Herpes simplex virus 1 entry into cells mediated by a novel member of the tnf/ngf receptor family

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756096A (en) * 1991-07-25 1998-05-26 Idec Pharmaceuticals Corporation Recombinant antibodies for human therapy
CA2135277C (en) * 1992-05-08 2001-04-24 Alton C. Morgan, Jr. Anti-receptor agents to the vitamin b12/transcobalamin ii receptor
WO1998012344A1 (en) * 1996-09-18 1998-03-26 Human Genome Sciences, Inc. Human tumor necrosis factor receptor-like genes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994009137A1 (en) * 1992-10-15 1994-04-28 Genentech, Inc. Antibodies against type 2 tumor necrosis factor receptor
WO1996034095A1 (en) * 1995-04-27 1996-10-31 Human Genome Sciences, Inc. Human tumor necrosis factor receptors
WO1997004658A1 (en) * 1995-07-28 1997-02-13 Northwestern University Herpes simplex virus 1 entry into cells mediated by a novel member of the tnf/ngf receptor family

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
B. KWON ET AL.: "A newly-identified member of the tumor necrosis factor receptor superfamily.", THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 99, no. 1 part 2, January 1997 (1997-01-01), St. Louis, MO, USA, pages S467, XP000929446 *
J. HARROP ET AL.: "Antibodies to TR2 (herpesvirus entry mediator), a new member of the TNF receptor superfamily, block T cell proliferation, expression of activation markers, and production of cytokines.", THE JOURNAL OF IMMUNOLOGY, vol. 161, no. 4, 15 August 1998 (1998-08-15), Baltimore, MD, USA, pages 1786 - 1794, XP002143292 *
See also references of WO9851346A1 *

Also Published As

Publication number Publication date
EP1009431A1 (en) 2000-06-21
CA2290067A1 (en) 1998-11-19
WO1998051346A1 (en) 1998-11-19
JP2001524985A (en) 2001-12-04

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Legal Events

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Owner name: SMITHKLINE BEECHAM PLC

Owner name: SMITHKLINE BEECHAM CORPORATION

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